AiPD: Autoinhibited Protein Database

P05023

Gene name	ATP1A1
Protein name	Sodium/potassium-transporting ATPase subunit alpha-1
Names	Na(+)/K(+) ATPase alpha-1 subunit, Sodium pump subunit alpha-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:476
EC number	7.2.2.13: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-50 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for P05023

Entry ID	Method	Resolution	Chain	Position	Source
7E1Z	EM	320 A	A	1-1023	PDB
7E20	EM	270 A	A	1-1023	PDB
7E21	EM	290 A	A	1-1023	PDB
AF-P05023-F1	Predicted				AlphaFoldDB

358 variants for P05023

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
VAR_081039 RCV001092891 rs1553190285 RCV000656712 CA341840480	48	L>R	Charcot-marie-tooth disease, axonal, type 2DD CMT2DD; no effect on Na(+)-dependent currents [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
rs724160008 RCV000149850	100	F>missing	Aldosterone-producing adrenal cortex adenoma [ClinVar]	Yes	ClinVar dbSNP
CA211218 rs11540945 RCV000149851	104	L>R	Aldosterone-producing adrenal cortex adenoma [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
rs193920762 COSM1178562 CA174297 RCV000149075	155	S>L	Malignant tumor of prostate prostate [ClinVar, Cosmic]	Yes	ClinGen cosmic curated ClinVar Ensembl dbSNP
CA341843960 rs1557785499 RCV000754797	302	L>P	Hypomagnesemia, seizures, and intellectual disability 2 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
VAR_081937	302	L>R	HOMGSMR2; results in altered sodium and potassium transport as shown by in vitro functional expression of the homologous rat variant [UniProt]	Yes	UniProt
RCV000754798 rs1557785503 CA341843963 VAR_081938	303	G>R	Hypomagnesemia, seizures, and intellectual disability 2 HOMGSMR2; results in altered sodium and potassium transport as shown by in vitro functional expression of the homologous rat variant [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
rs724160010 CA211223 RCV000149853	332	V>G	Variant assessed as Somatic; impact. Aldosterone-producing adrenal cortex adenoma [NCI-TCGA, ClinVar]	Yes	ClinGen ClinVar Ensembl NCI-TCGA dbSNP
rs1401759980 RCV000850471 CA341844195	333	P>R	Marfanoid habitus and intellectual disability [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
VAR_081040 rs1553192086 CA341771587 RCV000656715 RCV001855351	592	I>T	Charcot-marie-tooth disease, axonal, type 2DD CMT2DD; unknown pathological significance [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
VAR_081041	597	A>T	CMT2DD; unknown pathological significance [UniProt]	Yes	UniProt
VAR_081042 RCV000656713 rs1553192091 CA341771634	600	P>A	Charcot-marie-tooth disease, axonal, type 2DD CMT2DD; shows fewer Na(+)-dependent currents than wild-type protein [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
rs1553192091 RCV000656714 RCV002534251 CA341771633 VAR_081043	600	P>T	Charcot-marie-tooth disease, axonal, type 2DD CMT2DD; unknown pathological significance [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
VAR_081044	601	D>F	CMT2DD; unknown pathological significance; requires 2 nucleotide substitutions [UniProt]	Yes	UniProt
rs1652955697 RCV001280844	622	I>M	Hypomagnesemia, seizures, and intellectual disability 2 [ClinVar]	Yes	ClinVar dbSNP
CA341772440 rs1570973191 RCV000850440	674	T>S	Marfanoid habitus and intellectual disability [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV000656716 CA341773876 VAR_081045 rs1553192783	811	D>A	Charcot-marie-tooth disease, axonal, type 2DD CMT2DD; shows fewer Na(+)-dependent currents than wild-type protein [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
RCV001331357 rs1653241392 RCV001800984	844	L>P	Charcot-marie-tooth disease, axonal, type 2DD Intellectual disability [ClinVar]	Yes	ClinVar dbSNP
RCV001198395 rs1436880886 CA341774326	848	R>W	Hypomagnesemia, seizures, and intellectual disability 2 [ClinVar]	Yes	ClinGen ClinVar dbSNP gnomAD
rs781629728 CA341774769 VAR_081939 RCV000754799	859	M>R	Hypomagnesemia, seizures, and intellectual disability 2 HOMGSMR2; results in altered sodium and potassium transport as shown by in vitro functional expression of the homologous rat variant [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt ExAC dbSNP gnomAD
