Q8JZZ0

PR
Gene name
Ugt3a2
Protein name
UDP-glucuronosyltransferase 3A2
Names
UDPGT 3A2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:223337
EC number
2.4.1.17: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

405-476 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8JZZ0

Entry ID Method Resolution Chain Position Source
AF-Q8JZZ0-F1 Predicted AlphaFoldDB

57 variants for Q8JZZ0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs13467477 14 F>S No EVA
rs229247973 18 I>L No EVA
rs3389368363 27 T>S No EVA
rs3389316006 29 S>P No EVA
rs3389342298 30 T>R No EVA
rs3389350393 42 V>M No EVA
rs3389355174 54 T>A No EVA
rs236468473 61 A>D No EVA
rs236468473 61 A>G No EVA
rs263762668 62 N>D No EVA
rs213025010 62 N>T No EVA
rs245772041 72 S>P No EVA
rs214937667 74 Q>E No EVA
rs238159954 74 Q>L No EVA
rs48384395 87 K>N No EVA
rs1133205862 116 F>L No EVA
rs3389323537 116 F>Y No EVA
rs1133566940 118 D>E No EVA
rs1134873795 122 Q>H No EVA
rs233012578 148 L>F No EVA
rs233012578 148 L>I No EVA
rs3389368354 153 I>M No EVA
rs3389358081 155 E>D No EVA
rs244113921 172 M>I No EVA
rs3389358127 175 G>R No EVA
rs3389368387 183 Y>C No EVA
rs3389347788 187 Y>* No EVA
rs50743402 222 D>E No EVA
rs1133846940 230 V>A No EVA
rs226520144 234 Q>R No EVA
rs3389355248 247 W>* No EVA
rs3389354981 297 L>H No EVA
rs3405730459 368 T>P No EVA
rs3405754634 371 G>V No EVA
rs3406114685 372 M>I No EVA
rs3405730416 372 M>T No EVA
rs3389368362 373 N>K No EVA
rs255906134 380 H>Q No EVA
rs3389355015 389 P>T No EVA
rs3389305932 393 D>Y No EVA
rs48165358 396 E>D No EVA
rs3389348066 402 E>V No EVA
rs51679615 421 A>S No EVA
rs248640896 421 A>V No EVA
rs263044224 426 K>E No EVA
rs232448929 427 I>V No EVA
rs3389305970 431 K>N No EVA
rs254943019 431 K>Q No EVA
rs265592129 435 S>T No EVA
rs3389354990 439 A>D No EVA
rs3389350371 500 L>V No EVA
rs3405752459 510 V>I No EVA
rs3405310258 511 T>I No EVA
rs3405821754 511 T>P No EVA
rs3405957529 515 S>G No EVA
rs3405860037 515 S>I No EVA
rs3405754624 516 I>T No EVA

No associated diseases with Q8JZZ0

2 regional properties for Q8JZZ0

Type Name Position InterPro Accession
domain Peptidase C2, calpain, catalytic domain 16 - 339 IPR001300
domain Peptidase C2, calpain, large subunit, domain III 359 - 474 IPR022682

Functions

Description
EC Number 2.4.1.17 Hexosyltransferases
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
UDP-N-acetylglucosamine transferase complex A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis.

2 GO annotations of molecular function

Name Definition
glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
UDP-glycosyltransferase activity Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule.

1 GO annotations of biological process

Name Definition
cellular response to genistein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a genistein stimulus.

