P54708

PR
Gene name
Atp12a (Atp1al1)
Protein name
Potassium-transporting ATPase alpha chain 2
Names
HK alpha 2, Non-gastric H(+)/K(+) ATPase subunit alpha, Non-gastric Na(+)/K(+) ATPase subunit alpha, Proton pump, Sodium pump
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
7.2.2.13: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P54708

Entry ID Method Resolution Chain Position Source
7X20 X-ray 330 A A 53-1036 PDB
7X21 EM 280 A A 53-1036 PDB
7X22 EM 300 A A 53-1036 PDB
7X23 EM 320 A A 53-1036 PDB
7X24 EM 340 A A 53-1036 PDB
AF-P54708-F1 Predicted AlphaFoldDB

No variants for P54708

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P54708

No associated diseases with P54708

4 regional properties for P54708

Type Name Position InterPro Accession
domain Cation-transporting P-type ATPase, N-terminal 55 - 129 IPR004014
domain Cation-transporting P-type ATPase, C-terminal 811 - 1021 IPR006068
ptm P-type ATPase, phosphorylation site 388 - 394 IPR018303
domain P-type ATPase, haloacid dehalogenase domain 367 - 779 IPR044492

Functions

Description
EC Number 7.2.2.13 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Apical cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATPase-coupled cation transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).
metal ion binding Binding to a metal ion.
P-type potassium:proton transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in).
P-type sodium:potassium-exchanging transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).

9 GO annotations of biological process

Name Definition
cellular potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
cellular sodium ion homeostasis Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell.
potassium ion import across plasma membrane The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
proton transmembrane transport The directed movement of a proton across a membrane.
regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.
response to metal ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
response to organic cyclic compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
sodium ion export across plasma membrane The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P13607 Atpalpha Sodium/potassium-transporting ATPase subunit alpha Drosophila melanogaster (Fruit fly) PR
P20648 ATP4A Potassium-transporting ATPase alpha chain 1 Homo sapiens (Human) PR
P05023 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (Human) PR
P54707 ATP12A Potassium-transporting ATPase alpha chain 2 Homo sapiens (Human) PR
Q64436 Atp4a Potassium-transporting ATPase alpha chain 1 Mus musculus (Mouse) PR
Q8VDN2 Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 Mus musculus (Mouse) PR
Q6PIE5 Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2 Mus musculus (Mouse) PR
Q6PIC6 Atp1a3 Sodium/potassium-transporting ATPase subunit alpha-3 Mus musculus (Mouse) PR
Q9WV27 Atp1a4 Sodium/potassium-transporting ATPase subunit alpha-4 Mus musculus (Mouse) PR
Q9Z1W8 Atp12a Potassium-transporting ATPase alpha chain 2 Mus musculus (Mouse) PR
P19156 ATP4A Potassium-transporting ATPase alpha chain 1 Sus scrofa (Pig) PR
P06685 Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 Rattus norvegicus (Rat) PR
P09626 Atp4a Potassium-transporting ATPase alpha chain 1 Rattus norvegicus (Rat) PR
Q64541 Atp1a4 Sodium/potassium-transporting ATPase subunit alpha-4 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MRRKTEIYSV ELNGTKDVKP ADQRDDKKFK GAKNKDLEPN KSHEKEELKK ELDLDDHRLS
70 80 90 100 110 120
NTELEQKYGT NIIQGLSSVR ATELLARDGP NTLTPPKQTP EIIKFLKQMV GGFSILLWIG
130 140 150 160 170 180
AALCWIAFVI QYVNNSASLD NVYLGAILVL VVILTGIFAY YQEAKSTNIM ASFSKMIPQQ
190 200 210 220 230 240
ALVIRDAEKK VISAEQLVVG DVVEIKGGDQ IPADIRLVFS QGCKVDNSSL TGESEPQARS
250 260 270 280 290 300
TEFTHENPLE TKNIGFYSTT CLEGTATGIV INTGDRTIIG RIASLASGVG SEKTPIAIEI
310 320 330 340 350 360
EHFVHIVAGV AVSIDIIFFI TAVCMKYYVL DAIIFLISII VANVPEGLLA TVTVTLSLTA
370 380 390 400 410 420
KRMAKKNCLV KNLEAVETLG STSIICSDKT GTLTQNRMTV AHLWFDNQIF VADTSENQTK
430 440 450 460 470 480
QAFDQSSGTW ASLSKIITLC NRAEFRPGQE SVPIMKRTVV GDASETALLK FSEVILGDVM
490 500 510 520 530 540
GIRKRNHKVA EIPFNSTNKF QLSIHETEDP NNKRFLVVMK GAPERILEKC STIMINGQEQ
550 560 570 580 590 600
PLDKSSADSF HTAYMELGGL GERVLGFCHL YLPAEQFPQS YIFDVDSVNF PTSNFCFVGL
610 620 630 640 650 660
LSMIDPPRST VPDAVSKCRS AGIKVIMVTG DHPITAKAIA KSVGIISANN ETVEDIAKRR
670 680 690 700 710 720
NIAVEQVNKR EAKAAVVTGM ELKDMTPEQL DELLTNYQEI VFARTSPQQK LIIVEGCQRQ
730 740 750 760 770 780
DAIVAVTGDG VNDSPALKKA DIGIAMGIAG SDAAKNAADM VLLDDNFASI VTGVEEGRLI
790 800 810 820 830 840
FDNLKKTIAY TLTKNIAELC PFLIYIVAGL PLPIGTITIL FIDLGTDIIP SIALAYEKAE
850 860 870 880 890 900
SDIMNRKPRH KKKDRLVNTQ LAIYSYLHIG LMQALGGFLV YFTVYAQQGF WPTSLINLRV
910 920 930 940 950 960
AWETDDINDL EDSYGQEWTR YQRKYLEWTG STAFFVAIMI QQIADLIIRK TRRNSIFQQG
970 980 990 1000 1010 1020
LFRNKVIWVG IASQVIVALI LSYGLGSVPA LSFTMLRVQY WFVAVPHAIL IWVYDEMRKL
1030
FIRLYPGSWW DKNMYY