AiPD: Autoinhibited Protein Database

Gene name	ATP4A
Protein name	Potassium-transporting ATPase alpha chain 1
Names	Gastric H(+)/K(+) ATPase subunit alpha, Proton pump
Species	Sus scrofa (Pig)
KEGG Pathway	ssc:397552
EC number	7.2.2.19: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-82 (Predicted disordered autoinhibitory region) PR

1-82 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1IWC	NMR	-	A	1-34	PDB
1IWF	NMR	-	A	1-34	PDB
2XZB	EM	700 A	A	1-1034	PDB
2YN9	EM	800 A	A	1-1034	PDB
3IXZ	EM	650 A	A	1-1034	PDB
4UX1	EM	800 A	A	1-1034	PDB
4UX2	EM	700 A	A	1-1034	PDB
5Y0B	EM	670 A	A	1-1034	PDB
5YLU	X-ray	280 A	A	1-1034	PDB
5YLV	X-ray	280 A	A	1-1034	PDB
6JXH	X-ray	250 A	A	49-1034	PDB
6JXI	X-ray	260 A	A	49-1034	PDB
6JXJ	X-ray	250 A	A	49-1034	PDB
6JXK	X-ray	430 A	A/E	49-1034	PDB
7EFL	X-ray	340 A	A	49-1034	PDB
7EFM	X-ray	320 A	A	49-1034	PDB
7EFN	X-ray	320 A	A	50-1034	PDB
7ET1	EM	260 A	A	49-1034	PDB
7W47	X-ray	300 A	A	1-1034	PDB
7W48	X-ray	350 A	A	1-1034	PDB
7W49	X-ray	310 A	A	1-1034	PDB
7W4A	EM	276 A	A	1-1034	PDB
AF-P19156-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for P19156

Type	Name	Position	InterPro Accession
domain	Cation-transporting P-type ATPase, N-terminal	52 - 126	IPR004014
domain	Cation-transporting P-type ATPase, C-terminal	809 - 1018	IPR006068
domain	Gastric H+/K+-transporter P-type ATPase, N-terminal	2 - 42	IPR015127
ptm	P-type ATPase, phosphorylation site	386 - 392	IPR018303
domain	P-type ATPase, haloacid dehalogenase domain	365 - 777	IPR044492

		Description
EC Number	7.2.2.19	Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization	Apical cell membrane ; Multi-pass membrane protein Cell membrane ; Multi-pass membrane protein	Localized in the apical canalicular membrane of parietal cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
magnesium ion binding	Binding to a magnesium (Mg) ion.
P-type potassium:proton transporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in).
potassium ion binding	Binding to a potassium ion (K+).

Name	Definition
No GO annotations for biological process

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P50996	ATP4A	Potassium-transporting ATPase alpha chain 1	Canis lupus familiaris (Dog) (Canis familiaris)	PR
P13607	Atpalpha	Sodium/potassium-transporting ATPase subunit alpha	Drosophila melanogaster (Fruit fly)	PR
P54707	ATP12A	Potassium-transporting ATPase alpha chain 2	Homo sapiens (Human)	PR
P05023	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha-1	Homo sapiens (Human)	PR
P20648	ATP4A	Potassium-transporting ATPase alpha chain 1	Homo sapiens (Human)	PR
Q9Z1W8	Atp12a	Potassium-transporting ATPase alpha chain 2	Mus musculus (Mouse)	PR
Q8VDN2	Atp1a1	Sodium/potassium-transporting ATPase subunit alpha-1	Mus musculus (Mouse)	PR
Q6PIE5	Atp1a2	Sodium/potassium-transporting ATPase subunit alpha-2	Mus musculus (Mouse)	PR
Q6PIC6	Atp1a3	Sodium/potassium-transporting ATPase subunit alpha-3	Mus musculus (Mouse)	PR
Q9WV27	Atp1a4	Sodium/potassium-transporting ATPase subunit alpha-4	Mus musculus (Mouse)	PR
Q64436	Atp4a	Potassium-transporting ATPase alpha chain 1	Mus musculus (Mouse)	PR
P54708	Atp12a	Potassium-transporting ATPase alpha chain 2	Rattus norvegicus (Rat)	PR
P06685	Atp1a1	Sodium/potassium-transporting ATPase subunit alpha-1	Rattus norvegicus (Rat)	PR
Q64541	Atp1a4	Sodium/potassium-transporting ATPase subunit alpha-4	Rattus norvegicus (Rat)	PR
P09626	Atp4a	Potassium-transporting ATPase alpha chain 1	Rattus norvegicus (Rat)	PR