P58126

PR
Gene name
KCNQ3
Protein name
Potassium voltage-gated channel subfamily KQT member 3
Names
KQT-like 3, Potassium channel subunit alpha KvLQT3, Voltage-gated potassium channel subunit Kv7.3
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281884
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

46-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P58126

Entry ID Method Resolution Chain Position Source
AF-P58126-F1 Predicted AlphaFoldDB

282 variants for P58126

Variant ID(s) Position Change Description Diseaes Association Provenance
rs451566600 29 A>G No EVA
rs433567831 32 D>A No EVA
rs453686320 32 D>E No EVA
rs433567831 32 D>G No EVA
rs473615051 36 A>D No EVA
rs473615051 36 A>G No EVA
rs462495935 38 D>E No EVA
rs442434287 38 D>G No EVA
rs476591252 39 E>G No EVA
rs438998814 40 E>G No EVA
rs459237414 41 R>G No EVA
rs135071311 42 K>E No EVA
rs447965656 43 V>E No EVA
rs447965656 43 V>G No EVA
rs481428861 45 L>P No EVA
rs481428861 45 L>R No EVA
rs470305559 46 A>G No EVA
rs719418796 48 G>S No EVA
rs445031896 49 D>G No EVA
rs465265344 50 V>G No EVA
rs433822219 51 E>G No EVA
rs454006860 52 Q>R No EVA
rs476157328 60 G>A No EVA
rs452575801 62 D>E No EVA
rs472847620 64 D>A No EVA
rs441458668 64 D>E No EVA
rs461662532 66 T>I No EVA
rs481390130 68 L>R No EVA
rs443676703 69 L>M No EVA
rs443676703 69 L>V No EVA
rs463842460 71 G>R No EVA
rs446127446 72 G>R No EVA
rs478867267 75 D>A No EVA
rs447472690 75 D>E No EVA
rs467540076 78 Q>E No EVA
rs456023645 79 R>G No EVA
rs432024204 81 T>A No EVA
rs452195239 82 P>Q No EVA
rs441430723 83 Q>H No EVA
rs472749083 83 Q>P No EVA
rs472749083 83 Q>R No EVA
rs455210996 84 G>D No EVA
rs443642682 85 I>N No EVA
rs477447393 86 G>A No EVA
rs463703246 86 G>W No EVA
rs459866696 87 L>H No EVA
rs439651988 87 L>I No EVA
rs439651988 87 L>V No EVA
rs478835072 88 L>M No EVA
rs461080777 90 K>R No EVA
rs481075102 91 T>A No EVA
rs449904543 91 T>K No EVA
rs481075102 91 T>P No EVA
rs469576262 92 P>A No EVA
rs469576262 92 P>T No EVA
rs109144274 93 L>M No EVA
rs431979983 104 Y>D No EVA
rs431979983 104 Y>N No EVA
rs445670446 106 R>C No EVA
rs465913333 107 I>S No EVA
rs465604422 108 Q>* No EVA
rs434969512 109 T>P No EVA
rs455171800 112 Y>H No EVA
rs475201714 115 L>V No EVA
rs437449625 116 E>G No EVA
rs470942133 117 R>S No EVA
rs457644188 117 R>T No EVA
rs439619911 118 P>Q No EVA
rs473577696 123 L>Q No EVA
rs442073705 124 L>I No EVA
rs460941781 124 L>P No EVA
rs463694826 125 Y>* No EVA
rs449865681 125 Y>C No EVA
rs481037853 125 Y>D No EVA
rs449865681 125 Y>S No EVA
rs477027950 126 H>P No EVA
rs445664783 126 H>Q No EVA
rs465821712 127 A>G No EVA
rs434428385 129 V>G No EVA
rs136010147 180 C>F No EVA
rs133813481 180 C>W No EVA
rs136010147 180 C>Y No EVA
