AiPD: Autoinhibited Protein Database

Q16623

Gene name	STX1A (STX1)
Protein name	Syntaxin-1A
Names	Neuron-specific antigen HPC-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6804
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-225 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-225 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q16623

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q16623-F1	Predicted				AlphaFoldDB

161 variants for Q16623

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV001264639 rs200456346 RCV002226530	145	C>W	Intellectual disability [ClinVar]	Yes	ClinVar dbSNP
CA367838343 rs1305622716	2	K>R		No	ClinGen TOPMed
CA367838323 rs1274838274	3	D>H		No	ClinGen TOPMed
rs1343856512 CA367838287	5	T>S		No	ClinGen TOPMed
CA367838271 rs1208045282	6	Q>R		No	ClinGen TOPMed
rs547690713 CA367838246	7	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367837199 rs1554617572	11	A>V		No	ClinGen gnomAD
TCGA novel	13	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs782202692 CA4290860	13	D>V		No	ClinGen ExAC TOPMed gnomAD
rs782455881 CA4290858	15	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4290857 rs781810772	16	D>N		No	ClinGen ExAC gnomAD
TCGA novel	16	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1289948694 CA367837130	17	D>H		No	ClinGen TOPMed
rs782671628 CA4290856	18	D>E		No	ClinGen ExAC gnomAD
CA4290853 rs782653375	21	A>S		No	ClinGen ExAC TOPMed gnomAD
CA4290854 rs782653375	21	A>T		No	ClinGen ExAC TOPMed gnomAD
rs567231961 CA4290852	21	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1271164067 CA367837046	23	T>S		No	ClinGen TOPMed gnomAD
COSM3768472 rs369814636 CA4290850	24	V>M	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs267601564 CA160087749	26	R>*		No	ClinGen Ensembl
rs1364135079 CA367837019	26	R>Q		No	ClinGen TOPMed gnomAD
CA4290849 rs782703876	28	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA160087748 rs375523583	28	R>H		No	ClinGen ESP TOPMed
TCGA novel	33	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367836853 rs1178632016	37	V>G		No	ClinGen TOPMed
CA367836829 rs1554617460	39	E>D		No	ClinGen gnomAD
CA367836834 rs1584250219	39	E>G		No	ClinGen Ensembl
rs1554617458 CA367836812 COSM3833184	41	R>Q	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA367836802 rs1554617455	42	G>A		No	ClinGen gnomAD
rs1343838866 CA367836806	42	G>S		No	ClinGen TOPMed
rs1584250193 CA367836786	44	I>V		No	ClinGen Ensembl
rs144945504 CA367836740	48	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs144945504 CA4290832	48	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1554617450 CA367836733	49	E>Q		No	ClinGen gnomAD
rs2229854 CA4290831	50	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1554617448 CA367836707	51	V>A		No	ClinGen gnomAD
rs782757103 CA4290829	51	V>L		No	ClinGen ExAC gnomAD
CA160087498 rs782757103	51	V>M		No	ClinGen ExAC gnomAD
rs1346014749 CA367836694	52	E>D		No	ClinGen TOPMed gnomAD
CA4290828 rs782092932	56	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA367836623 rs1316169178	59	S>G		No	ClinGen TOPMed gnomAD
CA4290825 rs782151306	61	I>V		No	ClinGen ExAC gnomAD
CA367836576 rs1554617440	63	A>V		No	ClinGen gnomAD
rs1554617438 CA367836566	64	S>Y		No	ClinGen gnomAD
CA4290822 rs782259113	65	P>T		No	ClinGen ExAC gnomAD
rs2228607 CA367836523	68	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4290820 rs782309912	68	D>N		No	ClinGen ExAC TOPMed gnomAD
CA4290818 rs782665420	69	E>K		No	ClinGen ExAC gnomAD
