Q9Z1W8
PR
Gene name |
Atp12a (Atp1al1) |
Protein name |
Potassium-transporting ATPase alpha chain 2 |
Names |
HK alpha 2, Non-gastric H(+)/K(+) ATPase subunit alpha, Non-gastric Na(+)/K(+) ATPase subunit alpha, Proton pump, Sodium pump |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:192113 |
EC number |
7.2.2.13: Linked to the hydrolysis of a nucleoside triphosphate |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9Z1W8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9Z1W8-F1 | Predicted | AlphaFoldDB |
58 variants for Q9Z1W8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs30369624 | 18 | V>I | No | EVA | |
| rs3389315857 | 19 | E>* | No | EVA | |
| rs30124421 | 20 | L>P | No | EVA | |
| rs3389334983 | 25 | D>N | No | EVA | |
| rs233143823 | 34 | N>H | No | EVA | |
| rs260581520 | 39 | P>L | No | EVA | |
| rs3389328949 | 45 | E>* | No | EVA | |
| rs215540920 | 45 | E>D | No | EVA | |
| rs261494810 | 73 | Q>R | No | EVA | |
| rs258101270 | 83 | L>V | No | EVA | |
| rs3405132509 | 110 | G>R | No | EVA | |
| rs3389315855 | 112 | F>L | No | EVA | |
| rs3405222180 | 123 | C>Y | No | EVA | |
| rs3389306273 | 125 | I>T | No | EVA | |
| rs228528813 | 126 | A>S | No | EVA | |
| rs228528813 | 126 | A>T | No | EVA | |
| rs1134827698 | 128 | V>A | No | EVA | |
| rs3389322620 | 129 | I>V | No | EVA | |
| rs3404377548 | 131 | Y>H | No | EVA | |
| rs3389334982 | 148 | V>I | No | EVA | |
| rs3389349753 | 165 | S>N | No | EVA | |
| rs3389287351 | 194 | E>K | No | EVA | |
| rs249063302 | 218 | F>L | No | EVA | |
| rs3389306213 | 229 | L>F | No | EVA | |
| rs3389315842 | 233 | S>P | No | EVA | |
| rs3389329214 | 236 | Q>H | No | EVA | |
| rs3389315815 | 264 | T>R | No | EVA | |
| rs214676551 | 275 | R>C | No | EVA | |
| rs3389338692 | 316 | I>T | No | EVA | |
| rs3389297018 | 362 | M>L | No | EVA | |
| rs3389315850 | 395 | N>T | No | EVA | |
| rs48762376 | 398 | T>A | No | EVA | |
| rs3389288644 | 425 | S>R | No | EVA | |
| rs3389329000 | 430 | A>V | No | EVA | |
| rs3389328931 | 440 | N>S | No | EVA | |
| rs3389315832 | 448 | Q>* | No | EVA | |
| rs3389315860 | 470 | F>V | No | EVA | |
| rs3389315861 | 484 | R>G | No | EVA | |
| rs3389332107 | 485 | N>D | No | EVA | |
| rs3389306260 | 491 | I>S | No | EVA | |
| rs3389306207 | 531 | T>I | No | EVA | |
| rs3389297101 | 533 | M>L | No | EVA | |
| rs3389343094 | 611 | P>T | No | EVA | |
| rs3389288712 | 634 | T>A | No | EVA | |
| rs3389328976 | 645 | I>L | No | EVA | |
| rs3389334976 | 652 | V>G | No | EVA | |
| rs46010758 | 659 | R>C | No | EVA | |
| rs3405313754 | 666 | V>F | No | EVA | |
| rs3389332081 | 707 | Q>* | No | EVA | |
| rs3389306285 | 752 | A>D | No | EVA | |
| rs3389335445 | 753 | A>V | No | EVA | |
| rs3389333590 | 773 | V>L | No | EVA | |
| rs3389288686 | 977 | A>E | No | EVA | |
| rs1132365251 | 979 | V>I | No | EVA | |
| rs3389338664 | 989 | A>T | No | EVA | |
| rs3389332055 | 990 | L>Q | No | EVA | |
| rs3389335478 | 1003 | A>V | No | EVA | |
| rs3389306243 | 1013 | Y>H | No | EVA |
No associated diseases with Q9Z1W8
4 regional properties for Q9Z1W8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cation-transporting P-type ATPase, N-terminal | 54 - 128 | IPR004014 |
| domain | Cation-transporting P-type ATPase, C-terminal | 810 - 1020 | IPR006068 |
| ptm | P-type ATPase, phosphorylation site | 387 - 393 | IPR018303 |
| domain | P-type ATPase, haloacid dehalogenase domain | 366 - 778 | IPR044492 |
Functions
| Description | ||
|---|---|---|
| EC Number | 7.2.2.13 | Linked to the hydrolysis of a nucleoside triphosphate |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATPase-coupled cation transmembrane transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). |
| metal ion binding | Binding to a metal ion. |
| P-type potassium:proton transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in). |
| P-type sodium:potassium-exchanging transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular potassium ion homeostasis | Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell. |
| cellular sodium ion homeostasis | Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. |
| potassium ion homeostasis | Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. |
