P97414

PR
Gene name
Kcnq1
Protein name
Potassium voltage-gated channel subfamily KQT member 1
Names
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Voltage-gated potassium channel subunit Kv7.1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:16535
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-120 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P97414

Entry ID Method Resolution Chain Position Source
AF-P97414-F1 Predicted AlphaFoldDB

13 variants for P97414

Variant ID(s) Position Change Description Diseaes Association Provenance
rs241023817 72 A>V No EVA
rs3388969874 306 V>E No EVA
rs3388967588 334 F>L No EVA
rs3388966542 339 F>V No EVA
rs3388966488 388 S>L No EVA
rs3388957885 409 P>A No EVA
rs3388965257 512 T>I No EVA
rs3412695427 514 K>* No EVA
rs3388941026 586 T>I No EVA
rs3388941005 592 N>S No EVA
rs3388962550 606 V>L No EVA
rs33837959 618 M>L No EVA
rs3398217041 620 Q>H No EVA

No associated diseases with P97414

2 regional properties for P97414

Type Name Position InterPro Accession
domain Ion transport domain 124 - 353 IPR005821
domain Potassium channel, voltage dependent, KCNQ, C-terminal 503 - 617 IPR013821

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Cytoplasmic vesicle membrane
  • Early endosome
  • Membrane raft
  • Endoplasmic reticulum
  • Basolateral cell membrane
  • Apical cell membrane ; Multi-pass membrane protein
  • Colocalized with KCNE3 at the plasma membrane
  • Upon 17beta-oestradiol treatment, colocalizes with RAB5A at early endosome
  • Heterotetramer with KCNQ5 is highly retained at the endoplasmic reticulum and is localized outside of lipid raft microdomains
  • During the early stages of epithelial cell polarization induced by the calcium switch it is removed from the plasma membrane to the endoplasmic reticulum, where it is retained, and redistributed to the basolateral cell surface in a PI3K-dependent manner at a later stage
  • Colocalizes with SLC5A3 at the apical membrane of choroid plexus epithelium (PubMed:24595108)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

25 GO annotations of cellular component

Name Definition
apical part of cell The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basolateral part of cell The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cell surface The external part of the cell wall and/or plasma membrane.
ciliary base Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
ion channel complex A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
late endosome A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
potassium channel complex An ion channel complex through which potassium ions pass.
sarcolemma The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
transport vesicle Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
zymogen granule membrane The lipid bilayer surrounding a zymogen granule.

15 GO annotations of molecular function

Name Definition
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
delayed rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
identical protein binding Binding to an identical protein or proteins.
outward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force.
phosphatidylinositol-4,5-bisphosphate binding Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
potassium channel activity Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
protein kinase A catalytic subunit binding Binding to one or both of the catalytic subunits of protein kinase A.
protein kinase A regulatory subunit binding Binding to one or both of the regulatory subunits of protein kinase A.
protein phosphatase 1 binding Binding to a protein phosphatase 1.
scaffold protein binding Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
voltage-gated potassium channel activity Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

66 GO annotations of biological process

Name Definition
adrenergic receptor signaling pathway A G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
atrial cardiac muscle cell action potential An action potential that occurs in an atrial cardiac muscle cell.
auditory receptor cell development The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
cardiac conduction Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.
cardiac muscle contraction Muscle contraction of cardiac muscle tissue.
cellular chloride ion homeostasis Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell.
cellular response to cAMP Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
cellular response to epinephrine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.
cellular response to xenobiotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
chloride ion homeostasis Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell.
circulatory system development The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.
cochlea development The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.
corticosterone secretion The regulated release of corticosterone into the circulatory system. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
detection of mechanical stimulus involved in sensory perception of sound The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal.
erythrocyte differentiation The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
gastric acid secretion The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
gastrin-induced gastric acid secretion The regulated release of gastric acid induced by the interaction of gastrin with its receptor.
gene expression The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes.
glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
inner ear development The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
inner ear morphogenesis The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
intestinal absorption Any process in which nutrients are taken up from the contents of the intestine.
iodide transport The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
membrane repolarization The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.
membrane repolarization during action potential The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
membrane repolarization during atrial cardiac muscle cell action potential The process in which ions are transported across a membrane such that the atrial cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
membrane repolarization during cardiac muscle cell action potential The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
membrane repolarization during ventricular cardiac muscle cell action potential The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
negative regulation of delayed rectifier potassium channel activity Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of insulin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
negative regulation of voltage-gated potassium channel activity Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity.
non-motile cilium assembly The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium.
positive regulation of cardiac muscle contraction Any process that increases the frequency, rate or extent of cardiac muscle contraction.
positive regulation of gastric acid secretion Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
positive regulation of heart rate Any process that activates or increases the frequency or rate of heart contraction.
positive regulation of potassium ion transmembrane transport Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport.
potassium ion export across plasma membrane The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region.
potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell.
potassium ion import across plasma membrane The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
potassium ion transport The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of atrial cardiac muscle cell membrane repolarization Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte.
regulation of blood pressure Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
regulation of gastric acid secretion Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
regulation of gene expression by genomic imprinting An epigenetic mechanism of regulation of gene expression in which epigenetic modifications (imprints) are established during gametogenesis. For a given gene to show parentally biased expression, the imprint are established exclusively in one of the two parental genomes, thus generating an asymmetry between the maternal and paternal alleles.
regulation of heart rate Any process that modulates the frequency or rate of heart contraction.
regulation of heart rate by cardiac conduction A cardiac conduction process that modulates the frequency or rate of heart contraction.
regulation of membrane potential Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
regulation of membrane repolarization Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative.
regulation of transporter activity Any process that modulates the activity of a transporter.
regulation of ventricular cardiac muscle cell membrane repolarization Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.
regulation of voltage-gated sodium channel activity Any process that modulates the frequency, rate or extent of voltage-gated sodium channel activity.
renal absorption A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686).
renal sodium ion absorption A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.
response to anesthetic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anesthetic stimulus. An anesthetic is a substance that causes loss of feeling, awareness, or sensation.
response to epinephrine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.
response to insulin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
response to nicotine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
rhythmic behavior The specific behavior of an organism that recur with measured regularity.
sensory perception of sound The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
social behavior Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.
sodium ion transport The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
stomach development The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ.
ventricular cardiac muscle cell action potential An action potential that occurs in a ventricular cardiac muscle cell.

