Q6PIC6

PR
Gene name
Atp1a3
Protein name
Sodium/potassium-transporting ATPase subunit alpha-3
Names
Na(+)/K(+) ATPase alpha-3 subunit, Na(+)/K(+) ATPase alpha(III) subunit, Sodium pump subunit alpha-3
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:232975
EC number
7.2.2.13: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6PIC6

Entry ID Method Resolution Chain Position Source
AF-Q6PIC6-F1 Predicted AlphaFoldDB

57 variants for Q6PIC6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388849146 16 A>T No EVA
rs3388889388 17 K>N No EVA
rs3388884464 84 R>W No EVA
rs3388887307 97 G>R No EVA
rs3388849202 102 F>Y No EVA
rs252854186 117 G>R No EVA
rs3388893037 159 A>T No EVA
rs3388868919 167 K>R No EVA
rs3397649946 169 Q>E No EVA
rs3388891176 180 L>M No EVA
rs3397672935 201 C>W No EVA
rs3397279303 202 K>N No EVA
rs3388891136 257 M>I No EVA
rs3388876731 260 I>T No EVA
rs3388888369 264 A>V No EVA
rs3388889455 283 Q>R No EVA
rs3388872072 288 V>M No EVA
rs3388882098 290 V>L No EVA
rs3388890805 313 F>S No EVA
rs3388890771 348 V>M No EVA
rs3388876743 352 E>K No EVA
rs3388890813 359 S>F No EVA
rs3388849163 373 Q>E No EVA
rs3388879273 385 N>K No EVA
rs3388876786 386 Q>* No EVA
rs3411110614 391 D>A No EVA
rs3388888352 394 E>* No EVA
rs3388889459 427 Q>H No EVA
rs3388882081 458 K>E No EVA
rs3388882100 503 R>H No EVA
rs3388889318 510 T>N No EVA
rs3388884482 536 G>S No EVA
rs3388888392 563 C>Y No EVA
rs3412845499 595 K>Q No EVA
rs3388882129 600 G>S No EVA
rs3388882044 684 S>F No EVA
rs3413117351 687 Q>* No EVA
rs3388884531 697 R>I No EVA
rs3388891143 711 D>V No EVA
rs3388884731 717 K>R No EVA
rs1133316247 735 A>V No EVA
rs3388884703 744 N>S No EVA
rs3388868937 750 T>S No EVA
rs3388884506 751 G>DG* No EVA
rs3388884545 791 P>R No EVA
rs3397745965 799 C>F No EVA
rs3388876711 824 R>K No EVA
rs3388891149 830 R>G No EVA
rs3388872102 872 N>K No EVA
rs3388882120 892 Y>* No EVA
rs3388893029 922 A>V No EVA
rs3397649966 941 N>H No EVA
rs3396906928 941 N>K No EVA
rs3397745991 941 N>T No EVA
rs3388879303 947 G>S No EVA
rs3388884676 991 Y>C No EVA
rs3388887305 1010 E>K No EVA

No associated diseases with Q6PIC6

4 regional properties for Q6PIC6

Type Name Position InterPro Accession
domain Cation-transporting P-type ATPase, N-terminal 32 - 106 IPR004014
domain Cation-transporting P-type ATPase, C-terminal 789 - 998 IPR006068
ptm P-type ATPase, phosphorylation site 366 - 372 IPR018303
domain P-type ATPase, haloacid dehalogenase domain 345 - 757 IPR044492

Functions

Description
EC Number 7.2.2.13 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

20 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
calyx of Held The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendritic spine head Distal part of the dendritic spine, that carries the post-synaptic density.
dendritic spine neck Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of presynaptic membrane The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
myelin sheath An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
neuron to neuron synapse A synapse in which pre and post-synaptic cells are neurons.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
organelle membrane A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
photoreceptor inner segment The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynapse The part of a synapse that is part of the post-synaptic cell.
sarcolemma The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
sodium:potassium-exchanging ATPase complex Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

11 GO annotations of molecular function

Name Definition
amyloid-beta binding Binding to an amyloid-beta peptide/protein.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATPase-coupled cation transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).
chaperone binding Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
D1 dopamine receptor binding Binding to a D1 dopamine receptor.
heparan sulfate proteoglycan binding Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
ion antiporter activity involved in regulation of presynaptic membrane potential Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential.
metal ion binding Binding to a metal ion.
P-type sodium:potassium-exchanging transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in), that contributes to regulating the membrane potential of a cardiac muscle cell.

