AiPD: Autoinhibited Protein Database

Q12846

Gene name	STX4 (STX4A)
Protein name	Syntaxin-4
Names	Renal carcinoma antigen NY-REN-31
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6810
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-291 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-291 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q12846

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q12846-F1	Predicted				AlphaFoldDB

231 variants for Q12846

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1177739426 CA395648834	3	D>E		No	ClinGen gnomAD
CA395648828 rs1416796525	3	D>N		No	ClinGen gnomAD
CA395648840 rs1193334181	4	R>K		No	ClinGen gnomAD
TCGA novel	5	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395648852 rs1241136551	6	H>D		No	ClinGen gnomAD
rs1375705041 CA395648868	7	E>K		No	ClinGen TOPMed gnomAD
CA395648870 rs1375705041	7	E>Q		No	ClinGen TOPMed gnomAD
rs1405694324 CA395648889	8	L>P		No	ClinGen TOPMed
rs1321458125 CA395648905	9	R>I		No	ClinGen TOPMed
rs760104174 CA8018570	10	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs747824302 CA8018584	12	D>G		No	ClinGen ExAC TOPMed gnomAD
CA280563913 rs748093292	12	D>H		No	ClinGen gnomAD
CA395648982 rs748093292	12	D>N		No	ClinGen gnomAD
CA280563918 rs772128472	13	D>Y		No	ClinGen TOPMed gnomAD
CA395649024 rs1272164367	14	S>N		No	ClinGen gnomAD
CA395649074 rs1596734089	17	E>K		No	ClinGen Ensembl
rs1253154781 CA395649105	18	E>*		No	ClinGen gnomAD
CA395649152 rs370946455	19	D>N		No	ClinGen ESP ExAC gnomAD
CA8018587 rs370946455	19	D>Y		No	ClinGen ESP ExAC gnomAD
CA280563932 rs931321219	20	K>N		No	ClinGen TOPMed gnomAD
rs1249546293 CA395649225	21	E>G		No	ClinGen gnomAD
CA8018588 rs759958012	22	R>W		No	ClinGen ExAC TOPMed gnomAD
CA395649291 rs775695481	23	V>A		No	ClinGen ExAC TOPMed gnomAD
rs775695481 CA8018590	23	V>D		No	ClinGen ExAC TOPMed gnomAD
CA395649336 rs1437011293	24	A>V		No	ClinGen TOPMed
CA395649384 rs1596734152	26	V>G		No	ClinGen Ensembl
CA395649412 rs1596734175	27	V>G		No	ClinGen Ensembl
rs1347164142 CA395649406	27	V>L		No	ClinGen TOPMed
CA395649425 rs1438830400	28	H>Y		No	ClinGen gnomAD
CA8018592 rs764583237	29	P>A		No	ClinGen ExAC gnomAD
rs754062806 CA8018593	29	P>Q		No	ClinGen ExAC gnomAD
CA8018595 rs765337752	30	G>V		No	ClinGen ExAC gnomAD
CA8018597 rs369168805	31	T>M		No	ClinGen ExAC TOPMed gnomAD
CA395649590 rs1333479757	34	L>P		No	ClinGen gnomAD
rs1596734250 CA395649669	36	S>G		No	ClinGen Ensembl
rs1285892053 CA395649672	36	S>N		No	ClinGen gnomAD
CA395649680 rs1596734255	36	S>R		No	ClinGen Ensembl
rs754721884 CA8018600	37	P>L		No	ClinGen ExAC gnomAD
CA395649726 rs1596734267	38	D>G		No	ClinGen Ensembl
CA8018603 rs747734355	39	E>*		No	ClinGen ExAC TOPMed gnomAD
CA8018606 rs769504539	40	E>D		No	ClinGen ExAC TOPMed
CA280564022 rs1010575802	41	F>C		No	ClinGen TOPMed
rs1189207190 CA395649810	41	F>L		No	ClinGen gnomAD
CA395649802 rs1596734303	41	F>V		No	ClinGen Ensembl
CA395649871 rs1459911429	44	K>M		No	ClinGen gnomAD
CA280564117 rs990661615	45	V>I		No	ClinGen TOPMed
rs770424224 CA8018627	46	R>Q		No	ClinGen ExAC gnomAD
rs184925516 CA8018626	46	R>W		No	ClinGen 1000Genomes ExAC
CA8018628 rs778297706	47	T>K		No	ClinGen ExAC TOPMed gnomAD
CA395649954 rs1179466562	48	I>L		No	ClinGen TOPMed
CA8018629 rs747451911	49	R>G		No	ClinGen ExAC gnomAD
rs777119919 CA8018632	52	I>F		No	ClinGen ExAC TOPMed gnomAD
rs777119919 CA8018631	52	I>V		No	ClinGen ExAC TOPMed gnomAD
CA395650007 rs1454923298	56	G>A		No	ClinGen TOPMed gnomAD
rs1454923298 CA395650006	56	G>E		No	ClinGen TOPMed gnomAD
rs139470583 CA8018634	57	N>S		No	ClinGen ESP ExAC TOPMed
rs1173257513 CA395650016 COSM1235783	58	K>E	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated gnomAD
