P13607

PR
Gene name
Atpalpha (Na-p, CG5670)
Protein name
Sodium/potassium-transporting ATPase subunit alpha
Names
Na(+)/K(+) ATPase alpha subunit, Sodium pump subunit alpha
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG5670
EC number
7.2.2.13: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-125 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P13607

Entry ID Method Resolution Chain Position Source
AF-P13607-F1 Predicted AlphaFoldDB

1 variants for P13607

Variant ID(s) Position Change Description Diseaes Association Provenance
429 Y>C RNA edited version [UniProt] No

No associated diseases with P13607

4 regional properties for P13607

Type Name Position InterPro Accession
domain Cation-transporting P-type ATPase, N-terminal 60 - 134 IPR004014
domain Cation-transporting P-type ATPase, C-terminal 817 - 1025 IPR006068
ptm P-type ATPase, phosphorylation site 394 - 400 IPR018303
domain P-type ATPase, haloacid dehalogenase domain 373 - 785 IPR044492

Functions

Description
EC Number 7.2.2.13 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
septate junction A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in arthropods.
sodium:potassium-exchanging ATPase complex Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATPase-coupled cation transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).
P-type sodium:potassium-exchanging transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).

21 GO annotations of biological process

Name Definition
adult locomotory behavior Locomotory behavior in a fully developed and mature organism.
cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
cellular potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
cellular sodium ion homeostasis Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
determination of adult lifespan The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
jump response The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus.
locomotory behavior The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
neuromuscular process Any process pertaining to the functions of the nervous and muscular systems of an organism.
potassium ion import across plasma membrane The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
proton transmembrane transport The directed movement of a proton across a membrane.
regulation of tube diameter, open tracheal system Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size.
regulation of tube length, open tracheal system Ensuring that a tube in an open tracheal system is of the correct length.
response to mechanical stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
response to temperature stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.
sensory perception of sound The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
septate junction assembly The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space.
sodium ion export across plasma membrane The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.
synaptic assembly at neuromuscular junction The assembly of a synapse at a neuromuscular junction.
tissue homeostasis A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.
trachea morphogenesis The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P50996 ATP4A Potassium-transporting ATPase alpha chain 1 Canis lupus familiaris (Dog) (Canis familiaris) PR
P05023 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (Human) PR
P54707 ATP12A Potassium-transporting ATPase alpha chain 2 Homo sapiens (Human) PR
P20648 ATP4A Potassium-transporting ATPase alpha chain 1 Homo sapiens (Human) PR
Q6PIC6 Atp1a3 Sodium/potassium-transporting ATPase subunit alpha-3 Mus musculus (Mouse) PR
Q6PIE5 Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2 Mus musculus (Mouse) PR
Q8VDN2 Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 Mus musculus (Mouse) PR
Q9WV27 Atp1a4 Sodium/potassium-transporting ATPase subunit alpha-4 Mus musculus (Mouse) PR
Q9Z1W8 Atp12a Potassium-transporting ATPase alpha chain 2 Mus musculus (Mouse) PR
Q64436 Atp4a Potassium-transporting ATPase alpha chain 1 Mus musculus (Mouse) PR
P19156 ATP4A Potassium-transporting ATPase alpha chain 1 Sus scrofa (Pig) PR
P06685 Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 Rattus norvegicus (Rat) PR
Q64541 Atp1a4 Sodium/potassium-transporting ATPase subunit alpha-4 Rattus norvegicus (Rat) PR
P09626 Atp4a Potassium-transporting ATPase alpha chain 1 Rattus norvegicus (Rat) PR
P54708 Atp12a Potassium-transporting ATPase alpha chain 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MALRSDYEHG RADSYRVATV IATDDDNRTA DGQYKSRRKM PAKVNKKENL DDLKQELDID
70 80 90 100 110 120
FHKISPEELY QRFQTHPENG LSHAKAKENL ERDGPNALTP PKQTPEWVKF CKNLFGGFAM
130 140 150 160 170 180
LLWIGAILCF VAYSIQASTS EEPADDNLYL GIVLSAVVIV TGIFSYYQES KSSKIMESFK
190 200 210 220 230 240
NMVPQFATVI REGEKLTLRA EDLVLGDVVE VKFGDRIPAD IRIIEARNFK VDNSSLTGES
250 260 270 280 290 300
EPQSRGAEFT HENPLETKNL AFFSTNAVEG TAKGVVISCG DHTVMGRIAG LASGLDTGET
310 320 330 340 350 360
PIAKEIHHFI HLITGVAVFL GVTFFVIAFI LGYHWLDAVI FLIGIIVANV PEGLLATVTV
370 380 390 400 410 420
CLTLTAKRMA SKNCLVKNLE AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIIEADT
430 440 450 460 470 480
TEDQSGVQYD RTSPGFKALS RIATLCNRAE FKGGQDGVPI LKKEVSGDAS EAALLKCMEL
490 500 510 520 530 540
ALGDVMNIRK RNKKIAEVPF NSTNKYQVSI HETEDTNDPR YLLVMKGAPE RILERCSTIF
550 560 570 580 590 600
INGKEKVLDE EMKEAFNNAY MELGGLGERV LGFCDFMLPS DKYPNGFKFN TDDINFPIDN
610 620 630 640 650 660
LRFVGLMSMI DPPRAAVPDA VAKCRSAGIK VIMVTGDHPI TAKAIAKSVG IISEGNETVE
670 680 690 700 710 720
DIAQRLNIPV SEVNPREAKA AVVHGAELRD VSSDQLDEIL RYHTEIVFAR TSPQQKLIIV
730 740 750 760 770 780
EGCQRMGAIV AVTGDGVNDS PALKKADIGV AMGIAGSDVS KQAADMILLD DNFASIVTGV
790 800 810 820 830 840
EEGRLIFDNL KKSIAYTLTS NIPEISPFLA FILCDIPLPL GTVTILCIDL GTDMVPAISL
850 860 870 880 890 900
AYEHAEADIM KRPPRDPFND KLVNSRLISM AYGQIGMIQA AAGFFVYFVI MAENGFLPKK
910 920 930 940 950 960
LFGIRKMWDS KAVNDLTDSY GQEWTYRDRK TLEYTCHTAF FISIVVVQWA DLIICKTRRN
970 980 990 1000 1010 1020
SIFQQGMRNW ALNFGLVFET VLAAFLSYCP GMEKGLRMYP LKLVWWFPAI PFALAIFIYD
1030 1040
ETRRFYLRRN PGGWLEQETY Y