AiPD: Autoinhibited Protein Database

Q9BXS5

Gene name	AP1M1 (CLTNM)
Protein name	AP-1 complex subunit mu-1
Names	AP-mu chain family member mu1A, Adaptor protein complex AP-1 subunit mu-1, Adaptor-related protein complex 1 subunit mu-1, Clathrin assembly protein complex 1 mu-1 medium chain 1, Clathrin coat assembly protein AP47, Clathrin coat-associated protein AP47, Golgi adaptor HA1/AP1 adaptin mu-1 subunit, Mu-adaptin 1, Mu1A-adaptin
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8907
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

106-190 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

106-190 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9BXS5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9BXS5-F1	Predicted				AlphaFoldDB

214 variants for Q9BXS5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1215980229 CA404588124	3	A>S		No	ClinGen gnomAD
CA404588122 rs1215980229	3	A>T		No	ClinGen gnomAD
rs770895102 CA404588133	4	S>R		No	ClinGen ExAC gnomAD
CA9276559 rs746516632	4	S>T		No	ClinGen ExAC gnomAD
CA9276561 rs776608508	6	V>A		No	ClinGen ExAC gnomAD
rs1259051704 CA404588142	6	V>L		No	ClinGen gnomAD
CA404588767 rs1599451774	16	L>I		No	ClinGen Ensembl
rs766789996 CA9276589	18	C>F		No	ClinGen ExAC
TCGA novel	18	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA305916718 rs969307658	19	R>Q		No	ClinGen TOPMed
CA9276590 rs377502937	19	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs1262886604 CA404588836	21	Y>D		No	ClinGen TOPMed
rs970350647 CA305916723	22	R>C		No	ClinGen TOPMed gnomAD
CA9276591 rs534027489	22	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs117647142 CA404588887	24	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9276594 rs756722435	24	D>G		No	ClinGen ExAC gnomAD
rs200460904 COSM992431 CA9276593	24	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs372560384 CA9276596 COSM73688	25	V>M	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA404588918 rs1306565620	27	M>V		No	ClinGen gnomAD
CA9276597 rs769839602	28	S>L		No	ClinGen ExAC gnomAD
rs1460695035 CA404588990	34	M>V		No	ClinGen gnomAD
rs1300241870 CA404589006	35	P>A		No	ClinGen TOPMed gnomAD
CA404589009 rs1300241870	35	P>S		No	ClinGen TOPMed gnomAD
rs927596999 CA404589025	36	I>N		No	ClinGen gnomAD
rs927596999 CA305916739	36	I>T		No	ClinGen gnomAD
TCGA novel	39	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780111532 CA9276599	42	E>K		No	ClinGen ExAC gnomAD
CA9276600 rs749149339	47	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs146546344 CA9276605	52	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1252850380 CA404589216	52	H>Y		No	ClinGen gnomAD
rs944338208 CA305916773	53	G>E		No	ClinGen TOPMed
rs762029617 CA9276606	53	G>R		No	ClinGen ExAC TOPMed gnomAD
rs900683307 CA305916783	54	G>R		No	ClinGen Ensembl
rs753324780	55	V>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA404589234 rs1599451869	55	V>G		No	ClinGen Ensembl
rs781205990 CA305916796	55	V>I		No	ClinGen Ensembl
rs753324780	55	V>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1568347417 COSM242988 CA404589237	56	R>C	prostate [Cosmic]	No	ClinGen cosmic curated Ensembl
CA305916799 rs371850531	57	F>L		No	ClinGen ESP TOPMed
CA9276612 rs374334160	58	M>I		No	ClinGen ESP ExAC gnomAD
CA305916810 rs746086930	60	I>L		No	ClinGen Ensembl
CA404589284 rs1317219147	62	H>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA305916826 rs201225112	62	H>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA
rs1050012109 CA305916821	62	H>Y		No	ClinGen TOPMed
CA305916831 rs200294719	64	N>D		No	ClinGen 1000Genomes
CA404589296 rs1418955873	64	N>S		No	ClinGen gnomAD
CA9276613 rs765514475	65	L>V		No	ClinGen ExAC gnomAD
CA404589469 rs1291197244	70	T>P		No	ClinGen TOPMed gnomAD
rs749998518 CA9276636	75	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM3692459 CA404589536 rs1218074745	75	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA9276639 rs753840973	76	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs778991416 CA9276641	77	V>L		No	ClinGen ExAC gnomAD
CA9276642 rs778991416 COSM1733514	77	V>M	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs988117238 CA305918736	78	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	79	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9276644 rs199500241	82	S>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1402990807 CA404589589	82	S>C		No	ClinGen gnomAD
CA305918746 rs958351649	83	F>V		No	ClinGen TOPMed
rs1185806417 CA404589605	84	L>F		No	ClinGen TOPMed
CA305918758 rs992476982	84	L>H		No	ClinGen Ensembl
CA9276646 rs771009421	85	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1599453506 CA404589644	87	V>G		No	ClinGen Ensembl
rs866810370 CA305920294	92	S>F		No	ClinGen Ensembl