rs984078860 CA280564156	58	K>R		No	ClinGen TOPMed
CA280564161 rs908560895	60	Q>E		No	ClinGen TOPMed
CA395650032 rs1432654416	60	Q>R		No	ClinGen TOPMed gnomAD
CA395650038 rs1567388221	61	E>G		No	ClinGen Ensembl
CA8018635 rs763101653	61	E>K		No	ClinGen ExAC gnomAD
CA8018636 rs766416447	63	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1159653548 CA395650062	64	K>I		No	ClinGen TOPMed gnomAD
rs751659069 CA8018637	65	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA395650075 rs1399055544	66	Q>P		No	ClinGen TOPMed gnomAD
rs371627793 CA8018638	68	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1457381402 CA395650103	71	A>T		No	ClinGen TOPMed
CA395650135 rs1161670402	76	E>*		No	ClinGen TOPMed
rs930533328 CA395650137	76	E>G		No	ClinGen gnomAD
rs930533328 CA280564254	76	E>V		No	ClinGen gnomAD
CA395650149 rs1339376505	78	S>G		No	ClinGen TOPMed gnomAD
CA395650166 rs1289102779	78	S>R		No	ClinGen gnomAD
CA395650148 rs1339376505	78	S>R		No	ClinGen TOPMed gnomAD
CA8018668 rs749918866	80	K>N		No	ClinGen ExAC gnomAD
CA8018667 rs764843164	80	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1216693053 CA395650240	88	D>G		No	ClinGen gnomAD
rs1318817214 CA395650233	88	D>N		No	ClinGen gnomAD
rs139153719 CA8018671	90	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8018672 rs756647558	92	Q>K		No	ClinGen ExAC gnomAD
rs778189453 CA8018673	94	G>E		No	ClinGen ExAC gnomAD
CA8018675 rs771153904	95	R>S		No	ClinGen ExAC gnomAD
CA395650347 rs1596734961	96	E>Q		No	ClinGen Ensembl
CA8018676 rs374479299	97	I>V		No	ClinGen ESP ExAC gnomAD
CA8018677 rs746110338	98	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs377624173 CA280564407	98	R>S		No	ClinGen ESP TOPMed gnomAD
rs149926282 CA8018679	99	L>V		No	ClinGen ESP ExAC gnomAD
CA395650508 rs1360730651	104	I>T		No	ClinGen TOPMed
CA395650503 rs1216536490	104	I>V		No	ClinGen TOPMed
CA395650513 rs1027422217	105	E>K		No	ClinGen TOPMed
CA280564761 rs1027422217	105	E>Q		No	ClinGen TOPMed
rs1567388717 CA621870445	105	E>V*		No	ClinGen Ensembl
rs769649961 CA8018703	110	E>D		No	ClinGen ExAC TOPMed gnomAD
CA395650673 rs1195058329	111	A>G		No	ClinGen gnomAD
rs1270976066 CA395650688	112	D>A		No	ClinGen TOPMed
CA395650730 rs1324476752	114	N>K		No	ClinGen TOPMed
rs140610940 CA280564780	118	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs140610940 CA8018705	118	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs751049136 CA8018707	123	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1398146678 CA395650939	124	K>R		No	ClinGen TOPMed gnomAD
CA8018709 rs192745083	125	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8018712 rs565521300	126	Q>*		No	ClinGen 1000Genomes ExAC gnomAD
rs1435482161 CA395651004	126	Q>H		No	ClinGen gnomAD
CA8018740 rs748312857	127	H>L		No	ClinGen ExAC gnomAD
rs748312857 CA8018739	127	H>P		No	ClinGen ExAC gnomAD
rs1024123782 CA280566270	127	H>Y		No	ClinGen TOPMed
CA395652818 rs1417180106	129	V>A		No	ClinGen gnomAD
rs770790549 CA8018743	133	Q>H		No	ClinGen ExAC gnomAD
CA395652879 rs556202200	135	V>L		No	ClinGen ExAC TOPMed gnomAD
CA8018744 rs556202200	135	V>M		No	ClinGen ExAC TOPMed gnomAD
rs745502227 CA8018745	136	E>V		No	ClinGen ExAC TOPMed gnomAD
rs1258834401 CA395652902	137	L>H		No	ClinGen TOPMed
CA280566286 rs998256690	139	N>D		No	ClinGen Ensembl
rs1358538375 CA395652921 COSM3690948	139	N>S	large_intestine Variant assessed as Somatic; 4.619e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1416484319 CA395652927	140	K>Q		No	ClinGen gnomAD
rs1313434688 CA395652947	141	C>*		No	ClinGen gnomAD
rs144183945 CA8018746	144	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	145	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774836605 CA8018747	145	Q>K		No	ClinGen ExAC gnomAD
