AiPD: Autoinhibited Protein Database

Q92503

Gene name	SEC14L1 (SEC14L)
Protein name	SEC14-like protein 1
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6397
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

155-266 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

155-266 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q92503

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q92503-F1	Predicted				AlphaFoldDB

481 variants for Q92503

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs371430429 CA8792172	2	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs144668416 CA294270512	3	Q>*		No	ClinGen ESP
CA401198591 rs1376188644	6	Q>H		No	ClinGen gnomAD
CA401198589 rs1326636998	6	Q>R		No	ClinGen gnomAD
CA401198601 rs1309337675	8	P>S		No	ClinGen TOPMed gnomAD
CA401198619 rs1336590639	11	V>L		No	ClinGen gnomAD
rs1336590639 CA401198618	11	V>M		No	ClinGen gnomAD
CA401198636 rs1567891163	13	K>R		No	ClinGen Ensembl
rs1447477123 CA401195506	22	A>P		No	ClinGen TOPMed
rs1286293639 CA401195538	24	E>Q		No	ClinGen TOPMed
rs1252597469 CA401195569	26	R>T		No	ClinGen gnomAD
CA401195604 rs1199477253	29	T>A		No	ClinGen gnomAD
CA401195638 rs1284085508	31	P>H		No	ClinGen TOPMed
CA401195665 rs1459908475	33	I>T		No	ClinGen gnomAD
CA081098 rs776854628 RCV000208543	34	P>A		No	ClinGen ClinVar ExAC dbSNP gnomAD
rs1225578055 CA401195679	34	P>L		No	ClinGen TOPMed
CA8792195 rs776854628	34	P>T		No	ClinGen ExAC gnomAD
CA8792197 rs1049413	35	M>T		No	ClinGen ESP ExAC TOPMed
rs1049416 CA8792199	37	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
COSM195729 CA8792200 rs1049416 VAR_057173	37	V>M	large_intestine [Cosmic]	No	ClinGen cosmic curated UniProt ESP ExAC TOPMed dbSNP gnomAD
CA8792202 rs759524446	38	G>D		No	ClinGen ExAC TOPMed gnomAD
CA401195716 rs1377519018	39	S>G		No	ClinGen gnomAD
CA401195729 rs1339720998	40	D>E		No	ClinGen gnomAD
CA8792204 rs529549777	40	D>G		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel CA294266223 rs147719854	45	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP TOPMed gnomAD NCI-TCGA
CA8792206 rs777368731	46	K>E		No	ClinGen ExAC gnomAD
rs1049417 CA401195779	47	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1277676329 CA401195782	48	E>K		No	ClinGen TOPMed gnomAD
rs1475467145 CA401195804	51	A>D		No	ClinGen TOPMed
CA8792208 rs140880025	51	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA294266240 rs1049418	52	I>V		No	ClinGen TOPMed gnomAD
CA8792209 rs374486948	55	I>V		No	ClinGen ESP ExAC gnomAD
CA8792210 rs747406443	57	R>M		No	ClinGen ExAC gnomAD
COSM3421924 CA8792211 COSM3421925 rs769299770	58	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs781370833 CA401195849	58	R>H		No	ClinGen ExAC TOPMed gnomAD
rs781370833 CA8792212	58	R>L		No	ClinGen ExAC TOPMed gnomAD
rs773555679 CA401195872	62	D>H		No	ClinGen ExAC TOPMed gnomAD
rs773555679 CA8792216	62	D>N		No	ClinGen ExAC TOPMed gnomAD
rs763304442 CA8792217	62	D>V		No	ClinGen ExAC TOPMed gnomAD
rs770568448 CA8792218	63	V>I		No	ClinGen ExAC gnomAD
CA401195889 rs1215189636	64	D>E		No	ClinGen TOPMed
CA401195888 rs1272603132	64	D>G		No	ClinGen TOPMed
CA401195883 rs1428421214	64	D>N		No	ClinGen gnomAD
TCGA novel	65	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1290490368 CA401195918	69	L>P		No	ClinGen gnomAD
rs1035901834 CA294266510	72	I>M		No	ClinGen TOPMed
rs554918892 CA294266525	76	D>V		No	ClinGen Ensembl
rs773981078 CA8792246	77	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1157294306 CA401195996	79	Y>F		No	ClinGen gnomAD
rs1331392748 CA401196042	85	S>*		No	ClinGen TOPMed
rs578095610 CA8792248 COSM1386288	86	L>P	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
rs578095610 CA8792249	86	L>R		No	ClinGen 1000Genomes ExAC gnomAD
rs760669863 CA8792250	88	S>F		No	ClinGen ExAC TOPMed gnomAD
CA401196060 rs575025415	89	R>G		No	ClinGen TOPMed gnomAD
COSM378237 rs763526107 CA8792252	89	R>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs763526107 CA8792251	89	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA294266562 rs575025415	89	R>W		No	ClinGen TOPMed gnomAD
CA401196073 rs1461500024	91	R>H		No	ClinGen gnomAD
CA401196074 rs1461500024	91	R>P		No	ClinGen gnomAD
TCGA novel	92	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8792253 rs376407245	93	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs879201590 CA294266575	93	L>V		No	ClinGen Ensembl
