Q4ZHA6

PR
Gene name
KCNB2
Protein name
Potassium voltage-gated channel subfamily B member 2
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:535990
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

123-194 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4ZHA6

Entry ID Method Resolution Chain Position Source
AF-Q4ZHA6-F1 Predicted AlphaFoldDB

215 variants for Q4ZHA6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs453623060 3 E>G No EVA
rs464136893 8 G>A No EVA
rs456176058 14 S>* No EVA
rs476350641 16 S>P No EVA
rs435376918 18 L>P No EVA
rs455556559 21 P>Q No EVA
rs472472906 25 V>G No EVA
rs441110847 26 D>N No EVA
rs471761865 31 K>E No EVA
rs443606827 34 S>C No EVA
rs463854189 35 R>G No EVA
rs480565834 36 R>G No EVA
rs449371361 37 V>G No EVA
rs459811452 39 I>S No EVA
rs479841661 41 V>L No EVA
rs445480992 45 N>T No EVA
rs432761613 58 R>G No EVA
rs449648391 59 T>P No EVA
rs469853357 61 L>V No EVA
rs455444215 62 G>R No EVA
rs472356546 66 D>G No EVA
rs434580943 67 C>S No EVA
rs451540039 72 S>I No EVA
rs443607719 78 D>E No EVA
rs463744974 84 E>Q No EVA
rs474087708 86 E>A No EVA
rs442841943 87 Y>D No EVA
rs459685954 89 F>S No EVA
rs445433630 108 L>P No EVA
rs482613485 132 Y>F No EVA
rs449651065 140 R>S No EVA
rs469742527 146 E>D No EVA
rs435201286 149 N>D No EVA
rs448952929 150 E>D No EVA
rs465873957 158 T>A No EVA
rs451438746 159 M>K No EVA
rs434570318 159 M>L No EVA
rs451438746 159 M>R No EVA
rs465244980 160 R>L No EVA
rs457087374 165 E>* No EVA
rs473957217 170 T>S No EVA
rs473351553 175 K>N No EVA
rs438968000 178 K>N No EVA
rs459117715 180 W>S No EVA
rs482489786 181 D>A No EVA
rs444666761 191 A>P No EVA
rs444666761 191 A>T No EVA
rs461643777 193 K>* No EVA
rs480168739 193 K>R No EVA
rs440928931 336 G>C No EVA
rs457873150 339 I>V No EVA
rs477996533 346 I>V No EVA
rs443400086 348 I>V No EVA
rs463578039 353 V>A No EVA
rs449188733 375 A>D No EVA
rs466100232 376 T>N No EVA
rs479647731 416 I>T No EVA
rs445288585 436 R>S No EVA
rs465344280 474 E>D No EVA
rs437260254 478 T>P No EVA
rs457427990 482 T>P No EVA
rs436659118 484 D>N No EVA
rs453620825 486 H>P No EVA
rs440890416 489 P>Q No EVA
rs451326653 495 A>G No EVA
rs471453857 502 T>P No EVA
rs443332242 506 K>Q No EVA
rs463495609 509 E>V No EVA
rs480474427 515 V>L No EVA
rs442675107 517 Q>H No EVA
rs459522457 520 S>T No EVA
rs479610670 521 H>R No EVA
rs458786091 526 N>T No EVA
rs482089891 527 T>P No EVA
rs451003814 538 Q>E No EVA
rs467927328 542 M>I No EVA
rs436631177 544 Y>* No EVA
rs447097162 548 T>P No EVA
rs467222318 548 T>S No EVA
rs432654417 550 T>A No EVA
rs432654417 550 T>S No EVA
rs451284645 553 H>L No EVA
rs451284645 553 H>P No EVA
rs436855157 555 H>P No EVA
rs3423095364 559 D>N No EVA
rs442657093 560 G>A No EVA
rs459385406 561 Q>* No EVA
rs473067571 561 Q>P No EVA
rs438676481 566 R>S No EVA
rs458749086 569 T>P No EVA
rs482305566 570 Y>D No EVA
rs450887680 574 I>L No EVA
rs461502263 578 E>* No EVA
rs481580557 578 E>G No EVA
rs447026656 579 V>G No EVA
rs446391383 581 C>R No EVA
rs464943871 583 Q>E No EVA
rs456972212 588 V>G No EVA
rs473880090 591 T>A No EVA
rs436093993 595 V>M No EVA
