P27338
PR
Gene name |
MAOB |
Protein name |
Amine oxidase [flavin-containing] B |
Names |
Monoamine oxidase type B, MAO-B |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:4129 |
EC number |
1.4.3.4: With oxygen as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
53 structures for P27338
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1GOS | X-ray | 300 A | A/B | 2-520 | PDB |
| 1OJ9 | X-ray | 230 A | A/B | 2-520 | PDB |
| 1OJA | X-ray | 170 A | A/B | 2-520 | PDB |
| 1OJC | X-ray | 240 A | A/B | 2-520 | PDB |
| 1OJD | X-ray | 310 A | A/B/C/D/E/F/G/H/I/L | 2-520 | PDB |
| 1S2Q | X-ray | 207 A | A/B | 1-520 | PDB |
| 1S2Y | X-ray | 212 A | A/B | 1-520 | PDB |
| 1S3B | X-ray | 165 A | A/B | 1-520 | PDB |
| 1S3E | X-ray | 160 A | A/B | 1-520 | PDB |
| 2BK3 | X-ray | 180 A | A/B | 2-520 | PDB |
| 2BK4 | X-ray | 190 A | A/B | 2-520 | PDB |
| 2BK5 | X-ray | 183 A | A/B | 1-520 | PDB |
| 2BYB | X-ray | 220 A | A/B | 2-520 | PDB |
| 2C64 | X-ray | 220 A | A/B | 2-520 | PDB |
| 2C65 | X-ray | 170 A | A/B | 2-520 | PDB |
| 2C66 | X-ray | 250 A | A/B | 2-520 | PDB |
| 2C67 | X-ray | 170 A | A/B | 2-520 | PDB |
| 2C70 | X-ray | 206 A | A/B | 2-520 | PDB |
| 2C72 | X-ray | 200 A | A/B | 2-520 | PDB |
| 2C73 | X-ray | 220 A | A/B | 2-520 | PDB |
| 2C75 | X-ray | 170 A | A/B | 2-520 | PDB |
| 2C76 | X-ray | 170 A | A/B | 2-520 | PDB |
| 2V5Z | X-ray | 160 A | A/B | 2-520 | PDB |
| 2V60 | X-ray | 200 A | A/B | 2-520 | PDB |
| 2V61 | X-ray | 170 A | A/B | 2-520 | PDB |
| 2VRL | X-ray | 240 A | A/B | 1-520 | PDB |
| 2VRM | X-ray | 230 A | A/B | 1-520 | PDB |
| 2VZ2 | X-ray | 230 A | A/B | 1-520 | PDB |
| 2XCG | X-ray | 190 A | A/B | 1-520 | PDB |
| 2XFN | X-ray | 160 A | A/B | 1-520 | PDB |
| 2XFO | X-ray | 210 A | A/B | 1-520 | PDB |
| 2XFP | X-ray | 166 A | A/B | 1-520 | PDB |
| 2XFQ | X-ray | 220 A | A/B | 1-520 | PDB |
| 2XFU | X-ray | 220 A | A/B | 2-520 | PDB |
| 3PO7 | X-ray | 180 A | A/B | 1-520 | PDB |
| 3ZYX | X-ray | 220 A | A/B | 2-520 | PDB |
| 4A79 | X-ray | 189 A | A/B | 1-520 | PDB |
| 4A7A | X-ray | 170 A | A/B | 1-520 | PDB |
| 4CRT | X-ray | 180 A | A/B | 1-520 | PDB |
| 5MRL | X-ray | 242 A | A/B | 1-520 | PDB |
| 6FVZ | X-ray | 180 A | A/B | 1-520 | PDB |
| 6FW0 | X-ray | 160 A | A/B | 1-520 | PDB |
| 6FWC | X-ray | 170 A | A/B | 1-520 | PDB |
| 6RKB | X-ray | 230 A | A/B | 1-520 | PDB |
| 6RKP | X-ray | 170 A | A/B | 1-520 | PDB |
| 6RLE | X-ray | 230 A | A/B | 1-520 | PDB |
| 6YT2 | X-ray | 180 A | A/B | 2-520 | PDB |
| 7B0V | X-ray | 230 A | A/B | 1-520 | PDB |
| 7B0Z | X-ray | 210 A | A/B | 1-520 | PDB |
| 7P4F | X-ray | 230 A | A/B | 1-520 | PDB |
| 7P4H | X-ray | 210 A | A/B | 1-520 | PDB |
| 7ZW3 | X-ray | 200 A | AAA/BBB | 1-520 | PDB |
| AF-P27338-F1 | Predicted | AlphaFoldDB |
245 variants for P27338
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| TCGA novel | 2 | S>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10391387 rs778172877 |
2 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs1217654270 CA413008862 |
6 | D>E | No |
ClinGen gnomAD |
|
|
CA329478212 rs867906703 |
13 | G>D | No |
ClinGen Ensembl |
|
|
CA413010921 rs1332503515 |
17 | M>T | No |
ClinGen gnomAD |
|
|
rs762962154 CA10391371 |
18 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA10391370 rs773282941 |
19 | A>G | No |
ClinGen ExAC gnomAD |
|
|
CA10391368 rs770202748 |
22 | L>P | No |
ClinGen ExAC |
|
| TCGA novel | 22 | L>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1028364289 CA329475156 |
29 | N>D | No |
ClinGen TOPMed |
|
| TCGA novel | 30 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10391365 rs189979184 |
31 | V>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10391364 rs747346258 |
32 | V>I | No |
ClinGen ExAC |
|
|
CA10391362 rs756887426 |
36 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA413010685 rs778570953 |
36 | R>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA413010668 rs1171549806 |
37 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
CA10391361 rs778871584 |
38 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs17856663 CA10391360 |
38 | R>H | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 40 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10391341 rs747397495 |
