P35585
PR
Gene name |
Ap1m1 (Cltnm) |
Protein name |
AP-1 complex subunit mu-1 |
Names |
AP-mu chain family member mu1A, Adaptor protein complex AP-1 subunit mu-1, Adaptor-related protein complex 1 subunit mu-1, Clathrin assembly protein complex 1 mu-1 medium chain 1, Clathrin coat assembly protein AP47, Clathrin coat-associated protein AP47, Golgi adaptor HA1/AP1 adaptin mu-1 subunit, Mu-adaptin 1, Mu1A-adaptin |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:11767 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
24 structures for P35585
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1W63 | X-ray | 400 A | M/N/O/P/R/V | 1-423 | PDB |
| 4EMZ | X-ray | 290 A | A/M | 158-423 | PDB |
| 4EN2 | X-ray | 258 A | A/M | 158-423 | PDB |
| 4HMY | X-ray | 700 A | M | 1-423 | PDB |
| 4P6Z | X-ray | 300 A | M | 1-423 | PDB |
| 6CM9 | EM | 373 A | M | 1-423 | PDB |
| 6CRI | EM | 680 A | M/W/X | 2-423 | PDB |
| 6D83 | EM | 427 A | M | 1-423 | PDB |
| 6D84 | EM | 672 A | M/P | 1-423 | PDB |
| 6DFF | EM | 390 A | M | 1-423 | PDB |
| 7R4H | EM | 234 A | M | 1-423 | PDB |
| 7UX3 | EM | 960 A | M | 2-423 | PDB |
| 8D4C | EM | 930 A | J/M | 1-423 | PDB |
| 8D4D | EM | 960 A | J/M | 1-423 | PDB |
| 8D4E | EM | 920 A | M | 2-423 | PDB |
| 8D4F | EM | 980 A | J/M | 1-423 | PDB |
| 8D4G | EM | 1160 A | J/M | 1-423 | PDB |
| 8D9R | EM | 2000 A | M/j/k/l/m/n | 1-423 | PDB |
| 8D9S | EM | 2000 A | M/j/k/l/m/n | 1-423 | PDB |
| 8D9T | EM | 2000 A | M/i/j/k/l/m | 1-423 | PDB |
| 8D9U | EM | 2000 A | M/i/j/k/l/m | 1-423 | PDB |
| 8D9V | EM | 940 A | J/M | 1-423 | PDB |
| 8D9W | EM | 930 A | M/X/Z/a | 1-423 | PDB |
| AF-P35585-F1 | Predicted | AlphaFoldDB |
23 variants for P35585
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388972074 | 42 | E>G | No | EVA | |
| rs3388961654 | 45 | M>T | No | EVA | |
| rs3388991910 | 73 | K>R | No | EVA | |
| rs3388983686 | 100 | E>G | No | EVA | |
| rs3388991941 | 105 | D>E | No | EVA | |
| rs3388991320 | 111 | Y>* | No | EVA | |
| rs3388991313 | 133 | E>G | No | EVA | |
| rs3388988873 | 148 | R>M | No | EVA | |
| rs3388989033 | 149 | P>L | No | EVA | |
| rs3388996077 | 164 | I>T | No | EVA | |
| rs3388989032 | 178 | A>G | No | EVA | |
| rs3398346562 | 179 | V>I | No | EVA | |
| rs3388995995 | 187 | G>D | No | EVA | |
| rs3388979569 | 192 | S>G | No | EVA | |
| rs3388988426 | 196 | G>C | No | EVA | |
| rs3412846157 | 243 | R>L | No | EVA | |
| rs3388984662 | 246 | R>C | No | EVA | |
| rs3388968014 | 274 | K>N | No | EVA | |
| rs3388968090 | 281 | S>T | No | EVA | |
| rs3388988457 | 282 | V>A | No | EVA | |
| rs3388991916 | 310 | V>A | No | EVA | |
| rs3388984759 | 321 | D>E | No | EVA | |
| rs3388992211 | 356 | M>K | No | EVA |
No associated diseases with P35585
3 regional properties for P35585
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Clathrin adaptor, mu subunit, conserved site | 157 - 177 | IPR018240-1 |
| conserved_site | Clathrin adaptor, mu subunit, conserved site | 253 - 267 | IPR018240-2 |
| domain | Mu homology domain | 157 - 421 | IPR028565 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| AP-1 adaptor complex | A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). |
| clathrin-coated vesicle | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
| trans-Golgi network membrane | The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| clathrin adaptor activity | Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| endosome to melanosome transport | The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| melanosome assembly | The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. |
| melanosome organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. |
| platelet dense granule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q00776 | APM1 | AP-1 complex subunit mu-1-I | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q2KJ81 | AP1M1 | AP-1 complex subunit mu-1 | Bos taurus (Bovine) | PR |
| Q3SYW1 | AP1M2 | AP-1 complex subunit mu-2 | Bos taurus (Bovine) | PR |
| Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | Homo sapiens (Human) | PR |
| Q9BXS5 | AP1M1 | AP-1 complex subunit mu-1 | Homo sapiens (Human) | PR |
| Q9WVP1 | Ap1m2 | AP-1 complex subunit mu-2 | Mus musculus (Mouse) | PR |
| Q8CDJ8 | Ston1 | Stonin-1 | Mus musculus (Mouse) | PR |
| P84091 | Ap2m1 | AP-2 complex subunit mu | Mus musculus (Mouse) | PR |
| Q32Q06 | Ap1m1 | AP-1 complex subunit mu-1 | Rattus norvegicus (Rat) | PR |
| Q9SB50 | AP4M | AP-4 complex subunit mu | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22715 | AP1M2 | AP-1 complex subunit mu-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SAC9 | AP1M1 | AP-1 complex subunit mu-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSASAVYVLD | LKGKVLICRN | YRGDVDMSEV | EHFMPILMEK | EEEGMLSPIL | AHGGVRFMWI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KHNNLYLVAT | SKKNACVSLV | FSFLYKVVQV | FSEYFKELEE | ESIRDNFVII | YELLDELMDF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GYPQTTDSKI | LQEYITQEGH | KLETGAPRPP | ATVTNAVSWR | SEGIKYRKNE | VFLDVIEAVN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLVSANGNVL | RSEIVGSIKM | RVFLSGMPEL | RLGLNDKVLF | DNTGRGKSKS | VELEDVKFHQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CVRLSRFEND | RTISFIPPDG | EFELMSYRLN | THVKPLIWIE | SVIEKHSHSR | IEYMVKAKSQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FKRRSTANNV | EIHIPVPNDA | DSPKFKTTVG | SVKWVPENSE | IVWSVKSFPG | GKEYLMRAHF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GLPSVEAEDK | EGKPPISVKF | EIPYFTTSGI | QVRYLKIIEK | SGYQALPWVR | YITQNGDYQL |
| RTQ |