Q64436
PR
Gene name |
Atp4a |
Protein name |
Potassium-transporting ATPase alpha chain 1 |
Names |
Gastric H(+)/K(+) ATPase subunit alpha, Proton pump |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:11944 |
EC number |
7.2.2.19: Linked to the hydrolysis of a nucleoside triphosphate |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q64436
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q64436-F1 | Predicted | AlphaFoldDB |
44 variants for Q64436
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388886835 | 53 | D>H | No | EVA | |
| rs3388871847 | 53 | D>V | No | EVA | |
| rs3388871773 | 56 | L>P | No | EVA | |
| rs3388886842 | 58 | V>L | No | EVA | |
| rs3388892062 | 59 | S>T | No | EVA | |
| rs254759232 | 74 | K>R | No | EVA | |
| rs3388892033 | 131 | E>* | No | EVA | |
| rs3388902734 | 178 | Q>E | No | EVA | |
| rs3388879119 | 185 | G>E | No | EVA | |
| rs3388899586 | 254 | F>L | No | EVA | |
| rs3388900055 | 266 | G>S | No | EVA | |
| rs3388894773 | 287 | V>L | No | EVA | |
| rs3388894654 | 298 | I>V | No | EVA | |
| rs3388894814 | 302 | V>L | No | EVA | |
| rs3388896065 | 324 | G>D | No | EVA | |
| rs3388896120 | 331 | M>V | No | EVA | |
| rs3388858495 | 342 | V>M | No | EVA | |
| rs3388879043 | 361 | L>S | No | EVA | |
| rs3388897175 | 367 | V>A | No | EVA | |
| rs3388900036 | 368 | V>F | No | EVA | |
| rs3388900036 | 368 | V>I | No | EVA | |
| rs3388899560 | 399 | S>P | No | EVA | |
| rs3388889980 | 402 | W>* | No | EVA | |
| rs3388894596 | 433 | R>H | No | EVA | |
| rs3388871855 | 436 | T>I | No | EVA | |
| rs3388896068 | 458 | I>V | No | EVA | |
| rs3388858520 | 459 | G>E | No | EVA | |
| rs46773070 | 495 | I>T | No | EVA | |
| rs3388896071 | 521 | P>S | No | EVA | |
| rs3388882497 | 527 | R>C | No | EVA | |
| rs3388858509 | 560 | E>* | No | EVA | |
| rs51775397 | 576 | P>T | No | EVA | |
| rs3388899504 | 634 | A>T | No | EVA | |
| rs3388858448 | 796 | E>V | No | EVA | |
| rs3388890006 | 913 | G>C | No | EVA | |
| rs3388902160 | 925 | Q>H | No | EVA | |
| rs3413151820 | 926 | Y>H | No | EVA | |
| rs3397718563 | 926 | Y>S | No | EVA | |
| rs3388890016 | 930 | T>A | No | EVA | |
| rs3388902722 | 932 | F>S | No | EVA | |
| rs3388871803 | 948 | K>T | No | EVA | |
| rs3388896035 | 981 | Y>N | No | EVA | |
| rs3388901651 | 991 | F>V | No | EVA | |
| rs3388899575 | 1010 | F>Y | No | EVA |
No associated diseases with Q64436
5 regional properties for Q64436
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cation-transporting P-type ATPase, N-terminal | 52 - 126 | IPR004014 |
| domain | Cation-transporting P-type ATPase, C-terminal | 809 - 1018 | IPR006068 |
| domain | Gastric H+/K+-transporter P-type ATPase, N-terminal | 2 - 42 | IPR015127 |
| ptm | P-type ATPase, phosphorylation site | 386 - 392 | IPR018303 |
| domain | P-type ATPase, haloacid dehalogenase domain | 365 - 777 | IPR044492 |
Functions
| Description | ||
|---|---|---|
| EC Number | 7.2.2.19 | Linked to the hydrolysis of a nucleoside triphosphate |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATPase-coupled cation transmembrane transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| P-type potassium:proton transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in). |
| P-type sodium:potassium-exchanging transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). |
| potassium ion binding | Binding to a potassium ion (K+). |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular potassium ion homeostasis | Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell. |
| cellular sodium ion homeostasis | Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. |
| pH reduction | Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. |
| potassium ion import across plasma membrane | The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. |
| proton transmembrane transport | The directed movement of a proton across a membrane. |