CA401196091 rs1379639602	94	H>R		No	ClinGen TOPMed
VAR_060480 CA294266600 rs1049422	97	A>G		No	ClinGen UniProt Ensembl dbSNP
CA8792255 rs750093696	98	Y>C		No	ClinGen ExAC gnomAD
VAR_060481 rs1049423 CA294266609	98	Y>H		No	ClinGen UniProt Ensembl dbSNP
TCGA novel	98	Y>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401196122 rs1191052593	99	N>D		No	ClinGen TOPMed
rs1231848737 CA401196128	99	N>K		No	ClinGen gnomAD
rs1295587764 CA401196140	101	T>M		No	ClinGen TOPMed gnomAD
rs768061912 CA8792257	104	N>S		No	ClinGen ExAC TOPMed gnomAD
rs753191916 CA8792258	105	R>W		No	ClinGen ExAC gnomAD
rs200035066 CA8792259	108	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs777669180 CA8792260	109	N>S		No	ClinGen ExAC gnomAD
CA401196227 rs1237146918	111	H>R		No	ClinGen gnomAD
rs749420346 CA8792261	113	C>Y		No	ClinGen ExAC gnomAD
CA8792262 rs757317007	114	Y>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1419939404 CA401196278	115	T>A		No	ClinGen gnomAD
rs750523082 CA8792299	116	V>I		No	ClinGen ExAC gnomAD
CA294267547 rs977114287	117	H>Q		No	ClinGen Ensembl
rs1387744977 CA401196617	117	H>Y		No	ClinGen gnomAD
rs758578867 CA8792300	118	P>L		No	ClinGen ExAC gnomAD
CA401196642 rs1233385918	120	N>I		No	ClinGen gnomAD
TCGA novel rs780217945 CA8792302	120	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC gnomAD NCI-TCGA
rs751837900 CA8792304	123	W>*		No	ClinGen ExAC gnomAD
CA8792303 rs751837900	123	W>C		No	ClinGen ExAC gnomAD
CA401196674 rs1246025387	125	C>S		No	ClinGen TOPMed
TCGA novel	126	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401196715 rs1443206718	130	A>V		No	ClinGen gnomAD
rs548410006 CA8792305	131	S>N		No	ClinGen 1000Genomes ExAC gnomAD
rs748063423 CA8792306	134	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1238054749 CA401196765	137	F>S		No	ClinGen gnomAD
rs748780384 CA8792309	143	T>A		No	ClinGen ExAC
rs1198834491 CA401196814	144	V>E		No	ClinGen TOPMed
rs1286401174 CA401196811	144	V>M		No	ClinGen TOPMed
CA294267582 rs929821669	146	K>T		No	ClinGen Ensembl
CA401196834 rs1598376904	147	I>F		No	ClinGen Ensembl
rs34381783	147	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770618633 CA8792310	148	A>T		No	ClinGen ExAC gnomAD
rs774129327 CA8792311	149	M>I		No	ClinGen ExAC gnomAD
CA294267588 rs1048189359	151	Q>R		No	ClinGen Ensembl
rs1253237578 CA401196884	154	S>N		No	ClinGen gnomAD
rs1313692768 CA401196893	155	N>S		No	ClinGen gnomAD
TCGA novel	159	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401197181 rs1435247434	160	K>R		No	ClinGen gnomAD
rs1416326649 CA401197199	162	I>V		No	ClinGen TOPMed gnomAD
rs777012428 CA8792334	163	I>V		No	ClinGen ExAC TOPMed gnomAD
rs770192180 COSM247236 CA8792336	164	E>*	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA401197211 rs770192180	164	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs766389964 CA8792339	166	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs766389964 CA8792340	166	Y>F		No	ClinGen ExAC TOPMed gnomAD
rs763456421 CA8792338	166	Y>H		No	ClinGen ExAC gnomAD
CA8792341 rs759767028 COSM1225045	168	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA8792342 rs767606459 COSM984816	168	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1002582121 CA294267974	171	E>*		No	ClinGen TOPMed
CA294267980 rs1033778358	171	E>V		No	ClinGen TOPMed
rs952751530 CA294267990	172	E>G		No	ClinGen TOPMed gnomAD
rs1224629793 CA401197274	173	E>D		No	ClinGen TOPMed gnomAD
CA8792344 rs188191523	173	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs866152173 CA294267993	174	G>S		No	ClinGen TOPMed
rs755965082 CA8792345	176	T>A		No	ClinGen ExAC gnomAD
CA294267999 rs747124708	176	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA294268001 rs747124708	176	T>S		No	ClinGen TOPMed gnomAD
rs1255907301 CA401197307	179	P>L		No	ClinGen gnomAD
rs764043651 CA8792346	179	P>S		No	ClinGen ExAC gnomAD
rs753758732 CA8792347	180	R>C		No	ClinGen ExAC gnomAD
CA294268006 rs895124734	182	S>N		No	ClinGen TOPMed
CA8792348 rs757271773	183	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1172692532 CA401197336	184	P>T		No	ClinGen gnomAD
TCGA novel	185	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1211404114 CA401197352	186	I>N		No	ClinGen TOPMed
rs1211404114 CA401197351	186	I>T		No	ClinGen TOPMed
