Q5NU32
Gene name |
MAOA |
Protein name |
Amine oxidase [flavin-containing] A |
Names |
Monoamine oxidase type A, MAO-A |
Species |
Equus caballus (Horse) |
KEGG Pathway |
ecb:100033867 |
EC number |
1.4.3.4: With oxygen as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5NU32
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5NU32-F1 | Predicted | AlphaFoldDB |
No variants for Q5NU32
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5NU32 | |||||
No associated diseases with Q5NU32
1 regional properties for Q5NU32
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Amine oxidase | 23 - 460 | IPR002937 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.4.3.4 | With oxygen as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| aliphatic amine oxidase activity | Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+. |
| flavin adenine dinucleotide binding | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| monoamine oxidase activity | Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2. |
| phenethylamine:oxygen oxidoreductase (deaminating) activity | Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+. |
| primary amine oxidase activity | Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| catecholamine metabolic process | The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. |
| neurotransmitter catabolic process | The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P21398 | MAOA | Amine oxidase [flavin-containing] A | Bos taurus (Bovine) | PR |
| P58027 | MAOA | Amine oxidase [flavin-containing] A | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P21397 | MAOA | Amine oxidase [flavin-containing] A | Homo sapiens (Human) | PR |
| Q64133 | Maoa | Amine oxidase [flavin-containing] A | Mus musculus (Mouse) | PR |
| Q6Q2J0 | MAOA | Amine oxidase [flavin-containing] A | Sus scrofa (Pig) | PR |
| P21396 | Maoa | Amine oxidase [flavin-containing] A | Rattus norvegicus (Rat) | PR |
| Q6NSN2 | mao | Amine oxidase [flavin-containing] | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASQEKASMA | GHMFDVVVIG | GGISGLSAAK | LLAEHETNVL | VLEARDRVGG | RTYTVRNKHV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NYVDVGGAYV | GPTQNRILRL | SKELGLETYK | VNVNERLVQY | VKGKSYPFRG | AFPPVWNPIA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YLDYNNLWRT | MDNMGKEIPA | DAPWEAPHAE | EWDKMTMKDL | IDKICWTKTA | RQFASLFVNI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NVTSEPHQVS | ALWFLWYVKQ | CGGTTRIFSI | TNGGQERKFV | GGSGQVSERI | MELLGDRVKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EHPVTYVDQS | GDNIIVETLN | HEHFECKYVI | SAIPPALTAK | IHFKPELPSE | RNQLIQRLPM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GAIIKCMMYY | KEAFWKKKDY | CGSMIIEDEE | APISITLDDS | KPDGSLPAIM | GFILARKADR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LAKLHKEMRK | KKICELYAKV | LGSQEALQPV | HYEEKNWCEE | QYSGGCYTAY | FPPGIMTQYG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RVIRQPVGRI | YFAGTETATR | WSGYMEGAVE | AGERAAREIL | NALGKVAEKD | IWLQEPESKD |
| 490 | 500 | 510 | 520 | ||
| VPAVEITHSF | WERNLPSVGG | LLKIIGFSTS | ITALWIVVYK | FKLLTRS |