Q94AB5

PR
Gene name
UGT76E12
Protein name
Flavonol 3-O-glucosyltransferase UGT76E12
Names
Flavonol 7-O-beta-glucosyltransferase UGT76E12, UDP-glycosyltransferase 76E12
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G46660
EC number
2.4.1.91: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q94AB5

Entry ID Method Resolution Chain Position Source
AF-Q94AB5-F1 Predicted AlphaFoldDB

85 variants for Q94AB5

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06250818 5 G>V No 1000Genomes
tmp_3_17190829_T_A 12 R>W No 1000Genomes
ENSVATH00403400 14 S>R No 1000Genomes
tmp_3_17190820_C_G 15 V>L No 1000Genomes
tmp_3_17190811_C_T 18 V>I No 1000Genomes
ENSVATH12579121 27 S>C No 1000Genomes
ENSVATH00403399 29 M>L No 1000Genomes
ENSVATH12579120 30 M>I No 1000Genomes
ENSVATH02453380 37 H>N No 1000Genomes
ENSVATH02453380 37 H>Y No 1000Genomes
ENSVATH14385319 50 F>C No 1000Genomes
ENSVATH02453378 52 Y>N No 1000Genomes
ENSVATH06250815 54 S>I No 1000Genomes
ENSVATH14385318 57 D>E No 1000Genomes
ENSVATH02453376 58 D>E No 1000Genomes
ENSVATH02453377 58 D>N No 1000Genomes
ENSVATH12579119 59 F>L No 1000Genomes
ENSVATH14385317 60 T>A No 1000Genomes
ENSVATH12579118 60 T>I No 1000Genomes
ENSVATH06250814 62 D>G No 1000Genomes
ENSVATH06250813 71 S>C No 1000Genomes
tmp_3_17190576_C_T 96 S>N No 1000Genomes
tmp_3_17190549_A_T 105 V>E No 1000Genomes
ENSVATH06250812 113 S>T No 1000Genomes
tmp_3_17190493_C_A 124 A>S No 1000Genomes
ENSVATH14385315 130 E>D No 1000Genomes
tmp_3_17190454_T_A 137 I>F No 1000Genomes
ENSVATH00403398 143 A>V No 1000Genomes
tmp_3_17190423_G_C 147 A>G No 1000Genomes
tmp_3_17190393_G_T 157 A>E No 1000Genomes
ENSVATH06250810 163 P>S No 1000Genomes
tmp_3_17190283_G_T 167 T>N No 1000Genomes
ENSVATH02453371 171 Q>E No 1000Genomes
tmp_3_17190267_T_G 172 E>D No 1000Genomes
ENSVATH14385293 204 T>I No 1000Genomes
tmp_3_17190116_T_G 223 S>R No 1000Genomes
ENSVATH06250805 238 V>M No 1000Genomes
ENSVATH14385292 240 P>T No 1000Genomes
ENSVATH06250802 250 A>G No 1000Genomes
tmp_3_17190031_G_A 251 P>L No 1000Genomes
tmp_3_17190017_C_G 256 E>Q No 1000Genomes
ENSVATH00403397 260 S>I No 1000Genomes
tmp_3_17189986_T_C 266 N>S No 1000Genomes
ENSVATH14385291 268 Q>K No 1000Genomes
ENSVATH12579054 271 N>K No 1000Genomes
ENSVATH06250801 272 S>A No 1000Genomes
ENSVATH12579053 287 N>S No 1000Genomes
tmp_3_17189917_A_T 289 I>K No 1000Genomes
ENSVATH12579052 290 M>R No 1000Genomes
tmp_3_17189910_T_A 291 E>D No 1000Genomes
tmp_3_17189893_G_C 297 A>G No 1000Genomes
ENSVATH00403395 297 A>S No 1000Genomes
tmp_3_17189876_A_T 303 F>I No 1000Genomes
tmp_3_17189851_G_A 311 S>L No 1000Genomes
ENSVATH14385288 311 S>T No 1000Genomes
ENSVATH06250798 316 E>D No 1000Genomes
ENSVATH00403394 318 I>T No 1000Genomes
ENSVATH06250797 322 P>S No 1000Genomes
ENSVATH12579051 327 K>N No 1000Genomes
ENSVATH00403393 328 M>T No 1000Genomes
tmp_3_17189791_T_A 331 D>V No 1000Genomes
tmp_3_17189779_A_T 335 I>N No 1000Genomes
tmp_3_17189777_C_T 336 V>M No 1000Genomes
tmp_3_17189764_G_A 340 P>L No 1000Genomes
ENSVATH12579050 343 E>D No 1000Genomes
ENSVATH12579049 367 G>S No 1000Genomes
ENSVATH00403392 368 Q>E No 1000Genomes
tmp_3_17189616_C_G 389 E>D No 1000Genomes
ENSVATH02453367 390 C>S No 1000Genomes
ENSVATH02453366 391 V>I No 1000Genomes
ENSVATH12579048 394 I>F No 1000Genomes
ENSVATH02453364 401 E>D No 1000Genomes
tmp_3_17189579_G_C 402 L>V No 1000Genomes
ENSVATH00403389 404 R>S No 1000Genomes
ENSVATH12579047 405 G>R No 1000Genomes
tmp_3_17189557_C_G 409 R>T No 1000Genomes
tmp_3_17189530_T_G 418 E>A No 1000Genomes
ENSVATH02453361 421 E>D No 1000Genomes
ENSVATH06250796 423 M>I No 1000Genomes
tmp_3_17189506_C_T 426 R>K No 1000Genomes
tmp_3_17189489_C_G 432 E>Q No 1000Genomes
tmp_3_17189474_A_T 437 S>T No 1000Genomes
ENSVATH06250794 441 G>E No 1000Genomes
tmp_3_17189450_G_C 445 H>D No 1000Genomes
tmp_3_17189426_G_A 453 H>Y No 1000Genomes