CA341775664 rs1570980551 RCV000845571	931	W>R	Hypomagnesemia, seizures, and intellectual disability 2 [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
rs1653448255 RCV001290135	937	C>missing	Charcot-marie-tooth disease, axonal, type 2DD [ClinVar]	Yes	ClinVar dbSNP
rs976510541 CA30059094	3	K>R		No	ClinGen Ensembl
CA341838785 rs1307008508	4	G>R		No	ClinGen TOPMed
rs780694923 CA1025000	5	V>A		No	ClinGen ExAC TOPMed gnomAD
rs756724088 CA1024999	5	V>F		No	ClinGen ExAC TOPMed gnomAD
CA341840172 rs1429384765	7	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs146195513 CA30066711	7	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs146195513 CA341840174	7	R>L		No	ClinGen ESP TOPMed gnomAD
rs146195513 CA341840173	7	R>P		No	ClinGen ESP TOPMed gnomAD
rs1429384765 CA341840170	7	R>S		No	ClinGen gnomAD
CA341840177 rs1218878696	8	D>G		No	ClinGen gnomAD
rs745357199 CA1025001	8	D>H		No	ClinGen ExAC gnomAD
CA1025002 rs769191909	9	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA916269869 rs1557781915	15	V>G		No	ClinGen Ensembl
rs1557781926 CA916269870	16	S>*		No	ClinGen Ensembl
CA30066721 rs111860221	16	S>P		No	ClinGen gnomAD
CA341840229 rs111860221	16	S>T		No	ClinGen gnomAD
CA341840252 rs1446413621	19	G>C		No	ClinGen gnomAD
CA30066736 rs11540944	20	D>H		No	ClinGen Ensembl
rs772388569 CA1025007	23	G>D		No	ClinGen ExAC gnomAD
TCGA novel	25	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA30066740 rs906254720	27	K>Q		No	ClinGen TOPMed gnomAD
CA30066742 rs985672025	27	K>R		No	ClinGen Ensembl
CA341840361 rs1245475227	34	E>K		No	ClinGen TOPMed
TCGA novel	38	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341840411 rs1384870128	41	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA341840446 rs1354383018	43	D>E		No	ClinGen gnomAD
CA341840440 rs1217480321	43	D>N		No	ClinGen gnomAD
CA30067213 rs12564026 VAR_048374	47	S>I		No	ClinGen UniProt Ensembl dbSNP
CA30067216 rs200260779	47	S>R		No	ClinGen Ensembl
CA1025030 rs778261406	49	D>H		No	ClinGen ExAC gnomAD
rs1386911088 CA341840490	50	E>Q		No	ClinGen TOPMed
CA341840505 rs1347327000	52	H>Y		No	ClinGen gnomAD
CA1025031 rs747334872	53	R>C		No	ClinGen ExAC gnomAD
CA341840513 rs369738549	53	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA1025032 rs369738549	53	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs755576753 CA1025034	61	R>Q		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	61	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1158326714 CA341840714	64	T>R		No	ClinGen gnomAD
CA30068890 rs923288032	66	A>V		No	ClinGen Ensembl
rs764680790 CA1025072	67	R>C		No	ClinGen ExAC gnomAD
COSM243113 CA341840751 rs1159387961	67	R>H	prostate [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA341840769 rs1286662752	68	A>V		No	ClinGen TOPMed
CA1025073 rs751968061	73	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA1025076 rs564786229	74	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA341840854 rs1305466076	75	D>N		No	ClinGen gnomAD
rs1421893391 CA341840906	78	N>S		No	ClinGen gnomAD
rs1004452127 CA30068901	79	A>T		No	ClinGen TOPMed gnomAD
CA30068927 rs958115046	81	T>A		No	ClinGen TOPMed
rs974563697 CA30068931	81	T>S		No	ClinGen TOPMed
rs1346636921 CA341840975	83	P>R		No	ClinGen gnomAD
CA341840967 rs1455656263	83	P>S		No	ClinGen TOPMed
CA30068939 rs921800708	85	T>S		No	ClinGen TOPMed
rs780391814 CA1025078	86	T>A		No	ClinGen ExAC TOPMed gnomAD
CA1025079 rs749401049	87	P>A		No	ClinGen ExAC TOPMed gnomAD
CA341841022 rs749401049	87	P>S		No	ClinGen ExAC TOPMed gnomAD
CA1025083 rs145341046	94	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA341841154 rs1159259511	94	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA341841180 rs1412944529	95	Q>R		No	ClinGen gnomAD
CA1025085 rs760427027	98	G>R		No	ClinGen ExAC gnomAD
rs1570953900 CA341841260	100	F>V		No	ClinGen Ensembl
rs1360019202	100	F>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA341841288 rs764588242	102	M>L		No	ClinGen ExAC TOPMed gnomAD