rs1554616681 CA367836338	70	K>R		No	ClinGen gnomAD
TCGA novel	70	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM195749 rs781904935 CA4290787	71	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs781950897 CA4290784	76	E>G		No	ClinGen ExAC gnomAD
TCGA novel	77	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367836293 rs1315627336	77	E>K		No	ClinGen TOPMed
CA4290782 rs782043152	79	M>T		No	ClinGen ExAC TOPMed gnomAD
CA4290781 rs781939626	80	S>F		No	ClinGen ExAC gnomAD
rs147048336 CA4290779	81	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA367836265 rs147048336	81	D>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371575027 CA4290777	85	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA367836227 rs1469008260	86	A>G		No	ClinGen TOPMed
CA367836201 rs1192968907	90	R>C		No	ClinGen TOPMed gnomAD
rs944672566 CA160086042	90	R>H		No	ClinGen Ensembl
TCGA novel	94	K>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367836167 rs782219643	94	K>N		No	ClinGen ExAC TOPMed gnomAD
CA367836131 rs1554616488	97	E>D		No	ClinGen gnomAD
CA367836119 rs1390792461	99	S>A		No	ClinGen TOPMed
rs782236446 CA4290756	100	I>F		No	ClinGen ExAC
TCGA novel	100	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4290755 rs782657148	101	E>Q		No	ClinGen ExAC gnomAD
rs907617478 CA160085679	105	G>A		No	ClinGen Ensembl
rs782226371 CA4290753	108	R>C		No	ClinGen ExAC gnomAD
CA367836034 rs1584244001	112	D>A		No	ClinGen Ensembl
rs1554616484 CA367836030	112	D>E		No	ClinGen gnomAD
CA367836029 rs1554616482	113	L>V		No	ClinGen gnomAD
CA4290748 rs782517349	116	R>Q		No	ClinGen ExAC gnomAD
rs1554616478 CA367835997	118	T>S		No	ClinGen gnomAD
CA4290727 rs376660582	129	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1554616439 CA367835884	132	S>L		No	ClinGen gnomAD
CA367835887 rs1361778002	132	S>T		No	ClinGen TOPMed
CA367835877 rs1554616436	133	E>D		No	ClinGen gnomAD
TCGA novel	133	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367835857 rs1159515604	136	A>T		No	ClinGen TOPMed gnomAD
CA4290724 rs782758639	138	Q>L		No	ClinGen ExAC gnomAD
CA367835835 rs1438131669	139	S>F		No	ClinGen TOPMed gnomAD
rs782129449 CA367835834	140	D>H		No	ClinGen ExAC gnomAD
rs782129449 CA4290723	140	D>N		No	ClinGen ExAC gnomAD
CA367835818 rs1554616427	142	R>S		No	ClinGen gnomAD
rs144263690 CA4290720	144	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs144263690 CA4290719	144	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA367835802 rs1554616422	144	R>H		No	ClinGen gnomAD
CA4290717 rs782171983	145	C>S		No	ClinGen ExAC gnomAD
CA367835777 rs1554616419	148	R>H		No	ClinGen gnomAD
CA367835748 rs1554616416	152	Q>R		No	ClinGen gnomAD
CA4290714 rs782217059	154	E>A		No	ClinGen ExAC gnomAD
rs1554616412 CA367835725	155	I>M		No	ClinGen gnomAD
rs1025168062	156	T>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373330016 CA4290692	157	G>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA367835705 rs373330016	157	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA4290691 rs370111355	157	G>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA367835659 rs1554616291	164	E>K		No	ClinGen gnomAD
CA4290689 rs782404923	165	L>P		No	ClinGen ExAC gnomAD
CA367835603 rs782343806 CA4290686	171	S>R		No	ClinGen ExAC gnomAD
CA367835582 rs1350740883	175	A>T		No	ClinGen TOPMed gnomAD
CA367835560 rs1229777156	178	A>T		No	ClinGen TOPMed
rs782316927 CA4290642	182	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1325188922 CA367835487	183	M>L		No	ClinGen TOPMed gnomAD
