Q3SYW1

PR
Gene name
AP1M2
Protein name
AP-1 complex subunit mu-2
Names
AP-mu chain family member mu1B, Adaptor protein complex AP-1 subunit mu-2, Adaptor-related protein complex 1 subunit mu-2, Clathrin assembly protein complex 1 mu-2 medium chain 2, Golgi adaptor HA1/AP1 adaptin mu-2 subunit, Mu-adaptin 2, Mu1B-adaptin
Species
Bos taurus (Bovine)
KEGG Pathway
bta:515766
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

102-192 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3SYW1

Entry ID Method Resolution Chain Position Source
AF-Q3SYW1-F1 Predicted AlphaFoldDB

50 variants for Q3SYW1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs447436085 3 A>S No EVA
rs433809881 5 A>G No EVA
rs468478371 8 I>F No EVA
rs463713678 10 D>A No EVA
rs450110498 10 D>E No EVA
rs478298086 11 V>A No EVA
rs458211091 12 K>M No EVA
rs441387741 13 G>A No EVA
rs1117055346 14 K>N No EVA
rs468489942 18 S>I No EVA
rs448520255 25 V>G No EVA
rs438394157 27 M>T No EVA
rs482944785 39 Q>E No EVA
rs469370163 56 H>N No EVA
rs446231685 56 H>P No EVA
rs477755946 59 W>* No EVA
rs460890439 61 K>Q No EVA
rs467424680 67 L>F No EVA
rs469753770 134 Y>N No EVA
rs455168101 187 G>C No EVA
rs435193587 189 V>G No EVA
rs456193522 205 S>L No EVA
rs464288839 209 E>D No EVA
rs432890120 209 E>Q No EVA
rs447455887 218 V>G No EVA
rs449286373 222 L>P No EVA
rs468512866 222 L>V No EVA
rs480932241 338 K>Q No EVA
rs459399855 343 W>G No EVA
rs479898438 356 M>V No EVA
rs443021900 359 H>P No EVA
rs474379271 361 G>C No EVA
rs443847265 363 P>L No EVA
rs463974095 363 P>S No EVA
rs474729949 366 E>D No EVA
rs451190675 371 E>K No EVA
rs472083389 374 P>H No EVA
rs440803049 374 P>T No EVA
rs455247351 378 V>G No EVA
rs435293964 382 I>L No EVA
rs456315118 385 F>L No EVA
rs433072519 388 S>C No EVA
rs464496452 389 G>R No EVA
rs445238524 390 I>F No EVA
rs445238524 390 I>L No EVA
rs470768957 404 Q>K No EVA
rs481738440 412 I>M No EVA
rs455103293 413 T>S No EVA
rs443051247 420 L>R No EVA
rs456870027 424 S>Y No EVA

No associated diseases with Q3SYW1

3 regional properties for Q3SYW1

Type Name Position InterPro Accession
domain SH3 domain 613 - 686 IPR001452
domain BAR domain 12 - 240 IPR004148
domain Amphiphysin I, SH3 domain 614 - 685 IPR035470

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Golgi apparatus
  • Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane.
clathrin-coated vesicle A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
clathrin-coated vesicle membrane The lipid bilayer surrounding a clathrin-coated vesicle.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.

1 GO annotations of molecular function

Name Definition
clathrin adaptor activity Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles.

2 GO annotations of biological process

Name Definition
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q00776 APM1 AP-1 complex subunit mu-1-I Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q2KJ81 AP1M1 AP-1 complex subunit mu-1 Bos taurus (Bovine) PR
Q9BXS5 AP1M1 AP-1 complex subunit mu-1 Homo sapiens (Human) PR
Q9Y6Q5 AP1M2 AP-1 complex subunit mu-2 Homo sapiens (Human) PR
P35585 Ap1m1 AP-1 complex subunit mu-1 Mus musculus (Mouse) PR
Q9WVP1 Ap1m2 AP-1 complex subunit mu-2 Mus musculus (Mouse) PR
Q32Q06 Ap1m1 AP-1 complex subunit mu-1 Rattus norvegicus (Rat) PR
Q9SB50 AP4M AP-4 complex subunit mu Arabidopsis thaliana (Mouse-ear cress) PR
O22715 AP1M2 AP-1 complex subunit mu-2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SAC9 AP1M1 AP-1 complex subunit mu-1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSASAVFILD VKGKPLISRN YKGDVAMSEI DHFMPLLMQR EEEGALTPLL SHGRVHFLWI
70 80 90 100 110 120
KYSNLYLVAT TLKNANASLV YSFLYKIVEV FSEYFKELEE ESIRDNFVIV YELLDELMDF
130 140 150 160 170 180
GFPQTTDSKI LQEYITQQGN KLETGKSRVP PTVTNAVSWR SEGIKYKKNE VFIDVIESVN
190 200 210 220 230 240
LLVNANGSVL LSEIVGSIKL KVFLSGMPEL RLGLNDRVLF ELTGRSKNKS VELEDVKFHQ
250 260 270 280 290 300
CVRLSRFDND RTISFIPPDG DFELMSYRLS TQVKPLIWIE SVIEKFSHSR VEIMVKAKGQ
310 320 330 340 350 360
FKKQSVANGV EISVPVPSDA DSPRFKTSVG SAKYVPEKNT VIWSIKSFPG GKEYLMRAHF
370 380 390 400 410 420
GLPSVEKEEV EGRPPIGVKF EIPYFTVSGI QVRYMKIIEK SGYQALPWVR YITQSGDYQL
RTS