| potassium ion import across plasma membrane | The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. |
| proton transmembrane transport | The directed movement of a proton across a membrane. |
| regulation of pH | Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. |
| response to metal ion | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. |
| response to organic cyclic compound | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. |
| sodium ion export across plasma membrane | The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P13607 | Atpalpha | Sodium/potassium-transporting ATPase subunit alpha | Drosophila melanogaster (Fruit fly) | PR |
| P20648 | ATP4A | Potassium-transporting ATPase alpha chain 1 | Homo sapiens (Human) | PR |
| P05023 | ATP1A1 | Sodium/potassium-transporting ATPase subunit alpha-1 | Homo sapiens (Human) | PR |
| P54707 | ATP12A | Potassium-transporting ATPase alpha chain 2 | Homo sapiens (Human) | PR |
| Q6PIC6 | Atp1a3 | Sodium/potassium-transporting ATPase subunit alpha-3 | Mus musculus (Mouse) | PR |
| Q6PIE5 | Atp1a2 | Sodium/potassium-transporting ATPase subunit alpha-2 | Mus musculus (Mouse) | PR |
| Q8VDN2 | Atp1a1 | Sodium/potassium-transporting ATPase subunit alpha-1 | Mus musculus (Mouse) | PR |
| Q9WV27 | Atp1a4 | Sodium/potassium-transporting ATPase subunit alpha-4 | Mus musculus (Mouse) | PR |
| Q64436 | Atp4a | Potassium-transporting ATPase alpha chain 1 | Mus musculus (Mouse) | PR |
| P19156 | ATP4A | Potassium-transporting ATPase alpha chain 1 | Sus scrofa (Pig) | PR |
| P09626 | Atp4a | Potassium-transporting ATPase alpha chain 1 | Rattus norvegicus (Rat) | PR |
| P06685 | Atp1a1 | Sodium/potassium-transporting ATPase subunit alpha-1 | Rattus norvegicus (Rat) | PR |
| Q64541 | Atp1a4 | Sodium/potassium-transporting ATPase subunit alpha-4 | Rattus norvegicus (Rat) | PR |
| P54708 | Atp12a | Potassium-transporting ATPase alpha chain 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRRKTEIYSV | ELNGTKDVEL | ADQKDDKKFK | GGKNKDSEPN | KSQEEELKKE | LDLDDHRLSN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TDLEQKYGTN | IIQGLSSIRA | AELLARDGPN | ALTPPKQTPE | IIKFLKQMVG | GFSILLWIGA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALCWIAYVIQ | YVSSTASLDN | VYLGAILVLV | VILTGIFAYY | QEAKSTNIMA | SFSKMIPQQA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LVIRDAEKKI | IPAEQLVVGD | VVEIKGGDQI | PADIRLVFSQ | GCKVDNSSLT | GESEPQARST |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EFTHENPLET | KNIGFYSTTC | LEGTATGIVI | NTGDRTIIGR | IASLASGVGS | EKTPIAIEIE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HFVHIVAAVA | VSVGVIFFIT | AVCMKYYVLD | AIIFLISIIV | ANVPEGLLAT | VTVTLSLTAK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RMAKKNCLVK | NLEAVETLGS | TSIICSDKTG | TLTQNRMTVA | HLWFDNQIFV | ADTSENQTKQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AFDQSSGTWA | SLSKIITLCN | RAEFRPGQES | VPIMKRVVVG | DASETALLKF | SEVILGDVMD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IRKRNHKVAE | IPFNSTNKFQ | LSIHETEDPN | DKRFLMVMKG | APERILEKCS | TIMINGQEQP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LDKSSADAFH | TAYMELGGLG | ERVLGFCHLY | LPADKFPQSY | TFDVDSINFP | TSNLCFVGLL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SMIDPPRSTV | PDAVSKCRSA | GIKVIMVTGD | HPITAKAIAK | SVGIISANNE | TVEDIAKRRN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IAVEQVNKRE | AKAAVVTGME | LKDMTPEQLD | ELLINYQEIV | FARTSPQQKL | IIVEGCQRQD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AVVAVTGDGV | NDSPALKKAD | IGIAMGIAGS | DAAKNAADMV | LLDDNFASIV | TGVEEGRLIF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DNLKKTIAYT | LTKNIAELCP | FLIYIVAGLP | LPIGTITILF | IDLGTDIIPS | IALAYEKAES |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DIMNRKPRHK | KKDRLVNKQL | AIYSYLHIGL | MQALGGFLVY | FTVYAQQGFW | PTSLINLRVS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| WETDDINDLE | DSYGQEWTRY | QRKYLEWTGS | TAFFVAIMVQ | QIADLIIRKT | RRNSIFQQGL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| FRNKVIWVGI | ISQIIVALVL | SYGLGSVTAL | SFTMLRAQYW | FVAVPHAILI | WVYDEMRKLF |
| 1030 | |||||
| IRLYPGSWWD | KNMYY |