Q9SAC9

PR
Gene name
AP1M1 (At1g10730, F20B24.16, T16B5.13)
Protein name
AP-1 complex subunit mu-1
Names
Adaptor protein complex AP-1 subunit mu-1, Adaptor protein-1 mu-adaptin 1, Adaptor-related protein complex 1 subunit mu-1, At-muB1-Ad, Clathrin assembly protein complex 1 mu-1 medium chain, Mu1-adaptin 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G10730
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

109-193 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SAC9

Entry ID Method Resolution Chain Position Source
AF-Q9SAC9-F1 Predicted AlphaFoldDB

49 variants for Q9SAC9

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH04552653 2 A>V No 1000Genomes
tmp_1_3565482_C_T 7 A>V No 1000Genomes
tmp_1_3565500_T_A 13 I>N No 1000Genomes
ENSVATH04552654 16 R>L No 1000Genomes
ENSVATH04552655 27 V>I No 1000Genomes
ENSVATH04552656 32 A>V No 1000Genomes
tmp_1_3565577_C_A 39 L>I No 1000Genomes
tmp_1_3565782_C_A 60 Y>* No 1000Genomes
ENSVATH00016528 75 R>K No 1000Genomes
tmp_1_3565988_T_G 94 F>V No 1000Genomes
tmp_1_3566028_G_A 107 R>K No 1000Genomes
ENSVATH10933885 122 D>E No 1000Genomes
tmp_1_3566278_G_A 154 A>T No 1000Genomes
ENSVATH04552678 158 S>A No 1000Genomes
ENSVATH01033142 168 F>L No 1000Genomes
ENSVATH10933886 177 V>L No 1000Genomes
tmp_1_3566445_G_T 185 V>L No 1000Genomes
tmp_1_3566457_G_A 189 G>R No 1000Genomes
tmp_1_3566487_G_A 199 A>T No 1000Genomes
tmp_1_3566502_A_T 204 T>S No 1000Genomes
ENSVATH04552684 205 Y>F No 1000Genomes
tmp_1_3566618_T_C 212 C>R No 1000Genomes
ENSVATH04552690 212 C>Y No 1000Genomes
ENSVATH04552691 229 I>T No 1000Genomes
ENSVATH04552692 233 A>T No 1000Genomes
ENSVATH04552699 258 F>S No 1000Genomes
ENSVATH10933888 260 P>S No 1000Genomes
ENSVATH00016531 268 M>I No 1000Genomes
ENSVATH01033145 279 L>F No 1000Genomes
ENSVATH13876899 284 A>G No 1000Genomes
ENSVATH04552703 285 H>Q No 1000Genomes
ENSVATH04552704 287 E>K No 1000Genomes
tmp_1_3567091_C_G 297 L>V No 1000Genomes
ENSVATH04552706 306 D>E No 1000Genomes
ENSVATH04552707 307 R>K No 1000Genomes
tmp_1_3567270_C_T 323 A>V No 1000Genomes
ENSVATH04552714 328 V>A No 1000Genomes
ENSVATH04552715 330 T>I No 1000Genomes
ENSVATH04552715 330 T>K No 1000Genomes
tmp_1_3567455_A_G 360 K>E No 1000Genomes
tmp_1_3567477_G_A 367 S>N No 1000Genomes
tmp_1_3567479_A_T 368 I>L No 1000Genomes
tmp_1_3567497_A_C 374 T>P No 1000Genomes
tmp_1_3567501_C_T 375 P>L No 1000Genomes
tmp_1_3567704_G_T 404 E>D No 1000Genomes
ENSVATH04552724 409 Q>H No 1000Genomes
ENSVATH04552723 409 Q>L No 1000Genomes
ENSVATH00016533 417 I>V No 1000Genomes
tmp_1_3567771_C_A 427 L>I No 1000Genomes

No associated diseases with Q9SAC9

2 regional properties for Q9SAC9

Type Name Position InterPro Accession
domain Allantoicase domain 28 - 200 IPR015908-1
domain Allantoicase domain 222 - 384 IPR015908-2

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus
  • Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane.
clathrin-coated vesicle membrane The lipid bilayer surrounding a clathrin-coated vesicle.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q00776 APM1 AP-1 complex subunit mu-1-I Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q2KJ81 AP1M1 AP-1 complex subunit mu-1 Bos taurus (Bovine) PR
Q3SYW1 AP1M2 AP-1 complex subunit mu-2 Bos taurus (Bovine) PR
Q9Y6Q5 AP1M2 AP-1 complex subunit mu-2 Homo sapiens (Human) PR
Q9BXS5 AP1M1 AP-1 complex subunit mu-1 Homo sapiens (Human) PR
P35585 Ap1m1 AP-1 complex subunit mu-1 Mus musculus (Mouse) PR
Q9WVP1 Ap1m2 AP-1 complex subunit mu-2 Mus musculus (Mouse) PR
Q32Q06 Ap1m1 AP-1 complex subunit mu-1 Rattus norvegicus (Rat) PR
O22715 AP1M2 AP-1 complex subunit mu-2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SB50 AP4M AP-4 complex subunit mu Arabidopsis thaliana (Mouse-ear cress) PR
O23140 AP2M AP-2 complex subunit mu Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAGAASALFL LDIKGRVLVW RDYRGDVTAA QAERFFTKLI ETEGDSQSND PVAYDNGVTY
70 80 90 100 110 120
MFVQHSNIYL MIASRQNCNA ASLLFFLHRV VDVFKHYFEE LEEESLRDNF VVVYELLDEM
130 140 150 160 170 180
MDFGYPQFTE ARILSEFIKT DAYRMEVTQR PPMAVTNSVS WRSEGLKFKK NEVFLDVIES
190 200 210 220 230 240
VNILVNSNGQ IVRSDVVGAL KMRTYLSGMP ECKLGLNDRI LLEAQGRAIK GKAIDLEDIK
250 260 270 280 290 300
FHQCVRLARF ENDRTISFIP PDGSFDLMTY RLSTQVKPLI WVEAHIERHS RSRVEMLVKA
310 320 330 340 350 360
RSQFKDRSYA TSVEIELPVP TDAYNPDVRT SLGSAAYAPE KDALVWKIQY FYGNKEHTLK
370 380 390 400 410 420
ADFHLPSIAA EEATPERKAP IRVKFEIPKF IVSGIQVRYL KIIEKSGYQA HPWVRYITMA
GEYELRLM