Q9JK45
Gene name |
Kcnq5 |
Protein name |
Potassium voltage-gated channel subfamily KQT member 5 |
Names |
KQT-like 5, Potassium channel subunit alpha KvLQT5, Voltage-gated potassium channel subunit Kv7.5 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:226922 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JK45
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JK45-F1 | Predicted | AlphaFoldDB |
15 variants for Q9JK45
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388461690 | 246 | M>K | No | EVA | |
| rs3388459078 | 247 | D>G | No | EVA | |
| rs3388460634 | 248 | R>S | No | EVA | |
| rs3388460398 | 324 | L>M | No | EVA | |
| rs3388458984 | 336 | G>D | No | EVA | |
| rs3388459884 | 386 | E>G | No | EVA | |
| rs3388459101 | 394 | W>* | No | EVA | |
| rs3388460369 | 400 | A>G | No | EVA | |
| rs3389727432 | 406 | P>T | No | EVA | |
| rs3388460203 | 428 | M>T | No | EVA | |
| rs3388459014 | 459 | P>H | No | EVA | |
| rs3388461707 | 467 | S>I | No | EVA | |
| rs3388461653 | 492 | D>N | No | EVA | |
| rs3388460120 | 493 | T>I | No | EVA | |
| rs3388461587 | 572 | V>L | No | EVA |
No associated diseases with Q9JK45
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| clathrin coat | A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| voltage-gated potassium channel complex | A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| delayed rectifier potassium channel activity | Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. |
| voltage-gated potassium channel activity | Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| potassium ion transmembrane transport | A process in which a potassium ion is transported from one side of a membrane to the other. |
| potassium ion transport | The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P58126 | KCNQ3 | Potassium voltage-gated channel subfamily KQT member 3 | Bos taurus (Bovine) | PR |
| P56696 | KCNQ4 | Potassium voltage-gated channel subfamily KQT member 4 | Homo sapiens (Human) | PR |
| O43525 | KCNQ3 | Potassium voltage-gated channel subfamily KQT member 3 | Homo sapiens (Human) | PR |
| P97414 | Kcnq1 | Potassium voltage-gated channel subfamily KQT member 1 | Mus musculus (Mouse) | PR |
| Q8K3F6 | Kcnq3 | Potassium voltage-gated channel subfamily KQT member 3 | Mus musculus (Mouse) | PR |
| Q9JK97 | Kcnq4 | Potassium voltage-gated channel subfamily KQT member 4 | Mus musculus (Mouse) | PR |
| Q9JK96 | Kcnq4 | Potassium voltage-gated channel subfamily KQT member 4 | Rattus norvegicus (Rat) | PR |
| O88944 | Kcnq3 | Potassium voltage-gated channel subfamily KQT member 3 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPRHHAGGEE | GGAAGLWVRS | GAAAAAGAGG | GRPGSGMKDV | ESGRGRVLLN | SAAARGDGLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLGTRAAALG | GGGGGLRESR | RGKQGARMSL | LGKPLSYTSS | QSCRRNVKYR | RVQNYLYNVL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ERPRGWAFVY | HAFVFLLVFG | CLILSVFSTI | PEHTKLASSC | LLILEFVMIV | VFGLEFIIRI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WSAGCCCRYR | GWQGRLRFAR | KPFCVIDTIV | LIASIAVVSA | KTQGNIFATS | ALRSLRFLQI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LRMVRMDRRG | GTWKLLGSVV | YAHSKELITA | WYIGFLVLIF | SSFLVYLVEK | DANKEFSTYA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DALWWGTITL | TTIGYGDKTP | LTWLGRLLSA | GFALLGISFF | ALPAGILGSG | FALKVQEQHR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QKHFEKRRNP | AANLIQCVWR | SYAADEKSVS | IATWKPHLKA | LHTCSPTKKE | QGEASSSQKL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SFKERVRMAS | PRGQSIKSRQ | ASVGDRRSPS | TDITAEGSPT | KVQKSWSFND | RTRFRPSLRL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KSSQPKPVID | ADTALGIDDV | YDEKGCQCDV | SVEDLTPPLK | TVIRAIRIMK | FHVAKRKFKE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TLRPYDVKDV | IEQYSAGHLD | MLCRIKSLQT | RVDQILGKGQ | MTSDKKSREK | ITAEHETTDD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PSMLARVVKV | EKQVQSIESK | LDCLLDIYQQ | VLRKGSASAL | TLASFQIPPF | ECEQTSDYQS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PVDSKDLSGS | AQNSGCLTRS | ASANISRGLQ | FILTPNEFSA | QTFYALSPTM | HSQATQVPMS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QNDGSSVVAT | NNIANQISAA | PKPAAPTTLQ | IPPPLSAIKH | LSRPEPLLSN | PTGLQESISD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VTTCLVASKE | SVQFAQSNLT | KDRSLRKSFD | MGGETLLSVR | PMVPKDLGKS | LSVQNLIRST |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EELNLQFSGS | ESSGSRGSQD | FYPKWRESKL | FITDEEVGAE | ETETDTFDGT | PPPAGEAAFS |
| 910 | 920 | 930 | |||
| SDSLRTGRSR | SSQNICKTGD | STDALSLPHV | KLN |