AiPD: Autoinhibited Protein Database

Gene name	SYP112 (At2g18260, T30D6.23)
Protein name	Syntaxin-112
Names	AtSYP112
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT2G18260
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

142-233 (Predicted disordered autoinhibitory region) PR

142-233 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9ZPV9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_2_7942316_A_T	14	E>D	No	1000Genomes
ENSVATH05522394	41	P>T	No	1000Genomes
tmp_2_7942420_G_A	49	G>D	No	1000Genomes
tmp_2_7942419_G_A	49	G>S	No	1000Genomes
tmp_2_7942450_C_T	59	T>I	No	1000Genomes
tmp_2_7942507_C_A	78	T>N	No	1000Genomes
tmp_2_7942569_G_T	99	V>F	No	1000Genomes
ENSVATH05522396	141	N>S	No	1000Genomes
ENSVATH01835716	145	K>E	No	1000Genomes
ENSVATH01835717	145	K>T	No	1000Genomes
ENSVATH05522397	178	G>S	No	1000Genomes
tmp_2_7942819_G_T	182	S>I	No	1000Genomes
tmp_2_7942821_A_G	183	N>D	No	1000Genomes
ENSVATH01835721	187	E>A	No	1000Genomes
ENSVATH05522398	189	M>T	No	1000Genomes
ENSVATH00236354	201	K>N	No	1000Genomes
tmp_2_7942892_G_T	206	K>N	No	1000Genomes
tmp_2_7942938_G_A	222	D>N	No	1000Genomes
tmp_2_7942939_A_T	222	D>V	No	1000Genomes
tmp_2_7943062_G_A	263	S>N	No	1000Genomes
ENSVATH00236355	273	N>H	No	1000Genomes
tmp_2_7943122_T_C	283	V>A	No	1000Genomes
ENSVATH13258164	283	V>F	No	1000Genomes
ENSVATH05522401	296	V>L	No	1000Genomes
tmp_2_7943177_G_C	301	M>I	No	1000Genomes
ENSVATH05522403	302	L>H	No	1000Genomes
tmp_2_7943191_G_C	306	R>S	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Target SNARE coiled-coil homology domain	205 - 296	IPR000727
domain	Syntaxin, N-terminal domain	42 - 245	IPR006011
conserved_site	Syntaxin/epimorphin, conserved site	216 - 255	IPR006012

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endomembrane system	A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
SNARE complex	A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.

Name	Definition
SNAP receptor activity	Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
SNARE binding	Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.

Name	Definition
exocytosis	A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
vesicle docking	The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere.
vesicle fusion	Fusion of the membrane of a transport vesicle with its target membrane.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32867	SSO1	Protein SSO1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P39926	SSO2	Protein SSO2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P61267	STX1B	Syntaxin-1B	Bos taurus (Bovine)	PR
P32850	STX1A	Syntaxin-1A	Bos taurus (Bovine)	PR
Q3SWZ3	STX4	Syntaxin-4	Bos taurus (Bovine)	PR
Q7KVY7	Syx4	Syntaxin-4	Drosophila melanogaster (Fruit fly)	PR
Q24547	Syx1A	Syntaxin-1A	Drosophila melanogaster (Fruit fly)	PR
O75558	STX11	Syntaxin-11	Homo sapiens (Human)	PR
Q12846	STX4	Syntaxin-4	Homo sapiens (Human)	PR
P61266	STX1B	Syntaxin-1B	Homo sapiens (Human)	PR
Q16623	STX1A	Syntaxin-1A	Homo sapiens (Human)	PR
O35526	Stx1a	Syntaxin-1A	Mus musculus (Mouse)	PR
P61264	Stx1b	Syntaxin-1B	Mus musculus (Mouse)	PR
P70452	Stx4	Syntaxin-4	Mus musculus (Mouse)	PR
Q9D3G5	Stx11	Syntaxin-11	Mus musculus (Mouse)	PR
Q00262	Stx2	Syntaxin-2	Mus musculus (Mouse)	PR
P32851	Stx1a	Syntaxin-1A	Rattus norvegicus (Rat)	PR
P61265	Stx1b	Syntaxin-1B	Rattus norvegicus (Rat)	PR
Q08850	Stx4	Syntaxin-4	Rattus norvegicus (Rat)	PR
P50279	Stx2	Syntaxin-2	Rattus norvegicus (Rat)	PR
O16000	unc-64	Syntaxin-1A homolog	Caenorhabditis elegans	PR