Q80XM3
PR
Gene name |
Kcng4 |
Protein name |
Potassium voltage-gated channel subfamily G member 4 |
Names |
Voltage-gated potassium channel subunit Kv6.4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:66733 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80XM3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80XM3-F1 | Predicted | AlphaFoldDB |
22 variants for Q80XM3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs51737037 | 4 | S>P | No | EVA | |
| rs222617045 | 12 | P>L | No | EVA | |
| rs3389021119 | 25 | Q>L | No | EVA | |
| rs3389009267 | 31 | E>D | No | EVA | |
| rs259578742 | 35 | V>I | No | EVA | |
| rs3399937086 | 86 | R>K | No | EVA | |
| rs3399758004 | 92 | S>R | No | EVA | |
| rs47995635 | 93 | H>Y | No | EVA | |
| rs3389009303 | 103 | Y>* | No | EVA | |
| rs3399690903 | 160 | C>S | No | EVA | |
| rs3389013513 | 216 | L>Q | No | EVA | |
| rs3389021165 | 240 | T>I | No | EVA | |
| rs3388965745 | 280 | V>I | No | EVA | |
| rs3389008686 | 285 | K>R | No | EVA | |
| rs3388965728 | 287 | Q>* | No | EVA | |
| rs247321975 | 315 | P>R | No | EVA | |
| rs3389013307 | 351 | H>R | No | EVA | |
| rs3389002516 | 387 | V>I | No | EVA | |
| rs3389013451 | 414 | M>L | No | EVA | |
| rs3389013614 | 421 | D>G | No | EVA | |
| rs3389002576 | 479 | T>I | No | EVA | |
| rs3389013245 | 489 | S>G | No | EVA |
No associated diseases with Q80XM3
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| voltage-gated potassium channel complex | A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| delayed rectifier potassium channel activity | Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. |
| transmembrane transporter binding | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| voltage-gated potassium channel activity | Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| potassium ion transmembrane transport | A process in which a potassium ion is transported from one side of a membrane to the other. |
| protein homooligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q4ZHA6 | KCNB2 | Potassium voltage-gated channel subfamily B member 2 | Bos taurus (Bovine) | PR |
| P17972 | Shaw | Potassium voltage-gated channel protein Shaw | Drosophila melanogaster (Fruit fly) | PR |
| Q9ULS6 | KCNS2 | Potassium voltage-gated channel subfamily S member 2 | Homo sapiens (Human) | PR |
| Q9H3M0 | KCNF1 | Potassium voltage-gated channel subfamily F member 1 | Homo sapiens (Human) | PR |
| Q03721 | KCNC4 | Potassium voltage-gated channel subfamily C member 4 | Homo sapiens (Human) | PR |
| Q14721 | KCNB1 | Potassium voltage-gated channel subfamily B member 1 | Homo sapiens (Human) | PR |
| Q8TDN2 | KCNV2 | Potassium voltage-gated channel subfamily V member 2 | Homo sapiens (Human) | PR |
| Q92953 | KCNB2 | Potassium voltage-gated channel subfamily B member 2 | Homo sapiens (Human) | PR |
| A6H8H5 | Kcnb2 | Potassium voltage-gated channel subfamily B member 2 | Mus musculus (Mouse) | PR |
| O35174 | Kcns2 | Potassium voltage-gated channel subfamily S member 2 | Mus musculus (Mouse) | PR |
| Q03717 | Kcnb1 | Potassium voltage-gated channel subfamily B member 1 | Mus musculus (Mouse) | PR |
| Q61423 | Kcna4 | Potassium voltage-gated channel subfamily A member 4 | Mus musculus (Mouse) | PR |
| P16390 | Kcna3 | Potassium voltage-gated channel subfamily A member 3 | Mus musculus (Mouse) | PR |
| P16388 | Kcna1 | Potassium voltage-gated channel subfamily A member 1 | Mus musculus (Mouse) | PR |
| Q8K3F6 | Kcnq3 | Potassium voltage-gated channel subfamily KQT member 3 | Mus musculus (Mouse) | PR |
| Q9Z0V2 | Kcnd2 | Potassium voltage-gated channel subfamily D member 2 | Mus musculus (Mouse) | PR |
| P97414 | Kcnq1 | Potassium voltage-gated channel subfamily KQT member 1 | Mus musculus (Mouse) | PR |
| Q17ST2 | Kcna7 | Potassium voltage-gated channel subfamily A member 7 | Mus musculus (Mouse) | PR |
| Q9Z0V1 | Kcnd3 | Potassium voltage-gated channel subfamily D member 3 | Mus musculus (Mouse) | PR |
| Q7TSH7 | Kcnf1 | Potassium voltage-gated channel subfamily F member 1 | Mus musculus (Mouse) | PR |
| O18868 | KCNB1 | Potassium voltage-gated channel subfamily B member 1 | Sus scrofa (Pig) | PR |
| Q9ER26 | Kcns2 | Potassium voltage-gated channel subfamily S member 2 | Rattus norvegicus (Rat) | PR |
| P15387 | Kcnb1 | Potassium voltage-gated channel subfamily B member 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPMSSRDRDL | HPGHHHFGSC | SPLSQLWPGP | EPKSVKGLYY | SRARKVGNQD | ASPEANLKEI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LVNVGGQRYL | LPWSTLDAFP | LSRLSRLRLC | RSHEEITQLC | DDYDEDSQEF | FFDRNPSAFG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VIVSFLAAGK | LVLLREMCAL | SFREELSYWG | IEETNLERCC | LRKLLKKLEE | AAELRREEAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QRQQQRQACH | SEVQASRWAR | SMNQLREMVE | DPQSGLPGKV | FACLSVLFVA | TTAVSLCVST |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MPDFRAEEGK | GECTRKCYYI | FVVESICVAW | FSLEFCLRFV | QAPNKCQFFR | GPLNVIDILA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ISPYYVSLAV | SDESPEAGER | PSSSSYLEKV | GLVLRVLRAL | RILYVMRLAR | HSLGLQTLGL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TVRRCAREFG | LLMLFLAVAV | TLFSPLVYVA | ENESGRVLEF | TSIPASYWWA | IISMTTVGYG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DMVPRSVPGQ | MVALSSILSG | ILIMAFPATS | IFHTFSHSYL | ELKREQEQVQ | ARLRRLQNTN |
| 490 | 500 | ||||
| SASERELLSD | VDDLVPEGLT | SPGRYM |