P32850

PR
Gene name
STX1A
Protein name
Syntaxin-1A
Names
Neuron-specific antigen HPC-1, Synaptotagmin-associated 35 kDa protein, P35A
Species
Bos taurus (Bovine)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-228 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P32850

Entry ID Method Resolution Chain Position Source
AF-P32850-F1 Predicted AlphaFoldDB

140 variants for P32850

Variant ID(s) Position Change Description Diseaes Association Provenance
rs481573033 23 T>P No EVA
rs467225359 24 V>G No EVA
rs434191993 25 D>A No EVA
rs452152150 26 R>G No EVA
rs464227755 27 D>A No EVA
rs456169619 30 M>R No EVA
rs441968862 32 E>D No EVA
rs474897215 32 E>Q No EVA
rs472392809 34 F>L No EVA
rs453823526 34 F>S No EVA
rs439406232 35 E>G No EVA
rs458999539 36 Q>E No EVA
rs477350197 36 Q>R No EVA
rs466214689 39 E>* No EVA
rs433301817 51 V>A No EVA
rs445240570 54 V>E No EVA
rs445240570 54 V>G No EVA
rs470144027 61 I>L No EVA
rs437216593 61 I>T No EVA
rs455917344 64 S>A No EVA
rs455917344 64 S>P No EVA
rs474534236 66 N>T No EVA
rs434971881 68 D>G No EVA
rs453534891 69 E>D No EVA
rs478330572 86 A>S No EVA
rs445240305 90 R>L No EVA
rs456549144 96 I>L No EVA
rs475293491 105 G>A No EVA
rs110306308 105 G>S No EVA
rs435844305 107 N>S No EVA
rs435844305 107 N>T No EVA
rs454441127 108 R>S No EVA
rs472737609 109 S>A No EVA
rs439839551 110 S>P No EVA
rs476392132 112 D>G No EVA
rs457755069 112 D>N No EVA
rs443174049 114 R>G No EVA
rs461790600 115 I>F No EVA
rs480034320 116 R>S No EVA
rs447451249 119 Q>R No EVA
rs450123820 120 H>P No EVA
rs447731116 123 L>R No EVA
rs466447364 124 S>T No EVA
rs451925959 127 F>C No EVA
rs433502722 127 F>I No EVA
rs470369885 128 V>E No EVA
rs455263385 129 E>A No EVA
rs473749794 130 V>A No EVA
rs473749794 130 V>E No EVA
rs473749794 130 V>G No EVA
rs440743394 131 M>R No EVA
rs452823058 132 S>C No EVA
rs438654967 133 E>D No EVA
rs482030020 134 Y>* No EVA
rs463620392 134 Y>C No EVA
rs442636092 135 N>D No EVA
rs462241484 137 T>M No EVA
rs447669436 138 Q>H No EVA
rs466132358 139 S>P No EVA
rs445485080 140 D>A No EVA
rs437387248 141 Y>H No EVA
rs455802710 142 R>H No EVA
rs455802710 142 R>L No EVA
rs434411711 143 E>A No EVA
rs467284511 143 E>Q No EVA
rs452909206 148 R>G No EVA
rs438394628 152 Q>H No EVA
rs457226189 153 L>R No EVA
rs475758016 155 I>V No EVA
rs438852548 156 T>N No EVA
rs457437089 158 R>P No EVA
rs475564306 159 T>I No EVA
rs442816918 160 T>P No EVA
rs461477517 161 T>S No EVA
rs479950155 162 S>N No EVA
rs459049136 164 E>D No EVA
rs440551221 164 E>G No EVA
rs477662487 165 L>R No EVA
rs450452739 167 D>A No EVA
rs448114333 168 M>I No EVA
rs481010343 168 M>R No EVA
rs466851900 169 L>M No EVA
rs433827726 169 L>Q No EVA
rs452399322 171 S>N No EVA
rs464274722 171 S>R No EVA
rs452399322 171 S>T No EVA
rs457358492 173 N>K No EVA
rs475758934 174 P>T No EVA
rs442759797 175 A>D No EVA
rs440665007 177 F>C No EVA
rs459252146 177 F>L No EVA
rs473222898 177 F>V No EVA
rs477614567 178 A>T No EVA
rs444668075 179 S>Y No EVA
rs458221803 183 M>I No EVA
rs450230367 184 D>E No EVA
rs483152317 184 D>Y No EVA
rs462114486 189 K>N No EVA
rs447922420 193 S>R No EVA
rs466466300 195 I>V No EVA
rs433366236 199 H>L No EVA
rs445420984 202 I>V No EVA
rs469692709 207 N>K No EVA
rs455273982 208 S>I No EVA
rs436830190 208 S>R No EVA
rs473561927 213 H>P No EVA
rs434418963 218 D>G No EVA
rs453176684 220 A>P No EVA
rs471698698 221 M>L No EVA
rs438567145 223 V>A No EVA
rs438567145 223 V>G No EVA
rs463483617 224 E>A No EVA
rs433983752 264 K>Q No EVA
rs452770568 267 M>L No EVA
rs464888771 269 V>F No EVA
rs456693894 271 C>W No EVA
rs475218392 272 C>W No EVA
rs441656218 274 V>F No EVA
rs453750033 274 V>G No EVA
rs472218721 275 L>R No EVA
rs439234295 276 G>A No EVA
rs457860431 279 I>F No EVA
rs457860431 279 I>L No EVA
rs482762932 279 I>T No EVA
rs443506821 280 A>P No EVA
rs461749201 281 S>P No EVA
rs480479250 282 T>P No EVA
rs448527223 283 F>C No EVA
rs467079115 283 F>L No EVA
rs448527223 283 F>S No EVA
rs446095346 285 G>A No EVA
rs446095346 285 G>D No EVA
rs464574077 286 I>F No EVA
rs456828701 287 F>C No EVA
rs468726084 287 F>L No EVA
rs456828701 287 F>S No EVA
rs435822177 288 G>E No EVA
rs472310598 289 G>K No EVA
rs472310598 289 G>Q No EVA
rs432755327 289 G>Y No EVA