rs376369808 CA9276680	92	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA9276681 rs371060297	93	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA305920324 rs780828809	94	Y>*		No	ClinGen ExAC gnomAD
CA9276682 rs762852223	94	Y>C		No	ClinGen ExAC gnomAD
CA9276684 rs149396373	96	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs757026191 CA9276685	99	E>K		No	ClinGen ExAC
CA404589910 rs1568348670	104	R>P		No	ClinGen Ensembl
CA9276686 rs781418568	104	R>W		No	ClinGen ExAC TOPMed gnomAD
rs77274551 CA305920348	106	N>H		No	ClinGen Ensembl
rs1226886842 CA404589945	109	I>T		No	ClinGen gnomAD
CA404589988 rs1467508171	116	E>K		No	ClinGen gnomAD
rs1216173618 CA404590006	118	M>T		No	ClinGen gnomAD
CA404590003 rs1209263030	118	M>V		No	ClinGen TOPMed
CA404590040 rs1187302097	122	Y>*		No	ClinGen TOPMed gnomAD
CA404590039 rs1191971485	122	Y>F		No	ClinGen gnomAD
TCGA novel	124	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759206896 CA9276696	130	I>T		No	ClinGen ExAC gnomAD
TCGA novel	131	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769470393 CA9276697	132	Q>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	134	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143519787 CA9276724	136	T>S		No	ClinGen ESP ExAC TOPMed
CA404590274 rs1482127931	138	E>K		No	ClinGen gnomAD
CA9276728 rs760488719	146	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs766560881 CA9276729	147	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1207571821 CA404590389	148	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9276731 rs755015923	149	P>L		No	ClinGen ExAC gnomAD
TCGA novel	149	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9276733 rs374835622	153	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	155	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs940245777 CA305921354	156	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA9276735 rs369323152	156	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs779606736 CA9276738	164	I>T		No	ClinGen ExAC gnomAD
TCGA novel	165	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1378411542 CA404590526	165	K>R		No	ClinGen TOPMed gnomAD
rs1302106434 CA404590534	166	Y>C		No	ClinGen gnomAD
CA404590540 COSM238805 rs1276538675	167	R>Q	prostate [Cosmic]	No	ClinGen cosmic curated TOPMed
CA404590571 rs1599455163	171	V>G		No	ClinGen Ensembl
rs1568349139 CA404590633	180	N>S		No	ClinGen Ensembl
rs752308670 CA9276780	185	A>G		No	ClinGen ExAC gnomAD
CA305941758 rs777141997	185	A>T		No	ClinGen TOPMed gnomAD
CA9276779 rs752308670	185	A>V		No	ClinGen ExAC gnomAD
CA9276782 rs150789905	187	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA305941767 rs997387577	188	N>H		No	ClinGen Ensembl
CA9276783 rs770937090	188	N>S		No	ClinGen ExAC TOPMed gnomAD
CA9276784 rs780968690	191	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs745679023 CA9276785	191	R>H		No	ClinGen ExAC TOPMed gnomAD
CA305941794 rs769670450	193	E>*		No	ClinGen ExAC gnomAD
CA9276786 rs769670450	193	E>K		No	ClinGen ExAC gnomAD
CA404591078 rs1327759014	195	V>A		No	ClinGen TOPMed
CA9276788 rs763211790	195	V>M		No	ClinGen ExAC TOPMed gnomAD
rs866359375 CA305941807	197	S>F		No	ClinGen Ensembl
CA9276789 rs377436209	199	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs774557887 CA9276790	201	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1347412340 CA404591116	201	R>Q		No	ClinGen gnomAD
CA404591121 rs1217762009	202	V>I		No	ClinGen gnomAD
TCGA novel	210	L>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1459508738 CA404591211	216	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1179943711 CA404591222	217	K>R		No	ClinGen gnomAD
TCGA novel	219	L>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9276794 rs761062270	221	D>N		No	ClinGen ExAC gnomAD
rs1170449687 CA404591275	225	R>C		No	ClinGen gnomAD
COSM992435 rs200593906 CA9276809	226	G>S	Variant assessed as Somatic; 4.623e-05 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA404591326 rs1239191986	231	V>M		No	ClinGen TOPMed
CA404591353 rs1171321385	235	D>N		No	ClinGen gnomAD
rs777016904 CA9276813	243	R>Q		No	ClinGen ExAC gnomAD
rs766864704 CA9276812	243	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9276815 rs763828773	245	S>T		No	ClinGen ExAC TOPMed
CA9276816 rs199959764	246	R>C		No	ClinGen 1000Genomes ExAC
CA404591428 rs1399686897	246	R>H		No	ClinGen gnomAD
rs1599465159 CA404591469	252	T>P		No	ClinGen Ensembl
CA9276823 rs754683740	260	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1260699863 CA404591528	261	E>K		No	ClinGen TOPMed gnomAD
CA404591579 rs368590185	267	Y>*		No	ClinGen TOPMed gnomAD
rs1332342028 CA404591586	268	R>H		No	ClinGen TOPMed
rs1456371703 CA404591589	269	L>F		No	ClinGen gnomAD
rs748254657 CA9276825	270	N>I		No	ClinGen ExAC gnomAD
CA404591597 COSM3937915 rs748254657	270	N>S	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA305942813 rs772322734	272	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs897752772 CA305943222	274	K>R		No	ClinGen TOPMed gnomAD