48 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs775868592 CA10391340 |
49 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA10391338 rs201981141 |
59 | S>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs370820554 CA329474769 |
60 | Y>C | No |
ClinGen ESP TOPMed |
|
|
CA413010068 rs1298437740 |
63 | P>S | No |
ClinGen TOPMed |
|
|
CA10391337 rs777268698 |
67 | R>C | Variant assessed as Somatic; 6.27e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
COSM240587 rs755689863 CA10391336 |
67 | R>H | prostate [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA413010042 COSM488379 rs777268698 |
67 | R>S | kidney [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA329474768 rs148575315 |
72 | A>T | No |
ClinGen ESP TOPMed |
|
|
CA413009953 rs1280271793 |
80 | Y>C | No |
ClinGen gnomAD |
|
|
CA10391335 rs781299154 |
84 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776880004 CA329474767 |
87 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes NCI-TCGA TOPMed gnomAD |
|
CA413009905 rs776880004 |
87 | R>G | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA10391333 rs192154106 |
87 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 94 | G>= | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA413008619 rs1423670702 |
94 | G>D | No |
ClinGen gnomAD |
|
|
CA413008588 rs1215586148 |
97 | Y>H | No |
ClinGen TOPMed |
|
|
rs1426305009 CA413008573 |
98 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA10391304 rs767870404 |
100 | R>S | No |
ClinGen ExAC gnomAD |
|
|
rs1601986947 CA413008516 |
103 | F>S | No |
ClinGen Ensembl |
|
|
CA413008505 rs1489790682 |
104 | P>S | No |
ClinGen gnomAD |
|
|
CA413008488 rs1393975465 |
106 | V>A | No |
ClinGen TOPMed |
|
|
rs769571980 CA10391301 |
107 | W>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10391302 rs774521579 |
107 | W>R | No |
ClinGen ExAC gnomAD |
|
|
rs149395667 CA10391300 |
109 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA413008465 rs1307131428 |
110 | I>V | No |
ClinGen gnomAD |
|
|
rs952603149 CA329471876 |
111 | T>A | No |
ClinGen Ensembl |
|
|
CA413008456 rs1294657930 |
111 | T>N | No |
ClinGen gnomAD |
|
|
rs1219565046 CA413008450 |
112 | Y>C | No |
ClinGen gnomAD |
|
|
rs776406971 CA10391299 |
115 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA413008418 rs1440009738 |
116 | N>K | No |
ClinGen gnomAD |
|
|
CA329471874 rs994140054 |
118 | F>Y | No |
ClinGen Ensembl |
|
|
CA10391298 rs768327519 |
120 | R>K | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 123 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs780074639 CA10391296 |
124 | D>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780074639 CA10391297 |
124 | D>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs372591640 CA10391295 |
127 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs372591640 COSM3390642 CA329471873 |
127 | R>Q | pancreas [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs17852046 CA413008208 |
130 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs17852046 CA329471799 |
130 | P>Q | No |
ClinGen TOPMed |
|
|
rs766904222 CA10391283 |
131 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs763385013 CA10391282 |
133 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs1440909955 CA413008102 |
138 | P>S | No |
ClinGen gnomAD |
|
|
CA329471798 rs944307703 |
139 | L>F | No |
ClinGen Ensembl |
|
|
CA329471797 rs890050856 |
140 | A>T | No |
ClinGen Ensembl |
|
|
CA413008068 rs1378086580 |
140 | A>V | No |
ClinGen TOPMed |
|
|
rs147281288 CA10391280 |
142 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1179798721 CA413007903 |
148 | M>V | No |
ClinGen gnomAD |
|
|
rs1418610469 CA413007855 |
150 | E>K | No |
ClinGen gnomAD |
|
|
CA10391279 rs774808110 |
154 | K>N | No |
ClinGen ExAC gnomAD |
|
|
CA10391277 rs201889071 |
155 | L>F | No |
ClinGen 1000Genomes ExAC |
|
|
CA10391260 rs766994984 |
159 | E>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10391276 rs745859820 |
159 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs371973652 CA329471407 |
160 | S>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs143909840 CA10391258 |
161 | A>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1269258923 CA413007198 |