rs463881569 181 C>S No EVA
rs518662778 183 R>Q No EVA
rs437069668 194 A>T No EVA
rs450549291 195 R>G No EVA
rs464121744 201 L>V No EVA
rs466055372 202 D>G No EVA
rs434666643 204 F>C No EVA
rs468143065 205 V>G No EVA
rs448103967 205 V>L No EVA
rs436891015 206 L>M No EVA
rs456986060 206 L>Q No EVA
rs433417325 207 I>V No EVA
rs453456947 208 A>S No EVA
rs442271747 210 V>A No EVA
rs473736203 210 V>L No EVA
rs455596164 211 P>H No EVA
rs475568423 212 V>L No EVA
rs444391572 213 V>F No EVA
rs458126064 213 V>G No EVA
rs478330322 214 A>D No EVA
rs439424563 223 A>D No EVA
rs439424563 223 A>G No EVA
rs459515704 228 S>G No EVA
rs479783634 228 S>I No EVA
rs448340290 229 L>M No EVA
rs468175648 229 L>Q No EVA
rs481855002 232 L>V No EVA
rs432851826 237 M>I No EVA
rs464250229 237 M>L No EVA
rs453455276 239 R>L No EVA
rs467160379 241 D>G No EVA
rs435861291 243 R>W No EVA
rs475911823 244 G>A No EVA
rs455915853 244 G>C No EVA
rs451666172 245 G>C No EVA
rs440463672 246 T>A No EVA
rs440463672 246 T>P No EVA
rs440463672 246 T>S No EVA
rs459484175 246 T>S No EVA
rs479615401 247 W>G No EVA
rs479615401 247 W>R No EVA
rs441827884 247 W>S No EVA
rs462085840 248 K>E No EVA
rs482092649 248 K>N No EVA
rs462085840 248 K>Q No EVA
rs464126807 249 L>H No EVA
rs464126807 249 L>P No EVA
rs464126807 249 L>R No EVA
rs450551249 249 L>V No EVA
rs446487635 250 L>P No EVA
rs446487635 250 L>Q No EVA
rs477976713 250 L>V No EVA
rs466618031 251 G>A No EVA
rs455755513 252 S>P No EVA
rs455755513 252 S>T No EVA
rs469545417 252 S>W No EVA
rs451626349 253 A>G No EVA
rs471765777 254 I>F No EVA
rs471765777 254 I>L No EVA
rs434079774 254 I>T No EVA
rs474291453 255 C>R No EVA
rs441866659 255 C>Y No EVA
rs461924259 256 A>P No EVA
rs461924259 256 A>S No EVA
rs475712244 257 H>P No EVA
rs444318737 257 H>Q No EVA
rs457667297 258 S>I No EVA
rs457667297 258 S>N No EVA
rs457667297 258 S>T No EVA
rs477884897 259 K>Q No EVA
rs477358058 295 E>D No EVA
rs460066025 345 A>S No EVA
rs473329007 349 G>R No EVA
rs442023111 351 L>P No EVA
rs461114664 353 S>T No EVA
rs474867402 354 G>E No EVA
rs443374394 359 V>A No EVA
rs443374394 359 V>G No EVA
rs463700907 362 Q>R No EVA
rs477264335 363 H>P No EVA
rs445683832 363 H>Q No EVA
rs459292059 364 R>S No EVA
rs479514136 366 K>Q No EVA
rs526032480 369 E>K No EVA
rs448205628 373 K>E No EVA
rs468240128 376 A>D No EVA
rs458864575 431 R>G No EVA
rs478921082 437 G>A No EVA
rs478921082 437 G>V No EVA
rs447241048 443 K>N No EVA
rs460903318 457 P>T No EVA
rs481004375 466 S>A No EVA
rs449853265 481 Y>S No EVA
rs469857085 485 Q>P No EVA
rs477676406 488 E>* No EVA
rs449388659 491 G>R No EVA
rs468414794 491 G>V No EVA
rs436966616 514 T>P No EVA
rs719674661 577 P>L No EVA
rs452279995 579 T>P No EVA