CA8018750 rs376363400	147	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1350520690 COSM185196 CA395653059	149	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA395653055 rs1284242148	149	R>W		No	ClinGen gnomAD
rs1212161380 CA395653061	150	E>Q		No	ClinGen gnomAD
CA280566310 rs766650870	152	N>K		No	ClinGen ExAC gnomAD
CA395653091 rs1440740574	152	N>S		No	ClinGen gnomAD
CA8018753 rs752023820	153	V>M		No	ClinGen ExAC TOPMed gnomAD
COSM1266993 CA8018755 rs767822435	155	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA8018754 rs755136571 COSM970073	155	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1419276118 CA395653140	157	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs141075935 CA8018756	157	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA395653211 rs1567390313	163	T>P		No	ClinGen Ensembl
rs760980449 CA8018775	164	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1442076826 CA395653278	165	A>G		No	ClinGen gnomAD
rs982538191 CA280566427	165	A>T		No	ClinGen Ensembl
rs867510709 CA280566431	166	G>V		No	ClinGen Ensembl
CA395653362 rs1329712277	172	E>A		No	ClinGen gnomAD
CA280566451 rs1051195	174	E>D		No	ClinGen Ensembl
CA395653418 rs1171957879	176	M>I		No	ClinGen gnomAD
rs1230184420 CA395653446	179	S>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs754029888 CA8018777	182	S>N		No	ClinGen ExAC
CA8018779 rs376829665	183	E>K		No	ClinGen ESP ExAC gnomAD
rs750355371 CA8018780	184	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1167773750 CA395653534	185	F>S		No	ClinGen TOPMed
CA395653553 rs1462285024	187	S>P		No	ClinGen gnomAD
rs779834683 CA8018782	188	N>S		No	ClinGen ExAC TOPMed gnomAD
rs754597545 CA8018802	189	I>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	191	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143510048 CA8018803	192	D>A		No	ClinGen ESP ExAC gnomAD
TCGA novel	192	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8018804 rs150948517	193	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs150948517 CA395653713	193	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	195	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8018808 rs141062694	197	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA8018809 rs775974182	197	R>Q		No	ClinGen ExAC gnomAD
CA395653815 rs1319014234	199	A>D		No	ClinGen gnomAD
rs1240907057 CA395653825	200	L>V		No	ClinGen TOPMed gnomAD
CA280566688 rs1001322275	202	E>D		No	ClinGen TOPMed gnomAD
CA395653901 rs1165344395	204	S>L		No	ClinGen TOPMed
rs866878937 CA280566702	206	R>Q		No	ClinGen Ensembl
rs769170826 CA8018811	206	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	208	S>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1259583499 CA395654025	212	Q>*		No	ClinGen TOPMed gnomAD
CA8018815 rs761952530	212	Q>H		No	ClinGen ExAC gnomAD
CA395654028 rs1259583499	212	Q>K		No	ClinGen TOPMed gnomAD
CA8018816 rs370196565	215	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs540497072 COSM1301903 CA8018817	215	R>H	urinary_tract [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs540497072 CA395654129	215	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA395654143 rs1371068262	216	S>T		No	ClinGen TOPMed gnomAD
rs1462835263 CA395654187 COSM970074	218	R>C	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs373829816 COSM3361736 CA8018818	218	R>H	kidney [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA395654223 rs1370002590	219	E>G		No	ClinGen Ensembl
TCGA novel	221	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751532816 CA8018820	222	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs565199561 CA395654324	224	F>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs565199561 CA8018821	224	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA395654363 rs1360298642	225	T>S		No	ClinGen gnomAD