rs764588242 CA1025089	102	M>V		No	ClinGen ExAC TOPMed gnomAD
CA341841438 rs1312465041	113	L>F		No	ClinGen TOPMed gnomAD
CA341841465 rs1255922024	116	S>C		No	ClinGen gnomAD
rs756497821 CA1025094	124	E>D		No	ClinGen ExAC TOPMed gnomAD
CA341841545 rs1179203009	124	E>G		No	ClinGen gnomAD
CA341841591 rs1193050533	128	D>N		No	ClinGen gnomAD
rs773814995 CA1025110	131	Y>C		No	ClinGen ExAC gnomAD
rs761125134 CA1025111	135	V>G		No	ClinGen ExAC gnomAD
rs1483586374 CA341842210	141	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	144	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755220071 CA1025114	149	Y>C		No	ClinGen ExAC gnomAD
rs1398962674 CA341842265	149	Y>N		No	ClinGen gnomAD
TCGA novel	160	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	163	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	176	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1476953195 CA341842504	180	I>V		No	ClinGen TOPMed
rs139745455 CA1025143	182	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA341842574 rs1280983367	190	L>Q		No	ClinGen gnomAD
CA1025146 rs747627862	190	L>V		No	ClinGen ExAC TOPMed gnomAD
rs777143274 CA1025148	193	V>I		No	ClinGen ExAC gnomAD
CA30069731 rs145790737	194	K>N		No	ClinGen ESP TOPMed
rs759845712 CA1025149	198	R>*		No	ClinGen ExAC gnomAD
rs1444488629 CA341842645	202	D>H		No	ClinGen gnomAD
CA341842654 rs1311490781	203	L>F		No	ClinGen gnomAD
CA1025150 rs770133739	205	I>V		No	ClinGen ExAC gnomAD
CA341842672 rs1232676566	206	I>V		No	ClinGen gnomAD
CA1025151 rs775593117	208	A>S		No	ClinGen ExAC gnomAD
rs1347486125 CA341842688	208	A>V		No	ClinGen gnomAD
rs1264667039 CA341842753	216	S>A		No	ClinGen gnomAD
CA341842764 rs1452922227	217	S>L		No	ClinGen gnomAD
CA30069853 rs992887190	226	T>P		No	ClinGen Ensembl
CA341842902 rs1424170832	233	N>T		No	ClinGen gnomAD
CA1025169 rs775902817	234	E>G		No	ClinGen ExAC TOPMed gnomAD
CA341843018 rs1387469739	240	R>G		No	ClinGen gnomAD
CA1025172 rs202098437	240	R>T		No	ClinGen 1000Genomes ExAC
CA30069877 rs917361832	244	F>Y		No	ClinGen TOPMed
CA1025174 rs767575185	247	T>A		No	ClinGen ExAC gnomAD
RCV001317016 rs1652274501	248	N>S		No	ClinVar dbSNP
CA341843196 rs1321578905	250	V>I		No	ClinGen gnomAD
CA341843369 rs1263162539	254	A>T		No	ClinGen TOPMed
rs759405523 CA1025196	255	R>C		No	ClinGen ExAC gnomAD
CA341843391 rs1258171077	255	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA30070107 rs1036506727	260	Y>F		No	ClinGen Ensembl
rs1328025079 CA341843541	264	R>C		No	ClinGen TOPMed
CA1025197 rs765069962	264	R>H	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs866032260 CA30070134	277	L>P		No	ClinGen Ensembl
rs752531768 CA1025198	278	E>A		No	ClinGen ExAC gnomAD
TCGA novel	294	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA30070143 rs866444285	297	G>C		No	ClinGen Ensembl
rs77346051 CA1025202	300	V>G		No	ClinGen ExAC gnomAD
TCGA novel	302	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1471033105 CA341843966	303	G>A		No	ClinGen TOPMed
rs200841398 CA30070172	304	V>A		No	ClinGen 1000Genomes
rs930844243 CA30070173	308	I>S		No	ClinGen Ensembl
CA341844033 rs1307241673	314	E>Q		No	ClinGen gnomAD
rs779317338 CA1025207	326	G>S		No	ClinGen ExAC gnomAD
CA1025209 rs772383915	329	V>L		No	ClinGen ExAC gnomAD
CA341844196 rs1401759980	333	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA1025214 rs759607882	341	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA341844269 rs1426324449	343	C>F		No	ClinGen gnomAD
CA30070521 rs11540957	346	L>F		No	ClinGen Ensembl
CA341844301 rs1348829568	349	K>E		No	ClinGen gnomAD
rs747138813 CA1025230	350	R>C		No	ClinGen ExAC gnomAD
CA341844317 rs1477922183	351	M>T		No	ClinGen TOPMed gnomAD
rs771268719 CA1025231	353	R>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	355	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	370	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341844508 rs1289108099	379	G>R		No	ClinGen gnomAD
CA341844548 rs1269859843 COSM3417923	385	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