rs202179937 CA8792350	186	I>V		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	187	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1240150 rs1434393210 CA401197363	187	T>M	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
rs673918 CA294268018	188	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746733097 CA8792353	188	T>I		No	ClinGen ExAC gnomAD
TCGA novel	188	T>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
VAR_060482 CA8792352 rs673918	188	T>P		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs673918 CA294268021	188	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8792355 rs773581367	191	E>K		No	ClinGen ExAC gnomAD
rs1380025437 CA401197420	192	T>I		No	ClinGen gnomAD
CA401197428 rs1297147959	193	S>P		No	ClinGen gnomAD
CA401197468 rs1240866570	196	S>F		No	ClinGen TOPMed
CA8792357 rs771461335	198	K>M		No	ClinGen ExAC gnomAD
CA401197503 rs1260633836	199	K>E		No	ClinGen gnomAD
CA401197536 rs1378792482	201	A>V		No	ClinGen TOPMed
CA8792358 rs774964957	202	A>T		No	ClinGen ExAC gnomAD
rs1188338044 CA401197547	202	A>V		No	ClinGen gnomAD
rs1453907493 CA401197565	204	M>V		No	ClinGen gnomAD
rs775566630 CA8792361	205	A>D		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	205	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8792363 rs543667415	206	V>I		No	ClinGen ExAC TOPMed gnomAD
CA8792365 rs201160040	207	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA401197615 rs1451602713	208	I>F		No	ClinGen gnomAD
rs144875330 CA294268038	208	I>T		No	ClinGen ESP gnomAD
rs1451602713 CA401197613	208	I>V		No	ClinGen gnomAD
rs555422453 CA8792368	210	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757832642 CA8792369	211	A>T		No	ClinGen ExAC TOPMed gnomAD
rs200819182 CA8792371	213	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA401197685 rs1453351017	214	K>E		No	ClinGen TOPMed
CA401197704 rs1267626728	215	E>A		No	ClinGen TOPMed
rs1192624005 CA401197750	219	G>S		No	ClinGen TOPMed
CA294268050 rs767971561	220	D>G		No	ClinGen Ensembl
rs1333088984 CA401197754	220	D>N		No	ClinGen Ensembl
rs746353086 CA294268054	221	A>D		No	ClinGen TOPMed gnomAD
CA8792374 rs754648611	221	A>T		No	ClinGen ExAC gnomAD
rs746353086 CA294268056	221	A>V		No	ClinGen TOPMed gnomAD
rs1217215759 CA401197774	222	L>P		No	ClinGen TOPMed
CA401197781 rs1255120381	223	S>R		No	ClinGen gnomAD
CA401197798 rs1277880138	224	S>G		No	ClinGen TOPMed
CA401197830 rs1233302725	225	P>R		No	ClinGen TOPMed
CA401197824 rs1567924190	225	P>S		No	ClinGen Ensembl
rs1047860251 CA294268059	226	S>G		No	ClinGen Ensembl
rs369873363 CA8792377	227	A>T		No	ClinGen ExAC TOPMed gnomAD
CA401197866 rs1406910958	227	A>V		No	ClinGen gnomAD
CA8792379 rs533065668	228	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA401197882 rs1389300350	228	P>H		No	ClinGen gnomAD
CA8792380 rs533065668	228	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8792381 rs775649855	229	E>G		No	ClinGen ExAC gnomAD
CA8792383 rs374759819	231	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs367799028 CA8792384	232	V>M		No	ClinGen ESP ExAC
rs1371551132 CA401197943	233	G>D		No	ClinGen gnomAD
CA401197975 rs1334839409	235	P>H		No	ClinGen gnomAD
rs1289509591 CA401197970	235	P>S		No	ClinGen gnomAD
CA401197992 rs1231498200	236	D>G		No	ClinGen TOPMed gnomAD
TCGA novel	244	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773345347 CA8792425	245	K>E		No	ClinGen ExAC gnomAD
rs770687186 CA8792427	247	Y>S		No	ClinGen ExAC gnomAD
CA294268602 rs939180121 COSM164236	250	D>N	NS [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs939180121 CA401198381	250	D>Y		No	ClinGen TOPMed gnomAD
CA401198394 rs1598382266	252	T>P		No	ClinGen Ensembl
rs759470211 CA8792429 COSM984818	253	P>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs775007202 CA8792431	258	C>S		No	ClinGen ExAC gnomAD
rs201907210 CA294268610	259	L>P		No	ClinGen 1000Genomes
CA8792432 rs760207762	260	I>V		No	ClinGen ExAC TOPMed gnomAD
CA8792435 rs143538717	263	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA8792436 rs766918459	263	R>H		No	ClinGen ExAC gnomAD
CA8792434 rs143538717	263	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA8792437 rs752045564	264	Q>R		No	ClinGen ExAC gnomAD
CA401198487 rs1598382362	266	L>H		No	ClinGen Ensembl
rs1598382378 CA401198494	267	Q>P		No	ClinGen Ensembl
rs1208867619 CA401198505	268	E>D		No	ClinGen gnomAD
rs1177698597 CA401198518	270	H>L		No	ClinGen TOPMed
