Q3ZBT5
PR
Gene name |
STX7 |
Protein name |
Syntaxin-7 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:507031 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3ZBT5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3ZBT5-F1 | Predicted | AlphaFoldDB |
22 variants for Q3ZBT5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs482752289 | 6 | G>R | No | EVA | |
| rs479676247 | 87 | K>E | No | EVA | |
| rs474611876 | 103 | N>K | No | EVA | |
| rs460860944 | 104 | F>V | No | EVA | |
| rs440789247 | 105 | Q>K | No | EVA | |
| rs432133277 | 107 | V>M | No | EVA | |
| rs456416426 | 108 | Q>H | No | EVA | |
| rs467701816 | 111 | A>G | No | EVA | |
| rs434770307 | 113 | E>G | No | EVA | |
| rs466068738 | 116 | K>Q | No | EVA | |
| rs446132451 | 118 | F>S | No | EVA | |
| rs477405135 | 120 | A>D | No | EVA | |
| rs463961205 | 122 | V>G | No | EVA | |
| rs450271721 | 125 | S>C | No | EVA | |
| rs447979130 | 130 | G>A | No | EVA | |
| rs439617515 | 173 | S>C | No | EVA | |
| rs466525692 | 241 | I>S | No | EVA | |
| rs478088765 | 242 | I>M | No | EVA | |
| rs446564907 | 242 | I>S | No | EVA | |
| rs464443646 | 245 | L>R | No | EVA | |
| rs450744936 | 246 | V>G | No | EVA | |
| rs483058082 | 250 | V>L | No | EVA |
No associated diseases with Q3ZBT5
12 GO annotations of cellular component
| Name | Definition |
|---|---|
| azurophil granule | Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| endocytic vesicle | A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. |
| endomembrane system | A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. |
| immunological synapse | An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| late endosome | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| recycling endosome | An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. |
| SNARE complex | A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
| tertiary granule | A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| chloride channel inhibitor activity | Binds to and stops, prevents, or reduces the activity of a chloride channel. |
| SNAP receptor activity | Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. |
| SNARE binding | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. |
| syntaxin binding | Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| organelle assembly | The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. |
| positive regulation of receptor localization to synapse | Any process that activates or increases the frequency, rate or extent of receptor localization to synapse. |
| positive regulation of T cell mediated cytotoxicity | Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. |
| regulation of protein localization to plasma membrane | Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. |
| vesicle docking | The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. |
| vesicle fusion | Fusion of the membrane of a transport vesicle with its target membrane. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32854 | PEP12 | Syntaxin PEP12 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3SWZ3 | STX4 | Syntaxin-4 | Bos taurus (Bovine) | PR |
| P61267 | STX1B | Syntaxin-1B | Bos taurus (Bovine) | PR |
| P32850 | STX1A | Syntaxin-1A | Bos taurus (Bovine) | PR |
| Q7KVY7 | Syx4 | Syntaxin-4 | Drosophila melanogaster (Fruit fly) | PR |
| O15400 | STX7 | Syntaxin-7 | Homo sapiens (Human) | PR |
| O70439 | Stx7 | Syntaxin-7 | Mus musculus (Mouse) | PR |
| O70257 | Stx7 | Syntaxin-7 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSYTPGVGGD | PAQLAQRISS | NIQKITQCSA | EIQRTLNQLG | TPQDSPELRQ | QLQQKQQYTN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QLAKETDKYI | KEFGSLPTTP | SDQRQRKIQK | DRLVAEFTAS | LTNFQKVQRQ | AAEREKEFVA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RVRASSRVSG | GFPEESSKER | NLVSWESQTQ | PQAQLQDEEI | TEDDLRLIQE | RESSIRQLEA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DIMDINEIFK | DLGMMIHEQG | DVIDSIEANV | ENAEVHVQQA | NQQLSRAADY | QRKSRKTLCI |
| 250 | 260 | ||||
| IIFILVIGVV | IIGLIIWGVK | G |