rs556098749 CA404591672	279	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs376335032 CA9276857	280	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs1599465409 CA404591682	281	S>A		No	ClinGen Ensembl
rs1599465413 CA404591691	282	V>G		No	ClinGen Ensembl
CA404591693 rs1599465416	283	I>V		No	ClinGen Ensembl
CA9276861 rs752479355	284	E>K	Variant assessed as Somatic; 9.369e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1328679864 CA404591710	285	K>M		No	ClinGen gnomAD
rs758159905 CA9276862	286	H>P		No	ClinGen ExAC
CA9276863 rs778001987	287	S>P		No	ClinGen ExAC gnomAD
CA9276864 rs751713363	287	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs199710426 CA9276866	288	H>P		No	ClinGen ExAC gnomAD
CA404591733 rs1175263849	289	S>G		No	ClinGen TOPMed gnomAD
rs1181399861 CA404591747	291	I>V		No	ClinGen TOPMed
CA404591753 rs1263582788	292	E>K		No	ClinGen gnomAD
CA404591778 rs1196680088	295	I>L	Variant assessed as Somatic; 0.005653 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA404591837 rs1285612939	301	F>Y		No	ClinGen gnomAD
COSM32541 rs999036825 CA305943790 VAR_036536	303	R>Q	Variant assessed as Somatic; impact. breast a breast cancer sample; somatic mutation [NCI-TCGA, Cosmic, UniProt]	No	ClinGen cosmic curated UniProt NCI-TCGA dbSNP gnomAD
rs1599465735 CA404591861	305	S>A		No	ClinGen Ensembl
CA404591881 rs1219220232	308	N>S		No	ClinGen gnomAD
rs774173547 CA404591894	310	V>L		No	ClinGen ExAC TOPMed gnomAD
rs774173547 CA9276900	310	V>M		No	ClinGen ExAC TOPMed gnomAD
CA9276901 rs761575577	311	E>K		No	ClinGen ExAC gnomAD
rs1410930791 CA404591914	313	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA404591925 rs1163713305	314	I>M		No	ClinGen gnomAD
CA9276902 rs767655492	314	I>V		No	ClinGen ExAC gnomAD
rs774060620 CA404591944	318	N>D		No	ClinGen ExAC TOPMed gnomAD
rs143405159 CA9276906	318	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs774060620 CA9276905	318	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs779538071 CA9276908	327	T>A		No	ClinGen ExAC gnomAD
CA9276909 rs151315587	327	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA404592015 rs1351766838	328	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9276913 rs769317734	332	V>I		No	ClinGen ExAC TOPMed gnomAD
CA305943873 rs868848082	336	P>S		No	ClinGen Ensembl
rs1427640634 CA404592072	337	E>K		No	ClinGen gnomAD
rs748765049 CA9276915	339	S>T		No	ClinGen ExAC gnomAD
rs774225467 CA9276917	340	E>D		No	ClinGen ExAC
rs919365752 CA305943901	340	E>G		No	ClinGen Ensembl
CA404592094 rs1237111697	340	E>K		No	ClinGen gnomAD
CA9276919 rs767279011	342	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1323886622 CA404592119	343	W>C		No	ClinGen TOPMed
rs773324732 CA9276920	345	I>V		No	ClinGen ExAC TOPMed gnomAD
COSM711366 CA404592159 rs1453358092	349	P>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs766509522 CA9276922	349	P>T		No	ClinGen ExAC gnomAD
rs888741271	350	G>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1399746154 CA404592180	351	G>C		No	ClinGen TOPMed gnomAD
rs1399746154 CA404592178	351	G>S		No	ClinGen TOPMed gnomAD
CA404592221 rs1328692864	356	M>I		No	ClinGen gnomAD
CA404592224 rs1270205348	357	R>Q		No	ClinGen TOPMed gnomAD
COSM181767 rs1228874814 CA404592223	357	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA9276943 rs111489002	360	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145833370 CA9276944	361	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1490425955 CA404592258	363	P>S		No	ClinGen gnomAD
rs973576171 CA305948550	367	A>T		No	ClinGen TOPMed gnomAD
rs757515218 CA9276947	368	E>K		No	ClinGen ExAC gnomAD
CA404592348 rs1568356706	376	I>L		No	ClinGen Ensembl
rs753423243 CA9276950	377	S>T		No	ClinGen ExAC gnomAD
TCGA novel	379	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9276951 rs754498704	381	E>K		No	ClinGen ExAC gnomAD
CA404592436 rs1481586055	388	S>F		No	ClinGen TOPMed
CA305948594 rs111434021	388	S>P		No	ClinGen Ensembl
rs950393126 CA305948597	389	G>S		No	ClinGen TOPMed gnomAD
rs1295999171 CA404592477	393	R>C		No	ClinGen gnomAD
CA404592478 rs1414106796 COSM992439	393	R>H	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
TCGA novel	398	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	403	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404592596 rs1225215606	410	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA305949276 rs886291636	413	T>M		No	ClinGen TOPMed
rs762285943 CA9276982	414	Q>H		No	ClinGen ExAC gnomAD
CA404592635 rs1253211949	416	G>R		No	ClinGen gnomAD
CA305949586 rs930532373	420	L>R		No	ClinGen TOPMed
TCGA novel	423	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA404592699 rs1280842866	423	Q>H		No	ClinGen TOPMed gnomAD