| regulation of proton transport | Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| response to xenobiotic stimulus | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
| sodium ion export across plasma membrane | The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P50996 | ATP4A | Potassium-transporting ATPase alpha chain 1 | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P13607 | Atpalpha | Sodium/potassium-transporting ATPase subunit alpha | Drosophila melanogaster (Fruit fly) | PR |
| P54707 | ATP12A | Potassium-transporting ATPase alpha chain 2 | Homo sapiens (Human) | PR |
| P05023 | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 | Homo sapiens (Human) | PR |
| P20648 | ATP4A | Potassium-transporting ATPase alpha chain 1 | Homo sapiens (Human) | PR |
| Q6PIC6 | Atp1a3 | Sodium/potassium-transporting ATPase subunit alpha-3 | Mus musculus (Mouse) | PR |
| Q6PIE5 | Atp1a2 | Sodium/potassium-transporting ATPase subunit alpha-2 | Mus musculus (Mouse) | PR |
| Q8VDN2 | Atp1a1 | Sodium/potassium-transporting ATPase subunit alpha-1 | Mus musculus (Mouse) | PR |
| Q9WV27 | Atp1a4 | Sodium/potassium-transporting ATPase subunit alpha-4 | Mus musculus (Mouse) | PR |
| Q9Z1W8 | Atp12a | Potassium-transporting ATPase alpha chain 2 | Mus musculus (Mouse) | PR |
| P19156 | ATP4A | Potassium-transporting ATPase alpha chain 1 | Sus scrofa (Pig) | PR |
| P54708 | Atp12a | Potassium-transporting ATPase alpha chain 2 | Rattus norvegicus (Rat) | PR |
| P06685 | Atp1a1 | Sodium/potassium-transporting ATPase subunit alpha-1 | Rattus norvegicus (Rat) | PR |
| Q64541 | Atp1a4 | Sodium/potassium-transporting ATPase subunit alpha-4 | Rattus norvegicus (Rat) | PR |
| P09626 | Atp4a | Potassium-transporting ATPase alpha chain 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKAENYELY | SVELGSGPGG | DMTAKMSKKK | AGGGGGKKKE | KLENMKKEME | INDHQLSVSE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LEQKYQTSAT | KGLKASLAAE | LLLRDGPNAL | RPPRGTPEYV | KFARQLAGGL | QCLMWVAAAI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CLIAFAIQAS | EGDLTTDDNL | YLAVALIAVV | VVTGCFGYYQ | EFKSTNIIAS | FKNLVPQQAT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VIRDGDKFQI | NADQLVVGDL | VEMKGGDRVP | ADIRILSAQG | CKVDNSSLTG | ESEPQTRSPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CTHESPLETR | NIAFFSTMCL | EGTAQGLVVS | TGDRTIIGRI | ASLASGVENE | KTPIAIEIEH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FVDIIAGLAI | LFGATFFVVA | MCIGYTFLRA | MVFFMAIVVA | YVPEGLLATV | TVCLSLTAKR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LASKNCVVKN | LEAVETLGST | SVICSDKTGT | LTQNRMTVSH | LWFDNHIHTA | DTTEDQSGQT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FDQSSETWRA | LCRVLTLCNR | AAFKSGQDAV | PVPKRIVIGD | ASETALLKFS | ELTLGNAMGY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RDRFPKVCEI | PFNSINKFQL | SIHTLEDPRD | SRHLLVMKGA | PERVLERCSS | ILIKGQELPL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DEQWREAFQT | AYLSLGGLGE | RVLGFCQLYL | NEKDYPPGYA | FDVEAMNFPS | SGLCFAGLVS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MIDPPRATVP | DAVLKCRTAG | IRVIMVTGDH | PITAKAIAAS | VGIISEGSET | VEDIAARLRM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PVDQVNRKDA | RACVINGMQL | KDMDPSELVE | ALRTHPEMVF | ARTSPQQKLV | IVESCQRLGA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IVAVTGDGVN | DSPALKKADI | GVAMGIAGSD | AAKNAADMIL | LDDNFASIVT | GVEQGRLIFD |
| 790 | 800 | 810 | 820 | 830 | 840 |
| NLKKSIAYTL | TKNIPELTPY | LIYITVSVPL | PLGCITILFI | ELCTDIFPSV | SLAYEKAESD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IMHLRPRNPK | RDRLVNEPLA | AYSYFQIGAI | QSFAGFADYF | TAMAQEGWFP | LLCVGLRPQW |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EDHHLQDLQD | SYGQEWTFGQ | RLYQQYTCYT | VFFISIEMCQ | IADVLIRKTR | RLSVFQQGFF |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| RNKILVIAIV | FQVCIGCFLC | YCPGMPNIFN | FMPIRFQWWL | VPMPFGLLIF | VYDEIRKLGV |
| 1030 | |||||
| RCCPGSWWDQ | ELYY |