O23140
Gene name |
AP2M (AP47/50, At5g46630, MZA15.2) |
Protein name |
AP-2 complex subunit mu |
Names |
Adaptor protein complex AP-2 subunit mu, Adaptor protein-2 mu-adaptin, Adaptor-related protein complex 2 subunit mu, At-muA-Ad, Clathrin assembly protein complex 2 mu medium chain, Mu2-adaptin, Protein AP47/50, AtAP47/50 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G46630 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O23140
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O23140-F1 | Predicted | AlphaFoldDB |
1 variants for O23140
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH12586030 | 194 | S>F | No | 1000Genomes |
No associated diseases with O23140
No regional properties for O23140
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O23140 | |||
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| clathrin adaptor complex | A membrane coat adaptor complex that links clathrin to a membrane. |
| clathrin-coated pit | A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| lipid binding | Binding to a lipid. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38700 | APM2 | Adaptin medium chain homolog APM2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q99186 | APM4 | AP-2 complex subunit mu | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q96CW1 | AP2M1 | AP-2 complex subunit mu | Homo sapiens (Human) | PR |
| P84091 | Ap2m1 | AP-2 complex subunit mu | Mus musculus (Mouse) | PR |
| Q8CDJ8 | Ston1 | Stonin-1 | Mus musculus (Mouse) | PR |
| P35603 | dpy-23 | AP-2 complex subunit mu | Caenorhabditis elegans | PR |
| O22715 | AP1M2 | AP-1 complex subunit mu-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SAC9 | AP1M1 | AP-1 complex subunit mu-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SB50 | AP4M | AP-4 complex subunit mu | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPVAASAIYF | LNLRGDVLIN | RTYRDDVGGN | MVDAFRTHIM | QTKELGNCPV | RQIGGCSFVY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MRISNVYIVI | VVSSNANVAC | GFKFVVEAVA | LFKSYFGGAF | DEDAIRNNFV | LIYELLDEIM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DFGYPQNLSP | EILKLYITQE | GVRSPFSSKP | KDKPVPNATL | QVTGAVGWRR | EGLAYKKNEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FLDIVESVNL | LMSSKGNVLR | CDVTGKVLMK | CFLSGMPDLK | LGLNDKIGLE | KESEMKSRPA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KSGKTIELDD | VTFHQCVNLT | RFNSEKTVSF | VPPDGEFELM | KYRITEGVNL | PFRVLPTIKE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGRTRMEVNV | KVKSVFGAKM | FALGVVVKIP | VPKQTAKTNF | QVTTGRAKYN | PSIDCLVWKI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RKFPGQTEST | LSAEIELIST | MGEKKSWTRP | PIQMEFQVPM | FTASGLRVRF | LKVWEKSGYN |
| 430 | |||||
| TVEWVRYITK | AGSYEIRC |