rs748227073 CA8792440	270	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA294268633 rs940487037	273	K>E		No	ClinGen Ensembl
rs369833306 CA8792470	275	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA294273880 rs202211531	276	K>E		No	ClinGen 1000Genomes
rs759963930 CA401199096	277	D>G		No	ClinGen ExAC gnomAD
CA8792473 rs769539109	277	D>H		No	ClinGen ExAC TOPMed gnomAD
rs759963930 CA8792474	277	D>V		No	ClinGen ExAC gnomAD
CA8792472 rs769539109	277	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA401199126 rs1408931172	281	L>P		No	ClinGen TOPMed
rs868447396 CA294273886 COSM277197 COSM1736616	282	R>W	large_intestine Variant assessed as Somatic; impact. central_nervous_system [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA8792475 COSM3755910 rs373529746 COSM3755909	285	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs753178696 CA8792476	285	R>H		No	ClinGen ExAC TOPMed
rs150829875 CA8792477	287	R>W		No	ClinGen ESP ExAC gnomAD
CA401199203 rs1483605921	293	K>R		No	ClinGen gnomAD
rs1187778224 CA401199230	297	I>F		No	ClinGen gnomAD
CA8792478 rs142447733	297	I>N		No	ClinGen 1000Genomes ExAC gnomAD
CA294273891 rs893457804	298	M>I		No	ClinGen TOPMed
CA294273895 rs1010662538	302	L>W		No	ClinGen TOPMed
CA8792480 rs139227620	303	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA294273900 rs947110420	311	D>N		No	ClinGen Ensembl
TCGA novel	312	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1460702372 CA401199344	313	I>L		No	ClinGen TOPMed gnomAD
CA401199345 rs1460702372	313	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	314	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs375660465 CA8792483	314	L>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA8792482 rs779087898	314	L>V		No	ClinGen ExAC gnomAD
CA401199368 rs1430170166	316	T>I		No	ClinGen gnomAD
CA401199377 rs1312187194	317	W>C		No	ClinGen gnomAD
CA401199381 rs1376973272	318	T>N		No	ClinGen gnomAD
rs779719698 CA8792485	319	P>S		No	ClinGen ExAC gnomAD
CA8792486 rs530981190	321	Q>P		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	327	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8792488 rs147283848	328	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA401199517 rs1343249500	328	A>V		No	ClinGen gnomAD
rs1278804180 CA401199559	331	W>C		No	ClinGen gnomAD
CA8792490 rs769483985	334	H>D		No	ClinGen ExAC
CA401200155 rs1363217168	339	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs770517600 CA8792512	339	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1461447390 CA401200166	341	L>F		No	ClinGen TOPMed
COSM135777 CA8792515 rs144852225	343	V>M	skin [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1370100238 CA401200191	345	R>T		No	ClinGen gnomAD
rs1251422764 CA401200197	346	L>V		No	ClinGen TOPMed
rs1229512015 CA401200201	347	G>R		No	ClinGen TOPMed
rs777121236 CA8792516	357	A>V		No	ClinGen ExAC TOPMed gnomAD
CA8792519 rs373124926	359	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs966559484 CA294274824	361	E>K		No	ClinGen TOPMed
rs1489334360 CA401200304	362	A>P		No	ClinGen gnomAD
rs1164561331 CA775255779	366	Y>*		No	ClinGen TOPMed
rs1471594951	366	Y>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1441820067 CA401200363	369	S>Y		No	ClinGen gnomAD
CA8792548 rs566450330	370	I>M		No	ClinGen 1000Genomes ExAC
rs758094473 CA8792550	376	R>G		No	ClinGen ExAC
CA401200415 rs1385481222	377	R>*		No	ClinGen TOPMed
rs142961659 CA8792551 COSM1240151	377	R>Q	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs947024358 CA294275321	379	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA401200444 rs1458158249	381	N>S		No	ClinGen TOPMed
rs1419309214 CA401200454 COSM1225046	382	T>I	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs539907146 CA8792553	383	K>E		No	ClinGen ExAC TOPMed gnomAD
CA401200483 rs1359744783	387	R>Q		No	ClinGen gnomAD
CA8792555 COSM1225044 rs749805474	387	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	389	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA294275328 rs761159765	389	I>V		No	ClinGen TOPMed gnomAD
CA401200706 rs1265638251	392	W>G		No	ClinGen gnomAD
rs1265638251 CA401200705	392	W>R		No	ClinGen gnomAD
rs745935812 CA8792575	395	L>V		No	ClinGen ExAC gnomAD
CA8792577 rs775853361	396	V>L		No	ClinGen ExAC gnomAD
rs1201546704 CA401200749	398	L>W		No	ClinGen gnomAD
CA8792579 rs768516993	399	E>*		No	ClinGen ExAC gnomAD
