AiPD: Autoinhibited Protein Database

Gene name	Maoa
Protein name	Amine oxidase [flavin-containing] A
Names	Monoamine oxidase type A, MAO-A
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:17161
EC number	1.4.3.4: With oxygen as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

435-518 (Predicted disordered autoinhibitory region) PR

435-518 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q64133-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3409286768	45	R>W	No	EVA
rs248016747	109	R>H	No	EVA
rs3408513216	112	F>L	No	EVA
rs3409286715	153	D>G	No	EVA
rs3389553349	177	F>L	No	EVA
rs3389553353	194	F>V	No	EVA
rs3409854554	195	L>W	No	EVA
rs3389520621	200	Q>*	No	EVA
rs3389462876	227	S>I	No	EVA
rs3389510330	239	K>M	No	EVA
rs3389549916	241	S>R	No	EVA
rs3389552982	271	S>N	No	EVA
rs3408961618	290	E>K	No	EVA
rs3389510311	304	I>T	No	EVA
rs3389462889	315	W>G	No	EVA
rs3389547795	329	E>*	No	EVA
rs3409608181	345	S>*	No	EVA
rs33763875	346	M>I	No	EVA
rs234816846	346	M>L	No	EVA
rs3412867056	376	L>P	No	EVA
rs226576771	390	V>I	No	EVA
rs3413010743	396	N>Y	No	EVA
rs3389510391	398	C>Y	No	EVA
rs3409287938	466	V>A	No	EVA
rs3389520656	474	Q>P	No	EVA
rs3389510380	475	E>D	No	EVA
rs3389520598	479	K>M	No	EVA

Type	Name	Position	InterPro Accession
domain	Amine oxidase	23 - 460	IPR002937

		Description
EC Number	1.4.3.4	With oxygen as acceptor
Subcellular Localization	Mitochondrion outer membrane ; Single-pass type IV membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial outer membrane	The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

Name	Definition
aliphatic amine oxidase activity	Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+.
flavin adenine dinucleotide binding	Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
monoamine oxidase activity	Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.
phenethylamine:oxygen oxidoreductase (deaminating) activity	Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+.
primary amine oxidase activity	Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide.
serotonin binding	Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.

Name	Definition
dopamine catabolic process	The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
neurotransmitter catabolic process	The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
phenylethylamine metabolic process	The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds.
positive regulation of signal transduction	Any process that activates or increases the frequency, rate or extent of signal transduction.
serotonin metabolic process	The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P56560	MAOB	Amine oxidase [flavin-containing] B	Bos taurus (Bovine)	PR
P21398	MAOA	Amine oxidase [flavin-containing] A	Bos taurus (Bovine)	PR
P58027	MAOA	Amine oxidase [flavin-containing] A	Canis lupus familiaris (Dog) (Canis familiaris)	PR
Q5NU32	MAOA	Amine oxidase [flavin-containing] A	Equus caballus (Horse)	PR
Q8NB78	KDM1B	Lysine-specific histone demethylase 2	Homo sapiens (Human)	PR
O60341	KDM1A	Lysine-specific histone demethylase 1A	Homo sapiens (Human)	PR
P27338	MAOB	Amine oxidase [flavin-containing] B	Homo sapiens (Human)	PR
P21397	MAOA	Amine oxidase [flavin-containing] A	Homo sapiens (Human)	PR
Q6ZQ88	Kdm1a	Lysine-specific histone demethylase 1A	Mus musculus (Mouse)	PR
Q6Q2J0	MAOA	Amine oxidase [flavin-containing] A	Sus scrofa (Pig)	PR
P19643	Maob	Amine oxidase [flavin-containing] B	Rattus norvegicus (Rat)	PR
P21396	Maoa	Amine oxidase [flavin-containing] A	Rattus norvegicus (Rat)	PR
P28554	PDS	15-cis-phytoene desaturase, chloroplastic/chromoplastic	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	PR
Q6NSN2	mao	Amine oxidase [flavin-containing]	Danio rerio (Zebrafish) (Brachydanio rerio)	PR