rs472497719 580 P>Q No EVA
rs472497719 580 P>R No EVA
rs434714569 584 K>M No EVA
rs454821542 589 A>P No EVA
rs474629566 590 A>P No EVA
rs474629566 590 A>S No EVA
rs443199558 591 F>L No EVA
rs463438721 592 T>P No EVA
rs524619315 594 P>Q No EVA
rs521711155 604 Y>* No EVA
rs482671899 631 D>V No EVA
rs479211514 634 K>E No EVA
rs468085594 638 F>I No EVA
rs436714092 638 F>S No EVA
rs456797246 639 L>M No EVA
rs470217007 640 V>L No EVA
rs432346760 644 L>M No EVA
rs472455343 645 Q>H No EVA
rs452495696 645 Q>K No EVA
rs440182710 651 Q>P No EVA
rs453742831 652 V>G No EVA
rs474007380 653 H>L No EVA
rs474007380 653 H>R No EVA
rs462849470 656 G>R No EVA
rs476217624 658 S>A No EVA
rs438370894 659 P>A No EVA
rs718138741 661 K>N No EVA
rs478670001 663 A>G No EVA
rs458653599 663 A>P No EVA
rs478670001 663 A>V No EVA
rs447369275 665 S>P No EVA
rs461536112 666 P>A No EVA
rs481663409 667 A>D No EVA
rs799186926 670 E>K No EVA
rs450338293 670 E>V No EVA
rs432353201 678 A>G No EVA
rs445975243 686 N>K No EVA
rs466115171 698 S>R No EVA
rs434882613 699 F>L No EVA
rs454875431 704 V>G No EVA
rs474051627 707 V>A No EVA
rs456372672 729 K>T No EVA
rs476518413 739 P>T No EVA
rs438432412 741 V>A No EVA
rs458565511 743 P>R No EVA
rs472164469 744 I>F No EVA
rs440990294 749 D>E No EVA
rs481682605 752 G>R No EVA
rs718198782 755 R>H No EVA
rs450216244 755 R>S No EVA
rs517208870 758 V>A No EVA
rs464043345 761 H>D No EVA
rs477470160 761 H>P No EVA
rs446284021 761 H>Q No EVA
rs477470160 761 H>R No EVA
rs466052166 762 G>A No EVA
rs448496424 767 R>Q No EVA
rs522261112 774 R>C No EVA
rs468652879 775 S>R No EVA
rs436208447 776 I>S No EVA
rs456280723 780 S>R No EVA
rs476393306 782 T>P No EVA
rs432276074 783 P>T No EVA
rs452421428 786 L>V No EVA
rs440800258 791 H>P No EVA
rs472227868 791 H>Y No EVA
rs454544325 800 G>V No EVA
rs474693788 807 R>I No EVA
rs463994272 811 A>E No EVA
rs477384640 813 G>A No EVA
rs439906504 815 S>T No EVA
rs459839303 817 G>A No EVA
rs479620861 818 S>T No EVA
rs448442851 819 S>N No EVA
rs468667890 825 R>P No EVA
rs432137082 826 Y>* No EVA
rs450873803 826 Y>D No EVA
rs470022854 826 Y>S No EVA
rs452433521 827 L>M No EVA
rs466017258 827 L>R No EVA
rs465120929 829 E>D No EVA
rs454475285 829 E>K No EVA
rs443338550 831 E>A No EVA
rs471021675 834 T>P No EVA
rs439718234 835 D>A No EVA
rs439718234 835 D>V No EVA
rs479884714 836 T>N No EVA
rs459900426 836 T>P No EVA
rs482275950 839 F>L No EVA
rs462183209 839 F>V No EVA
rs477202289 844 S>A No EVA
rs434709741 848 S>A No EVA
rs436740679 854 I>S No EVA
rs468239314 854 I>V No EVA
rs456877520 855 S>T No EVA
rs433369134 856 D>G No EVA
rs470483680 856 D>Y No EVA
rs453417531 857 S>P No EVA
rs473572828 858 I>L No EVA
rs462413470 867 T>K No EVA

