Q2KJ81
PR
Gene name |
AP1M1 |
Protein name |
AP-1 complex subunit mu-1 |
Names |
AP-mu chain family member mu1A, Adaptor protein complex AP-1 subunit mu-1, Adaptor-related protein complex 1 subunit mu-1, Clathrin assembly protein complex 1 mu-1 medium chain 1, Golgi adaptor HA1/AP1 adaptin mu-1 subunit, Mu-adaptin 1, Mu1A-adaptin |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:504310 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2KJ81
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2KJ81-F1 | Predicted | AlphaFoldDB |
69 variants for Q2KJ81
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs433601586 | 2 | S>P | No | EVA | |
| rs472813904 | 4 | S>R | No | EVA | |
| rs454403282 | 5 | A>D | No | EVA | |
| rs436305369 | 6 | V>G | No | EVA | |
| rs432156226 | 10 | D>G | No | EVA | |
| rs450692794 | 10 | D>H | No | EVA | |
| rs464698645 | 13 | G>R | No | EVA | |
| rs448156580 | 24 | D>G | No | EVA | |
| rs480776971 | 28 | S>A | No | EVA | |
| rs444823681 | 67 | L>P | No | EVA | |
| rs478186637 | 68 | V>I | No | EVA | |
| rs459635639 | 69 | A>S | No | EVA | |
| rs437816061 | 112 | E>A | No | EVA | |
| rs464209971 | 113 | L>M | No | EVA | |
| rs469427547 | 134 | Y>* | No | EVA | |
| rs436621776 | 134 | Y>D | No | EVA | |
| rs465056781 | 137 | Q>H | No | EVA | |
| rs477177131 | 137 | Q>K | No | EVA | |
| rs446454152 | 139 | G>A | No | EVA | |
| rs479464251 | 140 | H>Q | No | EVA | |
| rs527105884 | 141 | K>R | No | EVA | |
| rs442762691 | 142 | L>R | No | EVA | |
| rs482088581 | 143 | E>K | No | EVA | |
| rs438569363 | 144 | T>A | No | EVA | |
| rs438569363 | 144 | T>P | No | EVA | |
| rs471115884 | 144 | T>R | No | EVA | |
| rs438569363 | 144 | T>S | No | EVA | |
| rs473220689 | 146 | A>G | No | EVA | |
| rs440452349 | 146 | A>P | No | EVA | |
| rs454748439 | 147 | P>A | No | EVA | |
| rs451866105 | 148 | R>P | No | EVA | |
| rs457505717 | 155 | N>H | No | EVA | |
| rs432559320 | 160 | R>P | No | EVA | |
| rs471026676 | 183 | V>G | No | EVA | |
| rs452365017 | 184 | S>C | No | EVA | |
| rs434280829 | 184 | S>R | No | EVA | |
| rs467090247 | 185 | A>S | No | EVA | |
| rs436590321 | 186 | N>K | No | EVA | |
| rs469516084 | 189 | V>G | No | EVA | |
| rs477114090 | 190 | L>P | No | EVA | |
| rs446443330 | 191 | R>L | No | EVA | |
| rs464993695 | 191 | R>S | No | EVA | |
| rs461242781 | 200 | M>I | No | EVA | |
| rs482080702 | 207 | M>I | No | EVA | |
| rs449153760 | 207 | M>L | No | EVA | |
| rs444549433 | 220 | F>L | No | EVA | |
| rs471053071 | 224 | G>S | No | EVA | |
| rs458816639 | 225 | R>G | No | EVA | |
| rs448005948 | 226 | G>D | No | EVA | |
| rs480927721 | 227 | K>N | No | EVA | |
| rs462358179 | 244 | L>P | No | EVA | |
| rs450253279 | 252 | T>P | No | EVA | |
| rs136397348 | 267 | Y>S | No | EVA | |
| rs439223673 | 268 | R>P | No | EVA | |
| rs452702085 | 275 | P>A | No | EVA | |
| rs135413913 | 287 | S>P | No | EVA | |
| rs133479321 | 288 | H>L | No | EVA | |
| rs133479321 | 288 | H>P | No | EVA | |
| rs520283302 | 365 | V>G | No | EVA | |
| rs525435213 | 365 | V>L | No | EVA | |
| rs445230392 | 397 | I>N | No | EVA | |
| rs466251372 | 405 | A>T | No | EVA | |
| rs469161091 | 410 | R>S | No | EVA | |
| rs468197664 | 418 | Y>* | No | EVA | |
| rs449827161 | 419 | Q>K | No | EVA | |
| rs482703999 | 420 | L>H | No | EVA | |
| rs445589467 | 422 | T>N | No | EVA | |
| rs441735995 | 423 | Q>H | No | EVA | |
| rs460204655 | 423 | Q>P | No | EVA |
No associated diseases with Q2KJ81
No regional properties for Q2KJ81
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q2KJ81 | |||
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| clathrin adaptor complex | A membrane coat adaptor complex that links clathrin to a membrane. |
| clathrin-coated vesicle | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. |
| clathrin-coated vesicle membrane | The lipid bilayer surrounding a clathrin-coated vesicle. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| clathrin adaptor activity | Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q00776 | APM1 | AP-1 complex subunit mu-1-I | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3SYW1 | AP1M2 | AP-1 complex subunit mu-2 | Bos taurus (Bovine) | PR |
| Q9Y6Q5 | AP1M2 | AP-1 complex subunit mu-2 | Homo sapiens (Human) | PR |
| Q9BXS5 | AP1M1 | AP-1 complex subunit mu-1 | Homo sapiens (Human) | PR |
| Q9WVP1 | Ap1m2 | AP-1 complex subunit mu-2 | Mus musculus (Mouse) | PR |
| P35585 | Ap1m1 | AP-1 complex subunit mu-1 | Mus musculus (Mouse) | PR |
| Q32Q06 | Ap1m1 | AP-1 complex subunit mu-1 | Rattus norvegicus (Rat) | PR |
| Q9SB50 | AP4M | AP-4 complex subunit mu | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O22715 | AP1M2 | AP-1 complex subunit mu-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SAC9 | AP1M1 | AP-1 complex subunit mu-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSASAVYVLD | LKGKVLICRN | YRGDVDMSEV | EHFMPILMEK | EEEGMLSPIL | AHGGVRFMWI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KHNNLYLVAT | SKKNACVSLV | FSFLYKVVQV | FSEYFKELEE | ESIRDNFVII | YELLDELMDF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GYPQTTDSKI | LQEYITQEGH | KLETGAPRPP | ATVTNAVSWR | SEGIKYRKNE | VFLDVIESVN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLVSANGNVL | RSEIVGSIKM | RVFLSGMPEL | RLGLNDKVLF | DNTGRGKSKS | VELEDVKFHQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CVRLSRFEND | RTISFIPPDG | EFELMSYRLN | THVKPLIWIE | SVIEKHSHSR | IEYMIKAKSQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FKRRSTANNV | EIHIPVPNDA | DSPKFKTTVG | SVKWVPENSE | IVWSIKSFPG | GKEYLMRAHF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GLPSVEAEDK | EGKPPISVKF | EIPYFTTSGI | QVRYLKIIEK | SGYQALPWVR | YITQNGDYQL |
| RTQ |