rs452954313 598 K>E No EVA
rs473030790 602 S>R No EVA
rs458718331 604 D>V No EVA
rs438645903 604 D>Y No EVA
rs475805390 605 S>R No EVA
rs444377527 606 F>L No EVA
rs461317485 608 S>N No EVA
rs481532582 609 C>S No EVA
rs460720343 619 S>A No EVA
rs469744541 622 P>Q No EVA
rs446349131 622 P>S No EVA
rs446349131 622 P>T No EVA
rs467356728 628 H>N No EVA
rs436062084 632 K>* No EVA
rs452917510 632 K>M No EVA
rs466595055 633 F>I No EVA
rs432198158 634 P>R No EVA
rs452195445 636 D>A No EVA
rs475710922 638 A>D No EVA
rs444309026 639 G>W No EVA
rs454892675 640 L>F No EVA
rs440521475 642 E>G No EVA
rs1114714111 642 E>Q No EVA
rs460675995 646 A>D No EVA
rs477591688 648 A>P No EVA
rs463121638 652 L>I No EVA
rs483288932 654 L>P No EVA
rs448703289 655 I>M No EVA
rs3423095306 657 Q>E No EVA
rs480861843 665 A>P No EVA
rs446497507 666 T>P No EVA
rs466458606 669 Y>H No EVA
rs432064142 669 Y>S No EVA
rs452250285 676 V>A No EVA
rs718190707 676 V>L No EVA
rs722548459 680 A>T No EVA
rs469177006 681 A>D No EVA
rs437872394 683 G>V No EVA
rs475016831 687 G>R No EVA
rs434007536 690 G>R No EVA
rs454125854 694 T>P No EVA
rs471041855 696 C>W No EVA
rs439745716 699 E>K No EVA
rs463131611 700 S>R No EVA
rs476864693 702 K>N No EVA
rs442290443 704 S>* No EVA
rs462470583 705 L>P No EVA
rs446361886 716 L>H No EVA
rs459992577 718 V>A No EVA
rs476881723 720 F>L No EVA
rs445723490 722 D>N No EVA
rs469190465 724 R>K No EVA
rs437829846 725 G>C No EVA
rs468421064 726 G>V No EVA
rs454087387 727 A>D No EVA
rs454087387 727 A>G No EVA
rs471004990 728 P>A No EVA
rs433233005 728 P>Q No EVA
rs476829421 729 P>A No EVA
rs462361405 730 T>N No EVA
rs459955734 732 P>S No EVA
rs459955734 732 P>T No EVA
rs445716261 733 S>I No EVA
rs445716261 733 S>N No EVA
rs476843245 733 S>R No EVA
rs445716261 733 S>T No EVA
rs482770408 735 A>G No EVA
rs462667162 735 A>S No EVA
rs462667162 735 A>T No EVA
rs433836066 736 R>K No EVA
rs464543405 738 L>P No EVA
rs433213671 739 P>A No EVA
rs470229487 740 V>G No EVA
rs455745572 741 T>A No EVA
rs455745572 741 T>P No EVA
rs441449702 742 A>E No EVA
rs472633401 742 A>P No EVA
rs472633401 742 A>T No EVA
rs470402566 743 A>G No EVA
rs482754440 744 D>G No EVA
rs462561697 744 D>Y No EVA
rs441730080 745 F>L No EVA
rs478841561 746 P>Q No EVA
rs461918586 746 P>S No EVA
rs464504714 747 L>P No EVA
rs478156861 748 T>P No EVA
rs449968925 749 A>P No EVA
rs455706839 751 Q>P No EVA
rs455706839 751 Q>R No EVA
rs451798070 758 L>V No EVA
rs472036968 759 E>V No EVA
rs443934310 760 E>A No EVA
rs476277529 763 S>A No EVA
rs476277529 763 S>P No EVA
rs441725616 764 Q>L No EVA
rs461881396 766 D>V No EVA
rs441002680 769 L>V No EVA
rs478125642 778 G>V No EVA
rs470151828 779 P>A No EVA
rs434862374 787 F>V No EVA
rs445370193 789 K>N No EVA
rs465600521 792 L>F No EVA
rs437463648 796 S>P No EVA
rs476197149 802 S>G No EVA
rs435225726 806 I>N No EVA
rs435225726 806 I>T No EVA
rs455331534 813 D>G No EVA
rs440964008 824 D>V No EVA
rs457843043 827 A>G No EVA
rs471641015 845 L>I No EVA
rs443486098 847 E>A No EVA
rs3423095366 866 G>D No EVA
rs459599950 883 C>G No EVA
rs479690433 896 S>P No EVA
rs465509086 906 T>A No EVA