163 | Q>K | No |
ClinGen TOPMed |
|
|
CA10391256 rs138342360 |
166 | T>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA413007172 rs1316591298 |
167 | L>V | No |
ClinGen gnomAD |
|
|
CA413007128 rs1159861627 |
173 | V>A | No |
ClinGen TOPMed |
|
| TCGA novel | 174 | T>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1459914959 CA413007123 |
174 | T>N | No |
ClinGen gnomAD |
|
| TCGA novel | 176 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs748373348 CA10391253 |
182 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 186 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA413007025 rs1555959206 |
188 | Y>F | No |
ClinGen Ensembl |
|
|
rs1428823353 CA413007007 |
191 | Q>E | No |
ClinGen TOPMed |
|
|
CA329471404 rs988819611 |
196 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs781450685 CA10391252 |
196 | T>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA329471403 rs12845783 |
197 | R>S | No |
ClinGen Ensembl |
|
| TCGA novel | 197 | R>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA413006947 rs12850496 |
200 | S>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10391250 rs12850496 |
200 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs768655609 CA10391251 |
200 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA329471402 rs12845773 |
201 | T>P | No |
ClinGen Ensembl |
|
|
CA10391247 rs375609221 |
203 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10391227 rs754192677 |
209 | K>T | No |
ClinGen ExAC gnomAD |
|
|
CA329471300 rs148264689 |
211 | V>A | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs780719254 CA10391226 |
212 | G>D | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 212 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10391223 rs765931652 |
217 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10391222 rs746209846 |
218 | S>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs750363747 CA10391221 |
219 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA329471298 rs980435225 |
220 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA413006455 rs1470898078 |
220 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA10391219 rs761533542 |
221 | I>M | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 221 | I>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA329471296 rs866352942 |
226 | G>* | No |
ClinGen Ensembl |
|
| TCGA novel | 226 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs776431835 CA10391218 |
228 | R>* | No |
ClinGen ExAC |
|
|
rs143144504 CA10391217 |
228 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 236 | I>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1347856793 CA413006294 |
238 | I>V | No |
ClinGen gnomAD |
|
|
rs1225926474 CA413006250 |
241 | T>I | No |
ClinGen gnomAD |
|
|
CA329471295 rs989269368 |
242 | R>K | No |
ClinGen gnomAD |
|
|
CA10391214 rs772327693 |
245 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA413006208 rs1278965110 |
245 | V>F | No |
ClinGen gnomAD |
|
|
CA10391212 rs781470264 |
249 | T>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs757880326 CA329471293 |
254 | M>K | No |
ClinGen TOPMed gnomAD |
|
|
rs757880326 CA329471292 |
254 | M>T | No |
ClinGen TOPMed gnomAD |
|
|
rs1374584798 CA413006105 |
254 | M>V | No |
ClinGen gnomAD |
|
|
rs749617681 CA10391210 |
255 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
rs778267238 CA10391209 |
256 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs994767552 CA329471103 |
259 | Y>C | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 259 | Y>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA413005877 rs1432887350 |
264 | I>V | No |
ClinGen gnomAD |
|
|
CA329471101 rs371337804 |
267 | T>I | No |
ClinGen ESP gnomAD |
|
|
rs774421335 CA10391195 |
267 | T>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 271 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10391194 rs770909931 |
271 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1242712359 CA413005794 |
272 | I>F | No |
ClinGen TOPMed |
|
|
rs149093619 CA329471100 |
272 | I>T | No |
ClinGen ESP TOPMed |
|
|
rs1162364751 CA413005739 |
276 | P>S | No |
ClinGen gnomAD |
|
|
CA10391193 rs749864192 |
277 | P>A | No |
ClinGen ExAC gnomAD |
