Q64676

PR
Gene name
Ugt8
Protein name
2-hydroxyacylsphingosine 1-beta-galactosyltransferase
Names
Ceramide UDP-galactosyltransferase, Cerebroside synthase, UDP-galactose-ceramide galactosyltransferase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:22239
EC number
2.4.1.47: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

397-466 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q64676

Entry ID Method Resolution Chain Position Source
AF-Q64676-F1 Predicted AlphaFoldDB

31 variants for Q64676

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3393386850 2 K>E No EVA
rs3393667858 3 S>C No EVA
rs8255224 4 Y>* No EVA
rs3393621397 4 Y>N No EVA
rs3393659423 6 P>S No EVA
rs3388658538 17 I>L No EVA
rs3388659863 22 K>I No EVA
rs3388652217 35 L>* No EVA
rs3388663125 87 Q>* No EVA
rs3388657783 101 V>I No EVA
rs3388663070 152 G>C No EVA
rs3388663614 165 P>S No EVA
rs3393404765 169 G>S No EVA
rs3393667916 171 P>A No EVA
rs3393659356 171 P>R No EVA
rs3388655611 189 N>D No EVA
rs3388663112 228 K>T No EVA
rs3388658587 235 H>N No EVA
rs3388663659 247 A>T No EVA
rs3388664805 261 V>G No EVA
rs3388667005 264 I>F No EVA
rs3388652195 363 S>N No EVA
rs3388666159 456 G>E No EVA
rs30455183 458 R>H No EVA
rs3388651113 467 I>F No EVA
rs30455180 511 E>K No EVA
rs49198348 524 R>P No EVA
rs50308186 533 R>H No EVA
rs49048363 534 V>I No EVA
rs3393642013 535 K>* No EVA
rs45927155 541 R>K No EVA

No associated diseases with Q64676

3 regional properties for Q64676

Type Name Position InterPro Accession
domain Target SNARE coiled-coil homology domain 187 - 279 IPR000727
domain Syntaxin, N-terminal domain 25 - 227 IPR006011
conserved_site Syntaxin/epimorphin, conserved site 198 - 237 IPR006012

Functions

Description
EC Number 2.4.1.47 Hexosyltransferases
Subcellular Localization
  • Membrane ; Single-pass membrane protein
  • Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine.
ceramide glucosyltransferase activity Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.
N-acylsphingosine galactosyltransferase activity Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP.
UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base.

7 GO annotations of biological process

Name Definition
cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
galactosylceramide biosynthetic process The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group.
glycolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).
myelination The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
neuron projection morphogenesis The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
paranodal junction assembly Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier.
protein localization to paranode region of axon A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon.

36 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1LZI1 UGT3A1 UDP-glucuronosyltransferase 3A1 Bos taurus (Bovine) PR
P36537 UGT2B10 UDP-glucuronosyltransferase 2B10 Homo sapiens (Human) PR
Q3SY77 UGT3A2 UDP-glucuronosyltransferase 3A2 Homo sapiens (Human) PR
P16662 UGT2B7 UDP-glucuronosyltransferase 2B7 Homo sapiens (Human) PR
O75310 UGT2B11 UDP-glucuronosyltransferase 2B11 Homo sapiens (Human) PR
Q16880 UGT8 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Homo sapiens (Human) PR
Q8JZZ0 Ugt3a2 UDP-glucuronosyltransferase 3A2 Mus musculus (Mouse) PR
Q09426 Ugt8 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Rattus norvegicus (Rat) PR
Q22295 ugt-50 Putative UDP-glucuronosyltransferase ugt-50 Caenorhabditis elegans PR
Q9LSY6 UGT71B6 UDP-glycosyltransferase 71B6 Arabidopsis thaliana (Mouse-ear cress) PR
O22822 UGT74F2 UDP-glycosyltransferase 74F2 Arabidopsis thaliana (Mouse-ear cress) PR
O23382 UGT71B5 UDP-glycosyltransferase 71B5 Arabidopsis thaliana (Mouse-ear cress) PR
Q5XF20 UGT84A1 UDP-glycosyltransferase 84A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AB5 UGT76E12 Flavonol 3-O-glucosyltransferase UGT76E12 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FE68 UGT71C5 UDP-glycosyltransferase 71C5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN28 UGT79B9 UDP-glycosyltransferase 79B9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LHJ2 UGT82A1 UDP-glycosyltransferase 82A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LME8 UGT85A7 UDP-glycosyltransferase 85A7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMF1 UGT85A3 UDP-glycosyltransferase 85A3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LML6 UGT71C4 Flavonol 3-O-glucosyltransferase UGT71C4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LML7 UGT71C3 UDP-glycosyltransferase 71C3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LS16 UGT76E7 UDP-glycosyltransferase 76E7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSY4 UGT71B8 UDP-glycosyltransferase 71B8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSY5 UGT71B7 UDP-glycosyltransferase 71B7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSY9 UGT71B1 UDP-glycosyltransferase 71B1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LXV0 UGT92A1 UDP-glycosyltransferase 92A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SCP5 UGT73C7 UDP-glycosyltransferase 73C7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SJL0 UGT86A1 UDP-glycosyltransferase 86A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ94 UGT73C5 UDP-glycosyltransferase 73C5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ95 UGT73C6 UDP-glycosyltransferase 73C6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ96 UGT73C3 UDP-glycosyltransferase 73C3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ97 UGT73C4 UDP-glycosyltransferase 73C4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ98 UGT73C2 UDP-glycosyltransferase 73C2 Arabidopsis thaliana (Mouse-ear cress) PR
O48676 UGT74B1 UDP-glycosyltransferase 74B1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQG4 UGT73B5 UDP-glycosyltransferase 73B5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZVX4 UGT90A1 UDP-glycosyltransferase 90A1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKSYTPYFML LWSAVGIARA AKIIIVPPIM FESHLYIFKT LASALHERGH HTVLLLSEGR
70 80 90 100 110 120
DIAPSNHYSL QRYPGIFNST TSDAFLQSKM RNIFSGRLTA VELVDILDHY TKNCDMMVGN
130 140 150 160 170 180
QALIQGLKKE KFDLLLVDPN DMCGFVIAHL LGVKYAVFST GLWYPAEVGA PAPLAYVPEF
190 200 210 220 230 240
NSLLTDRMNF LERMKNTGVY LISRIGVSFL VLPKYERIMQ KYNLLPAKSM YDLVHGSSLW
250 260 270 280 290 300
MLCTDVALEF PRPTLPNVVY VGGILTKPAS PLPEDLQRWV SGAQEHGFVL VSFGAGVKYL
310 320 330 340 350 360
SEDIANKLAG ALGRLPQKVI WRFSGTKPKN LGNNTKLIEW LPQNDLLGHS NIRAFLSHGG
370 380 390 400 410 420
LNSIFETMYH GVPVVGIPLF GDHYDTMTRV QAKGMGILLE WNTVTEGELY DALVKVINNP
430 440 450 460 470 480
SYRQRAQKLS EIHKDQPGHP VNRTTYWIDY ILRHDGARHL RSAVHQISFC QYFLLDIAFV
490 500 510 520 530 540
LLLGAVLLYF ILSYVTKFIY RKIKSLWSKN EHSTVNGHYQ NGIRNGKYKG NGRVKHEKKV
R