No associated diseases with Q94AB5

5 regional properties for Q94AB5

Type Name Position InterPro Accession
conserved_site TPP-binding enzyme, conserved site 503 - 522 IPR000399
domain Thiamine pyrophosphate enzyme, TPP-binding 466 - 621 IPR011766
domain Thiamine pyrophosphate enzyme, central domain 273 - 402 IPR012000
domain Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain 80 - 243 IPR012001
domain Acetolactate synthase large subunit, TPP binding domain 444 - 636 IPR039368

Functions

Description
EC Number 2.4.1.91 Hexosyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

6 GO annotations of molecular function

Name Definition
daphnetin 3-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 7,8-dihydroxycoumarin <=> UDP(3-) + 3-O-beta-D-glucosyl-daphnetin + H+.
flavonol 3-O-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside.
flavonol 7-O-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside.
myricetin 3-O-glucosyltransferase activity Catalysis of the reaction: myricetin + UDP-alpha-D-glucose <=> myricetin 3-O-beta-D-glucopyranoside + UDP.
quercetin 3-O-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3-hydroxy group of a quercetin molecule.
quercetin 7-O-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

36 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1LZI1 UGT3A1 UDP-glucuronosyltransferase 3A1 Bos taurus (Bovine) PR
P36537 UGT2B10 UDP-glucuronosyltransferase 2B10 Homo sapiens (Human) PR
Q3SY77 UGT3A2 UDP-glucuronosyltransferase 3A2 Homo sapiens (Human) PR
O75310 UGT2B11 UDP-glucuronosyltransferase 2B11 Homo sapiens (Human) PR
P16662 UGT2B7 UDP-glucuronosyltransferase 2B7 Homo sapiens (Human) PR
Q16880 UGT8 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Homo sapiens (Human) PR
Q64676 Ugt8 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Mus musculus (Mouse) PR
Q8JZZ0 Ugt3a2 UDP-glucuronosyltransferase 3A2 Mus musculus (Mouse) PR
Q09426 Ugt8 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Rattus norvegicus (Rat) PR
Q22295 ugt-50 Putative UDP-glucuronosyltransferase ugt-50 Caenorhabditis elegans PR
Q9FE68 UGT71C5 UDP-glycosyltransferase 71C5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LML6 UGT71C4 Flavonol 3-O-glucosyltransferase UGT71C4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LML7 UGT71C3 UDP-glycosyltransferase 71C3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQG4 UGT73B5 UDP-glycosyltransferase 73B5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZVX4 UGT90A1 UDP-glycosyltransferase 90A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ98 UGT73C2 UDP-glycosyltransferase 73C2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ97 UGT73C4 UDP-glycosyltransferase 73C4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ96 UGT73C3 UDP-glycosyltransferase 73C3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ95 UGT73C6 UDP-glycosyltransferase 73C6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ94 UGT73C5 UDP-glycosyltransferase 73C5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SJL0 UGT86A1 UDP-glycosyltransferase 86A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSY9 UGT71B1 UDP-glycosyltransferase 71B1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSY6 UGT71B6 UDP-glycosyltransferase 71B6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSY5 UGT71B7 UDP-glycosyltransferase 71B7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSY4 UGT71B8 UDP-glycosyltransferase 71B8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LHJ2 UGT82A1 UDP-glycosyltransferase 82A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SCP5 UGT73C7 UDP-glycosyltransferase 73C7 Arabidopsis thaliana (Mouse-ear cress) PR
O23382 UGT71B5 UDP-glycosyltransferase 71B5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LXV0 UGT92A1 UDP-glycosyltransferase 92A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN28 UGT79B9 UDP-glycosyltransferase 79B9 Arabidopsis thaliana (Mouse-ear cress) PR
O22822 UGT74F2 UDP-glycosyltransferase 74F2 Arabidopsis thaliana (Mouse-ear cress) PR
Q5XF20 UGT84A1 UDP-glycosyltransferase 84A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LME8 UGT85A7 UDP-glycosyltransferase 85A7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMF1 UGT85A3 UDP-glycosyltransferase 85A3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LS16 UGT76E7 UDP-glycosyltransferase 76E7 Arabidopsis thaliana (Mouse-ear cress) PR
O48676 UGT74B1 UDP-glycosyltransferase 74B1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MQVLGMEEKP ARRSVVLVPF PAQGHISPMM QLAKTLHLKG FSITVVQTKF NYFSPSDDFT
70 80 90 100 110 120
HDFQFVTIPE SLPESDFKNL GPIQFLFKLN KECKVSFKDC LGQLVLQQSN EISCVIYDEF
130 140 150 160 170 180
MYFAEAAAKE CKLPNIIFST TSATAFACRS VFDKLYANNV QAPLKETKGQ QEELVPEFYP
190 200 210 220 230 240
LRYKDFPVSR FASLESIMEV YRNTVDKRTA SSVIINTASC LESSSLSFLQ QQQLQIPVYP
250 260 270 280 290 300
IGPLHMVASA PTSLLEENKS CIEWLNKQKV NSVIYISMGS IALMEINEIM EVASGLAASN
310 320 330 340 350 360
QHFLWVIRPG SIPGSEWIES MPEEFSKMVL DRGYIVKWAP QKEVLSHPAV GGFWSHCGWN
370 380 390 400 410 420
STLESIGQGV PMICRPFSGD QKVNARYLEC VWKIGIQVEG ELDRGVVERA VKRLMVDEEG
430 440 450
EEMRKRAFSL KEQLRASVKS GGSSHNSLEE FVHFIRTL