Q7YRB7

PR
Gene name
MAOB
Protein name
Amine oxidase [flavin-containing] B
Names
Monoamine oxidase type B, MAO-B
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:403451
EC number
1.4.3.4: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

426-507 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7YRB7

Entry ID Method Resolution Chain Position Source
AF-Q7YRB7-F1 Predicted AlphaFoldDB

3 variants for Q7YRB7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs852713768 9 V>M No EVA
rs852501732 67 C>R No EVA
rs852591933 354 R>L No EVA

No associated diseases with Q7YRB7

1 regional properties for Q7YRB7

Type Name Position InterPro Accession
domain Amine oxidase 14 - 451 IPR002937

Functions

Description
EC Number 1.4.3.4 With oxygen as acceptor
Subcellular Localization
  • Mitochondrion outer membrane ; Single-pass type IV membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
aliphatic amine oxidase activity Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+.
monoamine oxidase activity Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.
phenethylamine:oxygen oxidoreductase (deaminating) activity Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+.
primary amine oxidase activity Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P56560 MAOB Amine oxidase [flavin-containing] B Bos taurus (Bovine) PR
P58027 MAOA Amine oxidase [flavin-containing] A Canis lupus familiaris (Dog) (Canis familiaris) PR
P27338 MAOB Amine oxidase [flavin-containing] B Homo sapiens (Human) PR
P19643 Maob Amine oxidase [flavin-containing] B Rattus norvegicus (Rat) PR
Q6NSN2 mao Amine oxidase [flavin-containing] Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSGKCDVVVV GGGISGMAAA KLLHDFGLNV VVLEARDRVG GRTYTIRNQK VKYLDLGGSY
70 80 90 100 110 120
VGPTQNCILR LAKELGLETY KVNEVERLIH HVKGKSYPFR GPFPPVWNPI AYLDHNNLWR
130 140 150 160 170 180
TMDDMGREIP SDAPWKAPLA EEWDHMTMKE LLDKICWTES AKQLATLFVN LCVTAETHEV
190 200 210 220 230 240
SALWFLWYVK QCGGTTRIIS TTNGGQERKF VGGSGQVSER IMDLLGDQVK LERPVTHIDQ
250 260 270 280 290 300
TGENVLVETL NHEVYEAKYV ISAIPPTLGM KIHFNPPLPM MRNQLITRVP LGSVIKCIVY
310 320 330 340 350 360
YKEPFWRKKD YCGTMIIEGE EAPIAYTLDD TKPDGNYAAI MGFILAHKAR KLARLTKDER
370 380 390 400 410 420
MKKLCELYAK VLGSQEALQP VHYEEKNWCE EQYSGGCYTT YFPPGIMTQY GRVLRQPVGR
430 440 450 460 470 480
IYFAGTETAT HWSGYMEGAV EAGERAAREI LHAMGKIPED EIWQSEPESV DVPAQPITTT
490 500 510
FLERHLPSVP GLLRLIGLTA IFSATALGVL AHKRGLLVRV