No associated diseases with Q9BXS5

1 regional properties for Q9BXS5

Type	Name	Position	InterPro Accession
domain	GPCR, rhodopsin-like, 7TM	84 - 543	IPR017452

Functions

		Description
EC Number
Subcellular Localization	Golgi apparatus Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side	Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

13 GO annotations of cellular component

Name	Definition
AP-1 adaptor complex	A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).
clathrin-coated vesicle	A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
cytoplasmic vesicle	A vesicle found in the cytoplasm of a cell.
cytoplasmic vesicle membrane	The lipid bilayer surrounding a cytoplasmic vesicle.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
early endosome	A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
specific granule membrane	The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
trans-Golgi network membrane	The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network.

1 GO annotations of molecular function

Name	Definition
clathrin adaptor activity	Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles.

6 GO annotations of biological process

Name	Definition
endosome to melanosome transport	The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle.
intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
melanosome assembly	The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.
melanosome organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.
platelet dense granule organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins.
vesicle-mediated transport	A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q00776	APM1	AP-1 complex subunit mu-1-I	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q3SYW1	AP1M2	AP-1 complex subunit mu-2	Bos taurus (Bovine)	PR
Q2KJ81	AP1M1	AP-1 complex subunit mu-1	Bos taurus (Bovine)	PR
Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	Homo sapiens (Human)	PR
Q96CW1	AP2M1	AP-2 complex subunit mu	Homo sapiens (Human)	PR
Q9WVP1	Ap1m2	AP-1 complex subunit mu-2	Mus musculus (Mouse)	PR
P35585	Ap1m1	AP-1 complex subunit mu-1	Mus musculus (Mouse)	PR
Q32Q06	Ap1m1	AP-1 complex subunit mu-1	Rattus norvegicus (Rat)	PR
Q9SB50	AP4M	AP-4 complex subunit mu	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SAC9	AP1M1	AP-1 complex subunit mu-1	Arabidopsis thaliana (Mouse-ear cress)	PR
O22715	AP1M2	AP-1 complex subunit mu-2	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MSASAVYVLD	LKGKVLICRN	YRGDVDMSEV	EHFMPILMEK	EEEGMLSPIL	AHGGVRFMWI
70	80	90	100	110	120
KHNNLYLVAT	SKKNACVSLV	FSFLYKVVQV	FSEYFKELEE	ESIRDNFVII	YELLDELMDF
130	140	150	160	170	180
GYPQTTDSKI	LQEYITQEGH	KLETGAPRPP	ATVTNAVSWR	SEGIKYRKNE	VFLDVIESVN
190	200	210	220	230	240
LLVSANGNVL	RSEIVGSIKM	RVFLSGMPEL	RLGLNDKVLF	DNTGRGKSKS	VELEDVKFHQ
250	260	270	280	290	300
CVRLSRFEND	RTISFIPPDG	EFELMSYRLN	THVKPLIWIE	SVIEKHSHSR	IEYMIKAKSQ
310	320	330	340	350	360
FKRRSTANNV	EIHIPVPNDA	DSPKFKTTVG	SVKWVPENSE	IVWSIKSFPG	GKEYLMRAHF
370	380	390	400	410	420
GLPSVEAEDK	EGKPPISVKF	EIPYFTTSGI	QVRYLKIIEK	SGYQALPWVR	YITQNGDYQL

RTQ