No associated diseases with P32850

3 regional properties for P32850

Type Name Position InterPro Accession
domain Target SNARE coiled-coil homology domain 187 - 279 IPR000727
domain Syntaxin, N-terminal domain 25 - 227 IPR006011
conserved_site Syntaxin/epimorphin, conserved site 198 - 237 IPR006012

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type IV membrane protein
  • Synapse, synaptosome
  • Cell membrane
  • Colocalizes with KCNB1 at the cell membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
presynaptic active zone membrane The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters.
SNARE complex A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
synaptic vesicle A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle.

2 GO annotations of molecular function

Name Definition
SNAP receptor activity Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
SNARE binding Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.

8 GO annotations of biological process

Name Definition
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
positive regulation of calcium ion-dependent exocytosis Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis.
positive regulation of catecholamine secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine.
positive regulation of norepinephrine secretion Any process that increases the frequency, rate or extent of the regulated release of norepinephrine.
synaptic vesicle fusion to presynaptic active zone membrane Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.
vesicle docking The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere.
vesicle fusion Fusion of the membrane of a transport vesicle with its target membrane.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32867 SSO1 Protein SSO1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P39926 SSO2 Protein SSO2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3SWZ3 STX4 Syntaxin-4 Bos taurus (Bovine) PR
P61267 STX1B Syntaxin-1B Bos taurus (Bovine) PR
Q3ZBT5 STX7 Syntaxin-7 Bos taurus (Bovine) PR
Q24547 Syx1A Syntaxin-1A Drosophila melanogaster (Fruit fly) PR
Q16623 STX1A Syntaxin-1A Homo sapiens (Human) PR
O35526 Stx1a Syntaxin-1A Mus musculus (Mouse) PR
P32851 Stx1a Syntaxin-1A Rattus norvegicus (Rat) PR
O16000 unc-64 Syntaxin-1A homolog Caenorhabditis elegans PR
Q9ZPV9 SYP112 Syntaxin-112 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKDRTQELRT AKDSDDDDDV TVTVDRDRFM DEFFEQVEEI RGFIDKISEN VEEVKRKHSA
70 80 90 100 110 120
ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI EQEEGLNRSS ADLRIRKTQH
130 140 150 160 170 180
STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFASG
190 200 210 220 230 240
IIMDSSISKQ ALSEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHS
250 260 270 280
VDYVERAVSD TKKAVKYQSK ARRKKIMIVI CCVVLGIVIA STFGGIFG