TCGA novel	404	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1264891219 CA401200834	410	G>A		No	ClinGen TOPMed
rs1457850017 CA401200831	410	G>R		No	ClinGen gnomAD
rs773073211 CA8792583	416	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA401200866 rs2280271	416	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA401200885 rs765876596	419	E>K		No	ClinGen ExAC TOPMed gnomAD
CA8792585 rs765876596	419	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1567933792 CA401200895	420	V>A		No	ClinGen Ensembl
rs1388156205 CA401200902	421	V>G		No	ClinGen TOPMed
rs1228530434 CA401200917	424	N>H		No	ClinGen gnomAD
CA294275577 rs144601920	428	T>I		No	ClinGen ESP TOPMed
CA8792588 rs764322549	431	R>C		No	ClinGen ExAC gnomAD
CA8792589 rs368040924	431	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8792590 rs757609461	432	L>F		No	ClinGen ExAC gnomAD
rs779458960 CA8792591	436	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs781464999 CA8792616	450	P>L		No	ClinGen ExAC gnomAD
TCGA novel	453	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769572555 CA8792618	453	D>N		No	ClinGen ExAC gnomAD
CA401201119 rs1308483211	454	D>H		No	ClinGen gnomAD
CA401201126 rs1233071553	455	N>H		No	ClinGen TOPMed gnomAD
CA401201129 rs1203294424	455	N>T		No	ClinGen TOPMed
CA294275689 rs946718047	461	L>F		No	ClinGen TOPMed gnomAD
rs749183190 CA8792620	462	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	464	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8792622 rs774316952	466	N>D		No	ClinGen ExAC gnomAD
CA401201210 rs1391743854	467	D>H		No	ClinGen gnomAD
rs1175255799 CA401201233	470	G>R		No	ClinGen gnomAD
rs1038579355 CA294275691	471	P>L		No	ClinGen TOPMed
CA8792625 rs775144695	477	Y>H		No	ClinGen ExAC gnomAD
CA8792627 rs146702569	478	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA294275694 rs200758467	479	D>H		No	ClinGen ExAC TOPMed gnomAD
rs200758467 CA8792628	479	D>N	Variant assessed as Somatic; 0.0001855 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA401201286 rs200758467	479	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs1370826591 CA401201293	480	K>E		No	ClinGen TOPMed
CA401201334 rs1432394558	484	P>A		No	ClinGen gnomAD
CA401201344 rs1363015858	485	D>H		No	ClinGen gnomAD
rs371973364 CA8792629	488	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs766971951 CA8792630	488	S>R		No	ClinGen ExAC gnomAD
CA294275699 rs1050255216	488	S>R		No	ClinGen gnomAD
CA401201400 rs1224174984	489	G>E		No	ClinGen gnomAD
rs554567260	493	C>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA401202132 rs1272063588	493	C>F		No	ClinGen TOPMed gnomAD
CA8792648 rs763399110	494	E>K		No	ClinGen ExAC TOPMed gnomAD
CA401202157 rs1285180292	496	P>T		No	ClinGen gnomAD
rs989792642 CA294276364	499	G>E		No	ClinGen Ensembl
CA401202200 CA401202198 rs1219676710	499	G>R		No	ClinGen TOPMed gnomAD
rs752053579 CA8792650	501	V>I		No	ClinGen ExAC gnomAD
rs752178447 CA294276369	503	K>R		No	ClinGen TOPMed gnomAD
rs371391724 CA294276371	505	L>V		No	ClinGen TOPMed gnomAD
rs1471319795 CA401202331	507	R>G		No	ClinGen TOPMed gnomAD
CA401202335 rs1183761964	507	R>Q		No	ClinGen gnomAD
CA401202333 rs1471319795	507	R>W		No	ClinGen TOPMed gnomAD
CA8792652 rs759980906	509	A>P		No	ClinGen ExAC gnomAD
rs759980906 CA8792651	509	A>T		No	ClinGen ExAC gnomAD
rs752687715 CA8792653	510	E>K	Variant assessed as Somatic; 4.622e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs756263182 CA8792654	511	E>*		No	ClinGen ExAC TOPMed gnomAD
CA401202384 rs756263182	511	E>K		No	ClinGen ExAC TOPMed gnomAD
CA401202398 rs1170373631	511	E>V		No	ClinGen TOPMed
CA401202424 rs756976977	513	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA401202441 rs140278418	514	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs745772340 CA8792659	515	E>D		No	ClinGen ExAC gnomAD
CA401202498 rs1446176479	518	K>N		No	ClinGen TOPMed gnomAD
rs758302839 CA8792661	521	T>P		No	ClinGen ExAC TOPMed gnomAD
rs758302839 CA8792660	521	T>S		No	ClinGen ExAC TOPMed gnomAD
CA8792662 rs746480471	524	I>V		No	ClinGen ExAC gnomAD
rs1462569903 CA401202603	527	S>T		No	ClinGen TOPMed
CA8792664 rs377578365	529	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs747815134 CA8792665	529	S>N		No	ClinGen ExAC gnomAD
