P21398

PR
Gene name
MAOA
Protein name
Amine oxidase [flavin-containing] A
Names
Monoamine oxidase type A, MAO-A
Species
Bos taurus (Bovine)
KEGG Pathway
bta:281293
EC number
1.4.3.4: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-41 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P21398

Entry ID Method Resolution Chain Position Source
AF-P21398-F1 Predicted AlphaFoldDB

107 variants for P21398

Variant ID(s) Position Change Description Diseaes Association Provenance
rs442515355 3 S>I No EVA
rs463385741 7 T>S No EVA
rs443211181 9 D>G No EVA
rs457921828 15 D>Y No EVA
rs441064599 16 V>G No EVA
rs472208008 17 V>G No EVA
rs455410361 20 G>A No EVA
rs435702633 22 G>V No EVA
rs459974339 57 N>K No EVA
rs443045870 58 E>K No EVA
rs474397532 59 H>N No EVA
rs454659119 60 V>D No EVA
rs454659119 60 V>G No EVA
rs437648978 61 D>E No EVA
rs475408462 62 Y>F No EVA
rs432270101 63 V>G No EVA
rs452091999 63 V>I No EVA
rs446692991 64 D>E No EVA
rs447272914 67 G>C No EVA
rs450905650 68 A>G No EVA
rs467541105 68 A>S No EVA
rs132976882 69 Y>F No EVA
rs137440205 70 V>L No EVA
rs445225199 72 P>A No EVA
rs479598527 72 P>Q No EVA
rs460091483 74 Q>P No EVA
rs463883438 96 R>H No EVA
rs444161374 98 V>I No EVA
rs444161374 98 V>L No EVA
rs475471800 99 H>R No EVA
rs452205816 100 Y>C No EVA
rs438452938 101 V>L No EVA
rs439731065 103 G>V No EVA
rs471014361 108 F>I No EVA
rs444207016 150 V>L No EVA
rs475351068 169 T>N No EVA
rs444053509 169 T>P No EVA
rs432262517 173 F>C No EVA
rs452425816 173 F>L No EVA
rs466824244 173 F>L No EVA
rs453004308 180 I>F No EVA
rs436121076 180 I>T No EVA
rs467717815 181 N>D No EVA
rs450854928 182 V>L No EVA
rs465316916 184 S>Y No EVA
rs480151782 185 E>* No EVA
rs460023980 190 S>P No EVA
rs443012772 193 W>G No EVA
rs480774367 193 W>S No EVA
rs461046611 194 F>S No EVA
rs475438852 211 T>A No EVA
rs458460012 213 G>S No EVA
rs471321408 216 E>K No EVA
rs455314567 238 V>A No EVA
rs455314567 238 V>G No EVA
rs435238709 242 S>R No EVA
rs469637435 247 V>G No EVA
rs449685934 258 T>P No EVA
rs432742386 260 N>D No EVA
rs469507346 273 I>T No EVA
rs137665679 278 T>P No EVA
rs385873719 287 L>I No EVA
rs477478347 296 Q>H No EVA
rs440694566 303 V>D No EVA
rs461444682 310 Y>* No EVA
rs444608130 311 K>M No EVA
rs475958323 311 K>N No EVA
rs1117087583 318 K>R No EVA
rs134256715 323 C>W No EVA
rs136815266 324 M>V No EVA
rs443989474 338 D>G No EVA
rs448307356 349 I>V No EVA
rs458532337 357 K>I No EVA
rs1115960288 360 R>C No EVA
rs438686839 363 K>N No EVA
rs442075745 364 V>L No EVA
rs463585855 371 R>G No EVA
rs449876844 380 V>G No EVA
rs462888697 392 Y>D No EVA
rs439554672 406 C>G No EVA
rs469463513 425 Q>R No EVA
rs446103994 434 G>R No EVA
rs432394220 440 Q>H No EVA
rs466786983 442 S>R No EVA
rs447129366 451 A>P No EVA
rs461619045 453 E>G No EVA
rs451003402 454 R>G No EVA
rs462669159 455 A>E No EVA
rs482424111 455 A>S No EVA
rs460930868 468 A>S No EVA
rs436799564 480 D>E No EVA
rs464780064 481 V>L No EVA
rs445124981 482 P>T No EVA
rs479536868 486 I>S No EVA
rs41626734 488 P>L No EVA
rs463908975 491 W>C No EVA
rs443731275 493 R>G No EVA
rs471821258 494 N>H No EVA
rs458155524 496 P>T No EVA
rs441206045 499 S>A No EVA
rs472897351 505 V>F No EVA
rs455915018 505 V>G No EVA
rs442251377 508 S>F No EVA
rs476825755 509 T>R No EVA
rs436836212 516 F>V No EVA
rs466131973 526 R>G No EVA
rs449076933 527 S>F No EVA