CA4290641 rs567608089	187	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1194587551 CA367835424	188	S>L		No	ClinGen TOPMed
rs149588890 CA4290640	191	A>D		No	ClinGen ESP ExAC gnomAD
CA367835338 rs1199098748	196	E>A		No	ClinGen TOPMed
TCGA novel	196	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367835320 rs1430272820	197	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs782589459 CA4290637	198	R>L		No	ClinGen ExAC gnomAD
CA367835207 rs1554616127	207	N>K		No	ClinGen gnomAD
CA367835179 rs1384422759	210	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA367835177 rs1401337421 COSM1240336	210	R>H	oesophagus [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs782529244 CA4290633	213	H>Y		No	ClinGen ExAC TOPMed gnomAD
COSM1091595 CA367835136 rs1435523092	214	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1435523092 CA367835139	214	D>Y		No	ClinGen TOPMed gnomAD
rs139237669 CA4290631	217	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1283617158 CA367835099	217	M>V		No	ClinGen TOPMed gnomAD
rs782121987 CA4290630	219	M>T		No	ClinGen ExAC gnomAD
rs370963256 CA4290628	221	M>T		No	ClinGen ESP ExAC gnomAD
rs781827788 CA4290629	221	M>V		No	ClinGen ExAC TOPMed gnomAD
CA367835033 rs782057252	222	L>F		No	ClinGen ExAC TOPMed gnomAD
CA4290627 rs782057252	222	L>I		No	ClinGen ExAC TOPMed gnomAD
rs782057252 CA367835035	222	L>V		No	ClinGen ExAC TOPMed gnomAD
CA367835026 rs1554616102	223	V>L		No	ClinGen gnomAD
TCGA novel	229	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1187928316 CA367833939	230	I>T		No	ClinGen TOPMed
rs529603065 CA4290572	231	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs782584153 CA4290571	233	I>V		No	ClinGen ExAC gnomAD
rs782747612 CA4290568	237	V>L		No	ClinGen ExAC gnomAD
CA367833868 rs1333991998	240	A>S		No	ClinGen TOPMed gnomAD
CA367833869 rs1333991998	240	A>T		No	ClinGen TOPMed gnomAD
CA4290565 rs782756808	241	V>I		No	ClinGen ExAC gnomAD
CA367833855 rs1554615742	242	D>H		No	ClinGen gnomAD
rs1554615733 CA367833811	247	A>T		No	ClinGen gnomAD
CA367833803 rs782801540	248	V>L		No	ClinGen ExAC gnomAD
CA4290562 rs782801540	248	V>M		No	ClinGen ExAC gnomAD
rs782658280 CA4290560	255	V>I		No	ClinGen ExAC gnomAD
CA367833732 rs1554615726	256	K>T		No	ClinGen gnomAD
rs782212937 CA4290558	262	R>C		No	ClinGen ExAC TOPMed gnomAD
rs202064998 CA4290557	262	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs202064998 CA367833680	262	R>P		No	ClinGen 1000Genomes ExAC gnomAD
CA160083585 rs782153036	263	R>Q		No	ClinGen TOPMed gnomAD
rs782058423 CA4290540	267	M>V		No	ClinGen ExAC gnomAD
rs991448424 CA160083462	269	I>F		No	ClinGen Ensembl
rs1554615661 CA367833606	270	I>T		No	ClinGen gnomAD
CA367833590 rs1554615659	272	C>S		No	ClinGen gnomAD
rs782413114 CA4290537	274	I>V		No	ClinGen ExAC gnomAD
rs1554615657 CA367833569	276	G>S		No	ClinGen gnomAD
CA367833562 rs1554615654	277	I>V		No	ClinGen gnomAD
CA4290534 rs782341932	278	V>A		No	ClinGen ExAC gnomAD
CA4290535 rs201037992	278	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA4290533 rs782224823	279	I>V		No	ClinGen ExAC gnomAD
rs782328797 CA4290531	280	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4290530 rs782275853	284	G>A		No	ClinGen ExAC gnomAD
CA4290528 rs782504771	286	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1311585207 CA367833504	287	F>I		No	ClinGen TOPMed
CA4290526 rs782606855	288	A>T		No	ClinGen ExAC gnomAD

