Q9WV27
PR
Gene name |
Atp1a4 |
Protein name |
Sodium/potassium-transporting ATPase subunit alpha-4 |
Names |
Na(+)/K(+) ATPase alpha-4 subunit, Sodium pump subunit alpha-4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:27222 |
EC number |
7.2.2.13: Linked to the hydrolysis of a nucleoside triphosphate |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9WV27
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9WV27-F1 | Predicted | AlphaFoldDB |
65 variants for Q9WV27
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs31572964 | 13 | G>S | No | EVA | |
| rs3388513790 | 49 | V>A | No | EVA | |
| rs31573822 | 74 | I>V | No | EVA | |
| rs247181103 | 79 | D>E | No | EVA | |
| rs3388520455 | 86 | P>S | No | EVA | |
| rs263424776 | 88 | V>A | No | EVA | |
| rs3388515744 | 91 | P>S | No | EVA | |
| rs3390995174 | 99 | V>F | No | EVA | |
| rs3388515674 | 132 | K>Q | No | EVA | |
| rs254825402 | 137 | K>R | No | EVA | |
| rs216521161 | 155 | C>G | No | EVA | |
| rs3388516929 | 169 | E>A | No | EVA | |
| rs3388511902 | 187 | K>T | No | EVA | |
| rs3388511849 | 227 | S>P | No | EVA | |
| rs3388516431 | 275 | T>S | No | EVA | |
| rs3388518142 | 303 | H>L | No | EVA | |
| rs3388517545 | 307 | A>V | No | EVA | |
| rs3388518115 | 323 | L>M | No | EVA | |
| rs3388515786 | 339 | V>M | No | EVA | |
| rs3388511894 | 343 | P>T | No | EVA | |
| rs3390910603 | 347 | L>P | No | EVA | |
| rs3388513380 | 358 | A>V | No | EVA | |
| rs3388518628 | 359 | K>E | No | EVA | |
| rs3388518620 | 363 | R>H | No | EVA | |
| rs3388513967 | 367 | L>V | No | EVA | |
| rs3390995178 | 372 | E>V | No | EVA | |
| rs3391008516 | 373 | A>D | No | EVA | |
| rs3391008513 | 376 | T>P | No | EVA | |
| rs3390995160 | 381 | S>A | No | EVA | |
| rs3388511829 | 416 | Q>R | No | EVA | |
| rs3390992080 | 472 | E>S | No | EVA | |
| rs31568958 | 476 | N>S | No | EVA | |
| rs3391024819 | 505 | L>I | No | EVA | |
| rs3388513838 | 520 | A>P | No | EVA | |
| rs3388520415 | 523 | R>K | No | EVA | |
| rs3388516366 | 525 | F>L | No | EVA | |
| rs3388516973 | 539 | P>S | No | EVA | |
| rs31569779 | 546 | M>T | No | EVA | |
| rs3388518121 | 619 | G>R | No | EVA | |
| rs3388513825 | 628 | D>N | No | EVA | |
| rs3388520412 | 638 | K>* | No | EVA | |
| rs3388520449 | 640 | V>A | No | EVA | |
| rs246518002 | 650 | A>V | No | EVA | |
| rs31572831 | 656 | R>Q | No | EVA | |
| rs264770655 | 657 | L>M | No | EVA | |
| rs3391007673 | 684 | S>F | No | EVA | |
| rs3388518582 | 688 | D>E | No | EVA | |
| rs257343890 | 689 | D>N | No | EVA | |
| rs3388516925 | 695 | K>R | No | EVA | |
| rs3388513840 | 724 | T>N | No | EVA | |
| rs3391003394 | 735 | K>Q | No | EVA | |
| rs3388516384 | 743 | M>V | No | EVA | |
| rs3388511822 | 747 | G>C | No | EVA | |
| rs3388515855 | 752 | K>N | No | EVA | |
| rs3388513977 | 758 | I>V | No | EVA | |
| rs3388515858 | 799 | F>L | No | EVA | |
| rs3388520439 | 812 | G>D | No | EVA | |
| rs3388517521 | 862 | A>* | No | EVA | |
| rs3388516369 | 876 | F>V | No | EVA | |
| rs3388514183 | 945 | I>N | No | EVA | |
| rs3388518090 | 947 | K>Q | No | EVA | |
| rs3388513991 | 981 | P>T | No | EVA | |
| rs3388518637 | 988 | R>Q | No | EVA | |
| rs3388511913 | 997 | W>C | No | EVA | |
| rs3388517733 | 1019 | R>W | No | EVA |
No associated diseases with Q9WV27
4 regional properties for Q9WV27
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cation-transporting P-type ATPase, N-terminal | 51 - 125 | IPR004014 |
| domain | Cation-transporting P-type ATPase, C-terminal | 808 - 1017 | IPR006068 |
| ptm | P-type ATPase, phosphorylation site | 386 - 392 | IPR018303 |
| domain | P-type ATPase, haloacid dehalogenase domain | 365 - 776 | IPR044492 |
Functions
| Description | ||
|---|---|---|
| EC Number | 7.2.2.13 | Linked to the hydrolysis of a nucleoside triphosphate |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| photoreceptor cell cilium | A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| rod photoreceptor outer segment | The outer segment of a vertebrate rod photoreceptor that contains sealed membrane discs that are not connected to the ciliary membrane and containing rhodopsin photoreceptor proteins. |
| sodium:potassium-exchanging ATPase complex | Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. |
| sperm midpiece | The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATPase-coupled cation transmembrane transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). |
| metal ion binding | Binding to a metal ion. |
| P-type sodium:potassium-exchanging transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular potassium ion homeostasis | Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell. |