CA395654389 rs945415027	227	L>V		No	ClinGen gnomAD
rs1362993918 CA395654427	229	T>I		No	ClinGen TOPMed
CA8018823 rs377468059	230	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA395654456 rs1375621480	231	V>A		No	ClinGen gnomAD
TCGA novel	232	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs903964919 CA280566771	232	E>G		No	ClinGen gnomAD
CA8018825 rs777322966	233	M>I		No	ClinGen ExAC TOPMed gnomAD
rs371244325 CA8018824	233	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1396756615 CA395654654	236	E>Q		No	ClinGen TOPMed
CA8018852 rs200012136	237	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	237	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA280567386 rs532998208	238	I>M		No	ClinGen Ensembl
TCGA novel	239	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs562489469 CA395654717	239	N>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs562489469 CA8018853	239	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs376701568 CA8018855	240	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA8018854 rs770931989	240	R>W		No	ClinGen ExAC TOPMed gnomAD
CA395654806 rs1342351625	244	N>K		No	ClinGen gnomAD
CA280567423 rs893251464	247	S>N		No	ClinGen TOPMed gnomAD
rs759458097 CA8018856	249	A>V		No	ClinGen ExAC TOPMed gnomAD
rs199709113 CA8018858	252	V>M		No	ClinGen ExAC TOPMed gnomAD
CA8018859 rs760346516	254	R>C		No	ClinGen ExAC gnomAD
CA280567439 rs200786971	254	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200786971 CA8018861	254	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200786971 CA8018860	254	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA280567452 rs966581561	257	E>D		No	ClinGen TOPMed
rs1488866019 CA395655033	259	V>F		No	ClinGen gnomAD
CA395655028 rs1488866019	259	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA280567460 rs1033941416	260	K>E		No	ClinGen TOPMed gnomAD
rs750008975 CA395655062	260	K>R		No	ClinGen ExAC gnomAD
rs750008975 CA8018864	260	K>T		No	ClinGen ExAC gnomAD
rs142253791 CA8018865	261	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1413409598 CA395655089	262	A>T		No	ClinGen gnomAD
rs1162505941 CA395655128	264	E>G		No	ClinGen gnomAD
rs376316073 CA280567507 COSM1478816	269	A>V	Variant assessed as Somatic; 4.622e-05 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP NCI-TCGA TOPMed gnomAD
CA280567612 rs1037975946	272	K>N		No	ClinGen Ensembl
CA8018885 rs753079913	274	V>I		No	ClinGen ExAC TOPMed gnomAD
rs138235448 CA8018886	279	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA395656334 rs1445294322	280	V>M		No	ClinGen gnomAD
rs1378073962 CA395656390	282	I>N		No	ClinGen gnomAD
CA8018887 rs764353518	282	I>V		No	ClinGen ExAC gnomAD
CA8018890 rs771745614	284	V>I		No	ClinGen ExAC TOPMed gnomAD
CA8018891 rs771745614	284	V>L		No	ClinGen ExAC TOPMed gnomAD
CA8018894 rs746913731	285	V>A		No	ClinGen ExAC gnomAD
CA8018892 rs149552887	285	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA8018893 rs149552887	285	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs890878699 CA280567672	288	A>S		No	ClinGen TOPMed gnomAD
rs890878699 CA395656551	288	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1177838249 CA395656628	291	I>T		No	ClinGen gnomAD
CA8018896 rs776543576	291	I>V		No	ClinGen ExAC TOPMed gnomAD
CA8018899 rs769736866	293	V>F		No	ClinGen ExAC TOPMed gnomAD
COSM212242 CA8018898 rs769736866	293	V>I	breast [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA8018900 rs762675311	295	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1412304008 CA395656735	297	G>A		No	ClinGen gnomAD
rs765803811 CA8018901	297	G>R		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with Q12846