COSM73775 CA1025235 rs775243249	385	R>W	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA341844587 rs1252478023	391	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA1025240 rs138556439	395	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	397	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA30070574 rs112808861	397	I>V		No	ClinGen gnomAD
CA341844657 rs1403085659	400	A>T		No	ClinGen gnomAD
CA341844676 rs1165006226	402	T>M		No	ClinGen gnomAD
rs1246192772 CA341844695	405	N>S		No	ClinGen TOPMed
CA341844705 rs1296073565	406	Q>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA341844732 rs1238127035	408	G>V		No	ClinGen gnomAD
CA341844765 rs1351759100	413	K>R		No	ClinGen gnomAD
rs372871986 CA1025266	416	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs891256379 CA30070932	417	T>A		No	ClinGen Ensembl
rs911157867 CA30070936	417	T>I		No	ClinGen TOPMed
CA341844791 rs1444588236	418	W>R		No	ClinGen gnomAD
CA341844801 rs1570959486	419	L>F		No	ClinGen Ensembl
rs764635041 CA1025267	421	L>V		No	ClinGen ExAC gnomAD
CA1025269 rs757650235	422	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA341844845 rs1266324574	426	G>A		No	ClinGen gnomAD
TCGA novel	429	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	431	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341844935 rs1427201017	439	N>Y		No	ClinGen TOPMed
TCGA novel	443	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750806208 CA1025291	445	R>Q		No	ClinGen ExAC gnomAD
CA29660272 rs747605557	456	L>P		No	ClinGen Ensembl
TCGA novel	458	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	459	C>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	460	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs922631358 CA29660281	460	I>V		No	ClinGen TOPMed
rs1250825397 CA341770428	468	K>R		No	ClinGen TOPMed
rs1181286163 CA341770434	469	E>K		No	ClinGen TOPMed
CA341770451 rs1347690405	470	M>K		No	ClinGen TOPMed gnomAD
rs1347690405 CA341770454	470	M>T		No	ClinGen TOPMed gnomAD
CA29660322 rs934067705	472	E>G		No	ClinGen TOPMed
CA1025299 rs370297737	473	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA1025302 rs148719009	475	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM894391 CA1025301 rs148719009	475	A>T	Variant assessed as Somatic; 0.0 impact. endometrium urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs201409287 CA1025305	478	V>I		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	483	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341770676 rs1320985329	488	Y>*		No	ClinGen TOPMed
CA341770779 rs1402054299	493	H>Y		No	ClinGen gnomAD
CA341770818 rs751451407	496	P>S		No	ClinGen ExAC gnomAD
rs751451407 CA1025336	496	P>T		No	ClinGen ExAC gnomAD
rs141400264 CA1025338	499	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs141400264 CA1025339	499	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA1025342 rs748836037	500	E>D		No	ClinGen ExAC gnomAD
CA1025341 rs779802423	500	E>K		No	ClinGen ExAC TOPMed gnomAD
rs768214820 CA1025343	502	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	503	H>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341770895 rs144872101	503	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA1025344 rs778154659	503	H>Y		No	ClinGen ExAC gnomAD
rs767656830 CA29661117	506	V>A		No	ClinGen Ensembl
rs574791429 CA341771037	517	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs574791429 CA1025348	517	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA341771039 rs11540949	517	R>H		No	ClinGen gnomAD
CA29661125 rs11540949	517	R>L		No	ClinGen gnomAD
CA341771087 rs1339242029	522	L>F		No	ClinGen TOPMed gnomAD
CA29661152 rs910066930	525	G>S		No	ClinGen Ensembl
rs1370663382 CA341771126	527	E>K		No	ClinGen gnomAD
CA341771140 rs1307308245	528	Q>H		No	ClinGen gnomAD
CA341771139 rs1225144480	528	Q>R		No	ClinGen gnomAD
TCGA novel	530	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341771167 rs1570964688	532	E>D		No	ClinGen Ensembl
rs764106140 CA1025352	532	E>K		No	ClinGen ExAC gnomAD