No associated diseases with P21398

1 regional properties for P21398

Type Name Position InterPro Accession
domain Amine oxidase 23 - 460 IPR002937

Functions

Description
EC Number 1.4.3.4 With oxygen as acceptor
Subcellular Localization
  • Mitochondrion outer membrane ; Single-pass type IV membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

5 GO annotations of molecular function

Name Definition
aliphatic amine oxidase activity Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+.
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
monoamine oxidase activity Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.
phenethylamine:oxygen oxidoreductase (deaminating) activity Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+.
primary amine oxidase activity Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide.

3 GO annotations of biological process

Name Definition
dopamine catabolic process The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
neurotransmitter catabolic process The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.
positive regulation of signal transduction Any process that activates or increases the frequency, rate or extent of signal transduction.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P56560 MAOB Amine oxidase [flavin-containing] B Bos taurus (Bovine) PR
P58027 MAOA Amine oxidase [flavin-containing] A Canis lupus familiaris (Dog) (Canis familiaris) PR
Q5NU32 MAOA Amine oxidase [flavin-containing] A Equus caballus (Horse) PR
Q8NB78 KDM1B Lysine-specific histone demethylase 2 Homo sapiens (Human) PR
O60341 KDM1A Lysine-specific histone demethylase 1A Homo sapiens (Human) PR
P27338 MAOB Amine oxidase [flavin-containing] B Homo sapiens (Human) PR
P21397 MAOA Amine oxidase [flavin-containing] A Homo sapiens (Human) PR
Q6ZQ88 Kdm1a Lysine-specific histone demethylase 1A Mus musculus (Mouse) PR
Q64133 Maoa Amine oxidase [flavin-containing] A Mus musculus (Mouse) PR
Q6Q2J0 MAOA Amine oxidase [flavin-containing] A Sus scrofa (Pig) PR
P19643 Maob Amine oxidase [flavin-containing] B Rattus norvegicus (Rat) PR
P21396 Maoa Amine oxidase [flavin-containing] A Rattus norvegicus (Rat) PR
P28554 PDS 15-cis-phytoene desaturase, chloroplastic/chromoplastic Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
Q6NSN2 mao Amine oxidase [flavin-containing] Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MESLQKTSDA GQMFDVVVIG GGISGLSAAK LLAEHEVNVL VLEARERVGG RTYTVRNEHV
70 80 90 100 110 120
DYVDVGGAYV GPTQNRILRL SKQLGLETYK VNVNERLVHY VKGKTYPFRG AFPPVWNPIA
130 140 150 160 170 180
YLDYNNLWRT MDNMGKEIPA DAPWEAPHAV EWDKMTMKDL IEKICWTKTA RQFASLFVNI
190 200 210 220 230 240
NVTSEPHEVS ALWFLWYVKQ CGGTTRIFSI TNGGQERKFV GGSGQVSERI MQLLGDRVKL
250 260 270 280 290 300
RSPVTYVDQS SENITVETLN RELYECRYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM
310 320 330 340 350 360
GAVIKCMMYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSLPAIM GFILARKADR
370 380 390 400 410 420
LAKVHKDIRK RKICELYAKV LGSQEALHPV HYEEKNWCQE QYSGGCYTAY FPPGIMTQYG
430 440 450 460 470 480
RVIRQPVGRI YFAGTETATQ WSGYMEGAVE AGERAAREVL NALGKLSAKD IWIQEPEAED
490 500 510 520
VPAVEITPSF WERNLPSVSG LLKIVGFSTS ITALWFVMYR FRLLSRS