No associated diseases with Q4ZHA6

3 regional properties for Q4ZHA6

Type Name Position InterPro Accession
domain BTB/POZ domain 35 - 144 IPR000210
domain Potassium channel tetramerisation-type BTB domain 37 - 136 IPR003131
domain Ion transport domain 193 - 427 IPR005821

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Perikaryon
  • Cell projection, dendrite
  • Localized uniformly throughout cell bodies and dendrites
  • Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
neuronal cell body membrane The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

3 GO annotations of molecular function

Name Definition
delayed rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
voltage-gated potassium channel activity Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

5 GO annotations of biological process

Name Definition
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
potassium ion transport The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q05037 KCNA4 Potassium voltage-gated channel subfamily A member 4 Bos taurus (Bovine) PR
Q95167 KCNB2 Potassium voltage-gated channel subfamily B member 2 Canis lupus familiaris (Dog) (Canis familiaris) PR
P17972 Shaw Potassium voltage-gated channel protein Shaw Drosophila melanogaster (Fruit fly) PR
Q9ULS6 KCNS2 Potassium voltage-gated channel subfamily S member 2 Homo sapiens (Human) PR
Q9H3M0 KCNF1 Potassium voltage-gated channel subfamily F member 1 Homo sapiens (Human) PR
Q03721 KCNC4 Potassium voltage-gated channel subfamily C member 4 Homo sapiens (Human) PR
Q14721 KCNB1 Potassium voltage-gated channel subfamily B member 1 Homo sapiens (Human) PR
Q8TDN2 KCNV2 Potassium voltage-gated channel subfamily V member 2 Homo sapiens (Human) PR
Q92953 KCNB2 Potassium voltage-gated channel subfamily B member 2 Homo sapiens (Human) PR
Q80XM3 Kcng4 Potassium voltage-gated channel subfamily G member 4 Mus musculus (Mouse) PR
Q03717 Kcnb1 Potassium voltage-gated channel subfamily B member 1 Mus musculus (Mouse) PR
O35174 Kcns2 Potassium voltage-gated channel subfamily S member 2 Mus musculus (Mouse) PR
Q7TSH7 Kcnf1 Potassium voltage-gated channel subfamily F member 1 Mus musculus (Mouse) PR
A6H8H5 Kcnb2 Potassium voltage-gated channel subfamily B member 2 Mus musculus (Mouse) PR
O18868 KCNB1 Potassium voltage-gated channel subfamily B member 1 Sus scrofa (Pig) PR
Q9ER26 Kcns2 Potassium voltage-gated channel subfamily S member 2 Rattus norvegicus (Rat) PR
P15387 Kcnb1 Potassium voltage-gated channel subfamily B member 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAEKVPPGLN RKTSRSTLSL PPEPVDIIRS KTCSRRVKIN VGGLNHEVLW RTLDRLPRTR
70 80 90 100 110 120
LGKLRDCNTH ESLLEVCDDY NLNENEYFFD RHPGAFTSIL NFYRTGKLHM MEEMCALSFG
130 140 150 160 170 180
QELDYWGIDE IYLESCCQAR YHQKKEQMNE ELRREAETMR EREGEEFDNT CCPEKRKKLW
190 200 210 220 230 240
DLLEKPNSSV AAKILAIVSI LFIVLSTIAL SLNTLPELQE MDEFGQPNDN PQLAHVEAVC
250 260 270 280 290 300
IAWFTMEYLL RFLSSPNKWK FFKGPLNVID LLAILPYYVT IFLTESNKSV LQFQNVRRVV
310 320 330 340 350 360
QIFRIMRILR ILKLARHSTG LQSLGFTLRR SYNELGLLIL FLAMGIMIFS SLVFFAEKDE
370 380 390 400 410 420
DATKFTSIPA SFWWATITMT TVGYGDIYPK TLLGKIVGGL CCIAGVLVIA LPIPIIVNNF
430 440 450 460 470 480
SEFYKEQKRQ EKAIKRREAL ERAKRNGSIV SMNLKDAFAR SMELIDVAVE KTGESANTKG
490 500 510 520 530 540
STDDNHLSPS RWKWARKALS ETSSNKSYEN KYQEVSQKDS HEQLNNTSSS SPQHLSAQKL
550 560 570 580 590 600
EMLYNEITKT QPHSHPNPDG QEQAERPSTY EEEIEMEEVV CPQEQLAVAQ TEGVVDMKST
610 620 630 640 650 660
SSIDSFTSCA TDFTETERSP LPPPSASHLQ MKFPPDLAGL EEHQRARAPP FLALIRQKGP
670 680 690 700 710 720
TVREATPEYA PIDITVNLDA AGGPQGGPHG PLPTDCASES PKSSLKGSNP LKSRSLKVNF
730 740 750 760 770 780
KDSRGGAPPT PPSTARPLPV TAADFPLTAP QLISTILLEE TPSQGDRPLL GAEVHCQGPS
790 800 810 820 830 840
KGLTPRFPKQ KLFTFSARER RSFTEIDTGE DDDFLELQGT RRPDKQADSS PNCLTDKPSD
850 860 870 880 890 900
GRDPLREEAC VGSSSAQDTS HNCRQGIYHG VAEVKKDNSQ EGCKMENHLF APEIHSNPGD
910
TGYCPTRETS M