rs142766448 CA1025354 COSM159267	536	D>E	NS [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs941562505 CA29661190	536	D>G		No	ClinGen Ensembl
TCGA novel	541	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs554306933 CA1025357	542	Y>C		No	ClinGen 1000Genomes ExAC gnomAD
rs766132580 CA1025358	544	E>Q		No	ClinGen ExAC gnomAD
rs760784617	547	G>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	548	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341771347 rs1411149485	557	H>Q		No	ClinGen gnomAD
rs754714789 CA1025379	564	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA29662455 rs866553949	568	G>E		No	ClinGen gnomAD
rs757809799 CA1025382	575	D>N		No	ClinGen ExAC gnomAD
rs77217304 CA1025384	580	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs796431957 CA29662482	582	N>D		No	ClinGen Ensembl
CA29662490 rs369543323	582	N>K		No	ClinGen ESP TOPMed gnomAD
rs780464509 CA1025387	586	V>I		No	ClinGen ExAC gnomAD
CA1025386 rs780464509	586	V>L		No	ClinGen ExAC gnomAD
rs768973685 CA1025388	590	S>C		No	ClinGen ExAC gnomAD
TCGA novel	591	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs893896136 CA29662529	603	V>M		No	ClinGen TOPMed gnomAD
rs1557789877 CA341771675	606	C>Y		No	ClinGen Ensembl
rs1283565006 CA341772089	624	A>T		No	ClinGen gnomAD
rs921744874 CA29663691	627	I>V		No	ClinGen Ensembl
TCGA novel	638	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA341772184 rs1436762122	638	N>S		No	ClinGen gnomAD
rs1570970680 CA341772197	640	T>P		No	ClinGen Ensembl
rs769421768 CA1025417	641	V>M		No	ClinGen ExAC TOPMed gnomAD
rs762583802 CA1025419	644	I>T		No	ClinGen ExAC gnomAD
rs1201285937 CA341772236	646	A>T		No	ClinGen gnomAD
CA1025420 rs372681379	646	A>V		No	ClinGen ESP ExAC gnomAD
CA341772241 rs1238522812	647	R>C		No	ClinGen TOPMed
rs201085928 CA1025421	647	R>H		No	ClinGen ExAC TOPMed gnomAD
rs919369021 CA29663725	648	L>P		No	ClinGen TOPMed
rs1395827507 CA341772255	649	N>S		No	ClinGen gnomAD
rs1439104737 CA341772271	651	P>L		No	ClinGen Ensembl
rs1336646309 CA341772276	652	V>A		No	ClinGen gnomAD
rs1194998549 CA341772282	653	S>T		No	ClinGen gnomAD
CA29663736 rs202066011	654	Q>E		No	ClinGen 1000Genomes
CA1025423 rs766905602	657	P>S		No	ClinGen ExAC gnomAD
rs1490776856 CA341772346	661	K>R		No	ClinGen gnomAD
rs1210280323 CA341772355	662	A>V		No	ClinGen gnomAD
rs200285355 CA1025458	664	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs140135222 CA1025460	667	G>S		No	ClinGen ESP ExAC
TCGA novel	671	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1025464 rs768375815	676	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	682	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1288667083 CA341772503	683	K>N		No	ClinGen gnomAD
CA341772508 rs1383372068	684	Y>F		No	ClinGen TOPMed gnomAD
rs1177991548 CA341772515	685	H>Y		No	ClinGen TOPMed
TCGA novel	687	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1266835711 CA341772546	689	V>A		No	ClinGen TOPMed
TCGA novel	689	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA29664678 rs181070201	702	V>M		No	ClinGen 1000Genomes
rs902103517	708	Q>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1402651344 CA341772970	709	G>S		No	ClinGen gnomAD
rs1407614555 CA341772975	709	G>V		No	ClinGen TOPMed
TCGA novel	721	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1293321023 CA341773122	731	G>V		No	ClinGen gnomAD
CA341773123 rs1288773906	732	V>I		No	ClinGen gnomAD
rs1221578816 CA341773136	734	M>V		No	ClinGen gnomAD
rs781780318 CA29665284	737	A>T		No	ClinGen Ensembl
CA341773161 rs1312834908	737	A>V		No	ClinGen gnomAD
rs758143918 CA1025501	743	K>R		No	ClinGen ExAC
CA341773302 rs1246429588	758	I>F		No	ClinGen gnomAD
rs11540954 CA29665327	761	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs138064651 CA1025504	762	V>I		No	ClinGen ESP ExAC gnomAD
rs956023678 CA29665573	766	R>H		No	ClinGen Ensembl
CA341773464 rs1201985754	776	I>F		No	ClinGen TOPMed
rs747283959 CA1025531	789	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA341773729 rs1446826980	795	I>M		No	ClinGen gnomAD
rs776767098 CA1025533	796	A>T		No	ClinGen ExAC gnomAD
CA341773752 rs1367224721	797	N>S		No	ClinGen Ensembl