16 GO annotations of biological process

Name Definition
adult locomotory behavior Locomotory behavior in a fully developed and mature organism.
cardiac muscle contraction Muscle contraction of cardiac muscle tissue.
cellular potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
cellular response to amyloid-beta Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
cellular sodium ion homeostasis Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
ionotropic glutamate receptor signaling pathway The series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription.
memory The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
neuron projection maintenance The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
potassium ion import across plasma membrane The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
potassium ion transport The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
proton transmembrane transport The directed movement of a proton across a membrane.
regulation of cardiac muscle cell membrane potential Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
sodium ion export across plasma membrane The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.
sodium ion transport The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
visual learning Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P13607 Atpalpha Sodium/potassium-transporting ATPase subunit alpha Drosophila melanogaster (Fruit fly) PR
P54707 ATP12A Potassium-transporting ATPase alpha chain 2 Homo sapiens (Human) PR
P20648 ATP4A Potassium-transporting ATPase alpha chain 1 Homo sapiens (Human) PR
P05023 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (Human) PR
Q6PIE5 Atp1a2 Sodium/potassium-transporting ATPase subunit alpha-2 Mus musculus (Mouse) PR
Q8VDN2 Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 Mus musculus (Mouse) PR
Q9WV27 Atp1a4 Sodium/potassium-transporting ATPase subunit alpha-4 Mus musculus (Mouse) PR
Q9Z1W8 Atp12a Potassium-transporting ATPase alpha chain 2 Mus musculus (Mouse) PR
Q64436 Atp4a Potassium-transporting ATPase alpha chain 1 Mus musculus (Mouse) PR
P19156 ATP4A Potassium-transporting ATPase alpha chain 1 Sus scrofa (Pig) PR
P54708 Atp12a Potassium-transporting ATPase alpha chain 2 Rattus norvegicus (Rat) PR
P09626 Atp4a Potassium-transporting ATPase alpha chain 1 Rattus norvegicus (Rat) PR
P06685 Atp1a1 Sodium/potassium-transporting ATPase subunit alpha-1 Rattus norvegicus (Rat) PR
Q64541 Atp1a4 Sodium/potassium-transporting ATPase subunit alpha-4 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGDKKDDKSS PKKSKAKERR DLDDLKKEVA MTEHKMSVEE VCRKYNTDCV QGLTHSKAQE
70 80 90 100 110 120
ILARDGPNAL TPPPTTPEWV KFCRQLFGGF SILLWIGAIL CFLAYGIQAG TEDDPSGDNL
130 140 150 160 170 180
YLGIVLAAVV IITGCFSYYQ EAKSSKIMES FKNMVPQQAL VIREGEKMQV NAEEVVVGDL
190 200 210 220 230 240
VEIKGGDRVP ADLRIISAHG CKVDNSSLTG ESEPQTRSPD CTHDNPLETR NITFFSTNCV
250 260 270 280 290 300
EGTARGVVVA TGDRTVMGRI ATLASGLEVG KTPIAIEIEH FIQLITGVAV FLGVSFFILS
310 320 330 340 350 360
LILGYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR MARKNCLVKN LEAVETLGST
370 380 390 400 410 420
STICSDKTGT LTQNRMTVAH MWFDNQIHEA DTTEDQSGTS FDKSSHTWVA LSHIAGLCNR
430 440 450 460 470 480
AVFKGGQDNI PVLKRDVAGD ASESALLKCI ELSSGSVKLM RERNKKVAEI PFNSTNKYQL
490 500 510 520 530 540
SIHETEDPND NRYLLVMKGA PERILDRCAT ILLQGKEQPL DEEMKEAFQN AYLELGGLGE
550 560 570 580 590 600
RVLGFCHYYL PEEQFPKGFA FDCDDVNFTT DNLCFVGLMS MIDPPRAAVP DAVGKCRSAG
610 620 630 640 650 660
IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI PVSQVNPRDA KACVIHGTDL
670 680 690 700 710 720
KDFTSEQIDE ILQNHTEIVF ARTSPQQKLI IVEGCQRQGA IVAVTGDGVN DSPALKKADI
730 740 750 760 770 780
GVAMGIAGSD VSKQAADMIL LDDNFASIVT GVEEGRLIFD NLKKSIAYTL TSNIPEITPF
790 800 810 820 830 840
LLFIMANIPL PLGTITILCI DLGTDMVPAI SLAYEAAESD IMKRQPRNPR TDKLVNERLI
850 860 870 880 890 900
SMAYGQIGMI QALGGFFSYF VILAENGFLP GNLVGIRLNW DDRTVNDLED SYGQQWTYEQ
910 920 930 940 950 960
RKVVEFTCHT AFFVSIVVVQ WADLIICKTR RNSVFQQGMK NKILIFGLFE ETALAAFLSY
970 980 990 1000 1010
CPGMDVALRM YPLKPSWWFC AFPYSFLIFV YDEIRKLILR RNPGGWVEKE TYY