COSM76363 CA8792667 rs774609620	530	V>I	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA8792668 RCV000970797 rs143320926	534	A>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA401202733 rs1179692590	536	H>D		No	ClinGen gnomAD
CA8792699 rs754995888	539	L>V		No	ClinGen ExAC gnomAD
CA8792701 rs752233244	540	I>T		No	ClinGen ExAC gnomAD
CA294277131 rs149537075	543	V>A		No	ClinGen ESP
CA294277133 rs948191599	546	S>L		No	ClinGen TOPMed gnomAD
CA8792703 rs777283135	549	I>N		No	ClinGen ExAC TOPMed gnomAD
rs1477299997 CA401203065	549	I>V		No	ClinGen gnomAD
CA8792705 rs748971355	550	T>A		No	ClinGen ExAC gnomAD
CA294277141 rs1038843617	550	T>S		No	ClinGen TOPMed
rs748971355 CA8792704	550	T>S		No	ClinGen ExAC gnomAD
CA8792706 rs780492684	552	D>G		No	ClinGen ExAC gnomAD
rs1456791711 CA401203106	552	D>Y		No	ClinGen TOPMed gnomAD
CA401203576 rs1402210474	554	D>N		No	ClinGen gnomAD
rs777176254 CA8792709	555	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs761868033 CA8792710	557	K>R		No	ClinGen ExAC
rs200380974 CA8792711	560	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1227312276 CA401203692	564	I>M		No	ClinGen gnomAD
CA8792713 rs200195840	565	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA401203694 rs896534728	565	Y>D		No	ClinGen gnomAD
rs896534728 CA294277152	565	Y>H		No	ClinGen gnomAD
rs766045456 CA8792714	568	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1450243922 CA401203715	568	K>R		No	ClinGen gnomAD
COSM1710840 COSM1710839 rs373923048 CA294277160	570	S>L	skin [Cosmic]	No	ClinGen cosmic curated ESP TOPMed gnomAD
CA294277165 rs1009222698	573	P>S		No	ClinGen TOPMed
rs1390703348 CA401203770	576	K>T		No	ClinGen TOPMed
CA401203790 rs1389671368	579	L>P		No	ClinGen gnomAD
rs78105087 CA8792724	581	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs78105087 CA8792725	581	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs781662548 CA8792726	582	H>Y		No	ClinGen ExAC gnomAD
CA8792727 rs748659173	583	S>G		No	ClinGen ExAC gnomAD
rs769706573 CA8792728	583	S>N		No	ClinGen ExAC TOPMed gnomAD
CA294277180 rs995835667	585	T>I		No	ClinGen TOPMed gnomAD
rs143885262 CA8792731	587	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs138920965 CA8792730	587	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs147239749 CA8792733	588	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143077359 CA294277189	590	N>D		No	ClinGen ESP TOPMed
rs1598408448 CA401203862	591	N>S		No	ClinGen Ensembl
CA8792736 rs760680963	592	V>A		No	ClinGen ExAC gnomAD
CA401203866 rs1252674494	592	V>M		No	ClinGen gnomAD
rs1367003282 CA401203885	595	I>L		No	ClinGen gnomAD
rs953211277 CA294277195	595	I>T		No	ClinGen TOPMed
rs1442509346 CA401203909	598	V>I		No	ClinGen TOPMed gnomAD
TCGA novel	598	V>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401203915 rs1598408499	599	W>G		No	ClinGen Ensembl
CA8792738 rs753360667	600	Q>R		No	ClinGen ExAC
CA8792739 rs756770033	602	G>D		No	ClinGen ExAC TOPMed gnomAD
CA8792740 rs369232367	603	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA401203940 rs369232367	603	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8792741 rs750143362	603	R>H		No	ClinGen ExAC gnomAD
COSM1265122 rs1333091981 CA401203945	604	D>N	oesophagus [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA294277207 rs371802733	606	S>G		No	ClinGen ESP
rs375253428 CA8792743	606	S>N		No	ClinGen ESP ExAC gnomAD
CA401203968 rs1567938600	607	M>T		No	ClinGen Ensembl
CA8792744 rs748607738	607	M>V		No	ClinGen ExAC gnomAD
CA8792745 rs756610867	608	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1357862798 CA401203973	608	V>M		No	ClinGen Ensembl
rs577941050 CA8792746	610	S>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs553388966 CA8792748	612	L>R		No	ClinGen 1000Genomes ExAC gnomAD
rs746097901 CA8792750	613	I>M		No	ClinGen ExAC gnomAD
CA8792749 rs774644762	613	I>S		No	ClinGen ExAC gnomAD
rs771941198 CA401204014	615	K>E		No	ClinGen ExAC gnomAD
rs771941198 CA8792751	615	K>Q		No	ClinGen ExAC gnomAD
rs1254019870	616	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8792752 rs775454713	616	E>G		No	ClinGen ExAC gnomAD
rs930042519 CA294277226	619	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs760430269 CA8792753	620	V>M		No	ClinGen ExAC gnomAD
rs764073785 CA8792754	621	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA401204104 rs1199572174	626	T>N		No	ClinGen TOPMed gnomAD
rs1410610149 CA401204106	627	R>G		No	ClinGen gnomAD