No associated diseases with P58126

3 regional properties for P58126

Type Name Position InterPro Accession
domain Ion transport domain 126 - 353 IPR005821
domain Potassium channel, voltage dependent, KCNQ, C-terminal 447 - 649 IPR013821
binding_site Ankyrin-G binding site 765 - 860 IPR020969

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
axon initial segment Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
cell surface The external part of the cell wall and/or plasma membrane.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
node of Ranvier An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.
voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

3 GO annotations of molecular function

Name Definition
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
delayed rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
voltage-gated potassium channel activity Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

4 GO annotations of biological process

Name Definition
establishment of localization in cell Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.
membrane hyperpolarization The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P56696 KCNQ4 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens (Human) PR
O43525 KCNQ3 Potassium voltage-gated channel subfamily KQT member 3 Homo sapiens (Human) PR
Q9JK45 Kcnq5 Potassium voltage-gated channel subfamily KQT member 5 Mus musculus (Mouse) PR
P97414 Kcnq1 Potassium voltage-gated channel subfamily KQT member 1 Mus musculus (Mouse) PR
Q8K3F6 Kcnq3 Potassium voltage-gated channel subfamily KQT member 3 Mus musculus (Mouse) PR
Q9JK97 Kcnq4 Potassium voltage-gated channel subfamily KQT member 4 Mus musculus (Mouse) PR
Q9JK96 Kcnq4 Potassium voltage-gated channel subfamily KQT member 4 Rattus norvegicus (Rat) PR
O88944 Kcnq3 Potassium voltage-gated channel subfamily KQT member 3 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGLKARRPAG AAGGGGDGGG GGGGAANPAG GDAAAAGDEE RKVGLAPGDV EQVTLALGAG
70 80 90 100 110 120
ADKDGTLLLE GGGRDEGQRR TPQGIGLLAK TPLSRPVKRN NAKYRRIQTL IYDALERPRG
130 140 150 160 170 180
WALLYHALVF LIVLGCLILA VLTTFREYET VSGDWLLLLE TFAIFIFGAE FALRIWAAGC
190 200 210 220 230 240
CCRYKGWRGR LKFARKPLCM LDIFVLIASV PVVAVGNQGN VLATSLRSLR FLQILRMLRM
250 260 270 280 290 300
DRRGGTWKLL GSAICAHSKE LITAWYIGFL TLILSSFLVY LVEKDVPEVD AQGEEMKEEF
310 320 330 340 350 360
ETYADALWWG LITLATIGYG DKTPKTWEGR LIAATFSLIG VSFFALPAGI LGSGLALKVQ
370 380 390 400 410 420
EQHRQKHFEK RRKPAAELIQ AAWRYYATNP NRIDLVATWR FYESVVSFPF FRKEQLDPAA
430 440 450 460 470 480
SQKLGLLDRV RLSNPRGSNT KGKLFTPLNV DAIEESPSKE PKPVGSNNKE RFRTAFRMKA
490 500 510 520 530 540
YAFWQSSEDA GTGDPTAEDR GYGNDFLIED MIPTLKAAIR AVRILQFRLY KKKFKETLRP
550 560 570 580 590 600
YDVKDVIEQY SAGHLDMLSR IKYLQTRIDM IFTPGPPSTP KHKKSQRGAA FTYPSQQSPR
610 620 630 640 650 660
NEPYVARPST SETEDQSMMG KFVKVERQVH DMGKKLDFLV DMHLQHMERL QVHVAGFSPS
670 680 690 700 710 720
KGASSPAEAE QKEDRRDADL KTIICNYSET GAPDAPYSFH QVPVDKVGPY GFFAHDPVNL
730 740 750 760 770 780
PLGGPSSGKG HATPYAERPT VLPILTLLDS RGSYRSQVEL HGPCSDRVSP RQRRSITRDS
790 800 810 820 830 840
DTPLSLMSVN HEELERSPSG FSISQDRDDY AFGPSGGSSW MREKRYLAEG ETDTDTEPFT
850 860
PSGSLPLSST GDGISDSIWT PSGKPT