1 associated diseases with Q16623

Without disease ID

3 regional properties for Q16623

Type	Name	Position	InterPro Accession
domain	Target SNARE coiled-coil homology domain	187 - 279	IPR000727
domain	Syntaxin, N-terminal domain	25 - 227	IPR006011
conserved_site	Syntaxin/epimorphin, conserved site	198 - 237	IPR006012

Functions

		Description
EC Number
Subcellular Localization	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type IV membrane protein Synapse, synaptosome Cell membrane	Colocalizes with KCNB1 at the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

22 GO annotations of cellular component

Name	Definition
actomyosin	Any complex of actin, myosin, and accessory proteins.
anchoring junction	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endomembrane system	A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of presynaptic membrane	The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of synaptic vesicle membrane	The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
presynaptic active zone membrane	The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.
secretory granule	A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
SNARE complex	A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
synaptic vesicle	A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
synaptobrevin 2-SNAP-25-syntaxin-1a complex	A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof).
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof).
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex	A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof).
voltage-gated potassium channel complex	A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

13 GO annotations of molecular function

Name	Definition
ATP-dependent protein binding	Binding to a protein or protein complex using energy from ATP hydrolysis.
calcium channel inhibitor activity	Binds to and stops, prevents, or reduces the activity of a calcium channel.
calcium-dependent protein binding	Binding to a protein or protein complex in the presence of calcium.
chloride channel inhibitor activity	Binds to and stops, prevents, or reduces the activity of a chloride channel.
identical protein binding	Binding to an identical protein or proteins.
kinase binding	Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
myosin head/neck binding	Binding to the head/neck region of a myosin heavy chain.
protein domain specific binding	Binding to a specific domain of a protein.
protein N-terminus binding	Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
protein-containing complex binding	Binding to a macromolecular complex.
SNAP receptor activity	Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
SNARE binding	Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
transmembrane transporter binding	Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

22 GO annotations of biological process

Name	Definition
calcium-ion regulated exocytosis	The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
exocytosis	A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
insulin secretion	The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
positive regulation of calcium ion-dependent exocytosis	Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.
positive regulation of catecholamine secretion	Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine.
positive regulation of excitatory postsynaptic potential	Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
positive regulation of neurotransmitter secretion	Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.
positive regulation of norepinephrine secretion	Any process that increases the frequency, rate or extent of the regulated release of norepinephrine.
protein localization to membrane	A process in which a protein is transported to, or maintained in, a specific location in a membrane.
protein sumoylation	The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
regulation of insulin secretion	Any process that modulates the frequency, rate or extent of the regulated release of insulin.
regulation of synaptic vesicle priming	Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.
response to gravity	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus.
secretion by cell	The controlled release of a substance by a cell.
SNARE complex assembly	The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
synaptic vesicle docking	The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
synaptic vesicle endocytosis	A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
synaptic vesicle exocytosis	Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
synaptic vesicle fusion to presynaptic active zone membrane	Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.
vesicle docking	The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere.
vesicle fusion	Fusion of the membrane of a transport vesicle with its target membrane.

22 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32867	SSO1	Protein SSO1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P39926	SSO2	Protein SSO2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q3SWZ3	STX4	Syntaxin-4	Bos taurus (Bovine)	PR
P61267	STX1B	Syntaxin-1B	Bos taurus (Bovine)	PR
P32850	STX1A	Syntaxin-1A	Bos taurus (Bovine)	PR
Q7KVY7	Syx4	Syntaxin-4	Drosophila melanogaster (Fruit fly)	PR
Q24547	Syx1A	Syntaxin-1A	Drosophila melanogaster (Fruit fly)	PR
Q12846	STX4	Syntaxin-4	Homo sapiens (Human)	PR
P61266	STX1B	Syntaxin-1B	Homo sapiens (Human)	PR
O75558	STX11	Syntaxin-11	Homo sapiens (Human)	PR
O15400	STX7	Syntaxin-7	Homo sapiens (Human)	PR
Q00262	Stx2	Syntaxin-2	Mus musculus (Mouse)	PR
P70452	Stx4	Syntaxin-4	Mus musculus (Mouse)	PR
Q9D3G5	Stx11	Syntaxin-11	Mus musculus (Mouse)	PR
P61264	Stx1b	Syntaxin-1B	Mus musculus (Mouse)	PR
O35526	Stx1a	Syntaxin-1A	Mus musculus (Mouse)	PR
P50279	Stx2	Syntaxin-2	Rattus norvegicus (Rat)	PR
P61265	Stx1b	Syntaxin-1B	Rattus norvegicus (Rat)	PR
Q08850	Stx4	Syntaxin-4	Rattus norvegicus (Rat)	PR
P32851	Stx1a	Syntaxin-1A	Rattus norvegicus (Rat)	PR
O16000	unc-64	Syntaxin-1A homolog	Caenorhabditis elegans	PR
Q9ZPV9	SYP112	Syntaxin-112	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MKDRTQELRT	AKDSDDDDDV	AVTVDRDRFM	DEFFEQVEEI	RGFIDKIAEN	VEEVKRKHSA
70	80	90	100	110	120
ILASPNPDEK	TKEELEELMS	DIKKTANKVR	SKLKSIEQSI	EQEEGLNRSS	ADLRIRKTQH
130	140	150	160	170	180
STLSRKFVEV	MSEYNATQSD	YRERCKGRIQ	RQLEITGRTT	TSEELEDMLE	SGNPAIFASG
190	200	210	220	230	240
IIMDSSISKQ	ALSEIETRHS	EIIKLENSIR	ELHDMFMDMA	MLVESQGEMI	DRIEYNVEHA
250	260	270	280
VDYVERAVSD	TKKAVKYQSK	ARRKKIMIII	CCVILGIVIA	STVGGIFA