A6H8H5
PR
Gene name |
Kcnb2 |
Protein name |
Potassium voltage-gated channel subfamily B member 2 |
Names |
Voltage-gated potassium channel subunit Kv2.2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:98741 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6H8H5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6H8H5-F1 | Predicted | AlphaFoldDB |
43 variants for A6H8H5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388457926 | 3 | E>* | No | EVA | |
| rs3388458128 | 33 | C>S | No | EVA | |
| rs3388458031 | 34 | S>F | No | EVA | |
| rs3388458077 | 140 | R>* | No | EVA | |
| rs3388458271 | 174 | E>* | No | EVA | |
| rs3389614637 | 221 | N>V | No | EVA | |
| rs3388458948 | 265 | P>L | No | EVA | |
| rs3388459802 | 284 | T>I | No | EVA | |
| rs3388458338 | 296 | V>A | No | EVA | |
| rs3388458300 | 297 | R>G | No | EVA | |
| rs3388459488 | 314 | L>I | No | EVA | |
| rs3388458432 | 319 | T>R | No | EVA | |
| rs3388458096 | 331 | S>R | No | EVA | |
| rs3388458365 | 332 | Y>H | No | EVA | |
| rs3388458359 | 363 | T>I | No | EVA | |
| rs3388459827 | 369 | P>H | No | EVA | |
| rs3388459402 | 396 | I>F | No | EVA | |
| rs3389659924 | 441 | E>A | No | EVA | |
| rs3389681349 | 448 | S>K | No | EVA | |
| rs3388458195 | 487 | L>P | No | EVA | |
| rs3388459643 | 502 | T>M | No | EVA | |
| rs3388458845 | 503 | S>C | No | EVA | |
| rs31948579 | 518 | N>K | No | EVA | |
| rs3388457631 | 519 | D>E | No | EVA | |
| rs3388459455 | 530 | S>F | No | EVA | |
| rs3388458228 | 557 | N>I | No | EVA | |
| rs236032835 | 568 | C>S | No | EVA | |
| rs3388458444 | 568 | C>S | No | EVA | |
| rs3388458026 | 586 | L>P | No | EVA | |
| rs3388458101 | 593 | V>A | No | EVA | |
| rs3388458843 | 641 | D>Y | No | EVA | |
| rs231015759 | 667 | V>M | No | EVA | |
| rs3388459696 | 676 | V>E | No | EVA | |
| rs32102788 | 694 | D>N | No | EVA | |
| rs3388458238 | 695 | S>I | No | EVA | |
| rs3388458076 | 712 | K>N | No | EVA | |
| rs3388458761 | 745 | P>S | No | EVA | |
| rs3388458237 | 775 | G>E | No | EVA | |
| rs3388458586 | 784 | F>L | No | EVA | |
| rs3388458543 | 785 | P>H | No | EVA | |
| rs3388459397 | 802 | E>G | No | EVA | |
| rs32102790 | 845 | G>S | No | EVA | |
| rs3389651981 | 856 | D>Y | No | EVA |
No associated diseases with A6H8H5
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| neuronal cell body membrane | The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| voltage-gated potassium channel complex | A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| delayed rectifier potassium channel activity | Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| transmembrane transporter binding | Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
| voltage-gated potassium channel activity | Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| potassium ion transmembrane transport | A process in which a potassium ion is transported from one side of a membrane to the other. |
| potassium ion transport | The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| protein homooligomerization | The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q4ZHA6 | KCNB2 | Potassium voltage-gated channel subfamily B member 2 | Bos taurus (Bovine) | PR |
| Q95167 | KCNB2 | Potassium voltage-gated channel subfamily B member 2 | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P17972 | Shaw | Potassium voltage-gated channel protein Shaw | Drosophila melanogaster (Fruit fly) | PR |
| Q9ULS6 | KCNS2 | Potassium voltage-gated channel subfamily S member 2 | Homo sapiens (Human) | PR |
| Q9H3M0 | KCNF1 | Potassium voltage-gated channel subfamily F member 1 | Homo sapiens (Human) | PR |
| Q03721 | KCNC4 | Potassium voltage-gated channel subfamily C member 4 | Homo sapiens (Human) | PR |