36 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1LZI1 UGT3A1 UDP-glucuronosyltransferase 3A1 Bos taurus (Bovine) PR
P36537 UGT2B10 UDP-glucuronosyltransferase 2B10 Homo sapiens (Human) PR
P16662 UGT2B7 UDP-glucuronosyltransferase 2B7 Homo sapiens (Human) PR
Q16880 UGT8 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Homo sapiens (Human) PR
O75310 UGT2B11 UDP-glucuronosyltransferase 2B11 Homo sapiens (Human) PR
Q3SY77 UGT3A2 UDP-glucuronosyltransferase 3A2 Homo sapiens (Human) PR
Q64676 Ugt8 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Mus musculus (Mouse) PR
Q09426 Ugt8 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Rattus norvegicus (Rat) PR
Q22295 ugt-50 Putative UDP-glucuronosyltransferase ugt-50 Caenorhabditis elegans PR
Q9LSY6 UGT71B6 UDP-glycosyltransferase 71B6 Arabidopsis thaliana (Mouse-ear cress) PR
O22822 UGT74F2 UDP-glycosyltransferase 74F2 Arabidopsis thaliana (Mouse-ear cress) PR
O23382 UGT71B5 UDP-glycosyltransferase 71B5 Arabidopsis thaliana (Mouse-ear cress) PR
Q5XF20 UGT84A1 UDP-glycosyltransferase 84A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AB5 UGT76E12 Flavonol 3-O-glucosyltransferase UGT76E12 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FE68 UGT71C5 UDP-glycosyltransferase 71C5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN28 UGT79B9 UDP-glycosyltransferase 79B9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LHJ2 UGT82A1 UDP-glycosyltransferase 82A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LME8 UGT85A7 UDP-glycosyltransferase 85A7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMF1 UGT85A3 UDP-glycosyltransferase 85A3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LML6 UGT71C4 Flavonol 3-O-glucosyltransferase UGT71C4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LML7 UGT71C3 UDP-glycosyltransferase 71C3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LS16 UGT76E7 UDP-glycosyltransferase 76E7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSY4 UGT71B8 UDP-glycosyltransferase 71B8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSY5 UGT71B7 UDP-glycosyltransferase 71B7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSY9 UGT71B1 UDP-glycosyltransferase 71B1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LXV0 UGT92A1 UDP-glycosyltransferase 92A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SCP5 UGT73C7 UDP-glycosyltransferase 73C7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SJL0 UGT86A1 UDP-glycosyltransferase 86A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ94 UGT73C5 UDP-glycosyltransferase 73C5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ95 UGT73C6 UDP-glycosyltransferase 73C6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ96 UGT73C3 UDP-glycosyltransferase 73C3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ97 UGT73C4 UDP-glycosyltransferase 73C4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ98 UGT73C2 UDP-glycosyltransferase 73C2 Arabidopsis thaliana (Mouse-ear cress) PR
O48676 UGT74B1 UDP-glycosyltransferase 74B1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQG4 UGT73B5 UDP-glycosyltransferase 73B5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZVX4 UGT90A1 UDP-glycosyltransferase 90A1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAAHRRWLLM SFLFLEVILL EAAKILTIST LSASHYIVIS RVSQVLHEGG HNVTKLLYES
70 80 90 100 110 120
ANIPDFRKEK PSYQVINWRP PEDQEKKFAD LRHRLTEEIT YGRSKHHTLL KIHQYFGDLC
130 140 150 160 170 180
SQLLSRKDIM DFLKNENFDL VLLDSMDLCS LLIVEKLGKR FVSFLPFQFS YMDFGLPSAP
190 200 210 220 230 240
LSYAPVYGSG LTDQMDFWGR VKNFLMFLDF SMKQREILSQ YDSTIQEHFV EGSQPVLSDL
250 260 270 280 290 300
LLKAELWFVN SDFALDFARP LFPNTVYVGG LLDKPVQPIP QDLENFISQF GDSGFVLVAL
310 320 330 340 350 360
GSIVSMIQSK EIIKEMNSAF AHLPQGVLWT CKTSHWPKDV SLAPNVKIMD WLPQTDLLAH
370 380 390 400 410 420
PSIRLFVTHG GMNSVMEAVH HGVPMVGIPF FFDQPENMVR VEAKNLGVSI QLQTLKAESF
430 440 450 460 470 480
ALTMKKIIED KRYKSAAMAS KIIRHSHPLT PAQRLLGWID HILQTGGAAH LKPYAFQQPW
490 500 510 520
HEQYMLDVFL FLLGLMLGTL WLSVKVLVAV TRYLSIATKV KEA