Q1LZI1

PR
Gene name
UGT3A1
Protein name
UDP-glucuronosyltransferase 3A1
Names
UDPGT 3A1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:537188
EC number
2.4.1.17: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

398-479 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q1LZI1

Entry ID Method Resolution Chain Position Source
AF-Q1LZI1-F1 Predicted AlphaFoldDB

67 variants for Q1LZI1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs432355574 5 Q>H No EVA
rs473347012 16 G>E No EVA
rs1117395394 18 L>M No EVA
rs461986710 19 F>L No EVA
rs473978701 24 K>N No EVA
rs444183837 25 I>V No EVA
rs462641825 26 L>I No EVA
rs477849046 26 L>P No EVA
rs460064352 30 L>R No EVA
rs449477926 31 V>A No EVA
rs449477926 31 V>G No EVA
rs479380242 31 V>M No EVA
rs468028663 32 G>R No EVA
rs442403136 35 H>R No EVA
rs522533602 39 M>I No EVA
rs718285816 40 H>N No EVA
rs460748223 47 Q>* No EVA
rs483151498 48 D>N No EVA
rs443876635 51 H>Y No EVA
rs459018812 61 N>K No EVA
rs525495436 82 P>L No EVA
rs517618770 96 F>S No EVA
rs480699152 102 G>W No EVA
rs715804575 124 L>S No EVA
rs1116682048 127 R>G No EVA
rs519457507 161 P>S No EVA
rs433435596 224 T>A No EVA
rs445450437 227 E>A No EVA
rs42345573 245 E>G No EVA
rs378997689 259 R>Q No EVA
rs455667584 263 P>L No EVA
rs474053002 264 N>H No EVA
rs437961335 267 C>G No EVA
rs475766119 273 S>P No EVA
rs42345572 280 P>S No EVA
rs457976590 281 Q>P No EVA
rs465146955 293 S>F No EVA
rs449825941 293 S>P No EVA
rs109332450 322 H>Y No EVA
rs446410627 351 W>R No EVA
rs469810721 369 H>L No EVA
rs448082773 369 H>N No EVA
rs432376079 405 K>N No EVA
rs445550190 424 M>T No EVA
rs1116264269 428 I>T No EVA
rs464883331 432 R>K No EVA
rs457784148 435 S>C No EVA
rs719880442 437 A>T No EVA
rs723034624 437 A>V No EVA
rs453684767 456 V>G No EVA
rs468883475 459 I>V No EVA
rs136857691 460 N>D No EVA
rs469540190 462 I>L No EVA
rs433306890 464 Q>P No EVA
rs466854532 468 A>G No EVA
rs455541244 470 H>P No EVA
rs474734465 471 L>P No EVA
rs475599678 472 K>N No EVA
rs441874402 472 K>Q No EVA
rs457166996 472 K>R No EVA
rs439333372 476 F>L No EVA
rs134098228 488 V>G No EVA
rs135350417 489 F>L No EVA
rs133951891 500 M>T No EVA
rs521747881 500 M>V No EVA
rs444590474 512 R>M No EVA
rs799197532 517 A>P No EVA

No associated diseases with Q1LZI1

1 regional properties for Q1LZI1

Type Name Position InterPro Accession
conserved_site UDP-glycosyltransferase family, conserved site 351 - 394 IPR035595

Functions

Description
EC Number 2.4.1.17 Hexosyltransferases
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
UDP-N-acetylglucosamine transferase complex A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis.