| Q14721 | KCNB1 | Potassium voltage-gated channel subfamily B member 1 | Homo sapiens (Human) | PR |
| Q8TDN2 | KCNV2 | Potassium voltage-gated channel subfamily V member 2 | Homo sapiens (Human) | PR |
| Q92953 | KCNB2 | Potassium voltage-gated channel subfamily B member 2 | Homo sapiens (Human) | PR |
| O35174 | Kcns2 | Potassium voltage-gated channel subfamily S member 2 | Mus musculus (Mouse) | PR |
| Q03717 | Kcnb1 | Potassium voltage-gated channel subfamily B member 1 | Mus musculus (Mouse) | PR |
| Q80XM3 | Kcng4 | Potassium voltage-gated channel subfamily G member 4 | Mus musculus (Mouse) | PR |
| Q61423 | Kcna4 | Potassium voltage-gated channel subfamily A member 4 | Mus musculus (Mouse) | PR |
| P16390 | Kcna3 | Potassium voltage-gated channel subfamily A member 3 | Mus musculus (Mouse) | PR |
| P16388 | Kcna1 | Potassium voltage-gated channel subfamily A member 1 | Mus musculus (Mouse) | PR |
| Q8K3F6 | Kcnq3 | Potassium voltage-gated channel subfamily KQT member 3 | Mus musculus (Mouse) | PR |
| Q9Z0V2 | Kcnd2 | Potassium voltage-gated channel subfamily D member 2 | Mus musculus (Mouse) | PR |
| P97414 | Kcnq1 | Potassium voltage-gated channel subfamily KQT member 1 | Mus musculus (Mouse) | PR |
| Q17ST2 | Kcna7 | Potassium voltage-gated channel subfamily A member 7 | Mus musculus (Mouse) | PR |
| Q9Z0V1 | Kcnd3 | Potassium voltage-gated channel subfamily D member 3 | Mus musculus (Mouse) | PR |
| Q7TSH7 | Kcnf1 | Potassium voltage-gated channel subfamily F member 1 | Mus musculus (Mouse) | PR |
| O18868 | KCNB1 | Potassium voltage-gated channel subfamily B member 1 | Sus scrofa (Pig) | PR |
| Q9ER26 | Kcns2 | Potassium voltage-gated channel subfamily S member 2 | Rattus norvegicus (Rat) | PR |
| P15387 | Kcnb1 | Potassium voltage-gated channel subfamily B member 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEKAPPGLN | RKTSRSTLSL | PPEPVDIIRS | KTCSRRVKIN | VGGLNHEVLW | RTLDRLPRTR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGKLRDCNTH | ESLLEVCDDY | NLNENEYFFD | RHPGAFTSIL | NFYRTGKLHM | MEEMCALSFG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QELDYWGIDE | IYLESCCQAR | YHQKKEQMNE | ELRREAETMR | EREGEEFDNT | CCPEKRKKLW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DLLEKPNSSV | AAKILAIVSI | LFIVLSTIAL | SLNTLPELQE | NDEFGQPSDN | RKLAHVEAVC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IAWFTMEYLL | RFLSSPNKWK | FFKGPLNVID | LLAILPYYVT | IFLTESNKSV | LQFQNVRRVV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QIFRIMRILR | ILKLARHSTG | LQSLGFTLRR | SYNELGLLIL | FLAMGIMIFS | SLVFFAEKDE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DATKFTSIPA | SFWWATITMT | TVGYGDIYPK | TLLGKIVGGL | CCIAGVLVIA | LPIPIIVNNF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SEFYKEQKRQ | EKAIKRREAL | ERAKRNGSIV | SMNLKDAFAR | SMELIDVAVE | KAGESANTKD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SVDDNHLSPS | RWKWARKALS | ETSSNKSYEN | KYQEVSQNDS | HEHLNNTSSS | SPQHLSAQKL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EMLYNEITKT | QPHSHPNPDC | QEQPERPCVY | EEEIEMEEVI | CPQEQLAVAQ | TEVIVDMKST |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SSIDSFTSCA | TDFTETERSP | LPPPSASHLQ | MKFPTDLPGT | DEHQRARAPP | FLTLSRDKGP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AAREAAVDYA | PIDITVNLDA | GASHGPLQPD | SASDSPKSSL | KGSNPLKSRS | LKVNFQENRA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SAPQTPPSTA | RPLPVTTADF | PLTTPQHMST | ILLEEALPQG | QPPLLEADDS | AHCQGPSKGF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SPRFPKQKLF | PFSSRERRSF | TEIDTGEDED | FLDLQRSRPD | KQADPSPNCL | ADKPGDARDS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LREEGCVGSS | SPQNTDHNCR | QDIYQAVGEV | KKDSSQEGYK | MENHLFAPEI | HSNPGDTGHC |
| PTRETSM |