19 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P58126 KCNQ3 Potassium voltage-gated channel subfamily KQT member 3 Bos taurus (Bovine) PR
O43525 KCNQ3 Potassium voltage-gated channel subfamily KQT member 3 Homo sapiens (Human) PR
P56696 KCNQ4 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens (Human) PR
Q9JK45 Kcnq5 Potassium voltage-gated channel subfamily KQT member 5 Mus musculus (Mouse) PR
Q9JK97 Kcnq4 Potassium voltage-gated channel subfamily KQT member 4 Mus musculus (Mouse) PR
Q8K3F6 Kcnq3 Potassium voltage-gated channel subfamily KQT member 3 Mus musculus (Mouse) PR
Q61423 Kcna4 Potassium voltage-gated channel subfamily A member 4 Mus musculus (Mouse) PR
P16390 Kcna3 Potassium voltage-gated channel subfamily A member 3 Mus musculus (Mouse) PR
Q17ST2 Kcna7 Potassium voltage-gated channel subfamily A member 7 Mus musculus (Mouse) PR
P16388 Kcna1 Potassium voltage-gated channel subfamily A member 1 Mus musculus (Mouse) PR
Q9Z0V1 Kcnd3 Potassium voltage-gated channel subfamily D member 3 Mus musculus (Mouse) PR
Q9Z0V2 Kcnd2 Potassium voltage-gated channel subfamily D member 2 Mus musculus (Mouse) PR
O35174 Kcns2 Potassium voltage-gated channel subfamily S member 2 Mus musculus (Mouse) PR
Q03717 Kcnb1 Potassium voltage-gated channel subfamily B member 1 Mus musculus (Mouse) PR
Q80XM3 Kcng4 Potassium voltage-gated channel subfamily G member 4 Mus musculus (Mouse) PR
Q7TSH7 Kcnf1 Potassium voltage-gated channel subfamily F member 1 Mus musculus (Mouse) PR
A6H8H5 Kcnb2 Potassium voltage-gated channel subfamily B member 2 Mus musculus (Mouse) PR
Q9JK96 Kcnq4 Potassium voltage-gated channel subfamily KQT member 4 Rattus norvegicus (Rat) PR
O88944 Kcnq3 Potassium voltage-gated channel subfamily KQT member 3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MDTASSPPSA ERKRAGWSRL LGARRGSAVV KKCPFSLELA EGGPEGSTVY APIAPTGAPG
70 80 90 100 110 120
LAPPMSTPVS PAPAPADLGP RPRVSLDPRV SIYSARRPLL ARTHIQGRVY NFLERPTGWK
130 140 150 160 170 180
CFVYHFTVFL IVLVCLIFSV LSTIEQYAAL ATGTLFWMEI VLVVFFGTEY VVRLWSAGCR
190 200 210 220 230 240
SKYVGIWGRL RFARKPISII DLIVVVASMV VLCVGSKGQV FATSAIRGIR FLQILRMLHV
250 260 270 280 290 300
DRQGGTWRLL GSVVFIHRQE LITTLYIGFL GLIFSSYFVY LAEKDAVNES GRIEFGSYAD
310 320 330 340 350 360
ALWWGVVTVT TIGYGDKVPQ TWVGKTIASC FSVFAISFFA LPAGILGSGF ALKVQQKQRQ
370 380 390 400 410 420
KHFNRQIPAA ASLIQTAWRC YAAENPDSAT WKIYVRKPAR SHTLLSPSPK PKKSVMVKKK
430 440 450 460 470 480
KFKLDKDNGM SPGEKMFNVP HITYDPPEDR RPDHFSIDGY DSSVRKSPTL LEVSTPHFLR
490 500 510 520 530 540
TNSFAEDLDL EGETLLTPIT HVSQLRDHHR ATIKVIRRMQ YFVAKKKFQQ ARKPYDVRDV
550 560 570 580 590 600
IEQYSQGHLN LMVRIKELQR RLDQSIGKPS LFIPISEKSK DRGSNTIGAR LNRVEDKVTQ
610 620 630 640 650 660
LDQRLVIITD MLHQLLSMQQ GGPTCNSRSQ VVASNEGGSI NPELFLPSNS LPTYEQLTVP
QTGPDEGS