No regional properties for Q12846

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q12846

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Single-pass type IV membrane protein Cell projection, neuron projection	Localizes to neurite tips in neuronal cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

28 GO annotations of cellular component

Name	Definition
basolateral plasma membrane	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cell surface	The external part of the cell wall and/or plasma membrane.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic spine	A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
endomembrane system	A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
lateral loop	Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
myelin sheath adaxonal region	The region of the myelin sheath nearest to the axon.
neuron projection membrane	The portion of the plasma membrane surrounding a neuron projection.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
phagocytic vesicle membrane	The lipid bilayer surrounding a phagocytic vesicle.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynapse	The part of a synapse that is part of the post-synaptic cell.
presynaptic active zone membrane	The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.
SNARE complex	A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
somatodendritic compartment	The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.
specific granule	Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
storage vacuole	A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
synaptic vesicle	A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
trans-Golgi network	The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
vacuole	A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

3 GO annotations of molecular function

Name	Definition
SNAP receptor activity	Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
SNARE binding	Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
sphingomyelin phosphodiesterase activator activity	Increases the activity of the enzyme sphingomyelin phosphodiesterase.

24 GO annotations of biological process

Name	Definition
cellular response to interferon-gamma	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
cellular response to oxidative stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
cornified envelope assembly	The aggregation, arrangement and bonding together of a set of components to form a cornified envelope.
exocytosis	A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
long-term synaptic potentiation	A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.
organelle fusion	The creation of a single organelle from two or more organelles.
positive regulation of catalytic activity	Any process that activates or increases the activity of an enzyme.
positive regulation of cell adhesion	Any process that activates or increases the frequency, rate or extent of cell adhesion.
positive regulation of cell migration	Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of chemotaxis	Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
positive regulation of eosinophil degranulation	Any process that activates or increases the frequency, rate or extent of eosinophil degranulation.
positive regulation of immunoglobulin production	Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.
positive regulation of insulin secretion involved in cellular response to glucose stimulus	Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
positive regulation of protein localization to cell surface	Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface.
positive regulation of protein localization to plasma membrane	Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
protein localization to cell surface	A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
regulation of exocytosis	Any process that modulates the frequency, rate or extent of exocytosis.
regulation of extrinsic apoptotic signaling pathway via death domain receptors	Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
SNARE complex assembly	The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
synaptic vesicle fusion to presynaptic active zone membrane	Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.
vesicle docking	The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere.
vesicle fusion	Fusion of the membrane of a transport vesicle with its target membrane.

21 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32867	SSO1	Protein SSO1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P39926	SSO2	Protein SSO2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P61267	STX1B	Syntaxin-1B	Bos taurus (Bovine)	PR
Q3SWZ3	STX4	Syntaxin-4	Bos taurus (Bovine)	PR
Q7KVY7	Syx4	Syntaxin-4	Drosophila melanogaster (Fruit fly)	PR
Q24547	Syx1A	Syntaxin-1A	Drosophila melanogaster (Fruit fly)	PR
P61266	STX1B	Syntaxin-1B	Homo sapiens (Human)	PR
O75558	STX11	Syntaxin-11	Homo sapiens (Human)	PR
Q16623	STX1A	Syntaxin-1A	Homo sapiens (Human)	PR
O15400	STX7	Syntaxin-7	Homo sapiens (Human)	PR
O35526	Stx1a	Syntaxin-1A	Mus musculus (Mouse)	PR
Q00262	Stx2	Syntaxin-2	Mus musculus (Mouse)	PR
Q9D3G5	Stx11	Syntaxin-11	Mus musculus (Mouse)	PR
P61264	Stx1b	Syntaxin-1B	Mus musculus (Mouse)	PR
P70452	Stx4	Syntaxin-4	Mus musculus (Mouse)	PR
P50279	Stx2	Syntaxin-2	Rattus norvegicus (Rat)	PR
P61265	Stx1b	Syntaxin-1B	Rattus norvegicus (Rat)	PR
P32851	Stx1a	Syntaxin-1A	Rattus norvegicus (Rat)	PR
Q08850	Stx4	Syntaxin-4	Rattus norvegicus (Rat)	PR
O16000	unc-64	Syntaxin-1A homolog	Caenorhabditis elegans	PR
Q9ZPV9	SYP112	Syntaxin-112	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MRDRTHELRQ	GDDSSDEEDK	ERVALVVHPG	TARLGSPDEE	FFHKVRTIRQ	TIVKLGNKVQ
70	80	90	100	110	120
ELEKQQVTIL	ATPLPEESMK	QELQNLRDEI	KQLGREIRLQ	LKAIEPQKEE	ADENYNSVNT
130	140	150	160	170	180
RMRKTQHGVL	SQQFVELINK	CNSMQSEYRE	KNVERIRRQL	KITNAGMVSD	EELEQMLDSG
190	200	210	220	230	240
QSEVFVSNIL	KDTQVTRQAL	NEISARHSEI	QQLERSIREL	HDIFTFLATE	VEMQGEMINR
250	260	270	280	290
IEKNILSSAD	YVERGQEHVK	TALENQKKAR	KKKVLIAICV	SITVVLLAVI	IGVTVVG