AiPD: Autoinhibited Protein Database

O15400

Gene name	STX7
Protein name	Syntaxin-7
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8417
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-256 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-256 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for O15400

Entry ID	Method	Resolution	Chain	Position	Source
AF-O15400-F1	Predicted				AlphaFoldDB

190 variants for O15400

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1562340319 CA365687632	2	S>C		No	ClinGen Ensembl
rs1479392994 CA365687630	3	Y>N		No	ClinGen TOPMed
CA365687622 rs752794991	4	T>A		No	ClinGen ExAC gnomAD
rs752794991 CA4003860	4	T>S		No	ClinGen ExAC gnomAD
rs1310681876 CA365687612	5	P>L		No	ClinGen TOPMed gnomAD
rs1354594719 CA365687615	5	P>S		No	ClinGen gnomAD
CA4003858 rs760092171	6	G>E		No	ClinGen ExAC gnomAD
rs369562473 CA4003857	11	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA365687577 rs369562473	11	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA4003854 rs1044057	12	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA365687569 rs1562340254	13	Q>E		No	ClinGen Ensembl
rs760207182 CA4003852	13	Q>H		No	ClinGen ExAC gnomAD
rs1186044216 CA365687551	15	A>D		No	ClinGen gnomAD
CA4003850 rs771903230	18	I>M		No	ClinGen ExAC gnomAD
CA4003849 rs745880493	19	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1364281387 CA365687521	20	S>C		No	ClinGen TOPMed
CA4003848 rs773991133	21	N>D		No	ClinGen ExAC TOPMed gnomAD
CA4003847 rs770796111	22	I>V		No	ClinGen ExAC gnomAD
CA4003846 rs372605930	26	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA4003845 rs777920429	27	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs756340040 CA4003843	28	C>Y		No	ClinGen ExAC
CA147979425 rs938409398	32	I>M		No	ClinGen Ensembl
rs755045655 CA4003820	32	I>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed
CA4003819 COSM277518 rs747083359	34	R>I	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA365687397 rs1187133503	37	N>S		No	ClinGen gnomAD
rs201355710 CA147979416	38	Q>*		No	ClinGen 1000Genomes
CA365687390 rs1453899868	38	Q>L		No	ClinGen TOPMed gnomAD
CA365687391 rs1453899868	38	Q>R		No	ClinGen TOPMed gnomAD
rs758981256 CA4003817	39	L>R		No	ClinGen ExAC TOPMed gnomAD
rs1459272607 CA365687385	39	L>V		No	ClinGen gnomAD
rs755811211 CA147979394	44	D>A		No	ClinGen ExAC TOPMed gnomAD
rs755811211 CA4003814	44	D>G		No	ClinGen ExAC TOPMed gnomAD
CA365687336 rs1201981928	47	E>*		No	ClinGen gnomAD
CA278780 rs864309676 RCV000203258	53	Q>H		No	ClinGen ClinVar Ensembl dbSNP
rs761610600 CA147977345	57	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs761610600 CA4003786	57	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA147977337 rs978366367	59	T>A		No	ClinGen Ensembl
CA365687220 rs1484513282	61	Q>*		No	ClinGen gnomAD
CA4003782 rs775613410	64	K>R		No	ClinGen ExAC gnomAD
CA4003781 rs772313425	65	E>Q		No	ClinGen ExAC gnomAD
CA365687175 rs1582653772	67	D>E		No	ClinGen Ensembl
CA365687172 rs1222194923	68	K>*		No	ClinGen TOPMed gnomAD
CA147977307 rs113421354	72	E>G		No	ClinGen Ensembl
CA4003779 rs779517620	73	F>I		No	ClinGen ExAC TOPMed gnomAD
rs1237596474 CA365687125 COSM164678	74	G>E	breast [Cosmic]	No	ClinGen cosmic curated gnomAD
TCGA novel	75	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	76	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778068381 CA4003776	77	P>L		No	ClinGen ExAC TOPMed gnomAD
rs778068381 CA365687108	77	P>R		No	ClinGen ExAC TOPMed gnomAD
rs754646108 CA4003774	78	T>I		No	ClinGen ExAC
CA147977254 rs772408320	79	T>I		No	ClinGen Ensembl
rs4410755 CA147977259	79	T>P		No	ClinGen Ensembl
CA4003772 rs779508895	80	P>R		No	ClinGen ExAC TOPMed gnomAD
CA4003771 rs757854094	81	S>N		No	ClinGen ExAC TOPMed gnomAD
CA365687078 rs1384422744	83	Q>K		No	ClinGen gnomAD
rs758050027 CA4003750	84	R>C		No	ClinGen ExAC gnomAD
rs745375542 CA4003749	84	R>H		No	ClinGen ExAC TOPMed gnomAD
rs758050027 CA4003751	84	R>S		No	ClinGen ExAC gnomAD