|
|
rs376954945 CA10391190 |
281 | M>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA413005703 rs1485204536 |
281 | M>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1485204536 CA413005705 |
281 | M>T | No |
ClinGen TOPMed gnomAD |
|
| TCGA novel | 282 | R>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10391188 rs757984992 |
287 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs954304565 CA329471099 |
288 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1232908450 CA413005654 |
288 | R>H | No |
ClinGen gnomAD |
|
|
rs1027907938 CA329471098 |
289 | V>M | No |
ClinGen Ensembl |
|
|
rs1308300908 CA413005645 |
290 | P>A | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA10391187 rs745377652 |
290 | P>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA413005636 rs778555521 |
291 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA413005629 rs1359832338 |
292 | G>A | No |
ClinGen gnomAD |
|
| TCGA novel | 292 | G>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs995154094 CA329471097 |
298 | I>M | No |
ClinGen Ensembl |
|
|
CA329471096 rs1014904448 |
299 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1323303188 CA413005557 |
303 | E>Q | No |
ClinGen gnomAD |
|
|
CA329471095 rs55815323 |
304 | P>L | No |
ClinGen Ensembl |
|
|
rs1457141723 CA413005549 |
304 | P>S | No |
ClinGen gnomAD |
|
|
CA10391183 rs373923364 |
310 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs373923364 CA10391184 |
310 | D>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 311 | Y>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10391167 rs745596328 |
314 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs778411983 CA10391166 |
315 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA413005446 rs1174652648 |
316 | I>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs376366701 CA329470104 |
317 | I>T | No |
ClinGen Ensembl |
|
|
CA10391165 rs756309138 |
320 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA413005412 rs1393788640 |
321 | E>K | No |
ClinGen gnomAD |
|
|
rs1486086634 CA413005405 |
322 | A>T | No |
ClinGen TOPMed |
|
| TCGA novel | 322 | A>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1213467496 CA413005394 |
323 | P>L | No |
ClinGen TOPMed |
|
|
CA413005341 rs1555956523 |
331 | T>N | No |
ClinGen Ensembl |
|
|
rs1292664919 CA413005333 |
332 | K>I | No |
ClinGen Ensembl |
|
|
rs1252701138 CA413005328 |
333 | P>L | No |
ClinGen gnomAD |
|
|
CA329470102 rs1036083502 |
333 | P>S | No |
ClinGen Ensembl |
|
|
CA413005317 rs1485643748 |
335 | G>S | No |
ClinGen TOPMed |
|
|
rs1187667482 CA413005310 |
336 | N>D | No |
ClinGen TOPMed |
|
|
rs1480425646 CA413005308 |
336 | N>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs756059483 CA10391162 |
338 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs781189374 CA10391160 |
340 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA10391159 rs754706218 |
341 | M>T | No |
ClinGen ExAC gnomAD |
|
|
CA10391142 rs748144817 |
344 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10391141 rs781240387 |
348 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA10391138 rs74980273 |
354 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs750641196 CA10391136 |
354 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10391137 rs74980273 |
354 | R>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA413013465 rs1167387008 |
357 | K>E | No |
ClinGen gnomAD |
|
|
rs761859790 CA10391134 |
358 | E>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs753432586 CA329469891 |
366 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
CA329469890 rs866950256 |
370 | K>N | No |
ClinGen Ensembl |
|
|
CA10391107 rs753231998 |
371 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs767818753 CA413013347 |
372 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1305784743 CA413013313 |
377 | A>G | No |
ClinGen gnomAD |
|
|
CA413013304 rs1330558368 |
379 | E>Q | No |
ClinGen gnomAD |
|
|
CA10391090 rs756193754 |
381 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1199459536 CA413013235 |
386 | K>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1430752211 CA413013219 |
388 | W>C | No |
ClinGen TOPMed |
|
