P19643

PR
Gene name
Maob
Protein name
Amine oxidase [flavin-containing] B
Names
Monoamine oxidase type B, MAO-B
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:25750
EC number
1.4.3.4: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

426-509 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P19643

Entry ID Method Resolution Chain Position Source
AF-P19643-F1 Predicted AlphaFoldDB

No variants for P19643

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P19643

No associated diseases with P19643

1 regional properties for P19643

Type Name Position InterPro Accession
domain Amine oxidase 14 - 451 IPR002937

Functions

Description
EC Number 1.4.3.4 With oxygen as acceptor
Subcellular Localization
  • Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

6 GO annotations of molecular function

Name Definition
aliphatic amine oxidase activity Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
identical protein binding Binding to an identical protein or proteins.
monoamine oxidase activity Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.
phenethylamine:oxygen oxidoreductase (deaminating) activity Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+.
primary amine oxidase activity Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide.

11 GO annotations of biological process

Name Definition
negative regulation of serotonin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.
neurotransmitter catabolic process The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
positive regulation of dopamine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine.
response to aluminum ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus.
response to corticosterone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.
response to ethanol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
response to lipopolysaccharide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
response to selenium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion.
response to steroid hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
response to toxic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P56560 MAOB Amine oxidase [flavin-containing] B Bos taurus (Bovine) PR
P21398 MAOA Amine oxidase [flavin-containing] A Bos taurus (Bovine) PR
Q7YRB7 MAOB Amine oxidase [flavin-containing] B Canis lupus familiaris (Dog) (Canis familiaris) PR
Q8NB78 KDM1B Lysine-specific histone demethylase 2 Homo sapiens (Human) PR
O60341 KDM1A Lysine-specific histone demethylase 1A Homo sapiens (Human) PR
P21397 MAOA Amine oxidase [flavin-containing] A Homo sapiens (Human) PR
P27338 MAOB Amine oxidase [flavin-containing] B Homo sapiens (Human) PR
Q6ZQ88 Kdm1a Lysine-specific histone demethylase 1A Mus musculus (Mouse) PR
Q64133 Maoa Amine oxidase [flavin-containing] A Mus musculus (Mouse) PR
Q6Q2J0 MAOA Amine oxidase [flavin-containing] A Sus scrofa (Pig) PR
P21396 Maoa Amine oxidase [flavin-containing] A Rattus norvegicus (Rat) PR
P28554 PDS 15-cis-phytoene desaturase, chloroplastic/chromoplastic Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
Q6NSN2 mao Amine oxidase [flavin-containing] Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSNKCDVIVV GGGISGMAAA KLLHDCGLSV VVLEARDRVG GRTYTIRNKN VKYVDLGGSY
70 80 90 100 110 120
VGPTQNRILR LAKELGLETY KVNEVERLIH FVKGKSYAFR GPFPPVWNPI TYLDYNNLWR
130 140 150 160 170 180
TMDEMGQEIP SDAPWKAPLA EEWDYMTMKE LLDKICWTNS TKQIATLFVN LCVTAETHEV
190 200 210 220 230 240
SALWFLWYVK QCGGTTRIIS TTNGGQERKF IGGSGQVSER IKDILGDRVK LERPVIHIDQ
250 260 270 280 290 300
TGENVVVKTL NHEIYEAKYV ISAIPPVLGM KIHHSPPLPI LRNQLITRVP LGSVIKCMVY
310 320 330 340 350 360
YKEPFWRKKD FCGTMVIEGE EAPIAYTLDD TKPDGSCAAI MGFILAHKAR KLVRLTKEER
370 380 390 400 410 420
LRKLCELYAK VLNSQEALQP VHYEEKNWCE EQYSGGCYTA YFPPGILTQY GRVLRQPVGK
430 440 450 460 470 480
IFFAGTETAS HWSGYMEGAV EAGERAAREI LHAIGKIPED EIWQPEPESV DVPARPITNT
490 500 510
FLERHLPSVP GLLKLLGLTT ILSATALGFL AHKKGLFVRF