| cellular sodium ion homeostasis | Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. |
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| fertilization | The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). |
| flagellated sperm motility | The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm. |
| potassium ion import across plasma membrane | The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. |
| potassium ion transmembrane transport | A process in which a potassium ion is transported from one side of a membrane to the other. |
| proton transmembrane transport | The directed movement of a proton across a membrane. |
| regulation of cellular pH | Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment. |
| regulation of membrane potential | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| sodium ion export across plasma membrane | The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. |
| sodium ion transmembrane transport | A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P13607 | Atpalpha | Sodium/potassium-transporting ATPase subunit alpha | Drosophila melanogaster (Fruit fly) | PR |
| P54707 | ATP12A | Potassium-transporting ATPase alpha chain 2 | Homo sapiens (Human) | PR |
| P20648 | ATP4A | Potassium-transporting ATPase alpha chain 1 | Homo sapiens (Human) | PR |
| P05023 | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 | Homo sapiens (Human) | PR |
| Q6PIC6 | Atp1a3 | Sodium/potassium-transporting ATPase subunit alpha-3 | Mus musculus (Mouse) | PR |
| Q6PIE5 | Atp1a2 | Sodium/potassium-transporting ATPase subunit alpha-2 | Mus musculus (Mouse) | PR |
| Q8VDN2 | Atp1a1 | Sodium/potassium-transporting ATPase subunit alpha-1 | Mus musculus (Mouse) | PR |
| Q9Z1W8 | Atp12a | Potassium-transporting ATPase alpha chain 2 | Mus musculus (Mouse) | PR |
| Q64436 | Atp4a | Potassium-transporting ATPase alpha chain 1 | Mus musculus (Mouse) | PR |
| P19156 | ATP4A | Potassium-transporting ATPase alpha chain 1 | Sus scrofa (Pig) | PR |
| P54708 | Atp12a | Potassium-transporting ATPase alpha chain 2 | Rattus norvegicus (Rat) | PR |
| P09626 | Atp4a | Potassium-transporting ATPase alpha chain 1 | Rattus norvegicus (Rat) | PR |
| P06685 | Atp1a1 | Sodium/potassium-transporting ATPase subunit alpha-1 | Rattus norvegicus (Rat) | PR |
| Q64541 | Atp1a4 | Sodium/potassium-transporting ATPase subunit alpha-4 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEPGKEKEVE | APGELNQKPR | PSTRSSTTNR | QPKMKRRKKD | LEELKKEVVM | DDHKLTLDEL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SAKYSVDLTK | GLSILEAQDI | LFQNGPNVLT | PPPTTPEWVK | FCRQLFGGFS | LLLWTGACLC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FLAYGIHVNY | YKENANKDNL | YLGIVLSAVV | IITGCFSYYQ | EAKSSKIMES | FKNMVPQQAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VIRDGEKMQI | NVRDVVLGDL | VEVKGGDQIP | ADIRVISAQG | CKVDNSSLTG | ESEPQSRCPD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CTHENPLETR | NIIFFSTNCV | EGTARGIVIA | TGDYTVMGRI | ASLTSGLQMG | KTPIATEIEH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FIHLITAVAV | FLGVSFFWLS | IILGYTWLDA | VIFLIGIIVA | NVPEGLLATV | TVCLTLTAKR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MARKNCLVKN | LEAVETLGST | STICSDKTGT | LTQNRMTVAH | LWFDKTVYEA | DTSEEQTTGK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TFPKSSDTWF | YLARIAGLCN | RADFKPHQES | VPIAKRATTG | DASESALLKF | IEQSYNPVSE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MRQKNPKVAE | IPFNSTNKYQ | MSIHLLEDNS | EAHVLLMKGA | PERIFDFCSS | FLLNGQEYPM |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DEEMKMDFQN | AYIELGGLGE | RVLGFCFLNL | PSNFSKGFQF | NTDELNFPME | NLCFAGLISM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IDPPRTAVPD | AVSKCRSAGI | KVIMVTGDHP | ITAKAIAKSV | GIISEGNDTA | EDIAARLNIP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ISQVNNKSVK | AIVVHGSELK | DMESQQLDDI | LKSYKEIVFA | RTSPQQKLII | VEGCQRLGAI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VAVTGDGVND | SPALKKADIG | IAMGITGSDV | SKQAADMILL | DDNFASIVTG | VEEGRLIFDN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LKKSIAYTLT | SNIPEITPFL | LFIILSIPLP | LGTITILCID | LGTDMVPAIS | LAYESPESDI |
| 850 | 860 | 870 | 880 | 890 | 900 |
| MKRLPRNPKT | DNLVNNRLIG | MAYGQIGMIQ | ALAGFFTYFV | ILAENGFKPL | DLLGIRLYWD |
| 910 | 920 | 930 | 940 | 950 | 960 |
| DTQLNDLEDS | YGQQWTYEQR | KVVEFTCQTA | FFISIVIVQW | ADLIICKTRR | NSLFKQGMKN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KILIFGLLEE | TVLAAFLSYV | PGMDVSLRMY | PLKINWWFCA | LPYSVLIFVY | DEIRKLIIRR |
| 1030 | |||||
| RPGGWLEKET | YY |