TCGA novel	86	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778450295 CA4003748	88	I>M		No	ClinGen ExAC gnomAD
rs1161993252 CA365687004	91	D>V		No	ClinGen gnomAD
COSM2153252 rs773741919 CA4003747	92	R>C	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA365686999 rs1365783081	92	R>H		No	ClinGen gnomAD
rs903617367 CA147976781	96	E>K		No	ClinGen Ensembl
CA365686955 rs1459624839	99	T>A		No	ClinGen TOPMed gnomAD
CA147976779 rs202107481	100	S>L		No	ClinGen 1000Genomes
rs1383897323 CA365686935	102	T>I		No	ClinGen TOPMed
rs200115851 CA4003745	103	N>D		No	ClinGen ExAC gnomAD
rs1461206436 CA365686920	104	F>L		No	ClinGen gnomAD
CA4003743 rs752556609	107	V>A		No	ClinGen ExAC gnomAD
rs755820982 CA4003744	107	V>F		No	ClinGen ExAC TOPMed gnomAD
CA4003742 rs767785107	110	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs767785107 CA365686883	110	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs770542402 CA147976743	111	A>P		No	ClinGen Ensembl
CA365686873 rs1562324571	111	A>V		No	ClinGen Ensembl
rs946492195 CA147976742	112	A>V		No	ClinGen TOPMed
rs1193625974 CA365686867	113	E>K		No	ClinGen gnomAD
CA4003739 rs763486294	114	R>*		No	ClinGen ExAC TOPMed gnomAD
CA4003738 rs763486294	114	R>G		No	ClinGen ExAC TOPMed gnomAD
CA4003737 rs773552054	114	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA365686856 rs1240326596	115	E>Q		No	ClinGen TOPMed
CA4003735 rs770348151	118	F>L		No	ClinGen ExAC gnomAD
CA4003734 rs748444335	119	V>I		No	ClinGen ExAC TOPMed gnomAD
CA4003733 rs777045654	121	R>*		No	ClinGen ExAC gnomAD
rs1042027145 CA147976701	121	R>L		No	ClinGen TOPMed
rs1042027145 CA365686813	121	R>Q		No	ClinGen TOPMed
TCGA novel	122	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365686799 rs1302570377	124	A>T		No	ClinGen gnomAD
CA4003732 rs771698278	125	S>G		No	ClinGen ExAC gnomAD
CA365686773 rs1372867837	128	V>M		No	ClinGen gnomAD
CA147976061 rs778849596	136	S>G		No	ClinGen TOPMed
rs1030879925 CA147976050	137	S>*		No	ClinGen TOPMed
CA365686691 rs1273748303	138	K>Q		No	ClinGen TOPMed
CA365686669 rs1374301510	141	N>H		No	ClinGen gnomAD
rs1218785494 CA365686666	141	N>S		No	ClinGen gnomAD
CA365686656 rs1436076870	143	V>I		No	ClinGen gnomAD
rs776955652 CA4003714	145	W>*		No	ClinGen ExAC gnomAD
CA365686634 rs1173683694	146	E>*		No	ClinGen gnomAD
rs1307445408 CA365686627	147	S>G		No	ClinGen TOPMed
rs201529204 CA4003696	149	T>I		No	ClinGen ExAC TOPMed gnomAD
rs201529204 CA4003697	149	T>S		No	ClinGen ExAC TOPMed gnomAD
rs369931134 CA4003694	151	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA4003693 rs142460328	153	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs775932086 CA4003692	154	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA365686567 rs775932086	154	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA147975539 rs540939045	155	V>M		No	ClinGen 1000Genomes TOPMed gnomAD
CA4003691 rs147685020	157	D>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772576698 CA4003690	158	E>D		No	ClinGen ExAC gnomAD
rs1270865726 CA365686516	161	T>I		No	ClinGen gnomAD
CA4003686 rs747692662	163	D>H		No	ClinGen ExAC gnomAD
CA4003685 rs781228048	165	L>F		No	ClinGen ExAC gnomAD
CA4003684 rs768719136	166	R>C		No	ClinGen ExAC TOPMed gnomAD
rs746775126 CA4003683	166	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA365686486 rs768719136	166	R>S		No	ClinGen ExAC TOPMed gnomAD
CA365686473 rs1379593472	168	I>T		No	ClinGen gnomAD
CA4003681 rs758525798	170	E>G		No	ClinGen ExAC gnomAD
CA365686377 rs148495140 COSM1073381	180	A>D	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA4003661 rs148495140	180	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs777889796 CA4003659 COSM1073380	181	D>G	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA4003660 rs749370601	181	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs756560065 CA4003658	182	I>T		No	ClinGen ExAC gnomAD
rs867860684 CA147974603	184	D>N		No	ClinGen Ensembl
rs1232962590 CA365686344	185	I>T		No	ClinGen gnomAD
rs1347746765 CA365686324	188	I>L		No	ClinGen gnomAD
