P38700
PR
Gene name |
APM2 (YHL019C) |
Protein name |
Adaptin medium chain homolog APM2 |
Names |
Adaptin-mu1-II |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YHL019C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38700
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38700-F1 | Predicted | AlphaFoldDB |
14 variants for P38700
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s08-69191 | 119 | I>V | No | SGRP | |
| s08-69085 | 154 | P>R | No | SGRP | |
| s08-69000 | 182 | K>N | No | SGRP | |
| s08-68983 | 188 | G>D | No | SGRP | |
| s08-68952 | 198 | K>N | No | SGRP | |
| s08-68902 | 215 | V>A | No | SGRP | |
| s08-68899 | 216 | E>G | No | SGRP | |
| s08-68851 | 232 | A>G | No | SGRP | |
| s08-68580 | 322 | R>S | No | SGRP | |
| s08-68505 | 347 | D>E | No | SGRP | |
| s08-68438 | 370 | I>V | No | SGRP | |
| s08-68281 | 422 | T>N | No | SGRP | |
| s08-68077 | 490 | S>T | No | SGRP | |
| s08-67849 | 566 | C>Y | No | SGRP |
No associated diseases with P38700
1 regional properties for P38700
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Clathrin/coatomer adaptor, adaptin-like, N-terminal | 40 - 621 | IPR002553 |
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| AP-1 adaptor complex | A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). |
| AP-2 adaptor complex | A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| clathrin adaptor activity | Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| clathrin-dependent endocytosis | An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| Golgi to vacuole transport | The directed movement of substances from the Golgi to the vacuole. |
| intracellular protein transport | The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. |
| vesicle targeting, trans-Golgi to endosome | The process in which vesicles are directed to specific destination membranes during transport from the trans-Golgi to the endosome. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q00776 | APM1 | AP-1 complex subunit mu-1-I | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q99186 | APM4 | AP-2 complex subunit mu | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q96CW1 | AP2M1 | AP-2 complex subunit mu | Homo sapiens (Human) | PR |
| Q8CDJ8 | Ston1 | Stonin-1 | Mus musculus (Mouse) | PR |
| P84091 | Ap2m1 | AP-2 complex subunit mu | Mus musculus (Mouse) | PR |
| P35603 | dpy-23 | AP-2 complex subunit mu | Caenorhabditis elegans | PR |
| O23140 | AP2M | AP-2 complex subunit mu | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSSLFILDE | NLEPLVSKNI | RALPNLSSVL | SSFKQCYHDG | SPPILSQNDW | FFIHLKRDFL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HFVSVIHTTD | KPNIDLMTIL | AFLEQFYHLL | QKYFEIEVLT | KNVILDNILL | VLELIDECID |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FGIVQVTDPS | IIKDYIRVKV | NVPRVTVDNE | EWSPGEESSS | SSGSDSDSEY | SNTNKRKDKK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KKRKKKKGTK | GKSVGKSKLK | SIMVNNKENR | GINVVETVKE | TLRNKNDTGK | EAANDELPND |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GNDLYINGDI | AKTIIMPISW | RTKGIHYAKN | EFFLDVIERV | QYLMDFEKGV | IRKNLIHGEI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VCRCYLSGMP | KLKISINKIL | NRDPQFMSNS | SFHQCVSLDS | INTIEKDEEK | NSDDDAGLQA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ATDAREIEFI | PPDGEFVLCQ | YELKRHVKDA | PMVRLKDFEI | KPKLKKFKIQ | IVTKIQTNFK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PTNSTSKLNV | RIPLTKVFQE | YKIDLSKQIR | FKANIGKVVF | NLSDDFLLWE | IQTMKGHREH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| STNKSSQYNS | DEDDPNTCAS | MVAEFPLFNQ | EEYDRLQEEM | KTSMNPPPLR | TGPRLEELYR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QVHDQQTSHV | TPRDKLVNID | FEIPYCTCSG | LKVEYLKVEE | PQLQYQSFPW | VRYKTVSDEE |
| YAYIV |