O18868

PR
Gene name
KCNB1
Protein name
Potassium voltage-gated channel subfamily B member 1
Names
Delayed rectifier potassium channel 1, DRK1, Voltage-gated potassium channel subunit Kv2.1
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:397433
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O18868

Entry ID Method Resolution Chain Position Source
AF-O18868-F1 Predicted AlphaFoldDB

No variants for O18868

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O18868

No associated diseases with O18868

3 regional properties for O18868

Type Name Position InterPro Accession
domain BTB/POZ domain 31 - 140 IPR000210
domain Potassium channel tetramerisation-type BTB domain 33 - 132 IPR003131
domain Ion transport domain 189 - 423 IPR005821

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane
  • Perikaryon
  • Cell projection, axon
  • Cell projection, dendrite
  • Membrane; Multi-pass membrane protein
  • Postsynaptic cell membrane
  • Synapse
  • Synapse, synaptosome
  • Lateral cell membrane
  • Cell membrane, sarcolemma
  • Localizes to high-density somatodendritic clusters and non-clustered sites on the surface of neocortical and hippocampal pyramidal neurons in a cortical actin cytoskeleton-dependent manner
  • Localizes also to high-density clusters in the axon initial segment (AIS), at ankyrin-G-deficient sites, on the surface of neocortical and hippocampal pyramidal neurons
  • KCNB1-containing AIS clusters localize either in close apposition to smooth endoplasmic reticulum cisternal organelles or with GABA-A receptor-containing synapses of hippocampal and cortical pyramidal neurons, respectively
  • Localizes to high-density clusters on the cell surface of atrial and ventricular myocytes and at the lateral plasma membrane in epithelial cells
  • Localizes both to the axial and transverse tubules (T tubule) and sarcolemma in ventricular myocytes
  • Associated with lipid raft domains
  • In cortical neurons, apoptotic injuries induce de novo plasma membrane insertion in a SNARE-dependent manner causing an apoptotic potassium current surge
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
lateral plasma membrane The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
neuronal cell body membrane The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
sarcolemma The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

2 GO annotations of molecular function

Name Definition
delayed rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.

19 GO annotations of biological process

Name Definition
action potential A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.
cellular response to glucose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
cellular response to nutrient levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
glucose homeostasis Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
glutamate receptor signaling pathway The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
negative regulation of insulin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
positive regulation of calcium ion-dependent exocytosis Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.
positive regulation of catecholamine secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine.
positive regulation of long-term synaptic depression Any process that activates or increases the frequency, rate or extent of long term synaptic depression.
positive regulation of norepinephrine secretion Any process that increases the frequency, rate or extent of the regulated release of norepinephrine.
positive regulation of protein targeting to membrane Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
potassium ion transport The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
regulation of action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
regulation of motor neuron apoptotic process Any process that modulates the frequency, rate or extent of motor neuron apoptotic process.
vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q4ZHA6 KCNB2 Potassium voltage-gated channel subfamily B member 2 Bos taurus (Bovine) PR
P17972 Shaw Potassium voltage-gated channel protein Shaw Drosophila melanogaster (Fruit fly) PR
Q9ULS6 KCNS2 Potassium voltage-gated channel subfamily S member 2 Homo sapiens (Human) PR
Q9H3M0 KCNF1 Potassium voltage-gated channel subfamily F member 1 Homo sapiens (Human) PR
Q03721 KCNC4 Potassium voltage-gated channel subfamily C member 4 Homo sapiens (Human) PR
Q8TDN2 KCNV2 Potassium voltage-gated channel subfamily V member 2 Homo sapiens (Human) PR
Q92953 KCNB2 Potassium voltage-gated channel subfamily B member 2 Homo sapiens (Human) PR
Q14721 KCNB1 Potassium voltage-gated channel subfamily B member 1 Homo sapiens (Human) PR
Q80XM3 Kcng4 Potassium voltage-gated channel subfamily G member 4 Mus musculus (Mouse) PR
O35174 Kcns2 Potassium voltage-gated channel subfamily S member 2 Mus musculus (Mouse) PR
A6H8H5 Kcnb2 Potassium voltage-gated channel subfamily B member 2 Mus musculus (Mouse) PR
Q7TSH7 Kcnf1 Potassium voltage-gated channel subfamily F member 1 Mus musculus (Mouse) PR
Q03717 Kcnb1 Potassium voltage-gated channel subfamily B member 1 Mus musculus (Mouse) PR
Q9ER26 Kcns2 Potassium voltage-gated channel subfamily S member 2 Rattus norvegicus (Rat) PR
P15387 Kcnb1 Potassium voltage-gated channel subfamily B member 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MPAGMTKHGS RSTSSLPPEP MEIVRSKACS RRVRLNVGGL AHEVLWRTLD RLPRTRLGKL
70 80 90 100 110 120
RDCNTHDSLL EVCDDYSLDD NEYFFDRHPG AFTSILNFYR TGRLHMMEEM CALSFSQELD
130 140 150 160 170 180
YWGIDEIYLE SCCQARYHQK KEQMNEELKR EAETLREREG EEFDNTCCAE KRKKLWDLLE
190 200 210 220 230 240
KPNSSVAAKI LAIISIMFIV LSTIALSLNT LPELQSLDEF GQTTDNPQLA HVEAVCIAWF
250 260 270 280 290 300
TMEYLLRFLS SPKKWKFFKG PLNAIDLLAI LPYYVTIFLT ESNKSVLQFQ NVRRVVQIFR
310 320 330 340 350 360
IMRILRILKL ARHSTGLQSL GFTLRRSYNE LGLLILFLAM GIMIFSSLVF FAEKDEDDTK
370 380 390 400 410 420
FKSIPASFWW ATITMTTVGY GDIYPKTLLG KIVGGLCCIA GVLVIALPIP IIVNNFSEFY
430 440 450 460 470 480
KEQKRQEKAI KRREALERAK RNGSIVSMNM KDAFPRSIEM MDIVVEKNVE NMGQKDKVQD
490 500 510 520 530 540
NHLSPNKWKW TKRTLSETSS SKSFETKEQG SPEKARSSSS PQHLNVQQLE DMYNKMAKTQ
550 560 570 580 590 600
SQPILNTKES ATQSKPKEEL EMESIPSPVA PLPTRTEGVI DMRSMSSIDS FISCATDFPE
610 620 630 640 650 660
ATRFSHSPLA SLPSKSGGSM APEVGWRGAL GATGGRFVEA NPTPDASHHS TFFIESPKSS
670 680 690 700 710 720
MKTTNPLKLR ALKVNFMEGD PSPLVPVLGM YHDPLRNRGG AAAAVAGLEC ATLLDRPVLS
730 740 750 760 770 780
PESSIYTTAS ARTPPRSPEK HTAIAFNFEA GIHQYIDADT DDEGQVLYSV DSSPPKSLHG
790 800 810 820 830 840
STSPKFSIGT RSEKNHFESS PLPTSPKFLR QNCIYSTEAL TGKAPSGQEK CKLENHISPD
850
VRVLPGGGAH GSTRDQSI