rs144864017 CA4003657	191	D>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA365686300 rs1299829879	191	D>Y		No	ClinGen gnomAD
rs149848428 CA4003656	193	G>R		No	ClinGen ESP ExAC gnomAD
CA4003654 rs751884427	194	M>I		No	ClinGen ExAC gnomAD
rs1459709466 CA365686261	196	I>M		No	ClinGen TOPMed
rs764975922 CA4003653	196	I>T		No	ClinGen ExAC gnomAD
CA4003651 rs201892382	200	G>R		No	ClinGen ExAC gnomAD
CA4003650 rs763736446	201	D>N		No	ClinGen ExAC gnomAD
rs760131896 CA4003649	202	V>G		No	ClinGen ExAC gnomAD
rs1407030823 CA365686213	203	I>M		No	ClinGen gnomAD
CA365686216 rs1433554186	203	I>T		No	ClinGen gnomAD
rs1251514865 CA365686195	204	D>G		No	ClinGen TOPMed
rs774112518 CA4003625	205	S>I		No	ClinGen ExAC gnomAD
rs770756173 CA4003624	206	I>K		No	ClinGen ExAC
rs1582646331 CA365686178	207	E>K		No	ClinGen Ensembl
rs1396711703 CA365686166	208	A>G		No	ClinGen gnomAD
CA365686169 rs1314883777	208	A>T		No	ClinGen gnomAD
rs762768849 CA4003623	209	N>S		No	ClinGen ExAC TOPMed gnomAD
rs773375272 CA4003622	210	V>M		No	ClinGen ExAC gnomAD
CA4003621 rs769921819	211	E>Q		No	ClinGen ExAC gnomAD
COSM1698008 rs748192631 CA4003620	212	N>K	skin [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA365686133 rs1179604332	213	A>G		No	ClinGen TOPMed
CA365686138 rs1163718645	213	A>T		No	ClinGen gnomAD
CA4003619 rs530542469	214	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs530542469 CA365686132	214	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1164816730 CA365686115	216	H>R		No	ClinGen gnomAD
CA4003616 rs780736873	217	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	220	A>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA365686086 rs1249089671	220	A>G		No	ClinGen gnomAD
CA365686090 rs1372443650	220	A>T		No	ClinGen gnomAD
rs1209640875 CA365686080	221	N>S		No	ClinGen TOPMed gnomAD
rs1209640875 CA365686081	221	N>T		No	ClinGen TOPMed gnomAD
rs970685870 CA147995765	222	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs750828676 CA4003614	223	Q>R		No	ClinGen ExAC gnomAD
COSM3777123 CA365686048 COSM3777124 rs777413406	226	R>K	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA4003613 rs777413406	226	R>T		No	ClinGen ExAC gnomAD
CA4003612 rs755786190	228	A>V		No	ClinGen ExAC gnomAD
CA4003577 rs773669589	232	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4003576 rs746429926	232	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4003575 rs376336706	234	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA365685890 rs1368781628	237	T>N		No	ClinGen gnomAD
TCGA novel	237	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1582643008 CA365685884	238	L>P		No	ClinGen Ensembl
rs1269626265 CA365685878	239	C>Y		No	ClinGen gnomAD
CA365685873 rs1228675641	240	I>V		No	ClinGen gnomAD
CA4003573 rs372354234	241	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1390827242 CA365685843	244	I>M		No	ClinGen TOPMed
CA365685844 rs964239635	244	I>S		No	ClinGen TOPMed
CA147993900 rs964239635	244	I>T		No	ClinGen TOPMed
rs1385676566 CA365685840	245	L>F		No	ClinGen TOPMed
rs1385676566 CA365685842	245	L>I		No	ClinGen TOPMed
CA147993894 rs1017026752	247	I>T		No	ClinGen TOPMed gnomAD
rs774205615 CA147993899	247	I>V		No	ClinGen Ensembl
CA4003572 rs780651725	248	G>E		No	ClinGen ExAC gnomAD
CA365685818 rs1342713051	249	V>I		No	ClinGen gnomAD
CA365685810 rs1335463098	250	A>G		No	ClinGen TOPMed gnomAD
CA365685809 rs1335463098	250	A>V		No	ClinGen TOPMed gnomAD
rs746519125 CA4003570	251	I>M		No	ClinGen ExAC gnomAD
rs368749896 CA4003571	251	I>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA4003569 rs779598894	254	L>F		No	ClinGen ExAC TOPMed gnomAD
CA365685787 rs779598894	254	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1006072855 CA147993866	256	I>V		No	ClinGen TOPMed gnomAD
CA4003567 rs375044570	258	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1355809552 CA365685757	258	G>V		No	ClinGen TOPMed
CA365685743 rs1187925289	260	N>K		No	ClinGen gnomAD
CA365685741 rs1463356594	261	H>N		No	ClinGen gnomAD