CA8792790 rs147825324	629	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8792792 rs780874685	631	F>L		No	ClinGen ExAC TOPMed gnomAD
CA401204143 rs1457772423	632	Y>C		No	ClinGen gnomAD
CA401204140 rs1228326571	632	Y>H		No	ClinGen Ensembl
TCGA novel	633	I>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8792793 rs748081978	635	Q>R		No	ClinGen ExAC gnomAD
rs778131840 CA294277566	638	F>L		No	ClinGen TOPMed
rs773188659 CA8792795	640	S>G		No	ClinGen ExAC TOPMed gnomAD
CA401204201 rs1598410383	640	S>T		No	ClinGen Ensembl
rs1225623534 CA401204225	643	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA8792798 rs773996990	645	A>S		No	ClinGen ExAC TOPMed gnomAD
rs773996990 CA401204235	645	A>T		No	ClinGen ExAC TOPMed gnomAD
CA8792799 rs565049186	646	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
TCGA novel	648	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401204255 rs1223168765	648	S>N		No	ClinGen gnomAD
COSM1710842 CA8792800 COSM1710841 rs764477669	649	L>F	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs114161301 RCV000907085 CA8792801	650	P>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA8792803 rs372869341	651	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1598410495 CA401204275	652	V>M		No	ClinGen Ensembl
rs751039561 CA8792804	653	D>Y		No	ClinGen ExAC gnomAD
rs776943334 CA8792806	654	D>N		No	ClinGen ExAC gnomAD
rs751760592 CA401204294	655	V>L		No	ClinGen ExAC TOPMed gnomAD
rs751760592 COSM473428 CA8792807	655	V>M	kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs749232562 CA8792813	660	Q>L		No	ClinGen ExAC gnomAD
rs1018849782 CA294277596	662	S>F		No	ClinGen TOPMed
rs770426103 CA8792814	663	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1567939810 CA401204347	664	H>P		No	ClinGen Ensembl
CA8792816 rs745423119	664	H>Y		No	ClinGen ExAC gnomAD
CA401204364 rs1206061901	666	C>Y		No	ClinGen gnomAD
rs1233076685 CA401204373	667	K>T		No	ClinGen gnomAD
rs1567939827 CA401204377	668	V>L		No	ClinGen Ensembl
rs1348458067 CA401204388	669	M>I		No	ClinGen TOPMed
CA8792818 rs775273700	672	T>A		No	ClinGen ExAC gnomAD
rs528782418 CA294277606	673	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs762265838 CA8792819	674	V>A		No	ClinGen ExAC gnomAD
rs1245289017 CA401204419	674	V>M		No	ClinGen gnomAD
rs773798440 CA8792821	676	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA294277614 COSM1582355 rs918646551	677	S>L	stomach [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
TCGA novel	678	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401204453 rs1271931278	679	D>G		No	ClinGen Ensembl
CA8792822 rs547610274	680	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA401204481 rs1236669396	681	R>S		No	ClinGen TOPMed gnomAD
rs200675740 CA8792906	685	T>M		No	ClinGen 1000Genomes ExAC
rs766287124 CA8792910	688	E>K		No	ClinGen ExAC gnomAD
rs146654495 CA294277794	690	S>N		No	ClinGen ESP TOPMed
rs935090302 CA294277799	693	G>D		No	ClinGen Ensembl
rs1417680404 CA401204558	693	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA401204582 rs1598411770	696	Q>P		No	ClinGen Ensembl
CA401204596 rs1192126844	698	S>R		No	ClinGen TOPMed
rs989247787 CA294277801	699	A>G		No	ClinGen TOPMed gnomAD
CA8792918 rs375335873	700	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs375335873 CA401204603	700	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8792917 rs375335873	700	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs753435985 CA8792919	701	T>P		No	ClinGen ExAC
CA8792920 rs758705868	701	T>S		No	ClinGen ExAC gnomAD
CA8792921 rs780421560	702	T>P		No	ClinGen ExAC
CA8792923 rs755448456	703	S>C		No	ClinGen ExAC TOPMed gnomAD
CA401204618 rs755448456	703	S>F		No	ClinGen ExAC TOPMed gnomAD
rs747475365 CA8792922	703	S>P		No	ClinGen ExAC gnomAD
TCGA novel	704	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8792924 rs200789514	704	S>P		No	ClinGen ExAC
CA401204628 rs1204110877	705	S>N		No	ClinGen TOPMed
rs142538392 CA8792927	706	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1371393880 CA401204638	706	Q>R		No	ClinGen TOPMed gnomAD
CA401204656 rs1369928142	708	H>L		No	ClinGen TOPMed
CA401204660 rs1303910007	709	S>P		No	ClinGen TOPMed
CA401204693 rs1311095495	712	M>I		No	ClinGen gnomAD
rs1438809026 CA401204691	712	M>T		No	ClinGen TOPMed
CA294277817 rs942368914	713	I>M		No	ClinGen gnomAD
CA8792928 rs769833979	716	R>Q		No	ClinGen ExAC gnomAD

