Q7KVY7
PR
Gene name |
Syx4 |
Protein name |
Syntaxin-4 |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG2715 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7KVY7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7KVY7-F1 | Predicted | AlphaFoldDB |
4 variants for Q7KVY7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 67 | T>S | strain: AF1, AF2, AF3, AF4, K11, K14, K16, K2, K21, K3, K5, K7, ZH1, ZH13, ZH16, ZH19, ZH2, ZH20, ZH21, ZH23, ZH25, ZH29, ZH31 and ZH33 [UniProt] | No | ||
| 71 | D>V | strain: ZH20 [UniProt] | No | ||
| 97 | Q>L | strain: wi3 [UniProt] | No | ||
| 107 | T>A | strain: AF1, AF2, AF3, AF4, K11, K14, K16, K2, K21, K3, K5, K7, ZH1, ZH13, ZH16, ZH19, ZH2, ZH20, ZH21, ZH23, ZH25, ZH29, ZH31 and ZH33 [UniProt] | No |
No associated diseases with Q7KVY7
No regional properties for Q7KVY7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q7KVY7 | |||
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endomembrane system | A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
| SNARE complex | A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| SNAP receptor activity | Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. |
| SNARE binding | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| membrane fusion | The membrane organization process that joins two lipid bilayers to form a single membrane. |
| regulation of synaptic assembly at neuromuscular junction | Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions. |
| retrograde trans-synaptic signaling | Cell-cell signaling from post to pre-synapse, across the synaptic cleft. |
| synaptic vesicle docking | The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process. |
| vesicle docking | The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. |
| vesicle fusion | Fusion of the membrane of a transport vesicle with its target membrane. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32854 | PEP12 | Syntaxin PEP12 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3SWZ3 | STX4 | Syntaxin-4 | Bos taurus (Bovine) | PR |
| P61267 | STX1B | Syntaxin-1B | Bos taurus (Bovine) | PR |
| Q3ZBT5 | STX7 | Syntaxin-7 | Bos taurus (Bovine) | PR |
| Q24547 | Syx1A | Syntaxin-1A | Drosophila melanogaster (Fruit fly) | PR |
| P61266 | STX1B | Syntaxin-1B | Homo sapiens (Human) | PR |
| Q16623 | STX1A | Syntaxin-1A | Homo sapiens (Human) | PR |
| Q12846 | STX4 | Syntaxin-4 | Homo sapiens (Human) | PR |
| O75558 | STX11 | Syntaxin-11 | Homo sapiens (Human) | PR |
| O15400 | STX7 | Syntaxin-7 | Homo sapiens (Human) | PR |
| O35526 | Stx1a | Syntaxin-1A | Mus musculus (Mouse) | PR |
| Q00262 | Stx2 | Syntaxin-2 | Mus musculus (Mouse) | PR |
| P70452 | Stx4 | Syntaxin-4 | Mus musculus (Mouse) | PR |
| Q9D3G5 | Stx11 | Syntaxin-11 | Mus musculus (Mouse) | PR |
| P61264 | Stx1b | Syntaxin-1B | Mus musculus (Mouse) | PR |
| O70439 | Stx7 | Syntaxin-7 | Mus musculus (Mouse) | PR |
| P50279 | Stx2 | Syntaxin-2 | Rattus norvegicus (Rat) | PR |
| P61265 | Stx1b | Syntaxin-1B | Rattus norvegicus (Rat) | PR |
| Q08850 | Stx4 | Syntaxin-4 | Rattus norvegicus (Rat) | PR |
| P32851 | Stx1a | Syntaxin-1A | Rattus norvegicus (Rat) | PR |
| O70257 | Stx7 | Syntaxin-7 | Rattus norvegicus (Rat) | PR |
| O16000 | unc-64 | Syntaxin-1A homolog | Caenorhabditis elegans | PR |
| Q9ZPV9 | SYP112 | Syntaxin-112 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKDRLPELL | QRSLSTNSSN | SSSNGSLLLN | VYSGTTEFII | GNTGGNNNSY | SVVSQNSHSC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SNNNSSTEPK | DRSSSKMTQY | GSNVDDILNP | YTEIRQQLAQ | IAANLETMNR | MAQTVNLRTF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NENEMDELHN | KNLRLGNQLM | TRFNDFKANL | PAENDYSLEA | RMKRTLFYGL | HQTFINLWHK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NELFLQNYET | KVKKNLRLHT | KIINSEASEQ | EIELLIENKT | TKLFVDNFLQ | ETEKERQTLR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EMMDRFNELR | RLEKSIEEVH | ALFMRIQTLV | MEQSEVIQRV | EFHAQQATLH | VDKGADELDQ |
| 310 | 320 | 330 | |||
| AEQHQKKARK | KKIMLIVILA | AVLLVLLLVG | IYL |