1 GO annotations of molecular function

Name Definition
glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

36 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P36537 UGT2B10 UDP-glucuronosyltransferase 2B10 Homo sapiens (Human) PR
P16662 UGT2B7 UDP-glucuronosyltransferase 2B7 Homo sapiens (Human) PR
Q16880 UGT8 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Homo sapiens (Human) PR
O75310 UGT2B11 UDP-glucuronosyltransferase 2B11 Homo sapiens (Human) PR
Q3SY77 UGT3A2 UDP-glucuronosyltransferase 3A2 Homo sapiens (Human) PR
Q64676 Ugt8 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Mus musculus (Mouse) PR
Q8JZZ0 Ugt3a2 UDP-glucuronosyltransferase 3A2 Mus musculus (Mouse) PR
Q09426 Ugt8 2-hydroxyacylsphingosine 1-beta-galactosyltransferase Rattus norvegicus (Rat) PR
Q22295 ugt-50 Putative UDP-glucuronosyltransferase ugt-50 Caenorhabditis elegans PR
Q9FE68 UGT71C5 UDP-glycosyltransferase 71C5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LML6 UGT71C4 Flavonol 3-O-glucosyltransferase UGT71C4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LML7 UGT71C3 UDP-glycosyltransferase 71C3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LME8 UGT85A7 UDP-glycosyltransferase 85A7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMF1 UGT85A3 UDP-glycosyltransferase 85A3 Arabidopsis thaliana (Mouse-ear cress) PR
O48676 UGT74B1 UDP-glycosyltransferase 74B1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQG4 UGT73B5 UDP-glycosyltransferase 73B5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZVX4 UGT90A1 UDP-glycosyltransferase 90A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ98 UGT73C2 UDP-glycosyltransferase 73C2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ97 UGT73C4 UDP-glycosyltransferase 73C4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ96 UGT73C3 UDP-glycosyltransferase 73C3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ95 UGT73C6 UDP-glycosyltransferase 73C6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZQ94 UGT73C5 UDP-glycosyltransferase 73C5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SJL0 UGT86A1 UDP-glycosyltransferase 86A1 Arabidopsis thaliana (Mouse-ear cress) PR
O22822 UGT74F2 UDP-glycosyltransferase 74F2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSY9 UGT71B1 UDP-glycosyltransferase 71B1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSY6 UGT71B6 UDP-glycosyltransferase 71B6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSY5 UGT71B7 UDP-glycosyltransferase 71B7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LSY4 UGT71B8 UDP-glycosyltransferase 71B8 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AB5 UGT76E12 Flavonol 3-O-glucosyltransferase UGT76E12 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SCP5 UGT73C7 UDP-glycosyltransferase 73C7 Arabidopsis thaliana (Mouse-ear cress) PR
O23382 UGT71B5 UDP-glycosyltransferase 71B5 Arabidopsis thaliana (Mouse-ear cress) PR
Q5XF20 UGT84A1 UDP-glycosyltransferase 84A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LXV0 UGT92A1 UDP-glycosyltransferase 92A1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LS16 UGT76E7 UDP-glycosyltransferase 76E7 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FN28 UGT79B9 UDP-glycosyltransferase 79B9 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LHJ2 UGT82A1 UDP-glycosyltransferase 82A1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAGQQALLLF GFILPGLLFS EAAKILTVSL VGGSHFLLMH QISQILQDHG HNVTMLLQKG
70 80 90 100 110 120
NLLLPGFKEE EKSYKVFNWF LPEDCNEEFK RSFHSFMEKT FGGRCKFEHF LNIMELLGHH
130 140 150 160 170 180
CSHLLRRKDV MKSLKNENFD LVIVEMFDYC PFLVAEKLGK PFVAILPSAL GTVDFGLPSP
190 200 210 220 230 240
LSYVPVFYSL LTDQMDFWGR VKNFLMFFEF FKKQWKIQSA YDDTIKEHFP DDSRPVLSHL
250 260 270 280 290 300
LTKAELWFVN TDFAFDFARP LLPNTVCIGG LMSKPVKPVP QEFENFITKF GDSGFVLVSL
310 320 330 340 350 360
GSMVSFIRSQ EVLKEMNAAF AHLPQGVIWK YNPSHWPKDI KLAPNVKIVH WLPQNDLLGH
370 380 390 400 410 420
PRIRLFVSHG GMNSIMEAIQ HGVPMVGIPL FGDQHENLLR VKAKKFGVSI QLKQIKAETL
430 440 450 460 470 480
ALKMKQVIED KRYKSAAEAA SIIRRSQPLT PAQRLVGWIN HILQTGGAAH LKPHAFQQPW
490 500 510 520
YEQYLLDVFL FLLVVTLGTM WLCGKLLGLV ARWLCGARKL KKA