No associated diseases with O15400

3 regional properties for O15400

Type	Name	Position	InterPro Accession
domain	Target SNARE coiled-coil homology domain	160 - 252	IPR000727
domain	Syntaxin, N-terminal domain	3 - 148	IPR006011
conserved_site	Syntaxin/epimorphin, conserved site	171 - 210	IPR006012

Functions

		Description
EC Number
Subcellular Localization	Early endosome membrane ; Single-pass type IV membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

19 GO annotations of cellular component

Name	Definition
azurophil granule	Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
early endosome	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
early endosome membrane	The lipid bilayer surrounding an early endosome.
endocytic vesicle	A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
endomembrane system	A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
immunological synapse	An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
late endosome	A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
recycling endosome	An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
SNARE complex	A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
synaptic vesicle	A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
tertiary granule	A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells.
vesicle	Any small, fluid-filled, spherical organelle enclosed by membrane.

4 GO annotations of molecular function

Name	Definition
chloride channel inhibitor activity	Binds to and stops, prevents, or reduces the activity of a chloride channel.
SNAP receptor activity	Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
SNARE binding	Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
syntaxin binding	Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.

8 GO annotations of biological process

Name	Definition
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
organelle assembly	The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
organelle localization	Any process in which an organelle is transported to, and/or maintained in, a specific location.
positive regulation of receptor localization to synapse	Any process that activates or increases the frequency, rate or extent of receptor localization to synapse.
positive regulation of T cell mediated cytotoxicity	Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.
regulation of protein localization to plasma membrane	Any process that modulates the frequency, rate or extent of protein localization to plasma membrane.
vesicle docking	The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere.
vesicle fusion	Fusion of the membrane of a transport vesicle with its target membrane.

9 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32854	PEP12	Syntaxin PEP12	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q3ZBT5	STX7	Syntaxin-7	Bos taurus (Bovine)	PR
Q7KVY7	Syx4	Syntaxin-4	Drosophila melanogaster (Fruit fly)	PR
Q12846	STX4	Syntaxin-4	Homo sapiens (Human)	PR
P61266	STX1B	Syntaxin-1B	Homo sapiens (Human)	PR
O75558	STX11	Syntaxin-11	Homo sapiens (Human)	PR
Q16623	STX1A	Syntaxin-1A	Homo sapiens (Human)	PR
O70439	Stx7	Syntaxin-7	Mus musculus (Mouse)	PR
O70257	Stx7	Syntaxin-7	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MSYTPGVGGD	PAQLAQRISS	NIQKITQCSV	EIQRTLNQLG	TPQDSPELRQ	QLQQKQQYTN
70	80	90	100	110	120
QLAKETDKYI	KEFGSLPTTP	SEQRQRKIQK	DRLVAEFTTS	LTNFQKVQRQ	AAEREKEFVA
130	140	150	160	170	180
RVRASSRVSG	SFPEDSSKER	NLVSWESQTQ	PQVQVQDEEI	TEDDLRLIHE	RESSIRQLEA
190	200	210	220	230	240
DIMDINEIFK	DLGMMIHEQG	DVIDSIEANV	ENAEVHVQQA	NQQLSRAADY	QRKSRKTLCI
250	260
IILILVIGVA	IISLIIWGLN	H