CA341773859 rs1242082318	809	C>F		No	ClinGen gnomAD
CA341773929 rs1248998698 COSM3801399	817	V>A	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs753467237 CA29666077	827	A>S		No	ClinGen Ensembl
rs756876559 CA29666078	827	A>V		No	ClinGen Ensembl
TCGA novel	830	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs865875870 CA29666093	839	P>T		No	ClinGen Ensembl
rs1261870395 CA341774218	840	K>T		No	ClinGen gnomAD
CA29666095 rs12724229	841	T>P		No	ClinGen Ensembl
rs1557793103 CA341774236	841	T>R		No	ClinGen Ensembl
CA341774256 rs1342249879	843	K>*		No	ClinGen gnomAD
CA341774255 rs1342249879	843	K>E		No	ClinGen gnomAD
rs1557793134 CA341774328	848	R>Q		No	ClinGen Ensembl
rs963515301 CA29666117	849	L>P		No	ClinGen TOPMed
TCGA novel	853	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781629728 CA1025588	859	M>T		No	ClinGen ExAC gnomAD
CA1025592 rs749535308	870	F>L		No	ClinGen ExAC gnomAD
CA341774951 rs1299272466	876	N>H		No	ClinGen gnomAD
rs772164096 CA1025596	877	G>A		No	ClinGen ExAC gnomAD
CA29667420 rs976897509	879	L>F		No	ClinGen Ensembl
CA1025599 rs770689048	881	I>V		No	ClinGen ExAC gnomAD
CA29667442 rs879242854	885	G>D		No	ClinGen Ensembl
rs1570979931 CA341775014	886	L>I		No	ClinGen Ensembl
rs1248823681 CA341775021	887	R>*		No	ClinGen gnomAD
CA341775030 rs1570979952	888	V>E		No	ClinGen Ensembl
CA341775031 rs1570979962	889	D>N		No	ClinGen Ensembl
CA1025601 rs759150142	891	D>H		No	ClinGen ExAC gnomAD
TCGA novel	892	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764919483 CA1025602	893	R>C		No	ClinGen ExAC gnomAD
CA1025603 rs775005099	893	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1570979998 CA341775095	894	W>R		No	ClinGen Ensembl
CA29667477 rs983463553	903	G>R		No	ClinGen Ensembl
TCGA novel	905	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1570980329 CA341775390	907	T>P		No	ClinGen Ensembl
CA1025625 rs373693545 CA341775452	909	E>D		No	ClinGen ESP ExAC gnomAD
CA29667711 rs11540950	910	Q>*		No	ClinGen ExAC
CA1025626 rs11540950	910	Q>E		No	ClinGen ExAC
CA1025629 rs765387548	915	E>A		No	ClinGen ExAC gnomAD
rs753022560 CA1025630	916	F>S		No	ClinGen ExAC TOPMed gnomAD
rs753022560 CA1025631	916	F>Y		No	ClinGen ExAC TOPMed gnomAD
rs747061651 CA1025633	917	T>P		No	ClinGen ExAC gnomAD
CA341775596 rs1319543170	921	A>T		No	ClinGen TOPMed
CA341775620 rs1479883375	924	V>I		No	ClinGen gnomAD
rs775252649 CA1025638	927	V>M		No	ClinGen ExAC TOPMed gnomAD
CA1025642 rs761343155	935	V>F		No	ClinGen ExAC TOPMed gnomAD
CA1025646 rs765762308	948	G>E		No	ClinGen ExAC gnomAD
rs1368453220 CA341775797	949	M>I		No	ClinGen gnomAD
CA1025658 rs768322777	955	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1295272161 CA341775866	956	F>L		No	ClinGen gnomAD
CA341775970 rs1205596969	964	L>V		No	ClinGen TOPMed
rs771666666 CA1025661	971	C>S		No	ClinGen ExAC gnomAD
CA1025663 rs760128653	976	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1287302513 CA341776171	979	R>T		No	ClinGen TOPMed
CA29668153 rs112208164	983	L>P		No	ClinGen Ensembl
CA1025665 rs776018998	984	K>E		No	ClinGen ExAC gnomAD
CA341776281 rs776018998	984	K>Q		No	ClinGen ExAC gnomAD
CA341776294 rs1247867551	984	K>R		No	ClinGen gnomAD
CA341777295 rs1159632321	985	P>H		No	ClinGen TOPMed
CA29669845 rs771215472	986	T>I		No	ClinGen Ensembl
CA341777369 rs1272955218	995	S>C		No	ClinGen TOPMed gnomAD
rs753827120 CA1025693	1000	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	1006	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1490428511 CA341777453	1007	L>R		No	ClinGen gnomAD
CA341777457 rs1440360198	1008	I>N		No	ClinGen gnomAD
CA341777463 rs1211929333	1009	I>L		No	ClinGen gnomAD
CA1025697 rs758090295	1011	R>Q	Variant assessed as Somatic; 9.24e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA1025698 rs777250534	1012	R>C		No	ClinGen ExAC gnomAD
CA341777480 rs777250534	1012	R>G		No	ClinGen ExAC gnomAD
rs746521823 CA1025699	1012	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA341777489 rs1414092859	1014	G>S		No	ClinGen gnomAD
CA341777903 rs1570987397	1017	V>G		No	ClinGen Ensembl

