Q09426
PR
Gene name |
Ugt8 |
Protein name |
2-hydroxyacylsphingosine 1-beta-galactosyltransferase |
Names |
Ceramide UDP-galactosyltransferase, CGalT, Cerebroside synthase, UDP-galactose-ceramide galactosyltransferase |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:50555 |
EC number |
2.4.1.47: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q09426
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q09426-F1 | Predicted | AlphaFoldDB |
No variants for Q09426
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q09426 | |||||
No associated diseases with Q09426
No regional properties for Q09426
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q09426 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.47 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity | Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine. |
| N-acylsphingosine galactosyltransferase activity | Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP. |
| UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity | Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| galactosylceramide biosynthetic process | The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group. |
| glycosphingolipid biosynthetic process | The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. |
| myelination | The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. |
| neuron projection morphogenesis | The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. |
| paranodal junction assembly | Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier. |
| protein localization to paranode region of axon | A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon. |
36 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q1LZI1 | UGT3A1 | UDP-glucuronosyltransferase 3A1 | Bos taurus (Bovine) | PR |
| P36537 | UGT2B10 | UDP-glucuronosyltransferase 2B10 | Homo sapiens (Human) | PR |
| Q3SY77 | UGT3A2 | UDP-glucuronosyltransferase 3A2 | Homo sapiens (Human) | PR |
| P16662 | UGT2B7 | UDP-glucuronosyltransferase 2B7 | Homo sapiens (Human) | PR |
| O75310 | UGT2B11 | UDP-glucuronosyltransferase 2B11 | Homo sapiens (Human) | PR |
| Q16880 | UGT8 | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | Homo sapiens (Human) | PR |
| Q8JZZ0 | Ugt3a2 | UDP-glucuronosyltransferase 3A2 | Mus musculus (Mouse) | PR |
| Q64676 | Ugt8 | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | Mus musculus (Mouse) | PR |
| Q22295 | ugt-50 | Putative UDP-glucuronosyltransferase ugt-50 | Caenorhabditis elegans | PR |
| Q9LSY6 | UGT71B6 | UDP-glycosyltransferase 71B6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22822 | UGT74F2 | UDP-glycosyltransferase 74F2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O23382 | UGT71B5 | UDP-glycosyltransferase 71B5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5XF20 | UGT84A1 | UDP-glycosyltransferase 84A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AB5 | UGT76E12 | Flavonol 3-O-glucosyltransferase UGT76E12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FE68 | UGT71C5 | UDP-glycosyltransferase 71C5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN28 | UGT79B9 | UDP-glycosyltransferase 79B9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LHJ2 | UGT82A1 | UDP-glycosyltransferase 82A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LME8 | UGT85A7 | UDP-glycosyltransferase 85A7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMF1 | UGT85A3 | UDP-glycosyltransferase 85A3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LML6 | UGT71C4 | Flavonol 3-O-glucosyltransferase UGT71C4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LML7 | UGT71C3 | UDP-glycosyltransferase 71C3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LS16 | UGT76E7 | UDP-glycosyltransferase 76E7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSY4 | UGT71B8 | UDP-glycosyltransferase 71B8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSY5 | UGT71B7 | UDP-glycosyltransferase 71B7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSY9 | UGT71B1 | UDP-glycosyltransferase 71B1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LXV0 | UGT92A1 | UDP-glycosyltransferase 92A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCP5 | UGT73C7 | UDP-glycosyltransferase 73C7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SJL0 | UGT86A1 | UDP-glycosyltransferase 86A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQ94 | UGT73C5 | UDP-glycosyltransferase 73C5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQ95 | UGT73C6 | UDP-glycosyltransferase 73C6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQ96 | UGT73C3 | UDP-glycosyltransferase 73C3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQ97 | UGT73C4 | UDP-glycosyltransferase 73C4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQ98 | UGT73C2 | UDP-glycosyltransferase 73C2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O48676 | UGT74B1 | UDP-glycosyltransferase 74B1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQG4 | UGT73B5 | UDP-glycosyltransferase 73B5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZVX4 | UGT90A1 | UDP-glycosyltransferase 90A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKSYTPYFML | LWSAVGIARA | AKIIIVPPIM | FESHLYIFKT | LASALHERGH | HTVFLLSEGR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DIDPSNHYSL | QRYPGIFNST | TSDAFLQSKM | RNIFSGRLTA | VELVDILDHY | TKNCDMMVGN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QALIQGLKKE | KFDLLLVDPN | DMCGFVIAHL | LGVKYAVFST | GLWYPAEVGA | PAPLAYVPEF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSLLTDRMNF | LERMKNTGVY | LISRMGVSFL | VLPKYERIMQ | KYNLLPAKSM | YDLVHGSSLW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MLCTDVALEF | PRPTLPNVVY | VGGILTKPAS | PLPEDLQRWV | DGAQEHGFVL | VSFGAGVKYL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SEDIANKLAG | ALGRLPQKVI | WRFSGTKPKN | LGNNTKLIEW | LPQNDLLGHS | NIRAFLSHGG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LNSIFETMYH | GVPVVGIPLF | GDHYDTMTRV | QAKGMGILLE | WNTVTEGELY | DALVKVINNP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SYRQRAQKLS | EIHKDQPGHP | VNRTTYWIDY | ILRHDGAHHL | RSAVHQISFC | QYFLLDIAFV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLLGAVALYF | IVSYVTKFIY | RKVKSLCSRS | THSTVNGHYQ | NGILNGRYKG | NGHIKHEKKV |
| K |