| TCGA novel | 391 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1280145389 CA413013187 |
392 | Q>H | No |
ClinGen gnomAD |
|
|
CA413013182 rs1444723292 |
393 | Y>C | No |
ClinGen gnomAD |
|
|
rs1334179941 CA413013177 |
394 | S>P | No |
ClinGen gnomAD |
|
|
rs771956465 CA10391089 |
399 | T>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| TCGA novel | 399 | T>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 402 | F>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs768025315 CA10391088 |
402 | F>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA413013110 rs1171627578 |
404 | P>A | No |
ClinGen TOPMed |
|
|
CA10391087 rs755412723 |
405 | G>R | No |
ClinGen ExAC gnomAD |
|
|
rs1408531108 CA413013100 |
406 | I>L | No |
ClinGen TOPMed |
|
| TCGA novel | 408 | T>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1009339370 CA329469074 |
412 | R>S | No |
ClinGen Ensembl |
|
|
rs771948015 CA10391078 |
413 | V>L | No |
ClinGen ExAC |
|
|
CA10391077 rs759343640 |
414 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA10391075 rs770711084 |
415 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200811997 CA329469073 |
415 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs200811997 CA10391074 |
415 | R>P | No |
ClinGen ExAC gnomAD |
|
|
rs868227475 CA329469072 |
418 | V>M | No |
ClinGen Ensembl |
|
|
CA413012969 rs1187159298 |
420 | R>G | No |
ClinGen TOPMed |
|
|
CA413012795 rs1050945927 |
431 | H>Q | No |
ClinGen gnomAD |
|
|
rs897686214 CA329469071 |
431 | H>R | No |
ClinGen TOPMed |
|
| TCGA novel | 434 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA413012732 rs1420562306 |
435 | Y>C | No |
ClinGen gnomAD |
|
|
CA10391071 rs748206527 |
436 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs201466768 CA10391069 |
442 | A>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1214624832 CA413012534 |
448 | R>L | No |
ClinGen gnomAD |
|
|
CA413012538 rs1214624832 |
448 | R>Q | No |
ClinGen gnomAD |
|
| TCGA novel | 449 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1047754089 | 450 | I>= | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 451 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10391054 rs769996765 |
459 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA329469020 rs929388248 |
462 | I>T | No |
ClinGen Ensembl |
|
|
rs748181140 CA10391053 |
466 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA413012178 rs1465342260 |
469 | S>F | No |
ClinGen TOPMed |
|
|
CA329468939 rs983846707 |
471 | D>E | No |
ClinGen Ensembl |
|
| TCGA novel | 471 | D>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10391039 rs766251341 |
475 | Q>L | No |
ClinGen ExAC gnomAD |
|
|
rs1358368216 CA413011898 |
477 | I>T | No |
ClinGen TOPMed |
|
|
rs1253763332 CA413011884 |
479 | T>I | No |
ClinGen TOPMed |
|
|
CA10391034 RCV000948151 rs149656736 |
482 | L>M | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
| TCGA novel | 482 | L>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1256798813 CA413011843 |
485 | H>R | No |
ClinGen TOPMed |
|
|
CA10391031 rs776163971 |
489 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746227085 CA10391029 |
491 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA413011781 rs1376063354 |
496 | I>V | No |
ClinGen gnomAD |
|
|
rs1169435306 CA413011761 |
499 | T>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA329468937 rs1028799694 |
499 | T>S | No |
ClinGen TOPMed |
|
|
rs780779587 CA10391025 |
505 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA10391024 rs200812794 |
505 | T>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1022361259 CA329468936 COSM289288 |
506 | A>T | large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated Ensembl NCI-TCGA |
|
rs1398301212 CA413011716 |
506 | A>V | No |
ClinGen TOPMed |
|
|
CA329468935 rs1031335251 |
509 | F>C | No |
ClinGen TOPMed |
|
|
CA10391022 rs766227337 |
512 | H>Q | No |
ClinGen ExAC |
|
|
CA413011667 rs1601958324 |
514 | R>T | No |
ClinGen Ensembl |
|
| TCGA novel | 517 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA413011633 rs1276371033 |
520 | V>I | No |
ClinGen TOPMed |
No associated diseases with P27338
1 regional properties for P27338
