Q8CDJ8
PR
Gene name |
Ston1 (Salf, Sblf, Stn1) |
Protein name |
Stonin-1 |
Names |
Stoned B-like factor |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:77057 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CDJ8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CDJ8-F1 | Predicted | AlphaFoldDB |
41 variants for Q8CDJ8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs214057572 | 46 | T>I | No | EVA | |
| rs108842630 | 48 | R>L | No | EVA | |
| rs46180639 | 93 | G>S | No | EVA | |
| rs3389496816 | 110 | S>* | No | EVA | |
| rs225149678 | 132 | S>F | No | EVA | |
| rs107782158 | 142 | S>A | No | EVA | |
| rs3389395391 | 149 | T>A | No | EVA | |
| rs3389488236 | 152 | F>Y | No | EVA | |
| rs236778283 | 160 | R>Q | No | EVA | |
| rs3389480059 | 164 | E>Q | No | EVA | |
| rs248242685 | 174 | H>N | No | EVA | |
| rs3389477041 | 183 | K>E | No | EVA | |
| rs107735794 | 185 | E>D | No | EVA | |
| rs3389486075 | 194 | D>H | No | EVA | |
| rs246050130 | 212 | G>D | No | EVA | |
| rs223880787 | 222 | D>N | No | EVA | |
| rs3389443251 | 225 | C>W | No | EVA | |
| rs244012857 | 234 | A>E | No | EVA | |
| rs217797638 | 235 | E>K | No | EVA | |
| rs107601707 | 304 | Y>F | No | EVA | |
| rs217978086 | 321 | H>Y | No | EVA | |
| rs13472688 | 339 | H>Q | No | EVA | |
| rs230787302 | 356 | A>S | No | EVA | |
| rs13472687 | 359 | E>* | No | EVA | |
| rs108763712 | 377 | H>Y | No | EVA | |
| rs225357861 | 441 | C>G | No | EVA | |
| rs3389485650 | 470 | P>T | No | EVA | |
| rs3389486045 | 501 | P>S | No | EVA | |
| rs107872086 | 519 | G>D | No | EVA | |
| rs46780125 | 577 | L>F | No | EVA | |
| rs3389500466 | 592 | M>L | No | EVA | |
| rs3389488227 | 606 | S>T | No | EVA | |
| rs3389488243 | 656 | Q>* | No | EVA | |
| rs3407490456 | 657 | E>A | No | EVA | |
| rs3410870256 | 658 | V>I | No | EVA | |
| rs45672137 | 673 | L>F | No | EVA | |
| rs3389488306 | 695 | K>* | No | EVA | |
| rs3389500459 | 702 | C>R | No | EVA | |
| rs3389486076 | 711 | K>R | No | EVA | |
| rs232560379 | 721 | A>P | No | EVA | |
| rs3389488209 | 723 | K>* | No | EVA |
No associated diseases with Q8CDJ8
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell leading edge | The area of a motile cell closest to the direction of movement. |
| cell projection | A prolongation or process extending from a cell, e.g. a flagellum or axon. |
| clathrin-coated pit | A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. |
| clathrin-coated vesicle | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. |
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cargo adaptor activity | Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery. |
| clathrin adaptor activity | Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| focal adhesion assembly | The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. |
| focal adhesion disassembly | The disaggregation of a focal adhesion into its constituent components. A focal adhesion is a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also functions as a locus of signal transduction activity. |
| platelet-derived growth factor receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| regulation of endocytosis | Any process that modulates the frequency, rate or extent of endocytosis. |
| ruffle assembly | The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42. |
| substrate-dependent cell migration | The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. |
| synaptic vesicle endocytosis | A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. |
| vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P38700 | APM2 | Adaptin medium chain homolog APM2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q99186 | APM4 | AP-2 complex subunit mu | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9WVP1 | Ap1m2 | AP-1 complex subunit mu-2 | Mus musculus (Mouse) | PR |
| P35585 | Ap1m1 | AP-1 complex subunit mu-1 | Mus musculus (Mouse) | PR |
| P84091 | Ap2m1 | AP-2 complex subunit mu | Mus musculus (Mouse) | PR |
| O23140 | AP2M | AP-2 complex subunit mu | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MYSTNPGSWV | TFDDDPAFQS | SQKRKDFSLE | TQGVCRPNGL | KLTLPTLRDP | PSTPSSASST |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PLSSPMVDFY | FSPGPPSNSP | LSTPTKDFPG | FPGIPKAGTH | VLYPIPECSS | SSAPTTAGGV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GPPLLLTKPD | CSPHVSLPSS | HSHTQPTPTL | GFTEDAGPQR | VQSEARQFEY | FQDHCAFSNP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FWKDEGSASP | FPLDSLASRK | PFSPKDKEVP | IGHKSLTQCS | LDYICEKLEH | LHSAETQDPL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GDLSMQDPYA | GDTVSFVPHS | LFRSQPRAGW | SFMLRIPEKK | NMMSSRQWGP | IFLKVLPGGI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LQMYYEKGLE | KPFKEFQLDP | HCRLSEPKLE | NFSMAGKIHT | VKVEHVSYSE | KRKYHAKTEV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VHEPEVEQML | KLGSTEHRDF | LEFLTTVEEE | LIKLPATAKP | KNKSYEEQEI | CLDIQDSLWG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KVTKEGQLVE | SAVVTQICCL | CFLNGPAECF | LALNDRELQK | RDECYFEKEP | EKKGIAILDY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HFHTCVKAEE | FEQSRIIKFV | PLDACRFELM | RFKTSYEAGE | LPFAVKSVVT | VQGAYVELQA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FVNMTPAAQG | SPHAGALRSC | NNIMIHFPVP | AQWIKALWTR | NLQRQKSLKA | KMNRRACLGS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LQEPESEPVI | QVTVGSAKYE | SAYRAVVWKI | DRLPDKNSSP | DQPHCLSYKL | ELGSDQEVPS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DWYPFATVQF | SMLEACASRT | EVRSLGVESD | AQPQKHVCQR | ACYNIQVEIE | KKWIQVDGED |
| ADKTGGCVTQ |