Q6Q2J0
Gene name |
MAOA |
Protein name |
Amine oxidase [flavin-containing] A |
Names |
Monoamine oxidase type A, MAO-A |
Species |
Sus scrofa (Pig) |
KEGG Pathway |
ssc:414424 |
EC number |
1.4.3.4: With oxygen as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6Q2J0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6Q2J0-F1 | Predicted | AlphaFoldDB |
No variants for Q6Q2J0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6Q2J0 | |||||
No associated diseases with Q6Q2J0
1 regional properties for Q6Q2J0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Amine oxidase | 23 - 460 | IPR002937 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.4.3.4 | With oxygen as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| aliphatic amine oxidase activity | Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+. |
| monoamine oxidase activity | Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2. |
| phenethylamine:oxygen oxidoreductase (deaminating) activity | Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+. |
| primary amine oxidase activity | Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| catecholamine metabolic process | The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. |
| neurotransmitter catabolic process | The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P56560 | MAOB | Amine oxidase [flavin-containing] B | Bos taurus (Bovine) | PR |
| P21398 | MAOA | Amine oxidase [flavin-containing] A | Bos taurus (Bovine) | PR |
| P58027 | MAOA | Amine oxidase [flavin-containing] A | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q5NU32 | MAOA | Amine oxidase [flavin-containing] A | Equus caballus (Horse) | PR |
| Q8NB78 | KDM1B | Lysine-specific histone demethylase 2 | Homo sapiens (Human) | PR |
| P27338 | MAOB | Amine oxidase [flavin-containing] B | Homo sapiens (Human) | PR |
| O60341 | KDM1A | Lysine-specific histone demethylase 1A | Homo sapiens (Human) | PR |
| P21397 | MAOA | Amine oxidase [flavin-containing] A | Homo sapiens (Human) | PR |
| Q6ZQ88 | Kdm1a | Lysine-specific histone demethylase 1A | Mus musculus (Mouse) | PR |
| Q64133 | Maoa | Amine oxidase [flavin-containing] A | Mus musculus (Mouse) | PR |
| P19643 | Maob | Amine oxidase [flavin-containing] B | Rattus norvegicus (Rat) | PR |
| P21396 | Maoa | Amine oxidase [flavin-containing] A | Rattus norvegicus (Rat) | PR |
| P28554 | PDS | 15-cis-phytoene desaturase, chloroplastic/chromoplastic | Solanum lycopersicum (Tomato) (Lycopersicon esculentum) | PR |
| Q6NSN2 | mao | Amine oxidase [flavin-containing] | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MERQEKANNA | GHMVDVVVIG | GGISGLSAAK | LLNEYGINVL | VLEARDRVGG | RTYTVRNENV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DYVDVGGAYV | GPTQNRILRL | SKELGLETYK | VNVNECLVQY | VKGKSYPFRG | AFPPVWNPIA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YLDYNNLWRT | MDDMGKKIPA | DAPWESPHAE | EWDKMTMKDL | IDKICWTKTA | KRFASLFVNI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NVTSEPHEVS | ALWFLWYVKQ | CGGTTRIFSV | TNGGQERKFV | GGSGQVSERI | MHLLGDRVKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RCPVTYVDQS | GDNIIVETLN | HELYECQYVI | SAIPPTLTAK | IHFRPELPSE | RNQLIQRLPM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GAIIKCMMYY | KEAFWKKKNY | CGCMIIEDEE | APISITLDDT | KPDGSLPAIM | GFILARKADR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LAKVHKEVRK | RKICELYAKV | LGSQEASHPV | HYEEKNWCEE | QYSGGCYTAY | FPPGIMTQYG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RVIRQPVGRI | FFAGTETATQ | WSGYMEGAVE | AGERAAREIL | NALGKVSKKD | IWLREPESED |
| 490 | 500 | 510 | 520 | ||
| VPAFEITRTF | WERNLPSVTG | LLKIIGFSTS | VTALWLAVYK | FRLLTRS |