P58027
Gene name |
MAOA |
Protein name |
Amine oxidase [flavin-containing] A |
Names |
Monoamine oxidase type A, MAO-A |
Species |
Canis lupus familiaris (Dog) (Canis familiaris) |
KEGG Pathway |
cfa:403450 |
EC number |
1.4.3.4: With oxygen as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P58027
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P58027-F1 | Predicted | AlphaFoldDB |
No variants for P58027
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P58027 | |||||
No associated diseases with P58027
4 regional properties for P58027
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helix-hairpin-helix DNA-binding motif, class 1 | 71 - 90 | IPR003583-1 |
| domain | Helix-hairpin-helix DNA-binding motif, class 1 | 106 - 125 | IPR003583-2 |
| domain | Holliday junction DNA helicase RuvA, C-terminal | 158 - 200 | IPR011114 |
| domain | DNA helicase, Holliday junction RuvA type, domain I, bacterial | 1 - 60 | IPR013849 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.4.3.4 | With oxygen as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| aliphatic amine oxidase activity | Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+. |
| flavin adenine dinucleotide binding | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| monoamine oxidase activity | Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2. |
| phenethylamine:oxygen oxidoreductase (deaminating) activity | Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+. |
| primary amine oxidase activity | Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| catecholamine metabolic process | The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. |
| neurotransmitter catabolic process | The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P21398 | MAOA | Amine oxidase [flavin-containing] A | Bos taurus (Bovine) | PR |
| Q7YRB7 | MAOB | Amine oxidase [flavin-containing] B | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q5NU32 | MAOA | Amine oxidase [flavin-containing] A | Equus caballus (Horse) | PR |
| P21397 | MAOA | Amine oxidase [flavin-containing] A | Homo sapiens (Human) | PR |
| Q64133 | Maoa | Amine oxidase [flavin-containing] A | Mus musculus (Mouse) | PR |
| Q6Q2J0 | MAOA | Amine oxidase [flavin-containing] A | Sus scrofa (Pig) | PR |
| P21396 | Maoa | Amine oxidase [flavin-containing] A | Rattus norvegicus (Rat) | PR |
| Q6NSN2 | mao | Amine oxidase [flavin-containing] | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASREKTSIE | GHMFDVVVIG | GGISGLSAAK | LLAEHEVDVL | VLEARDRVGG | RTYTVRNEHV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DYVDVGGAYV | GPTQNRILRL | SKELGLETYK | VNVNERLVQY | VKGKTYPFRG | AFPPVWNPIA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YLDYNNLWRT | MDNMGKEIPA | DAPWEAPHAE | EWDKMTMKDL | IDKICWTKTA | RRFASLFVNI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NVTSEPHEVS | ALWFLWYVKQ | CGGTTRIFSV | TNGGQERKFV | GGSGQVSERI | MERLGDRVKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KRPVTYVDQS | DDNIIIETLN | HELYECKYVI | SAIPPTLTAK | IHFRPELPSE | RNQLIQRLPM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GAIIKCMMYY | KEAFWKKKDY | CGCMIIEDEE | APISITLDDT | KPDGSLPAIM | GFILARKADR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LAKLHKEIRK | RKICELYAKV | LGSQEALQPV | HYEEKNWCEE | QYSGGCYTAY | FPPGIMTHYG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RVIRQPFGRI | YFAGTETATH | WSGYMEGAVE | AGERTAREVL | NALGRVAEKD | LKTQEPESKD |
| 490 | 500 | 510 | 520 | ||
| VPAMEITHTF | WERNLPSVTG | LLKLIGFTTS | VTALWIVAYK | FRLLRRS |