2 associated diseases with P05023

[MIM: 618036]: Charcot-Marie-Tooth disease 2DD (CMT2DD)

A dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology

[MIM: 618314]: Hypomagnesemia, seizures, and intellectual disability 2 (HOMGSMR2)

An autosomal dominant disease characterized by generalized seizures in infancy, severe hypomagnesemia, and renal magnesium wasting. Seizures persist despite magnesium supplementation and are associated with significant intellectual disability. {ECO:0000269|PubMed:30388404}. Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

A dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology
An autosomal dominant disease characterized by generalized seizures in infancy, severe hypomagnesemia, and renal magnesium wasting. Seizures persist despite magnesium supplementation and are associated with significant intellectual disability. {ECO:0000269|PubMed:30388404}. Note=The disease is caused by variants affecting the gene represented in this entry.

No regional properties for P05023

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P05023

Functions

		Description
EC Number	7.2.2.13	Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization	Cell membrane ; Multi-pass membrane protein Basolateral cell membrane ; Multi-pass membrane protein Cell membrane, sarcolemma ; Multi-pass membrane protein Cell projection, axon Melanosome	Identified by mass spectrometry in melanosome fractions from stage I to stage IV
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

21 GO annotations of cellular component

Name	Definition
apical plasma membrane	The region of the plasma membrane located at the apical end of the cell.
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
basolateral plasma membrane	The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
extracellular vesicle	Any vesicle that is part of the extracellular region.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lateral plasma membrane	The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
melanosome	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
membrane raft	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
organelle membrane	A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
photoreceptor inner segment membrane	The membrane surrounding the inner segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
sarcolemma	The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
sodium:potassium-exchanging ATPase complex	Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
sperm flagellum	A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.
T-tubule	Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.

10 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATPase-coupled cation transmembrane transporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).
chaperone binding	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
P-type sodium:potassium-exchanging transporter activity	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
phosphatase activity	Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
potassium ion binding	Binding to a potassium ion (K+).
protein heterodimerization activity	Binding to a nonidentical protein to form a heterodimer.
sodium ion binding	Binding to a sodium ion (Na+).
steroid hormone binding	Binding to a steroid hormone.

21 GO annotations of biological process

Name	Definition
cardiac muscle cell action potential involved in contraction	An action potential that occurs in a cardiac muscle cell and is involved in its contraction.
cell communication by electrical coupling involved in cardiac conduction	The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction.
cellular potassium ion homeostasis	Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
cellular response to steroid hormone stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
cellular sodium ion homeostasis	Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
establishment or maintenance of transmembrane electrochemical gradient	The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore.
membrane repolarization	The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.
membrane repolarization during cardiac muscle cell action potential	The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
negative regulation of glucocorticoid biosynthetic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.
negative regulation of heart contraction	Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.
positive regulation of heart contraction	Any process that activates or increases the frequency, rate or extent of heart contraction.
positive regulation of striated muscle contraction	Any process that activates or increases the frequency, rate or extent of striated muscle contraction.
potassium ion import across plasma membrane	The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
proton transmembrane transport	The directed movement of a proton across a membrane.
regulation of blood pressure	Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
regulation of sodium ion transport	Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of the force of heart contraction	Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
relaxation of cardiac muscle	The process in which the extent of cardiac muscle contraction is reduced.
response to glycoside	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoside stimulus.
response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
sodium ion export across plasma membrane	The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.

