O48676
PR
Gene name |
UGT74B1 (At1g24100, F3I6.2) |
Protein name |
UDP-glycosyltransferase 74B1 |
Names |
N-hydroxythioamide S-beta-glucosyltransferase, Thiohydroximate S-glucosyltransferase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G24100 |
EC number |
2.4.1.195: Hexosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O48676
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O48676-F1 | Predicted | AlphaFoldDB |
34 variants for O48676
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00041619 | 5 | T>S | No | 1000Genomes | |
| tmp_1_8526901_T_C | 37 | N>S | No | 1000Genomes | |
| tmp_1_8526862_G_A | 50 | S>F | No | 1000Genomes | |
| tmp_1_8526863_A_G | 50 | S>P | No | 1000Genomes | |
| ENSVATH04634617 | 53 | T>I | No | 1000Genomes | |
| ENSVATH11946792 | 67 | D>H | No | 1000Genomes | |
| ENSVATH01097575 | 91 | E>K | No | 1000Genomes | |
| ENSVATH00041613 | 103 | T>S | No | 1000Genomes | |
| ENSVATH01097574 | 106 | P>S | No | 1000Genomes | |
| ENSVATH04634615 | 107 | I>M | No | 1000Genomes | |
| ENSVATH00041611 | 151 | D>E | No | 1000Genomes | |
| tmp_1_8526527_G_A | 162 | P>S | No | 1000Genomes | |
| ENSVATH00041610 | 165 | I>L | No | 1000Genomes | |
| ENSVATH01097572 | 166 | R>H | No | 1000Genomes | |
| ENSVATH04634612 | 178 | S>T | No | 1000Genomes | |
| ENSVATH00041608 | 202 | E>D | No | 1000Genomes | |
| ENSVATH11946790 | 219 | Q>H | No | 1000Genomes | |
| tmp_1_8526254_A_C | 226 | S>A | No | 1000Genomes | |
| tmp_1_8526243_C_A | 229 | M>I | No | 1000Genomes | |
| ENSVATH00041607 | 230 | K>R | No | 1000Genomes | |
| ENSVATH00041605 | 245 | D>A | No | 1000Genomes | |
| ENSVATH11946787 | 251 | K>R | No | 1000Genomes | |
| ENSVATH00041602 | 270 | E>G | No | 1000Genomes | |
| ENSVATH00041601 | 274 | A>S | No | 1000Genomes | |
| ENSVATH00041600 | 278 | A>V | No | 1000Genomes | |
| tmp_1_8526050_C_G | 294 | A>P | No | 1000Genomes | |
| tmp_1_8525888_T_C | 348 | I>V | No | 1000Genomes | |
| ENSVATH11946584 | 349 | G>C | No | 1000Genomes | |
| ENSVATH11946584 | 349 | G>S | No | 1000Genomes | |
| ENSVATH11946583 | 408 | E>A | No | 1000Genomes | |
| ENSVATH00041594 | 409 | E>Q | No | 1000Genomes | |
| tmp_1_8525663_T_A | 423 | S>C | No | 1000Genomes | |
| tmp_1_8525608_A_G | 441 | M>T | No | 1000Genomes | |
| ENSVATH01097562 | 461 | K>K | No | 1000Genomes |
No associated diseases with O48676
8 regional properties for O48676
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Cysteine peptidase, cysteine active site | 91 - 102 | IPR000169 |
| domain | Peptidase C2, calpain, catalytic domain | 24 - 345 | IPR001300 |
| domain | EF-hand domain | 533 - 593 | IPR002048-1 |
| domain | EF-hand domain | 591 - 626 | IPR002048-2 |
| binding_site | EF-Hand 1, calcium-binding site | 604 - 616 | IPR018247 |
| domain | Peptidase C2, calpain, large subunit, domain III | 354 - 486 | IPR022682 |
| domain | Peptidase C2, calpain, domain III | 348 - 494 | IPR022683 |
| domain | Calpain subdomain III | 347 - 496 | IPR033883 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.1.195 | Hexosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| quercetin 3-O-glucosyltransferase activity | Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3-hydroxy group of a quercetin molecule. |
| quercetin 7-O-glucosyltransferase activity | Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule. |
| thiohydroximate beta-D-glucosyltransferase activity | Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP. |
| UDP-glucose: 4-methylthiobutylhydroximate S-glucosyltransferase activity | Catalysis of the reaction: UDP-alpha-D-glucose + 4-methylthiobutylhydroximate <=> H+ + 3-methylthiopropyl-desulfoglucosinolate + UDP. |
| UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity | Catalysis of the reaction: UDP-alpha-D-glucose + 6-methylthiohexylhydroximate <=> H+ + 5-methylthiopentyldesulfoglucosinolate + UDP(3-). |
| UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity | Catalysis of the reaction: UDP-alpha-D-glucose + 9-methylthiononylhydroximate <=> 8-methylthiooctyldesulfoglucosinolate + UDP + H+. |
| UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity | Catalysis of the reaction: UDP-alpha-D-glucose + 5-methylthiopentylhydroximate <=> H+ + 4-methylthiobutyldesulfoglucosinolate + UDP. |
| UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity | Catalysis of the reaction: UDP-alpha-D-glucose + 7-methylthioheptylhydroximate <=> H+ + 6-methylthiohexyldesulfoglucosinolate + UDP. |
| UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity | Catalysis of the reaction: UDP-alpha-D-glucose + 8-methylthiooctylhydroximate <=> H+ + 7-methylthioheptyldesulfoglucosinolate + UDP. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response by callose deposition in cell wall | Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. |
| defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. |
| glucosinolate biosynthetic process | The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. |
36 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q1LZI1 | UGT3A1 | UDP-glucuronosyltransferase 3A1 | Bos taurus (Bovine) | PR |
| P36537 | UGT2B10 | UDP-glucuronosyltransferase 2B10 | Homo sapiens (Human) | PR |
| Q3SY77 | UGT3A2 | UDP-glucuronosyltransferase 3A2 | Homo sapiens (Human) | PR |
| O75310 | UGT2B11 | UDP-glucuronosyltransferase 2B11 | Homo sapiens (Human) | PR |
| P16662 | UGT2B7 | UDP-glucuronosyltransferase 2B7 | Homo sapiens (Human) | PR |
| Q16880 | UGT8 | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | Homo sapiens (Human) | PR |
| Q64676 | Ugt8 | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | Mus musculus (Mouse) | PR |
| Q8JZZ0 | Ugt3a2 | UDP-glucuronosyltransferase 3A2 | Mus musculus (Mouse) | PR |
| Q09426 | Ugt8 | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | Rattus norvegicus (Rat) | PR |
| Q22295 | ugt-50 | Putative UDP-glucuronosyltransferase ugt-50 | Caenorhabditis elegans | PR |
| Q9FE68 | UGT71C5 | UDP-glycosyltransferase 71C5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LML6 | UGT71C4 | Flavonol 3-O-glucosyltransferase UGT71C4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LML7 | UGT71C3 | UDP-glycosyltransferase 71C3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQG4 | UGT73B5 | UDP-glycosyltransferase 73B5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZVX4 | UGT90A1 | UDP-glycosyltransferase 90A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQ98 | UGT73C2 | UDP-glycosyltransferase 73C2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQ97 | UGT73C4 | UDP-glycosyltransferase 73C4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQ96 | UGT73C3 | UDP-glycosyltransferase 73C3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQ95 | UGT73C6 | UDP-glycosyltransferase 73C6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZQ94 | UGT73C5 | UDP-glycosyltransferase 73C5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SJL0 | UGT86A1 | UDP-glycosyltransferase 86A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSY9 | UGT71B1 | UDP-glycosyltransferase 71B1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSY6 | UGT71B6 | UDP-glycosyltransferase 71B6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSY5 | UGT71B7 | UDP-glycosyltransferase 71B7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSY4 | UGT71B8 | UDP-glycosyltransferase 71B8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LHJ2 | UGT82A1 | UDP-glycosyltransferase 82A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCP5 | UGT73C7 | UDP-glycosyltransferase 73C7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O23382 | UGT71B5 | UDP-glycosyltransferase 71B5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LXV0 | UGT92A1 | UDP-glycosyltransferase 92A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN28 | UGT79B9 | UDP-glycosyltransferase 79B9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22822 | UGT74F2 | UDP-glycosyltransferase 74F2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q5XF20 | UGT84A1 | UDP-glycosyltransferase 84A1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AB5 | UGT76E12 | Flavonol 3-O-glucosyltransferase UGT76E12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LME8 | UGT85A7 | UDP-glycosyltransferase 85A7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LMF1 | UGT85A3 | UDP-glycosyltransferase 85A3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LS16 | UGT76E7 | UDP-glycosyltransferase 76E7 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAETTPKVKG | HVVILPYPVQ | GHLNPMVQFA | KRLVSKNVKV | TIATTTYTAS | SITTPSLSVE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PISDGFDFIP | IGIPGFSVDT | YSESFKLNGS | ETLTLLIEKF | KSTDSPIDCL | IYDSFLPWGL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EVARSMELSA | ASFFTNNLTV | CSVLRKFSNG | DFPLPADPNS | APFRIRGLPS | LSYDELPSFV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GRHWLTHPEH | GRVLLNQFPN | HENADWLFVN | GFEGLEETQD | CENGESDAMK | ATLIGPMIPS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AYLDDRMEDD | KDYGASLLKP | ISKECMEWLE | TKQAQSVAFV | SFGSFGILFE | KQLAEVAIAL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QESDLNFLWV | IKEAHIAKLP | EGFVESTKDR | ALLVSWCNQL | EVLAHESIGC | FLTHCGWNST |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LEGLSLGVPM | VGVPQWSDQM | NDAKFVEEVW | KVGYRAKEEA | GEVIVKSEEL | VRCLKGVMEG |
| 430 | 440 | 450 | |||
| ESSVKIRESS | KKWKDLAVKA | MSEGGSSDRS | INEFIESLGK |