Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P21396
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1O5W | X-ray | 320 A | A/B/C/D | 1-526 | PDB |
| AF-P21396-F1 | Predicted | AlphaFoldDB |
No variants for P21396
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P21396 | |||||
No associated diseases with P21396
5 regional properties for P21396
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | BTB/POZ domain | 19 - 118 | IPR000210 |
| repeat | WD40 repeat | 277 - 313 | IPR001680-1 |
| repeat | WD40 repeat | 419 - 457 | IPR001680-2 |
| repeat | WD40 repeat | 527 - 577 | IPR001680-3 |
| domain | Potassium channel tetramerisation-type BTB domain | 21 - 106 | IPR003131 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| aliphatic amine oxidase activity | Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+. |
| flavin adenine dinucleotide binding | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| monoamine oxidase activity | Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2. |
| phenethylamine:oxygen oxidoreductase (deaminating) activity | Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+. |
| primary amine oxidase activity | Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. |
| serotonin binding | Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| catecholamine catabolic process | The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. |
| dopamine catabolic process | The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. |
| neurotransmitter catabolic process | The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. |
| phenylethylamine metabolic process | The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. |
| positive regulation of signal transduction | Any process that activates or increases the frequency, rate or extent of signal transduction. |
| serotonin metabolic process | The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P56560 | MAOB | Amine oxidase [flavin-containing] B | Bos taurus (Bovine) | PR |
| P21398 | MAOA | Amine oxidase [flavin-containing] A | Bos taurus (Bovine) | PR |
| P58027 | MAOA | Amine oxidase [flavin-containing] A | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q5NU32 | MAOA | Amine oxidase [flavin-containing] A | Equus caballus (Horse) | PR |
| Q8NB78 | KDM1B | Lysine-specific histone demethylase 2 | Homo sapiens (Human) | PR |
| P27338 | MAOB | Amine oxidase [flavin-containing] B | Homo sapiens (Human) | PR |
| O60341 | KDM1A | Lysine-specific histone demethylase 1A | Homo sapiens (Human) | PR |
| P21397 | MAOA | Amine oxidase [flavin-containing] A | Homo sapiens (Human) | PR |
| Q6ZQ88 | Kdm1a | Lysine-specific histone demethylase 1A | Mus musculus (Mouse) | PR |
| Q64133 | Maoa | Amine oxidase [flavin-containing] A | Mus musculus (Mouse) | PR |
| Q6Q2J0 | MAOA | Amine oxidase [flavin-containing] A | Sus scrofa (Pig) | PR |
| P19643 | Maob | Amine oxidase [flavin-containing] B | Rattus norvegicus (Rat) | PR |
| P28554 | PDS | 15-cis-phytoene desaturase, chloroplastic/chromoplastic | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| Q6NSN2 | mao | Amine oxidase [flavin-containing] | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTDLEKPNLA | GHMFDVGLIG | GGISGLAAAK | LLSEYKINVL | VLEARDRVGG | RTYTVRNEHV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KWVDVGGAYV | GPTQNRILRL | SKELGIETYK | VNVNERLVQY | VKGKTYPFRG | AFPPVWNPLA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YLDYNNLWRT | MDEMGKEIPV | DAPWQARHAQ | EWDKMTMKDL | IDKICWTKTA | REFAYLFVNI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NVTSEPHEVS | ALWFLWYVRQ | CGGTARIFSV | TNGGQERKFV | GGSGQVSEQI | MGLLGDKVKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSPVTYIDQT | DDNIIVETLN | HEHYECKYVI | SAIPPILTAK | IHFKPELPPE | RNQLIQRLPM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GAVIKCMVYY | KEAFWKKKDY | CGCMIIEDEE | APIAITLDDT | KPDGSLPAIM | GFILARKADR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QAKLHKDIRK | RKICELYAKV | LGSQEALYPV | HYEEKNWCEE | QYSGGCYTAY | FPPGIMTQYG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RVIRQPVGRI | YFAGTETATQ | WSGYMEGAVE | AGERAAREVL | NALGKVAKKD | IWVEEPESKD |
| 490 | 500 | 510 | 520 | ||
| VPAIEITHTF | LERNLPSVPG | LLKITGVSTS | VALLCFVLYK | IKKLPC |