No associated diseases with Q92503

4 regional properties for Q92503

Type	Name	Position	InterPro Accession
domain	CRAL-TRIO lipid binding domain	319 - 495	IPR001251
domain	PRELI/MSF1 domain	3 - 175	IPR006797
domain	GOLD domain	521 - 674	IPR009038
domain	CRAL/TRIO, N-terminal domain	275 - 301	IPR011074

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Golgi apparatus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

1 GO annotations of molecular function

Name	Definition
RIG-I binding	Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA.

3 GO annotations of biological process

Name	Definition
choline transport	The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of RIG-I signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of the RIG-I signaling pathway.

26 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5SYC1	CLVS2	Clavesin-2	Homo sapiens (Human)	PR
Q9BTX7	TTPAL	Alpha-tocopherol transfer protein-like	Homo sapiens (Human)	PR
Q8IUQ0	CLVS1	Clavesin-1	Homo sapiens (Human)	PR
B5MCN3	SEC14L6	Putative SEC14-like protein 6	Homo sapiens (Human)	PR
Q9UDX3	SEC14L4	SEC14-like protein 4	Homo sapiens (Human)	PR
Q8BG92	Clvs2	Clavesin-2	Mus musculus (Mouse)	PR
Q9D4C9	Clvs1	Clavesin-1	Mus musculus (Mouse)	PR
Q9D3D0	Ttpal	Alpha-tocopherol transfer protein-like	Mus musculus (Mouse)	PR
Q8R0F9	Sec14l4	SEC14-like protein 4	Mus musculus (Mouse)	PR
A6JFQ6	Clvs1	Clavesin-1	Rattus norvegicus (Rat)	PR
A6JUQ6	Clvs2	Clavesin-2	Rattus norvegicus (Rat)	PR
Q09270	C34C12.6	CRAL-TRIO domain-containing protein C34C12.6	Caenorhabditis elegans	PR
Q56ZI2	PATL2	Patellin-2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q94C59	PATL4	Patellin-4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q56WK6	PATL1	Patellin-1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q56Z59	PATL3	Patellin-3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8GXC6	SFH5	Phosphatidylinositol/phosphatidylcholine transfer protein SFH5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SIW3	SFH7	Phosphatidylinositol/phosphatidylcholine transfer protein SFH7	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SI13	SFH10	Phosphatidylinositol/phosphatidylcholine transfer protein SFH10	Arabidopsis thaliana (Mouse-ear cress)	PR
F4IHJ0	SFH8	Phosphatidylinositol/phosphatidylcholine transfer protein SFH8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q93ZE9	SFH3	Phosphatidylinositol/phosphatidylcholine transfer protein SFH3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M0R2	PATL5	Patellin-5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q94A34	SFH12	Phosphatidylinositol/phosphatidylcholine transfer protein SFH12	Arabidopsis thaliana (Mouse-ear cress)	PR
F4JVA6	SFH6	Phosphatidylinositol/phosphatidylcholine transfer protein SFH6	Arabidopsis thaliana (Mouse-ear cress)	PR
F4J7S8	SFH9	Phosphatidylinositol/phosphatidylcholine transfer protein SFH9	Arabidopsis thaliana (Mouse-ear cress)	PR
Q5SPP0	clvs2	Clavesin-2	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MVQKYQSPVR	VYKYPFELIM	AAYERRFPTC	PLIPMFVGSD	TVNEFKSEDG	AIHVIERRCK
70	80	90	100	110	120
LDVDAPRLLK	KIAGVDYVYF	VQKNSLNSRE	RTLHIEAYNE	TFSNRVIINE	HCCYTVHPEN
130	140	150	160	170	180
EDWTCFEQSA	SLDIKSFFGF	ESTVEKIAMK	QYTSNIKKGK	EIIEYYLRQL	EEEGITFVPR
190	200	210	220	230	240
WSPPSITTSS	ETSSSSSKKQ	AASMAVVIPE	AALKEGLSGD	ALSSPSAPEP	VVGTPDDKLD
250	260	270	280	290	300
ADYIKRYLGD	LTPLQESCLI	RLRQWLQETH	KGKIPKDEHI	LRFLRARDFN	IDKAREIMCQ
310	320	330	340	350	360
SLTWRKQHQV	DYILETWTPP	QVLQDYYAGG	WHHHDKDGRP	LYVLRLGQMD	TKGLVRALGE
370	380	390	400	410	420
EALLRYVLSI	NEEGLRRCEE	NTKVFGRPIS	SWTCLVDLEG	LNMRHLWRPG	VKALLRIIEV
430	440	450	460	470	480
VEANYPETLG	RLLILRAPRV	FPVLWTLVSP	FIDDNTRRKF	LIYAGNDYQG	PGGLLDYIDK
490	500	510	520	530	540
EIIPDFLSGE	CMCEVPEGGL	VPKSLYRTAE	ELENEDLKLW	TETIYQSASV	FKGAPHEILI
550	560	570	580	590	600
QIVDASSVIT	WDFDVCKGDI	VFNIYHSKRS	PQPPKKDSLG	AHSITSPGGN	NVQLIDKVWQ
610	620	630	640	650	660
LGRDYSMVES	PLICKEGESV	QGSHVTRWPG	FYILQWKFHS	MPACAASSLP	RVDDVLASLQ
670	680	690	700	710
VSSHKCKVMY	YTEVIGSEDF	RGSMTSLESS	HSGFSQLSAA	TTSSSQSHSS	SMISR