P50996

PR
Gene name
ATP4A
Protein name
Potassium-transporting ATPase alpha chain 1
Names
Gastric H(+)/K(+) ATPase subunit alpha, Proton pump
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:431686
EC number
7.2.2.19: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P50996

Entry ID Method Resolution Chain Position Source
AF-P50996-F1 Predicted AlphaFoldDB

No variants for P50996

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P50996

No associated diseases with P50996

5 regional properties for P50996

Type Name Position InterPro Accession
domain Cation-transporting P-type ATPase, N-terminal 52 - 126 IPR004014
domain Cation-transporting P-type ATPase, C-terminal 809 - 1018 IPR006068
domain Gastric H+/K+-transporter P-type ATPase, N-terminal 2 - 42 IPR015127
ptm P-type ATPase, phosphorylation site 386 - 392 IPR018303
domain P-type ATPase, haloacid dehalogenase domain 365 - 777 IPR044492

Functions

Description
EC Number 7.2.2.19 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Apical cell membrane ; Multi-pass membrane protein
  • Localized in the apical canalicular membrane of parietal cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATPase-coupled cation transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).
magnesium ion binding Binding to a magnesium (Mg) ion.
P-type potassium:proton transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in).
P-type sodium:potassium-exchanging transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
potassium ion binding Binding to a potassium ion (K+).

5 GO annotations of biological process

Name Definition
cellular potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
cellular sodium ion homeostasis Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
potassium ion import across plasma membrane The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
proton transmembrane transport The directed movement of a proton across a membrane.
sodium ion export across plasma membrane The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P13607 Atpalpha Sodium/potassium-transporting ATPase subunit alpha Drosophila melanogaster (Fruit fly) PR
P20648 ATP4A Potassium-transporting ATPase alpha chain 1 Homo sapiens (Human) PR
Q64436 Atp4a Potassium-transporting ATPase alpha chain 1 Mus musculus (Mouse) PR
P19156 ATP4A Potassium-transporting ATPase alpha chain 1 Sus scrofa (Pig) PR
P09626 Atp4a Potassium-transporting ATPase alpha chain 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGKAENYEMY SVELGPGPGG DMAAKMSKKK AGKGGGKKKE KLENMKKEME INDHQLSVAE
70 80 90 100 110 120
LEQKYQTSAT KGLSASLAAD LLLRDGPNAL RPPRGTPEYV KFARQLAGGL QCLMWVAAAI
130 140 150 160 170 180
CLIAFAIQAS EGDLTTDDNL YLALALIAVV VVTGCFGYYQ EFKSTNIIAS FKNLVPQQAT
190 200 210 220 230 240
VIRDGDKFQI NADQLVVGDL VEMKGGDRVP ADIRILQAQG CKVDNSSLTG ESEPQTRSPE
250 260 270 280 290 300
CTHESPLETR NIALFSTMCL EGTAQGLVVN TGDRTIIGRI ASLASGVENE KTPIAIEIEH
310 320 330 340 350 360
FVDIIAGLAI LFGATFFVVA MCIGYTFLRA MVFFMAIVVA YVPEGLLATV TVCLSLTAKR
370 380 390 400 410 420
LASKNCVVKN LEAVETLGSK SVICSDKTGT LTQNSMTVSN LWFDNHIHTA DTTEDQSGQK
430 440 450 460 470 480
FDQSSETWRA LCRVLTLCNR AAFKSGQDAV PVPKRIVIGD ASETALLKFS ELTLGNAMGY
490 500 510 520 530 540
RERFPKVCEI PFNSTNKFQL SIHTLEDPRD PRHVLVMKGA PERVLERCSS ILIKGQELPL
550 560 570 580 590 600
DEQWREAFQT AYLSLGGLGE RVLGFCQLYL SEKDYPPGYA FDVEAMNFPT SGLCFAGLVS
610 620 630 640 650 660
MIDPPRATVP DAVLKCRTAG IRVIMVTGDH PITAKAIAAS VGIISEGSET VEDIAARLRV
670 680 690 700 710 720
PVDQVNRKDA RACVINGMQL KDMDPSELVE ALRTHPEMVF ARTSPQQKLV IVESCQRLGA
730 740 750 760 770 780
IVAVTGDGVN DSPALKKADI GVAMGIAGSD AAKNAADMIL LDDNFASIVT GVEQGRLIFD
790 800 810 820 830 840
NLKKSIAYTL TKNIPELTPY LIYITVSVPL PLGCITILFI ELCTDIFPSV SLAYEKAESD
850 860 870 880 890 900
IMHLRPRNPK RDRLVNEPLA AYSYFQIGAI QSFAGFTDYF TAMAQEGWFP LLCVGLRPYW
910 920 930 940 950 960
ENHHLQDLQD SYGQEWTFGQ RLYQQYTCYT VFFISIEMCQ IADVLIRKTR RLSAFQQGFF
970 980 990 1000 1010 1020
RNRILVIAIV FQVCIGCFLC YCPGMPNIFN FMPIRYQWWL VPMPFGLLIF VYDEIRKLGV
1030
RCCPGSWWDQ ELYY