Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for O70439
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1GL2 | X-ray | 190 A | B | 169-228 | PDB |
| AF-O70439-F1 | Predicted | AlphaFoldDB |
No variants for O70439
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O70439 | |||||
No associated diseases with O70439
20 GO annotations of cellular component
| Name | Definition |
|---|---|
| azurophil granule | Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| endocytic vesicle | A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. |
| endomembrane system | A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| immunological synapse | An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of synaptic vesicle membrane | The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| late endosome membrane | The lipid bilayer surrounding a late endosome. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| recycling endosome | An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. |
| SNARE complex | A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
| tertiary granule | A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells. |
| vesicle | Any small, fluid-filled, spherical organelle enclosed by membrane. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| chloride channel inhibitor activity | Binds to and stops, prevents, or reduces the activity of a chloride channel. |
| protein-containing complex binding | Binding to a macromolecular complex. |
| SNAP receptor activity | Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. |
| SNARE binding | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. |
| syntaxin binding | Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| endosome to lysosome transport | The directed movement of substances from endosomes to lysosomes. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| organelle assembly | The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. |
| organelle localization | Any process in which an organelle is transported to, and/or maintained in, a specific location. |
| positive regulation of receptor localization to synapse | Any process that activates or increases the frequency, rate or extent of receptor localization to synapse. |
| positive regulation of T cell mediated cytotoxicity | Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. |
| regulation of protein localization to plasma membrane | Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. |
| vesicle docking | The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. |
| vesicle fusion | Fusion of the membrane of a transport vesicle with its target membrane. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32854 | PEP12 | Syntaxin PEP12 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3ZBT5 | STX7 | Syntaxin-7 | Bos taurus (Bovine) | PR |
| Q7KVY7 | Syx4 | Syntaxin-4 | Drosophila melanogaster (Fruit fly) | PR |
| O15400 | STX7 | Syntaxin-7 | Homo sapiens (Human) | PR |
| P70452 | Stx4 | Syntaxin-4 | Mus musculus (Mouse) | PR |
| P61264 | Stx1b | Syntaxin-1B | Mus musculus (Mouse) | PR |
| Q00262 | Stx2 | Syntaxin-2 | Mus musculus (Mouse) | PR |
| Q9D3G5 | Stx11 | Syntaxin-11 | Mus musculus (Mouse) | PR |
| O35526 | Stx1a | Syntaxin-1A | Mus musculus (Mouse) | PR |
| O70257 | Stx7 | Syntaxin-7 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSYTPGIGGD | SAQLAQRISS | NIQKITQCSV | EIQRTLNQLG | TPQDSPELRQ | LLQQKQQYTN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QLAKETDKYI | KEFGSLPTTP | SEQRQRKIQK | DRLVAEFTTS | LTNFQKAQRQ | AAEREKEFVA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RVRASSRVSG | GFPEDSSKEK | NLVSWESQTQ | PQVQVQDEEI | TEDDLRLIHE | RESSIRQLEA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DIMDINEIFK | DLGMMIHEQG | DMIDSIEANV | ESAEVHVQQA | NQQLSRAADY | QRKSRKTLCI |
| 250 | 260 | ||||
| IIFILVVRIV | IICLIVWGLK | G |