Q6NSN2

PR
Gene name
mao
Protein name
Amine oxidase [flavin-containing]
Names
Monoamine oxidase, MAO, Z-MAO
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:404730
EC number
1.4.3.4: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

424-500 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NSN2

Entry ID Method Resolution Chain Position Source
AF-Q6NSN2-F1 Predicted AlphaFoldDB

No variants for Q6NSN2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NSN2

No associated diseases with Q6NSN2

1 regional properties for Q6NSN2

Type Name Position InterPro Accession
domain Amine oxidase 15 - 452 IPR002937

Functions

Description
EC Number 1.4.3.4 With oxygen as acceptor
Subcellular Localization
  • Mitochondrion outer membrane ; Single-pass type IV membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

5 GO annotations of molecular function

Name Definition
aliphatic amine oxidase activity Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
monoamine oxidase activity Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.
phenethylamine:oxygen oxidoreductase (deaminating) activity Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+.
primary amine oxidase activity Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide.

3 GO annotations of biological process

Name Definition
catecholamine metabolic process The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.
cellular biogenic amine catabolic process The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
neurotransmitter catabolic process The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P56560 MAOB Amine oxidase [flavin-containing] B Bos taurus (Bovine) PR
P21398 MAOA Amine oxidase [flavin-containing] A Bos taurus (Bovine) PR
Q7YRB7 MAOB Amine oxidase [flavin-containing] B Canis lupus familiaris (Dog) (Canis familiaris) PR
P58027 MAOA Amine oxidase [flavin-containing] A Canis lupus familiaris (Dog) (Canis familiaris) PR
Q5NU32 MAOA Amine oxidase [flavin-containing] A Equus caballus (Horse) PR
Q8NB78 KDM1B Lysine-specific histone demethylase 2 Homo sapiens (Human) PR
O60341 KDM1A Lysine-specific histone demethylase 1A Homo sapiens (Human) PR
P27338 MAOB Amine oxidase [flavin-containing] B Homo sapiens (Human) PR
P21397 MAOA Amine oxidase [flavin-containing] A Homo sapiens (Human) PR
Q6ZQ88 Kdm1a Lysine-specific histone demethylase 1A Mus musculus (Mouse) PR
Q64133 Maoa Amine oxidase [flavin-containing] A Mus musculus (Mouse) PR
Q6Q2J0 MAOA Amine oxidase [flavin-containing] A Sus scrofa (Pig) PR
P19643 Maob Amine oxidase [flavin-containing] B Rattus norvegicus (Rat) PR
P21396 Maoa Amine oxidase [flavin-containing] A Rattus norvegicus (Rat) PR
P28554 PDS 15-cis-phytoene desaturase, chloroplastic/chromoplastic Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MTANAYDVIV IGGGISGLSA AKLLVDSGLN PVVLEARSRV GGRTYTVQNK ETKWVDLGGA
70 80 90 100 110 120
YIGPTQNRIL RIAKQYGVKT YKVNEEESLV HYVKGKSYPF KGPFPPMWNP FAYMDYNNLW
130 140 150 160 170 180
RTMDKMGMEI PKEAPWRAPH AEEWDKMTMQ QLFDKICWTR SARRFATLFV NVNVTSEPHE
190 200 210 220 230 240
VSALWFLWYV KQCGGTMRIF STTNGGQERK FAGGANQISE GMARELGDRV KLSRAVCSID
250 260 270 280 290 300
QTGDLVEVRT VNEEVYKAKY VILAIPPGLN LKIHFNPELP PLRNQLIHRV PMGSVIKCMV
310 320 330 340 350 360
YYKENFWRKK GYCGSMVIEE EDAPIGLTLD DTKPDGSVPA IMGFILARKS RKLANLTRDE
370 380 390 400 410 420
RKRRICEIYA RVLGSEEALY PVHYEEKNWC EEEYSGGCYT AYFPPGIMTQ FGRVLREPVG
430 440 450 460 470 480
RLYFAGTETA TEWSGYMEGA VQAGERASRE VMCAMGKLHA SQIWQSEPES MDVPARPFVT
490 500 510 520
TFWERNLPSV GGFLKFMGVS SFLAAATAAG LVACKKGLLP RC