14 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P13607	Atpalpha	Sodium/potassium-transporting ATPase subunit alpha	Drosophila melanogaster (Fruit fly)	PR
P20648	ATP4A	Potassium-transporting ATPase alpha chain 1	Homo sapiens (Human)	PR
P54707	ATP12A	Potassium-transporting ATPase alpha chain 2	Homo sapiens (Human)	PR
Q64436	Atp4a	Potassium-transporting ATPase alpha chain 1	Mus musculus (Mouse)	PR
Q9Z1W8	Atp12a	Potassium-transporting ATPase alpha chain 2	Mus musculus (Mouse)	PR
Q6PIE5	Atp1a2	Sodium/potassium-transporting ATPase subunit alpha-2	Mus musculus (Mouse)	PR
Q6PIC6	Atp1a3	Sodium/potassium-transporting ATPase subunit alpha-3	Mus musculus (Mouse)	PR
Q9WV27	Atp1a4	Sodium/potassium-transporting ATPase subunit alpha-4	Mus musculus (Mouse)	PR
Q8VDN2	Atp1a1	Sodium/potassium-transporting ATPase subunit alpha-1	Mus musculus (Mouse)	PR
P19156	ATP4A	Potassium-transporting ATPase alpha chain 1	Sus scrofa (Pig)	PR
P54708	Atp12a	Potassium-transporting ATPase alpha chain 2	Rattus norvegicus (Rat)	PR
P09626	Atp4a	Potassium-transporting ATPase alpha chain 1	Rattus norvegicus (Rat)	PR
Q64541	Atp1a4	Sodium/potassium-transporting ATPase subunit alpha-4	Rattus norvegicus (Rat)	PR
P06685	Atp1a1	Sodium/potassium-transporting ATPase subunit alpha-1	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MGKGVGRDKY	EPAAVSEQGD	KKGKKGKKDR	DMDELKKEVS	MDDHKLSLDE	LHRKYGTDLS
70	80	90	100	110	120
RGLTSARAAE	ILARDGPNAL	TPPPTTPEWI	KFCRQLFGGF	SMLLWIGAIL	CFLAYSIQAA
130	140	150	160	170	180
TEEEPQNDNL	YLGVVLSAVV	IITGCFSYYQ	EAKSSKIMES	FKNMVPQQAL	VIRNGEKMSI
190	200	210	220	230	240
NAEEVVVGDL	VEVKGGDRIP	ADLRIISANG	CKVDNSSLTG	ESEPQTRSPD	FTNENPLETR
250	260	270	280	290	300
NIAFFSTNCV	EGTARGIVVY	TGDRTVMGRI	ATLASGLEGG	QTPIAAEIEH	FIHIITGVAV
310	320	330	340	350	360
FLGVSFFILS	LILEYTWLEA	VIFLIGIIVA	NVPEGLLATV	TVCLTLTAKR	MARKNCLVKN
370	380	390	400	410	420
LEAVETLGST	STICSDKTGT	LTQNRMTVAH	MWFDNQIHEA	DTTENQSGVS	FDKTSATWLA
430	440	450	460	470	480
LSRIAGLCNR	AVFQANQENL	PILKRAVAGD	ASESALLKCI	ELCCGSVKEM	RERYAKIVEI
490	500	510	520	530	540
PFNSTNKYQL	SIHKNPNTSE	PQHLLVMKGA	PERILDRCSS	ILLHGKEQPL	DEELKDAFQN
550	560	570	580	590	600
AYLELGGLGE	RVLGFCHLFL	PDEQFPEGFQ	FDTDDVNFPI	DNLCFVGLIS	MIDPPRAAVP
610	620	630	640	650	660
DAVGKCRSAG	IKVIMVTGDH	PITAKAIAKG	VGIISEGNET	VEDIAARLNI	PVSQVNPRDA
670	680	690	700	710	720
KACVVHGSDL	KDMTSEQLDD	ILKYHTEIVF	ARTSPQQKLI	IVEGCQRQGA	IVAVTGDGVN
730	740	750	760	770	780
DSPALKKADI	GVAMGIAGSD	VSKQAADMIL	LDDNFASIVT	GVEEGRLIFD	NLKKSIAYTL
790	800	810	820	830	840
TSNIPEITPF	LIFIIANIPL	PLGTVTILCI	DLGTDMVPAI	SLAYEQAESD	IMKRQPRNPK
850	860	870	880	890	900
TDKLVNERLI	SMAYGQIGMI	QALGGFFTYF	VILAENGFLP	IHLLGLRVDW	DDRWINDVED
910	920	930	940	950	960
SYGQQWTYEQ	RKIVEFTCHT	AFFVSIVVVQ	WADLVICKTR	RNSVFQQGMK	NKILIFGLFE
970	980	990	1000	1010	1020
ETALAAFLSY	CPGMGVALRM	YPLKPTWWFC	AFPYSLLIFV	YDEVRKLIIR	RRPGGWVEKE

TYY