P09626

PR
Gene name
Atp4a (Hka)
Protein name
Potassium-transporting ATPase alpha chain 1
Names
Gastric H(+)/K(+) ATPase subunit alpha, Proton pump
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
7.2.2.19: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P09626

Entry ID Method Resolution Chain Position Source
AF-P09626-F1 Predicted AlphaFoldDB

No variants for P09626

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P09626

No associated diseases with P09626

5 regional properties for P09626

Type Name Position InterPro Accession
domain Cation-transporting P-type ATPase, N-terminal 51 - 125 IPR004014
domain Cation-transporting P-type ATPase, C-terminal 808 - 1017 IPR006068
domain Gastric H+/K+-transporter P-type ATPase, N-terminal 4 - 41 IPR015127
ptm P-type ATPase, phosphorylation site 385 - 391 IPR018303
domain P-type ATPase, haloacid dehalogenase domain 364 - 776 IPR044492

Functions

Description
EC Number 7.2.2.19 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Apical cell membrane ; Multi-pass membrane protein
  • Localized in the apical canalicular membrane of parietal cells (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATPase-coupled cation transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).
magnesium ion binding Binding to a magnesium (Mg) ion.
P-type potassium:proton transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in).
P-type sodium:potassium-exchanging transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
potassium ion binding Binding to a potassium ion (K+).

9 GO annotations of biological process

Name Definition
cellular potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
cellular sodium ion homeostasis Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
gastric acid secretion The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.
pH reduction Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.
potassium ion import across plasma membrane The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
proton transmembrane transport The directed movement of a proton across a membrane.
regulation of proton transport Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
sodium ion export across plasma membrane The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P50996 ATP4A Potassium-transporting ATPase alpha chain 1 Canis lupus familiaris (Dog) (Canis familiaris) PR
P13607 Atpalpha Sodium/potassium-transporting ATPase subunit alpha Drosophila melanogaster (Fruit fly) PR
P54707 ATP12A Potassium-transporting ATPase alpha chain 2 Homo sapiens (Human) PR
P05023 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (Human) PR
P20648 ATP4A Potassium-transporting ATPase alpha chain 1 Homo sapiens (Human) PR
Q9Z1W8 Atp12a Potassium-transporting ATPase alpha chain 2 Mus musculus (Mouse) PR
Q8VDN2 Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 Mus musculus (Mouse) PR
Q6PIE5 Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2 Mus musculus (Mouse) PR
Q6PIC6 Atp1a3 Sodium/potassium-transporting ATPase subunit alpha-3 Mus musculus (Mouse) PR
Q9WV27 Atp1a4 Sodium/potassium-transporting ATPase subunit alpha-4 Mus musculus (Mouse) PR
Q64436 Atp4a Potassium-transporting ATPase alpha chain 1 Mus musculus (Mouse) PR
P19156 ATP4A Potassium-transporting ATPase alpha chain 1 Sus scrofa (Pig) PR
P06685 Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 Rattus norvegicus (Rat) PR
P54708 Atp12a Potassium-transporting ATPase alpha chain 2 Rattus norvegicus (Rat) PR
Q64541 Atp1a4 Sodium/potassium-transporting ATPase subunit alpha-4 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGKENYELYS VELGTGPGGD MAAKMSKKKA GGGGGKKKEK LENMKKEMEM NDHQLSVSEL
70 80 90 100 110 120
EQKYQTSATK GLKASLAAEL LLRDGPNALR PPRGTPEYVK FARQLAGGLQ CLMWVAAAIC
130 140 150 160 170 180
LIAFAIQASE GDLTTDDNLY LALALIAVVV VTGCFGYYQE FKSTNIIASF KNLVPQQATV
190 200 210 220 230 240
IRDGDKFQIN ADQLVVGDLV EMKGGDRVPA DIRILSAQGC KVDNSSLTGE SEPQTRSPEC
250 260 270 280 290 300
THESPLETRN IAFFSTMCLE GTAQGLVVST GDRTIIGRIA SLASGVENEK TPIAIEIEHF
310 320 330 340 350 360
VDIIAGLAIL FGATFFVVAM CIGYTFLRAM VFFMAIVVAY VPEGLLATVT VCLSLTAKRL
370 380 390 400 410 420
ASKNCVVKNL EAVETLGSTS VICSDKTGTL TQNRMTVSHL WFDNHIHTAD TTEDQSGQTF
430 440 450 460 470 480
DQSSETWRAL CRVLTLCNRA AFKSGQDAVP VPKRIVIGDA SETALLKFSE LTLGNAMGYR
490 500 510 520 530 540
DRFPKVCEIP FNSTNKFQLS IHTLEDPRDP RHLLVMKGAP ERVLERCSSI LIKGQELPLD
550 560 570 580 590 600
EQWREAFQTA YLSLGGLGER VLGFCQLYLN EKDYPPGYTF DVEAMNFPSS GLCFAGLVSM
610 620 630 640 650 660
IDPPRATVPD AVLKCRTAGI RVIMVTGDHP ITAKAIAASV GIISEGSETV EDIAARLRMP
670 680 690 700 710 720
VDQVNKKDAR ACVINGMQLK DMDPSELVEA LRTHPEMVFA RTSPQQKLVI VESCQRLGAI
730 740 750 760 770 780
VAVTGDGVND SPALKKADIG VAMGIAGSDA AKNAADMILL DDNFASIVTG VEQGRLIFDN
790 800 810 820 830 840
LKKSIAYTLT KNIPELTPYL IYITVSVPLP LGCITILFIE LCTDIFPSVS LAYEKAESDI
850 860 870 880 890 900
MHLRPRNPRR DRLVNEPLAA YSYFQIGAIQ SFAGFADYFT AMAQEGWFPL LCVGLRPQWE
910 920 930 940 950 960
DHHLQDLQDS YGQEWTFGQR LYQQYTCYTV FFISIEMCQI ADVLIRKTRR LSAFQQGFFR
970 980 990 1000 1010 1020
NRILVIAIVF QVCIGCFLCY CPGMPNIFNF MPIRFQWWLV PMPFGLLIFV YDEIRKLGVR
1030
CCPGSWWDQE LYY