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Amine oxidase | 14 - 451 | IPR002937 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.4.3.4 | With oxygen as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial envelope | The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| aliphatic amine oxidase activity | Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+. |
| electron transfer activity | Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. |
| flavin adenine dinucleotide binding | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| identical protein binding | Binding to an identical protein or proteins. |
| monoamine oxidase activity | Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2. |
| phenethylamine:oxygen oxidoreductase (deaminating) activity | Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+. |
| primary amine oxidase activity | Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| dopamine catabolic process | The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. |
| hydrogen peroxide biosynthetic process | The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. |
| negative regulation of serotonin secretion | Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. |
| neurotransmitter catabolic process | The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. |
| positive regulation of dopamine metabolic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine. |
| response to aluminum ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus. |
| response to corticosterone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. |
| response to ethanol | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. |
| response to lipopolysaccharide | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| response to selenium ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion. |
| response to toxic substance | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| substantia nigra development | The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P21398 | MAOA | Amine oxidase [flavin-containing] A | Bos taurus (Bovine) | PR |
| P56560 | MAOB | Amine oxidase [flavin-containing] B | Bos taurus (Bovine) | PR |
| Q7YRB7 | MAOB | Amine oxidase [flavin-containing] B | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q8NB78 | KDM1B | Lysine-specific histone demethylase 2 | Homo sapiens (Human) | PR |
| O60341 | KDM1A | Lysine-specific histone demethylase 1A | Homo sapiens (Human) | PR |
| P21397 | MAOA | Amine oxidase [flavin-containing] A | Homo sapiens (Human) | PR |
| Q6ZQ88 | Kdm1a | Lysine-specific histone demethylase 1A | Mus musculus (Mouse) | PR |
| Q64133 | Maoa | Amine oxidase [flavin-containing] A | Mus musculus (Mouse) | PR |
| Q6Q2J0 | MAOA | Amine oxidase [flavin-containing] A | Sus scrofa (Pig) | PR |
| P21396 | Maoa | Amine oxidase [flavin-containing] A | Rattus norvegicus (Rat) | PR |
| P19643 | Maob | Amine oxidase [flavin-containing] B | Rattus norvegicus (Rat) | PR |
| P28554 | PDS | 15-cis-phytoene desaturase, chloroplastic/chromoplastic | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| Q6NSN2 | mao | Amine oxidase [flavin-containing] | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNKCDVVVV | GGGISGMAAA | KLLHDSGLNV | VVLEARDRVG | GRTYTLRNQK | VKYVDLGGSY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VGPTQNRILR | LAKELGLETY | KVNEVERLIH | HVKGKSYPFR | GPFPPVWNPI | TYLDHNNFWR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TMDDMGREIP | SDAPWKAPLA | EEWDNMTMKE | LLDKLCWTES | AKQLATLFVN | LCVTAETHEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SALWFLWYVK | QCGGTTRIIS | TTNGGQERKF | VGGSGQVSER | IMDLLGDRVK | LERPVIYIDQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TRENVLVETL | NHEMYEAKYV | ISAIPPTLGM | KIHFNPPLPM | MRNQMITRVP | LGSVIKCIVY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YKEPFWRKKD | YCGTMIIDGE | EAPVAYTLDD | TKPEGNYAAI | MGFILAHKAR | KLARLTKEER |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LKKLCELYAK | VLGSLEALEP | VHYEEKNWCE | EQYSGGCYTT | YFPPGILTQY | GRVLRQPVDR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IYFAGTETAT | HWSGYMEGAV | EAGERAAREI | LHAMGKIPED | EIWQSEPESV | DVPAQPITTT |
| 490 | 500 | 510 | |||
| FLERHLPSVP | GLLRLIGLTT | IFSATALGFL | AHKRGLLVRV |